MA55511A - Inhibiteurs de protéine tyrosine phosphatase - Google Patents
Inhibiteurs de protéine tyrosine phosphataseInfo
- Publication number
- MA55511A MA55511A MA055511A MA55511A MA55511A MA 55511 A MA55511 A MA 55511A MA 055511 A MA055511 A MA 055511A MA 55511 A MA55511 A MA 55511A MA 55511 A MA55511 A MA 55511A
- Authority
- MA
- Morocco
- Prior art keywords
- protein tyrosine
- tyrosine phosphatase
- phosphatase inhibitors
- inhibitors
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962828356P | 2019-04-02 | 2019-04-02 | |
| US202062992558P | 2020-03-20 | 2020-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA55511A true MA55511A (fr) | 2022-02-09 |
Family
ID=70277430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA055511A MA55511A (fr) | 2019-04-02 | 2020-03-30 | Inhibiteurs de protéine tyrosine phosphatase |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US11634417B2 (fr) |
| EP (1) | EP3947367A1 (fr) |
| JP (2) | JP7284830B2 (fr) |
| KR (1) | KR20210146389A (fr) |
| CN (1) | CN113874363A (fr) |
| AU (1) | AU2020251841A1 (fr) |
| BR (1) | BR112021018664A2 (fr) |
| CA (1) | CA3135555C (fr) |
| CL (1) | CL2021002542A1 (fr) |
| CO (1) | CO2021013030A2 (fr) |
| CR (1) | CR20210501A (fr) |
| CU (1) | CU20210080A7 (fr) |
| DO (1) | DOP2021000206A (fr) |
| EC (1) | ECSP21072994A (fr) |
| GE (1) | GEP20237561B (fr) |
| IL (1) | IL286462A (fr) |
| MA (1) | MA55511A (fr) |
| MX (1) | MX2021012122A (fr) |
| PE (1) | PE20220141A1 (fr) |
| SG (1) | SG11202110502PA (fr) |
| TW (1) | TWI766261B (fr) |
| UY (1) | UY38628A (fr) |
| WO (1) | WO2020201991A1 (fr) |
| ZA (1) | ZA202108443B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11179397B2 (en) | 2018-10-03 | 2021-11-23 | Gilead Sciences, Inc. | Imidazopyrimidine derivatives |
| CN115916194A (zh) | 2020-06-18 | 2023-04-04 | 锐新医药公司 | 用于延迟、预防和治疗针对ras抑制剂的获得性抗性的方法 |
| EP4208261A1 (fr) | 2020-09-03 | 2023-07-12 | Revolution Medicines, Inc. | Utilisation d'inhibiteurs de sos1 pour traiter des malignités à mutations de shp2 |
| PE20231207A1 (es) | 2020-09-15 | 2023-08-17 | Revolution Medicines Inc | Derivados indolicos como inhibidores de ras en el tratamiento del cancer |
| CN117083285A (zh) * | 2021-03-31 | 2023-11-17 | 南京明德新药研发有限公司 | 一系列含Se的吡嗪类化合物及其应用 |
| TWI825637B (zh) | 2021-03-31 | 2023-12-11 | 美商輝瑞股份有限公司 | 啶－１，６（２ｈ，７ｈ）－二酮 |
| KR20230165309A (ko) | 2021-04-01 | 2023-12-05 | 어레이 바이오파마 인크. | Shp2 억제제의 결정질 형태 |
| IL308195A (en) | 2021-05-05 | 2024-01-01 | Revolution Medicines Inc | RAS inhibitors for cancer treatment |
| KR20240004960A (ko) | 2021-05-05 | 2024-01-11 | 레볼루션 메디슨즈, 인크. | Ras 억제제 |
| JP2024516450A (ja) | 2021-05-05 | 2024-04-15 | レボリューション メディシンズ インコーポレイテッド | 共有結合性ｒａｓ阻害剤及びその使用 |
| TW202244049A (zh) * | 2021-05-12 | 2022-11-16 | 大陸商藥雅科技（上海）有限公司 | Shp2磷酸酶抑制劑的製備及其應用 |
| CN115960109A (zh) * | 2021-05-31 | 2023-04-14 | 药雅科技(上海)有限公司 | 稠环类shp2磷酸酶抑制剂的制备及其应用 |
| AU2022309195A1 (en) | 2021-07-09 | 2024-01-25 | Kanaph Therapeutics Inc. | Shp2 inhibitor and use thereof |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| WO2023061263A1 (fr) * | 2021-10-14 | 2023-04-20 | 北京泰德制药股份有限公司 | Inhibiteur de shp2, composition pharmaceutique le comprenant et son utilisation |
| WO2023172940A1 (fr) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Méthodes de traitement du cancer du poumon réfractaire immunitaire |
| WO2023180898A1 (fr) | 2022-03-23 | 2023-09-28 | Array Biopharma Inc. | Forme de sel cristallin d'un inhibiteur de shp2 |
| WO2023240263A1 (fr) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Inhibiteurs de ras macrocycliques |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| US7834178B2 (en) | 2006-03-01 | 2010-11-16 | Bristol-Myers Squibb Company | Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors |
| US10280171B2 (en) | 2016-05-31 | 2019-05-07 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| SG11201401460PA (en) | 2011-10-14 | 2014-09-26 | Array Biopharma Inc | POLYMORPHS OF ARRY-380, A SELECTIVE ErbB2 (HER2) INHIBITOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| BR112015004548A2 (pt) | 2012-08-27 | 2017-08-08 | Array Biopharma Inc | inibidores de serina/treonina para tratamento de doenças hiperproliferativas |
| US9403831B2 (en) | 2013-09-30 | 2016-08-02 | Korea Research Institute Of Chemical Technology | Triazolopyrazine derivative and use thereof |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| JP6473457B2 (ja) * | 2014-01-17 | 2019-02-20 | ノバルティス アーゲー | Ｓｈｐ２の活性を阻害するための１−（トリアジン−３−イル／ピリダジン−３−イル）−ピペリジン／ピペラジン誘導体およびその組成物 |
| US10093646B2 (en) | 2014-01-17 | 2018-10-09 | Novartis Ag | 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2 |
| WO2016203405A1 (fr) | 2015-06-19 | 2016-12-22 | Novartis Ag | Composés et compositions pour inhiber l'activité de shp2 |
| CN112625028A (zh) | 2015-06-19 | 2021-04-09 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物 |
| EP3310779B1 (fr) | 2015-06-19 | 2019-05-08 | Novartis AG | Composés et compositions pour l'inhibition de l'activité de shp2 |
| EP4108659A1 (fr) | 2016-06-07 | 2022-12-28 | Jacobio Pharmaceuticals Co., Ltd. | Nouveaux dérivés hétérocycliques utiles en tant qu'inhibiteurs shp2 |
| EA036446B1 (ru) | 2016-06-14 | 2020-11-11 | Новартис Аг | Соединения и композиции для подавления активности shp2 |
| CN116478132A (zh) | 2016-07-12 | 2023-07-25 | 锐新医药公司 | 作为变构shp2抑制剂的2,5-双取代型及2,5,6-三取代型3-甲基吡嗪 |
| EP3515916B1 (fr) | 2016-09-22 | 2023-06-07 | Relay Therapeutics, Inc. | Inhibiteurs de phosphatase shp2 et leurs procédés d'utilisation |
| TW201819386A (zh) | 2016-10-24 | 2018-06-01 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
| MX2019008695A (es) | 2017-01-23 | 2019-09-11 | Revolution Medicines Inc | Compuestos biciclicos como inhibidores alostericos de shp2. |
| MX2019008696A (es) | 2017-01-23 | 2019-09-13 | Revolution Medicines Inc | Compuestos de piridina como inhibidores de shp2 alostericos. |
| AU2018239542C1 (en) * | 2017-03-23 | 2021-02-11 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as SHP2 inhibitors |
| US11591336B2 (en) | 2017-05-26 | 2023-02-28 | D. E. Shaw Research, Llc | Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors |
| CA3074690A1 (fr) | 2017-09-07 | 2019-03-14 | Revolution Medicines, Inc. | Compositions d'inhibiteur de la shp2 et methodes de traitement du cancer |
| EP3681879A1 (fr) | 2017-09-11 | 2020-07-22 | Krouzon Pharmaceuticals, Inc. | Inhibiteurs allostériques octahydrocyclopenta[c]pyrrole de shp2 |
| US11701354B2 (en) | 2017-09-29 | 2023-07-18 | D. E. Shaw Research, Llc | Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors |
| EP3694848A1 (fr) | 2017-10-12 | 2020-08-19 | Revolution Medicines, Inc. | Pyridine, pyrazine et composés de triazine utilisés en tant qu'inhibiteurs allostériques de shp2 |
| EP3724189B1 (fr) | 2017-12-15 | 2023-10-04 | Revolution Medicines, Inc. | Composés polycycliques comme inhibiteurs allosteriques de la shp2 |
| WO2019152454A1 (fr) | 2018-01-30 | 2019-08-08 | Research Development Foundation | Inhibiteurs de shp2 et méthodes d'utilisation associées |
| WO2019183364A1 (fr) | 2018-03-21 | 2019-09-26 | Relay Therapeutics, Inc. | Inhibiteurs de la phosphatase pyrazolo[3,4-b]pyrazine shp2 et leurs procédés d'utilisation |
| US10561655B2 (en) | 2018-03-21 | 2020-02-18 | Synblia Therapeutics, Inc. | SHP2 inhibitors and uses thereof |
| EP3768668A1 (fr) | 2018-03-21 | 2021-01-27 | Relay Therapeutics, Inc. | Inhibiteurs de la phosphatase shp2 et leurs procédés d'utilisation |
| SG11202100199UA (en) | 2018-08-10 | 2021-02-25 | Navire Pharma Inc | 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one derivatives and related compounds as ptpn11 (shp2) inhibitors for treating cancer |
| CN112839935A (zh) * | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| PE20211465A1 (es) | 2018-10-17 | 2021-08-05 | Array Biopharma Inc | Inhibidores de la proteina tirosina fosfatasa |
-
2020
- 2020-03-30 CA CA3135555A patent/CA3135555C/fr active Active
- 2020-03-30 MX MX2021012122A patent/MX2021012122A/es unknown
- 2020-03-30 PE PE2021001646A patent/PE20220141A1/es unknown
- 2020-03-30 WO PCT/IB2020/053019 patent/WO2020201991A1/fr unknown
- 2020-03-30 CR CR20210501A patent/CR20210501A/es unknown
- 2020-03-30 CU CU2021000080A patent/CU20210080A7/es unknown
- 2020-03-30 KR KR1020217035641A patent/KR20210146389A/ko not_active Application Discontinuation
- 2020-03-30 CN CN202080036271.6A patent/CN113874363A/zh active Pending
- 2020-03-30 EP EP20718387.2A patent/EP3947367A1/fr active Pending
- 2020-03-30 BR BR112021018664A patent/BR112021018664A2/pt unknown
- 2020-03-30 SG SG11202110502PA patent/SG11202110502PA/en unknown
- 2020-03-30 JP JP2021558566A patent/JP7284830B2/ja active Active
- 2020-03-30 MA MA055511A patent/MA55511A/fr unknown
- 2020-03-30 AU AU2020251841A patent/AU2020251841A1/en active Pending
- 2020-03-30 GE GEAP202015746A patent/GEP20237561B/en unknown
- 2020-03-31 US US16/835,702 patent/US11634417B2/en active Active
- 2020-04-01 UY UY0001038628A patent/UY38628A/es unknown
- 2020-04-01 TW TW109111284A patent/TWI766261B/zh active
-
2021
- 2021-09-19 IL IL286462A patent/IL286462A/en unknown
- 2021-09-29 CO CONC2021/0013030A patent/CO2021013030A2/es unknown
- 2021-09-30 EC ECSENADI202172994A patent/ECSP21072994A/es unknown
- 2021-09-30 DO DO2021000206A patent/DOP2021000206A/es unknown
- 2021-09-30 CL CL2021002542A patent/CL2021002542A1/es unknown
- 2021-10-29 ZA ZA2021/08443A patent/ZA202108443B/en unknown
-
2022
- 2022-04-13 US US17/720,070 patent/US11884664B2/en active Active
-
2023
- 2023-03-27 JP JP2023049681A patent/JP2023078421A/ja active Pending
- 2023-11-17 US US18/512,473 patent/US20240124453A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW202102490A (zh) | 2021-01-16 |
| DOP2021000206A (es) | 2021-11-21 |
| CA3135555C (fr) | 2023-09-19 |
| US20200317665A1 (en) | 2020-10-08 |
| PE20220141A1 (es) | 2022-01-27 |
| CR20210501A (es) | 2021-11-02 |
| CN113874363A (zh) | 2021-12-31 |
| SG11202110502PA (en) | 2021-10-28 |
| IL286462A (en) | 2021-10-31 |
| ZA202108443B (en) | 2023-04-26 |
| CL2021002542A1 (es) | 2022-06-24 |
| TWI766261B (zh) | 2022-06-01 |
| KR20210146389A (ko) | 2021-12-03 |
| MX2021012122A (es) | 2021-11-03 |
| CU20210080A7 (es) | 2022-05-11 |
| CA3135555A1 (fr) | 2020-10-08 |
| US11884664B2 (en) | 2024-01-30 |
| AU2020251841A1 (en) | 2021-10-07 |
| CO2021013030A2 (es) | 2021-10-20 |
| JP2022527796A (ja) | 2022-06-06 |
| US20220251083A1 (en) | 2022-08-11 |
| JP7284830B2 (ja) | 2023-05-31 |
| ECSP21072994A (es) | 2021-11-18 |
| US20240124453A1 (en) | 2024-04-18 |
| US11634417B2 (en) | 2023-04-25 |
| GEP20237561B (en) | 2023-10-25 |
| JP2023078421A (ja) | 2023-06-06 |
| EP3947367A1 (fr) | 2022-02-09 |
| WO2020201991A1 (fr) | 2020-10-08 |
| BR112021018664A2 (pt) | 2021-11-23 |
| UY38628A (es) | 2020-10-30 |
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| MA54550A (fr) | Inhibiteurs de kif18a | |
| DK3844147T3 (da) | Forbindelser | |
| IL286373A (en) | Protein tyrosine phosphatase inhibitor compounds and uses thereof | |
| MA52413A (fr) | Inhibiteurs de cd73 | |
| MA51616A (fr) | Inhibiteurs d'adn-pk | |
| MA52812A (fr) | Inhibiteurs de sarm1 | |
| MA49908A (fr) | Composés inhibant la protéine mcl-1 | |
| MA53287A (fr) | Inhibiteurs de prmt5 | |
| MA52635A (fr) | Inhibiteurs de magl | |
| CL2021000426A1 (es) | Inhibidores de la interacción proteína-proteína keap1-nrf2. | |
| MA55909A (fr) | Inhibiteurs de cdk | |
| MA52629A (fr) | Agents inhibiteurs de la tyrosine kinase de bruton | |
| MA50675A (fr) | Inhibiteurs de la creb binding protein (cbp) | |
| MA55477A (fr) | Inhibiteurs de hpk1 | |
| MA51611A (fr) | Inhibiteurs de pi4kiiibêta | |
| DK3591122T3 (da) | Hurtigskifter | |
| MA52809A (fr) | Inhibiteurs de sarm1 | |
| MA52813A (fr) | Inhibiteurs de sarm1 | |
| DK3797662T3 (da) | Vippedyvel | |
| TH191170S (th) | เสื้อสูบสำหรับเครื่องยนต์ | |
| AR128365A1 (es) | Inhibidores de parp7 | |
| UA41551S (uk) | Пательня |