CU20210080A7 - Triazinas sustituidas como inhibidores de proteína tirosina fosfatasa - Google Patents
Triazinas sustituidas como inhibidores de proteína tirosina fosfatasaInfo
- Publication number
- CU20210080A7 CU20210080A7 CU2021000080A CU20210080A CU20210080A7 CU 20210080 A7 CU20210080 A7 CU 20210080A7 CU 2021000080 A CU2021000080 A CU 2021000080A CU 20210080 A CU20210080 A CU 20210080A CU 20210080 A7 CU20210080 A7 CU 20210080A7
- Authority
- CU
- Cuba
- Prior art keywords
- protein tyrosine
- tyrosine phosphatase
- phosphatase inhibitors
- substituted triazines
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
<p>La presente invención se refiere a compuestos de la Fórmula I</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>útiles para tratar enfermedades hiperproliferativas y neoplásicas. Se refiere también a composiciones farmacéuticas que los comprenden.</p>
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962828356P | 2019-04-02 | 2019-04-02 | |
US202062992558P | 2020-03-20 | 2020-03-20 | |
PCT/IB2020/053019 WO2020201991A1 (en) | 2019-04-02 | 2020-03-30 | Protein tyrosine phosphatase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20210080A7 true CU20210080A7 (es) | 2022-05-11 |
Family
ID=70277430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2021000080A CU20210080A7 (es) | 2019-04-02 | 2020-03-30 | Triazinas sustituidas como inhibidores de proteína tirosina fosfatasa |
Country Status (24)
Country | Link |
---|---|
US (3) | US11634417B2 (es) |
EP (1) | EP3947367A1 (es) |
JP (2) | JP7284830B2 (es) |
KR (1) | KR20210146389A (es) |
CN (1) | CN113874363A (es) |
AU (1) | AU2020251841A1 (es) |
BR (1) | BR112021018664A2 (es) |
CA (1) | CA3135555C (es) |
CL (1) | CL2021002542A1 (es) |
CO (1) | CO2021013030A2 (es) |
CR (1) | CR20210501A (es) |
CU (1) | CU20210080A7 (es) |
DO (1) | DOP2021000206A (es) |
EC (1) | ECSP21072994A (es) |
GE (1) | GEP20237561B (es) |
IL (1) | IL286462A (es) |
MA (1) | MA55511A (es) |
MX (1) | MX2021012122A (es) |
PE (1) | PE20220141A1 (es) |
SG (1) | SG11202110502PA (es) |
TW (1) | TWI766261B (es) |
UY (1) | UY38628A (es) |
WO (1) | WO2020201991A1 (es) |
ZA (1) | ZA202108443B (es) |
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WO2020072656A1 (en) | 2018-10-03 | 2020-04-09 | Gilead Sciences, Inc. | Imidozopyrimidine derivatives |
WO2021257736A1 (en) | 2020-06-18 | 2021-12-23 | Revolution Medicines, Inc. | Methods for delaying, preventing, and treating acquired resistance to ras inhibitors |
IL301062A (en) | 2020-09-03 | 2023-05-01 | Revolution Medicines Inc | Use of SOS1 inhibitors to treat malignancies with SHP2 mutations |
US11690915B2 (en) | 2020-09-15 | 2023-07-04 | Revolution Medicines, Inc. | Ras inhibitors |
WO2022206684A1 (zh) * | 2021-03-31 | 2022-10-06 | 南京明德新药研发有限公司 | 一系列含Se的吡嗪类化合物及其应用 |
TWI825637B (zh) | 2021-03-31 | 2023-12-11 | 美商輝瑞股份有限公司 | 啶-1,6(2h,7h)-二酮 |
JP2024513798A (ja) | 2021-04-01 | 2024-03-27 | アレイ バイオファーマ インコーポレイテッド | Shp2阻害剤の結晶形態 |
CN117500811A (zh) | 2021-05-05 | 2024-02-02 | 锐新医药公司 | 共价ras抑制剂及其用途 |
JP2024517847A (ja) | 2021-05-05 | 2024-04-23 | レボリューション メディシンズ インコーポレイテッド | Ras阻害剤 |
WO2022235870A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
CN115960109A (zh) * | 2021-05-31 | 2023-04-14 | 药雅科技(上海)有限公司 | 稠环类shp2磷酸酶抑制剂的制备及其应用 |
TW202244049A (zh) * | 2021-05-12 | 2022-11-16 | 大陸商藥雅科技(上海)有限公司 | Shp2磷酸酶抑制劑的製備及其應用 |
CA3226206A1 (en) | 2021-07-09 | 2023-01-12 | Kanaph Therapeutics Inc. | Shp2 inhibitor and use thereof |
AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
WO2023061263A1 (zh) * | 2021-10-14 | 2023-04-20 | 北京泰德制药股份有限公司 | Shp2抑制剂、包含其的药物组合物及其用途 |
WO2023172940A1 (en) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Methods for treating immune refractory lung cancer |
WO2023180898A1 (en) | 2022-03-23 | 2023-09-28 | Array Biopharma Inc. | Crystalline salt form of a shp2 inhibitor |
WO2023240263A1 (en) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
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KR20210019607A (ko) | 2016-06-07 | 2021-02-22 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
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2020
- 2020-03-30 JP JP2021558566A patent/JP7284830B2/ja active Active
- 2020-03-30 MX MX2021012122A patent/MX2021012122A/es unknown
- 2020-03-30 WO PCT/IB2020/053019 patent/WO2020201991A1/en unknown
- 2020-03-30 CA CA3135555A patent/CA3135555C/en active Active
- 2020-03-30 AU AU2020251841A patent/AU2020251841A1/en active Pending
- 2020-03-30 GE GEAP202015746A patent/GEP20237561B/en unknown
- 2020-03-30 KR KR1020217035641A patent/KR20210146389A/ko not_active Application Discontinuation
- 2020-03-30 EP EP20718387.2A patent/EP3947367A1/en active Pending
- 2020-03-30 SG SG11202110502PA patent/SG11202110502PA/en unknown
- 2020-03-30 CN CN202080036271.6A patent/CN113874363A/zh active Pending
- 2020-03-30 CU CU2021000080A patent/CU20210080A7/es unknown
- 2020-03-30 PE PE2021001646A patent/PE20220141A1/es unknown
- 2020-03-30 MA MA055511A patent/MA55511A/fr unknown
- 2020-03-30 BR BR112021018664A patent/BR112021018664A2/pt unknown
- 2020-03-30 CR CR20210501A patent/CR20210501A/es unknown
- 2020-03-31 US US16/835,702 patent/US11634417B2/en active Active
- 2020-04-01 UY UY0001038628A patent/UY38628A/es unknown
- 2020-04-01 TW TW109111284A patent/TWI766261B/zh active
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2021
- 2021-09-19 IL IL286462A patent/IL286462A/en unknown
- 2021-09-29 CO CONC2021/0013030A patent/CO2021013030A2/es unknown
- 2021-09-30 EC ECSENADI202172994A patent/ECSP21072994A/es unknown
- 2021-09-30 DO DO2021000206A patent/DOP2021000206A/es unknown
- 2021-09-30 CL CL2021002542A patent/CL2021002542A1/es unknown
- 2021-10-29 ZA ZA2021/08443A patent/ZA202108443B/en unknown
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2022
- 2022-04-13 US US17/720,070 patent/US11884664B2/en active Active
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2023
- 2023-03-27 JP JP2023049681A patent/JP2023078421A/ja active Pending
- 2023-11-17 US US18/512,473 patent/US20240124453A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220251083A1 (en) | 2022-08-11 |
UY38628A (es) | 2020-10-30 |
EP3947367A1 (en) | 2022-02-09 |
WO2020201991A1 (en) | 2020-10-08 |
BR112021018664A2 (pt) | 2021-11-23 |
CO2021013030A2 (es) | 2021-10-20 |
JP2023078421A (ja) | 2023-06-06 |
AU2020251841A1 (en) | 2021-10-07 |
SG11202110502PA (en) | 2021-10-28 |
MX2021012122A (es) | 2021-11-03 |
CN113874363A (zh) | 2021-12-31 |
ZA202108443B (en) | 2023-04-26 |
TWI766261B (zh) | 2022-06-01 |
GEP20237561B (en) | 2023-10-25 |
IL286462A (en) | 2021-10-31 |
US11634417B2 (en) | 2023-04-25 |
US11884664B2 (en) | 2024-01-30 |
JP2022527796A (ja) | 2022-06-06 |
JP7284830B2 (ja) | 2023-05-31 |
CL2021002542A1 (es) | 2022-06-24 |
TW202102490A (zh) | 2021-01-16 |
PE20220141A1 (es) | 2022-01-27 |
CR20210501A (es) | 2021-11-02 |
MA55511A (fr) | 2022-02-09 |
US20200317665A1 (en) | 2020-10-08 |
ECSP21072994A (es) | 2021-11-18 |
DOP2021000206A (es) | 2021-11-21 |
KR20210146389A (ko) | 2021-12-03 |
CA3135555A1 (en) | 2020-10-08 |
CA3135555C (en) | 2023-09-19 |
US20240124453A1 (en) | 2024-04-18 |
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