MA55478A - Inhibiteurs bicycliques de hpk1 - Google Patents

Inhibiteurs bicycliques de hpk1

Info

Publication number
MA55478A
MA55478A MA055478A MA55478A MA55478A MA 55478 A MA55478 A MA 55478A MA 055478 A MA055478 A MA 055478A MA 55478 A MA55478 A MA 55478A MA 55478 A MA55478 A MA 55478A
Authority
MA
Morocco
Prior art keywords
bicyclic
hpk1 inhibitors
hpk1
inhibitors
bicyclic hpk1
Prior art date
Application number
MA055478A
Other languages
English (en)
Inventor
Christophe Denis Pascal Adelinet
Sophie Coupa
James Patrick Edwards
Laurence Anne Mevellec
Jorge Eduardo Vialard
Berthold Wroblowski
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA55478A publication Critical patent/MA55478A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
MA055478A 2019-03-26 2020-03-24 Inhibiteurs bicycliques de hpk1 MA55478A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962823712P 2019-03-26 2019-03-26
EP19167828 2019-04-08

Publications (1)

Publication Number Publication Date
MA55478A true MA55478A (fr) 2022-02-09

Family

ID=69845448

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055478A MA55478A (fr) 2019-03-26 2020-03-24 Inhibiteurs bicycliques de hpk1

Country Status (7)

Country Link
US (1) US20220169644A1 (fr)
EP (1) EP3947373A1 (fr)
AU (1) AU2020249397A1 (fr)
CA (1) CA3129772A1 (fr)
MA (1) MA55478A (fr)
TW (1) TW202102500A (fr)
WO (1) WO2020193512A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3873608A1 (fr) 2018-10-31 2021-09-08 Gilead Sciences, Inc. Composés 6-azabenzimidazole substitués ayant une activité inhibitrice de hpk1
CA3117556A1 (fr) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Composes de 6-azabenzimidazole substitues en tant qu'inhibiteurs de hpk1
TWI826690B (zh) 2019-05-23 2023-12-21 美商基利科學股份有限公司 經取代之烯吲哚酮化物及其用途
WO2022184152A1 (fr) * 2021-03-03 2022-09-09 劲方医药科技(上海)有限公司 Composé hétérocyclique à six chaînons substitué par un cycle condensé, son procédé de préparation et son utilisation
EP4353721A1 (fr) * 2021-05-11 2024-04-17 Evopoint Biosciences Co., Ltd. Composé hétérocyclique contenant de l'azote
TW202321239A (zh) 2021-07-20 2023-06-01 瑞典商阿斯特捷利康公司 作為ｈｐｋ１抑制劑用於治療癌症之經取代的吡𠯤—２—甲醯胺
CN113861188B (zh) * 2021-08-23 2023-02-28 杭州医学院 吡唑并[3,4-b]吡啶类衍生物及其制备方法和作为HPK1抑制剂的应用
CA3233233A1 (fr) * 2021-10-15 2023-04-20 Ruben Abagyan 1h-pyrazolo[4,3-c]quinoleines substituees, leurs procedes de preparation et leur utilisation

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3227337A1 (fr) 2014-12-05 2017-10-11 F. Hoffmann-La Roche AG Procédés et compositions de traitement du cancer à l'aide d'antagonistes de l'axe pd-1 et d'antagonistes de hpk1
EP3322711B1 (fr) 2015-06-25 2021-03-10 University Health Network Inhibiteurs de hpk1 et leurs procédés d'utilisation
WO2018049191A1 (fr) 2016-09-09 2018-03-15 Incyte Corporation Dérivés de pyrazolopyridone en tant que modulateurs de hpk1 et leurs utilisations pour le traitement du cancer
TW201811799A (zh) 2016-09-09 2018-04-01 美商英塞特公司 吡唑并嘧啶化合物及其用途
EP4119558A1 (fr) 2016-09-09 2023-01-18 Incyte Corporation Composés de pyrazolopyridine et leurs utilisations
WO2018049214A1 (fr) 2016-09-09 2018-03-15 Incyte Corporation Dérivés de pyrazolopyridine comme modulateurs de hpk1 et leurs utilisations pour le traitement du cancer
WO2018081531A2 (fr) 2016-10-28 2018-05-03 Ariad Pharmaceuticals, Inc. Méthodess d'activation de lymphocytes t humains
WO2018102366A1 (fr) 2016-11-30 2018-06-07 Ariad Pharmaceuticals, Inc. Anilinopyrimidines en tant qu'inhibiteurs de kinase 1 progénitrices hématopoïétiques (hpk1)
EP3596075B1 (fr) 2017-03-15 2023-10-11 F. Hoffmann-La Roche AG Azaindoles utilisés en tant qu'inhibiteurs de hpk1
BR112019018093A2 (pt) 2017-03-30 2020-06-16 F. Hoffmann-La Roche Ag Compostos, composição, método de inibição de hpk1, métodos para melhorar uma resposta imune e para tratar um distúrbio e usos do composto
MX2019010302A (es) 2017-03-30 2019-11-21 Hoffmann La Roche Isoquinolinas como inhibidores de hpk1.
CN112601752A (zh) 2017-05-26 2021-04-02 伊克诺斯科学公司 Map4k1的新颖抑制剂
WO2018228925A1 (fr) 2017-06-13 2018-12-20 Bayer Pharma Aktiengesellschaft Dérivés de pyrrolopyridine substitués
WO2018228923A1 (fr) 2017-06-13 2018-12-20 Bayer Pharma Aktiengesellschaft Dérivés de pyrrolopyridine substitués utilisés en tant que modulateurs de map4k1 pour le traitement de maladies cancéreuses
CA3066859A1 (fr) 2017-06-13 2018-12-20 Bayer Pharma Aktiengesellschaft Derives de pyrrolopyridine substitues
WO2019051199A1 (fr) 2017-09-08 2019-03-14 Incyte Corporation Composés de 6-cyano-indazole utilisés en tant que modulateurs de kinase 1 progénitrices hématopoïétiques (hpk1)

Also Published As

Publication number Publication date
US20220169644A1 (en) 2022-06-02
WO2020193512A1 (fr) 2020-10-01
EP3947373A1 (fr) 2022-02-09
AU2020249397A1 (en) 2021-09-30
TW202102500A (zh) 2021-01-16
CA3129772A1 (fr) 2020-10-01

Similar Documents

Publication Publication Date Title
MA54543A (fr) Inhibiteurs de kif18a
DK3873903T3 (da) Substituerede 6-azabenzimidazolforbindelser som hpk1-hæmmere
MA55478A (fr) Inhibiteurs bicycliques de hpk1
MA54550A (fr) Inhibiteurs de kif18a
MA52413A (fr) Inhibiteurs de cd73
IL292116A (en) Bicyclic amines as cdk2 repressors
AR119765A1 (es) Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2
MA52812A (fr) Inhibiteurs de sarm1
MA44006A (fr) Inhibiteur pde1
MA55477A (fr) Inhibiteurs de hpk1
MA47301A (fr) Inhibiteurs sélectifs de jak1
MA55909A (fr) Inhibiteurs de cdk
MA51611A (fr) Inhibiteurs de pi4kiiibêta
MA52813A (fr) Inhibiteurs de sarm1
MA53841A (fr) Inhibiteurs pde9 de pyrazolopyrimidine
DK3519419T3 (da) Beta-lactamase-inhibitorer
MA52809A (fr) Inhibiteurs de sarm1
DK3738452T3 (da) Fordamper
KR20220035377A (ko) 람노오스-다당류
DE112020005796A5 (de) Spannfutter
ES1239439Y (es) Torno trepanador
ES1243687Y (es) Salmorejo
IT201900020430A1 (it) Espositore
DE202019004111U8 (de) Weichenstellvorichtung
TH190914S (th) ขันโตก