BR112012017535A2 - uso de compostos de vanádio para cicatrização de osso - Google Patents

uso de compostos de vanádio para cicatrização de osso

Info

Publication number
BR112012017535A2
BR112012017535A2 BR112012017535A BR112012017535A BR112012017535A2 BR 112012017535 A2 BR112012017535 A2 BR 112012017535A2 BR 112012017535 A BR112012017535 A BR 112012017535A BR 112012017535 A BR112012017535 A BR 112012017535A BR 112012017535 A2 BR112012017535 A2 BR 112012017535A2
Authority
BR
Brazil
Prior art keywords
bone healing
vanadium compounds
vanadium
compounds
healing
Prior art date
Application number
BR112012017535A
Other languages
English (en)
Inventor
Of Medicine And Dentistry Of New Jersey University
Original Assignee
Of Medicine And Dentistry Of New Jersey University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Of Medicine And Dentistry Of New Jersey University filed Critical Of Medicine And Dentistry Of New Jersey University
Publication of BR112012017535A2 publication Critical patent/BR112012017535A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112012017535A 2010-01-15 2011-01-14 uso de compostos de vanádio para cicatrização de osso BR112012017535A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29523410P 2010-01-15 2010-01-15
PCT/US2011/021296 WO2011088318A1 (en) 2010-01-15 2011-01-14 Use of vanadium compounds to accelerate bone healing

Publications (1)

Publication Number Publication Date
BR112012017535A2 true BR112012017535A2 (pt) 2019-09-24

Family

ID=44304667

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012017535A BR112012017535A2 (pt) 2010-01-15 2011-01-14 uso de compostos de vanádio para cicatrização de osso

Country Status (7)

Country Link
US (2) US8936804B2 (pt)
EP (1) EP2523672B1 (pt)
JP (1) JP5878477B2 (pt)
KR (1) KR20120113265A (pt)
BR (1) BR112012017535A2 (pt)
CA (1) CA2787208C (pt)
WO (1) WO2011088318A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8936804B2 (en) 2010-01-15 2015-01-20 Rutgers, The State University Of New Jersey Use of vanadium compounds to accelerate bone healing
US20170035803A1 (en) * 2010-12-10 2017-02-09 Rutgers, The State University Of New Jersey Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion
WO2013006798A1 (en) 2011-07-06 2013-01-10 University Of Medicine And Dentistry Of New Jersey Vandium compounds as therapeutic adjuncts for cartilage regeneration and repair
EP2648718B1 (en) * 2010-12-10 2019-05-08 Rutgers, the State University of New Jersey Implantable devices coated with insulin-mimetic agent composites and methods thereof
US20140322292A1 (en) 2010-12-10 2014-10-30 Rutgers, The State University Of New Jersey Insulin-mimetics as therapeutic adjuncts for bone regeneration
JP6214548B2 (ja) * 2011-11-29 2017-10-18 ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー 骨再生のための治療補助薬としてのインスリン−疑似剤
AU2013334111A1 (en) * 2012-10-25 2015-05-28 Rutgers, The State University Of New Jersey Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion
WO2018089795A1 (en) 2016-11-10 2018-05-17 Qoravita LLC System and method for applying a low frequency magnetic field to biological tissues
GB2590692A (en) * 2019-12-24 2021-07-07 Corthotec Ltd Composition for improved bone fracture healing
CN113121118A (zh) * 2021-03-08 2021-07-16 四川大学 一种钒掺杂硅钙磷介孔生物活性玻璃粉

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2314573C2 (de) 1973-03-23 1986-12-18 Werner Dipl.-Ing. 8000 München Kraus Gerät zur Förderung von Heilungsprozessen
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US5019383A (en) 1981-01-09 1991-05-28 New York Blood Center, Inc. Fatty acid carriers for synthetic peptides
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4725442A (en) 1983-06-17 1988-02-16 Haynes Duncan H Microdroplets of water-insoluble drugs and injectable formulations containing same
US4622219A (en) 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
US4891225A (en) 1984-05-21 1990-01-02 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
IT1198449B (it) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US4834757A (en) 1987-01-22 1989-05-30 Brantigan John W Prosthetic implant
US5061286A (en) 1989-08-18 1991-10-29 Osteotech, Inc. Osteoprosthetic implant
JP2811331B2 (ja) * 1989-10-02 1998-10-15 ゼリア新薬工業株式会社 骨形成促進剤
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US6099457A (en) 1990-08-13 2000-08-08 Endotech, Inc. Endocurietherapy
JP3245202B2 (ja) * 1991-11-14 2002-01-07 松尾 壽之 新規骨形成誘導蛋白質及びそれを有効成分とする骨形成誘導剤
WO1994012158A1 (en) 1992-12-02 1994-06-09 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
CN1156255C (zh) 1993-10-01 2004-07-07 美商-艾克罗米德公司 脊椎植入物
US5871779A (en) 1994-01-18 1999-02-16 Mount Sinai Hospital Corporation Treatment of arthropathies with vanadate compounds or analogues thereof
JP3738281B2 (ja) * 1994-07-22 2006-01-25 アベンティス ファーマ株式会社 新規な骨芽細胞増殖因子
AU695323B2 (en) 1994-09-09 1998-08-13 Takeda Chemical Industries Ltd. Sustained release preparation containing metal salt of a peptide
US5614206A (en) 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
US5545661A (en) * 1995-05-16 1996-08-13 Eli Lilly And Company Methods for inhibiting bone loss with bis-pyrone oxovanadium compounds
PT831787E (pt) 1995-06-07 2002-02-28 Alkermes Inc Composicao para libertacao sustentada da hormona de crescimento humano
ZA965368B (en) 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
DE29600241U1 (de) 1996-01-09 1996-02-29 Gebo-Armaturen GmbH, 58332 Schwelm Lösbare Rohrverbindung für Kunststoffrohre
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
NL1006681C2 (nl) 1997-07-29 1999-02-08 Gho St Holding Bv Toepassing van fysiologisch acceptabele vanadiumverbindingen, -zouten en -complexen.
AU6184499A (en) * 1998-10-28 2000-05-15 University Of British Columbia, The Organic vanadium(iii) complexes and their use
CN100441688C (zh) 1999-04-30 2008-12-10 埃默里大学 Lim矿化蛋白剪接变体
US6630153B2 (en) 2001-02-23 2003-10-07 Smith & Nephew, Inc. Manufacture of bone graft substitutes
EP2085055B1 (en) 2000-10-24 2012-06-06 Warsaw Orthopedic, Inc. Spinal fusion devices
US6958359B1 (en) 2000-11-15 2005-10-25 Parker Hughes Institute Vanadium compounds as anti-angiogenic agents
WO2003105752A2 (en) 2002-05-02 2003-12-24 Osteoscreen, Inc. Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates (no-bisphosphonate)
US7291179B2 (en) 2002-06-24 2007-11-06 Wright Medical Technology, Inc. Bone graft substitute composition
DE10238161A1 (de) * 2002-08-15 2004-02-26 Köhler Pharma GmbH Mineralstoff-Ampulle für die mucosale und topische Wirkstoffapplikation
US20040121025A1 (en) * 2002-12-20 2004-06-24 Mckee Dwight Oral composition for the treatment and prevention of bone loss
CN100344334C (zh) 2002-12-31 2007-10-24 华中科技大学同济医学院附属协和医院 骨组织填充材料
MXPA05008653A (es) 2003-02-14 2006-04-27 Depuy Spine Inc Dispositivo de fusion intervertebral formado in situ.
US9199005B2 (en) 2003-10-01 2015-12-01 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
US7419680B2 (en) 2003-10-01 2008-09-02 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
US7208172B2 (en) 2003-11-03 2007-04-24 Medlogics Device Corporation Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices
US9016221B2 (en) 2004-02-17 2015-04-28 University Of Florida Research Foundation, Inc. Surface topographies for non-toxic bioadhesion control
US7189409B2 (en) 2004-03-09 2007-03-13 Inion Ltd. Bone grafting material, method and implant
EP1743021B1 (en) 2004-03-19 2014-03-26 Cytori Therapeutics, Inc. Method of preparing regenerative cells on a cell carrier and cell carrier containment device
EP1812090A1 (en) 2004-10-28 2007-08-01 Microchips, Inc. Orthopedic and dental implant devices providing controlled drug delivery
US20070027543A1 (en) 2005-08-01 2007-02-01 Gimble Jeffrey M Use of adipose tissue-derived stromal cells in spinal fusion
SG2014011944A (en) 2005-08-30 2014-08-28 Advanced Tech Materials Boron ion implantation using alternative fluorinated boron precursors, and formation of large boron hydrides for implantation
US20070073385A1 (en) 2005-09-20 2007-03-29 Cook Incorporated Eluting, implantable medical device
EP1991284A4 (en) 2006-02-01 2012-07-04 Jake Barralet BIOIMPLANTS FOR USE IN TISSUE GROWTH
WO2007098479A2 (en) * 2006-02-21 2007-08-30 University Of Medicine And Dentistry Of New Jersey Localized insulin delivery for bone healing
US9089437B2 (en) 2006-10-16 2015-07-28 Pioneer Surgical Technology, Inc. Fusion device, systems and methods thereof
WO2008048647A1 (en) 2006-10-17 2008-04-24 Cythera, Inc. Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
DE102007007865A1 (de) 2007-02-14 2008-08-21 Jennissen, Herbert, Prof. Dr. Verfahren zur Herstellung von lagerfähigen Implantaten mit einer ultrahydrophilen Oberfläche
EP2219823A2 (en) 2007-10-16 2010-08-25 HKPB Scientific Limited Surface coating processes and uses of same
CN101878324B (zh) 2007-10-19 2013-04-03 比奥因特费斯公司 新颖组合物和相关方法、涂料和物件
WO2009068285A1 (de) 2007-11-27 2009-06-04 Johnson Controls Gmbh Optische anordnung
CN102014975A (zh) * 2008-02-29 2011-04-13 史密夫和内修有限公司 用于生物医学应用的梯度涂层
JP2011513034A (ja) 2008-03-10 2011-04-28 マーフライ・２・リミテッド・パートナーシップ 骨セメント組成物
US20120141599A1 (en) 2009-04-01 2012-06-07 Difusion Technologies, Inc. Regulation Of Bone Growth Using Zeolite In Combination With Bone Graft Substitutes
US8936804B2 (en) 2010-01-15 2015-01-20 Rutgers, The State University Of New Jersey Use of vanadium compounds to accelerate bone healing
EP2648718B1 (en) * 2010-12-10 2019-05-08 Rutgers, the State University of New Jersey Implantable devices coated with insulin-mimetic agent composites and methods thereof
JP6214548B2 (ja) 2011-11-29 2017-10-18 ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー 骨再生のための治療補助薬としてのインスリン−疑似剤

Also Published As

Publication number Publication date
WO2011088318A1 (en) 2011-07-21
JP5878477B2 (ja) 2016-03-08
US20130171094A1 (en) 2013-07-04
US9730946B2 (en) 2017-08-15
EP2523672A1 (en) 2012-11-21
AU2011205741A1 (en) 2012-08-16
KR20120113265A (ko) 2012-10-12
EP2523672A4 (en) 2013-05-08
US20150099804A1 (en) 2015-04-09
CA2787208C (en) 2017-06-06
US8936804B2 (en) 2015-01-20
JP2013517287A (ja) 2013-05-16
CA2787208A1 (en) 2011-07-21
EP2523672B1 (en) 2016-07-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.