MA55477A - Inhibiteurs de hpk1 - Google Patents
Inhibiteurs de hpk1Info
- Publication number
- MA55477A MA55477A MA055477A MA55477A MA55477A MA 55477 A MA55477 A MA 55477A MA 055477 A MA055477 A MA 055477A MA 55477 A MA55477 A MA 55477A MA 55477 A MA55477 A MA 55477A
- Authority
- MA
- Morocco
- Prior art keywords
- hpk1 inhibitors
- hpk1
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962823708P | 2019-03-26 | 2019-03-26 | |
| EP19167820 | 2019-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA55477A true MA55477A (fr) | 2022-02-09 |
Family
ID=69845447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA055477A MA55477A (fr) | 2019-03-26 | 2020-03-24 | Inhibiteurs de hpk1 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220177458A1 (fr) |
| EP (1) | EP3947366A1 (fr) |
| AU (1) | AU2020249409A1 (fr) |
| CA (1) | CA3129768A1 (fr) |
| MA (1) | MA55477A (fr) |
| TW (1) | TW202102488A (fr) |
| WO (1) | WO2020193511A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019372046B2 (en) | 2018-10-31 | 2022-05-26 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds as HPK1 inhibitors |
| EP3873608A1 (fr) | 2018-10-31 | 2021-09-08 | Gilead Sciences, Inc. | Composés 6-azabenzimidazole substitués ayant une activité inhibitrice de hpk1 |
| US11453681B2 (en) | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
| WO2022184152A1 (fr) * | 2021-03-03 | 2022-09-09 | 劲方医药科技(上海)有限公司 | Composé hétérocyclique à six chaînons substitué par un cycle condensé, son procédé de préparation et son utilisation |
| EP4373817A1 (fr) | 2021-07-20 | 2024-05-29 | Astrazeneca AB | Pyrazine-2-carboxamides substituées utilisées en tant qu'inhibiteurs de hpk1 pour le traitement du cancer |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115653B2 (en) * | 2000-03-30 | 2006-10-03 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
| US20160158360A1 (en) | 2014-12-05 | 2016-06-09 | Genentech, Inc. | Methods and compositions for treating cancer using pd-1 axis antagonists and hpk1 antagonists |
| SG10202105964RA (en) | 2015-06-25 | 2021-07-29 | Univ Health Network | Hpk1 inhibitors and methods of using same |
| AR109595A1 (es) | 2016-09-09 | 2018-12-26 | Incyte Corp | Compuestos de pirazolopirimidina y usos de estos como inhibidores de hpk1 |
| WO2018049214A1 (fr) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Dérivés de pyrazolopyridine comme modulateurs de hpk1 et leurs utilisations pour le traitement du cancer |
| WO2018049191A1 (fr) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Dérivés de pyrazolopyridone en tant que modulateurs de hpk1 et leurs utilisations pour le traitement du cancer |
| ES2927104T3 (es) | 2016-09-09 | 2022-11-02 | Incyte Corp | Derivados de pirazolopiridina como moduladores de HPK1 y usos de los mismos para el tratamiento del cáncer |
| WO2018081531A2 (fr) | 2016-10-28 | 2018-05-03 | Ariad Pharmaceuticals, Inc. | Méthodess d'activation de lymphocytes t humains |
| WO2018102366A1 (fr) | 2016-11-30 | 2018-06-07 | Ariad Pharmaceuticals, Inc. | Anilinopyrimidines en tant qu'inhibiteurs de kinase 1 progénitrices hématopoïétiques (hpk1) |
| EP3596075B1 (fr) | 2017-03-15 | 2023-10-11 | F. Hoffmann-La Roche AG | Azaindoles utilisés en tant qu'inhibiteurs de hpk1 |
| PE20200008A1 (es) | 2017-03-30 | 2020-01-06 | Hoffmann La Roche | Isoquinolinas como inhibidores de hpk1 |
| TW201904964A (zh) | 2017-03-30 | 2019-02-01 | 瑞士商赫孚孟拉羅股份公司 | 作為ｈｐｋ1之抑制劑的啶 |
| WO2018215668A1 (fr) | 2017-05-26 | 2018-11-29 | Glenmark Pharmaceuticals S.A. | Nouveaux inhibiteurs de map4k1 |
| CA3066859A1 (fr) | 2017-06-13 | 2018-12-20 | Bayer Pharma Aktiengesellschaft | Derives de pyrrolopyridine substitues |
| EP3638671A1 (fr) | 2017-06-13 | 2020-04-22 | Bayer Pharma Aktiengesellschaft | Dérivés de pyrrolopyridine substitués |
| EP3638670B1 (fr) | 2017-06-13 | 2021-07-21 | Bayer Pharma Aktiengesellschaft | Dérivés de pyrrolopyridine substitués utilisés en tant que modulateurs de map4k1 pour le traitement de maladies cancéreuses |
| WO2019051199A1 (fr) | 2017-09-08 | 2019-03-14 | Incyte Corporation | Composés de 6-cyano-indazole utilisés en tant que modulateurs de kinase 1 progénitrices hématopoïétiques (hpk1) |
-
2020
- 2020-03-24 US US17/442,650 patent/US20220177458A1/en active Pending
- 2020-03-24 CA CA3129768A patent/CA3129768A1/fr active Pending
- 2020-03-24 WO PCT/EP2020/058081 patent/WO2020193511A1/fr unknown
- 2020-03-24 EP EP20711972.8A patent/EP3947366A1/fr active Pending
- 2020-03-24 AU AU2020249409A patent/AU2020249409A1/en active Pending
- 2020-03-24 TW TW109109735A patent/TW202102488A/zh unknown
- 2020-03-24 MA MA055477A patent/MA55477A/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3129768A1 (fr) | 2020-10-01 |
| AU2020249409A1 (en) | 2021-09-30 |
| EP3947366A1 (fr) | 2022-02-09 |
| WO2020193511A1 (fr) | 2020-10-01 |
| TW202102488A (zh) | 2021-01-16 |
| US20220177458A1 (en) | 2022-06-09 |
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