CN115697386A - 一种治疗帕金森病的方法和药物 - Google Patents
一种治疗帕金森病的方法和药物 Download PDFInfo
- Publication number
- CN115697386A CN115697386A CN202180023651.0A CN202180023651A CN115697386A CN 115697386 A CN115697386 A CN 115697386A CN 202180023651 A CN202180023651 A CN 202180023651A CN 115697386 A CN115697386 A CN 115697386A
- Authority
- CN
- China
- Prior art keywords
- plasminogen
- mice
- group
- plasmin
- parkinson
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
提供一种预防和治疗帕金森病的方法，包括给药受试者治疗有效量的纤维蛋白溶酶原激活途径组分；涉及用于治疗上述病症的包含纤维蛋白溶酶原激活途径组分的药物、药物组合物、制品、试剂盒。
Description
PCT国内申请，说明书已公开。
Claims (14)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010212922 | 2020-03-24 | ||
| CN2020102129224 | 2020-03-24 | ||
| PCT/CN2021/082715 WO2021190561A1 (zh) | 2020-03-24 | 2021-03-24 | 一种治疗帕金森病的方法和药物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115697386A true CN115697386A (zh) | 2023-02-03 |
Family
ID=77890662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180023651.0A Pending CN115697386A (zh) | 2020-03-24 | 2021-03-24 | 一种治疗帕金森病的方法和药物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230143354A1 (zh) |
| EP (1) | EP4122490A4 (zh) |
| JP (1) | JP2023518563A (zh) |
| KR (1) | KR20220158036A (zh) |
| CN (1) | CN115697386A (zh) |
| CA (1) | CA3176934A1 (zh) |
| TW (1) | TW202144000A (zh) |
| WO (1) | WO2021190561A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024094216A1 (zh) * | 2022-11-04 | 2024-05-10 | 泰伦基国际有限公司 | 一种促进泛素蛋白酶体系统和自噬溶酶体系统对病理性蛋白清除的方法和药物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| CN102416176A (zh) | 1995-07-27 | 2012-04-18 | 基因技术股份有限公司 | 稳定等渗的冻干蛋白质制剂 |
| EP1223969A2 (en) * | 1999-10-04 | 2002-07-24 | Fujisawa Pharmaceutical Co., Ltd. | Combined use of a plasminogen activator and il-2 inhibitors for neuroprotection |
| WO2006023530A2 (en) * | 2004-08-16 | 2006-03-02 | Massachusetts Institute Of Technology | Compositions and methods for enhancing structural and functional nervous system reorganization and recovery |
| PL2578212T3 (pl) * | 2010-05-24 | 2017-01-31 | Farmalider Sa | Związek hamujący aktywację enzymu Erk 1/2 do zastosowania w leczeniu chorób neurodegeneracyjnych |
| CN102154253A (zh) | 2011-01-06 | 2011-08-17 | 郑州大学 | 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途 |
| DE102011003944A1 (de) * | 2011-02-10 | 2012-08-16 | Oxprotect Gmbh | Detektion und Entfernung von missgefalteten Proteinen/Peptiden |
| WO2018107689A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗脂质肾损伤的方法 |
| JP7335609B2 (ja) * | 2017-06-19 | 2023-08-30 | タレンゲン インターナショナル リミテッド | Ｇｌｐ－１／ｇｌｐ－１ｒを調節制御する方法および薬剤 |
| CN109125715A (zh) * | 2017-06-19 | 2019-01-04 | 深圳瑞健生命科学研究院有限公司 | 一种调控glp-1/glp-1r的方法和药物 |
| TW201904990A (zh) * | 2017-06-23 | 2019-02-01 | 美商波麥堤克生物治療股份有限公司 | 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療 |
| CN109925507A (zh) * | 2017-12-15 | 2019-06-25 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗骨关节炎的方法和药物 |
| US20240000903A1 (en) * | 2020-11-17 | 2024-01-04 | Talengen International Limited | Method and drug for increasing bdnf level |
| KR20230107634A (ko) * | 2020-11-17 | 2023-07-17 | 탈렌젠 인터내셔널 리미티드 | Ngf 수준의 향상을 위한 방법 및 약물 |
-
2021
- 2021-03-24 JP JP2022557660A patent/JP2023518563A/ja active Pending
- 2021-03-24 US US17/914,267 patent/US20230143354A1/en active Pending
- 2021-03-24 EP EP21774984.5A patent/EP4122490A4/en active Pending
- 2021-03-24 TW TW110110713A patent/TW202144000A/zh unknown
- 2021-03-24 CA CA3176934A patent/CA3176934A1/en active Pending
- 2021-03-24 KR KR1020227036798A patent/KR20220158036A/ko unknown
- 2021-03-24 CN CN202180023651.0A patent/CN115697386A/zh active Pending
- 2021-03-24 WO PCT/CN2021/082715 patent/WO2021190561A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4122490A4 (en) | 2023-04-05 |
| TW202144000A (zh) | 2021-12-01 |
| JP2023518563A (ja) | 2023-05-02 |
| EP4122490A1 (en) | 2023-01-25 |
| US20230143354A1 (en) | 2023-05-11 |
| KR20220158036A (ko) | 2022-11-29 |
| CA3176934A1 (en) | 2021-09-30 |
| WO2021190561A1 (zh) | 2021-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |