EA201891968A1 - Комбинированное лечение с использованием liv1-adc и химиотерапевтического средства - Google Patents

Комбинированное лечение с использованием liv1-adc и химиотерапевтического средства

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Publication number
EA201891968A1
EA201891968A1 EA201891968A EA201891968A EA201891968A1 EA 201891968 A1 EA201891968 A1 EA 201891968A1 EA 201891968 A EA201891968 A EA 201891968A EA 201891968 A EA201891968 A EA 201891968A EA 201891968 A1 EA201891968 A1 EA 201891968A1
Authority
EA
Eurasian Patent Office
Prior art keywords
liv1
adc
combined treatment
chemotherapeutic means
chemotherapeutic
Prior art date
Application number
EA201891968A
Other languages
English (en)
Inventor
Джанго Сассман
Фу Ли
Ана Костик
Original Assignee
Сиэтл Дженетикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сиэтл Дженетикс, Инк. filed Critical Сиэтл Дженетикс, Инк.
Publication of EA201891968A1 publication Critical patent/EA201891968A1/ru

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к способам лечения пациента, страдающего злокачественным новообразованием или имеющего риск возникновения злокачественного новообразования, путем введения конъюгата анти-LIV1-антитело-лекарственное средство и химиотерапевтического средства.
EA201891968A 2016-03-15 2017-03-15 Комбинированное лечение с использованием liv1-adc и химиотерапевтического средства EA201891968A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662308639P 2016-03-15 2016-03-15
US201662317792P 2016-04-04 2016-04-04
US201662367510P 2016-07-27 2016-07-27
PCT/US2017/022541 WO2017161007A1 (en) 2016-03-15 2017-03-15 Combination therapy using a liv1-adc and a chemotherapeutic

Publications (1)

Publication Number Publication Date
EA201891968A1 true EA201891968A1 (ru) 2019-02-28

Family

ID=59852409

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891968A EA201891968A1 (ru) 2016-03-15 2017-03-15 Комбинированное лечение с использованием liv1-adc и химиотерапевтического средства

Country Status (14)

Country Link
US (2) US11325980B2 (ru)
EP (1) EP3429626A4 (ru)
JP (2) JP2019508433A (ru)
KR (3) KR20180121571A (ru)
CN (1) CN108697801A (ru)
AU (2) AU2017235545A1 (ru)
BR (1) BR112018068129A2 (ru)
CA (1) CA3016485A1 (ru)
EA (1) EA201891968A1 (ru)
IL (1) IL261505A (ru)
MA (1) MA45324A (ru)
MX (2) MX2018010847A (ru)
SG (2) SG11201807526SA (ru)
WO (1) WO2017161007A1 (ru)

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