CO2021013030A2 - Inhibidores de la proteína tirosina fosfatasa - Google Patents

Inhibidores de la proteína tirosina fosfatasa

Info

Publication number
CO2021013030A2
CO2021013030A2 CONC2021/0013030A CO2021013030A CO2021013030A2 CO 2021013030 A2 CO2021013030 A2 CO 2021013030A2 CO 2021013030 A CO2021013030 A CO 2021013030A CO 2021013030 A2 CO2021013030 A2 CO 2021013030A2
Authority
CO
Colombia
Prior art keywords
protein tyrosine
tyrosine phosphatase
phosphatase inhibitors
tautomer
stereoisomer
Prior art date
Application number
CONC2021/0013030A
Other languages
English (en)
Inventor
Yutong Jiang
James F Blake
Jay Bradford Fell
John P Fischer
Ronald Jay Hinklin
Oren T Mcnulty
Mark Laurence Boys
Mark Joseph Chicarelli
Mohamed S A Elsayed
Macedonio J Mejia
Martha E Rodriguez
Christina E Wong
Adam W Cook
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of CO2021013030A2 publication Critical patent/CO2021013030A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan compuestos de la Fórmula I o un estereoisómero, tautómero, profármaco o sal aceptable desde el punto de vista farmacéutico de este, que son útiles para el tratamiento de enfermedades hiperproliferativas. Se divulgan métodos para usar los compuestos de la Fórmula I o un estereoisómero, tautómero, profármaco o sal aceptable desde el punto de vista farmacéutico de estos, para el diagnóstico in vitro, in situ e in vivo, la prevención o el tratamiento de dichos trastornos en células de mamífero, o las afecciones patológicas relacionadas.
CONC2021/0013030A 2019-04-02 2021-09-29 Inhibidores de la proteína tirosina fosfatasa CO2021013030A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962828356P 2019-04-02 2019-04-02
US202062992558P 2020-03-20 2020-03-20
PCT/IB2020/053019 WO2020201991A1 (en) 2019-04-02 2020-03-30 Protein tyrosine phosphatase inhibitors

Publications (1)

Publication Number Publication Date
CO2021013030A2 true CO2021013030A2 (es) 2021-10-20

Family

ID=70277430

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0013030A CO2021013030A2 (es) 2019-04-02 2021-09-29 Inhibidores de la proteína tirosina fosfatasa

Country Status (24)

Country Link
US (3) US11634417B2 (es)
EP (1) EP3947367A1 (es)
JP (2) JP7284830B2 (es)
KR (1) KR20210146389A (es)
CN (1) CN113874363A (es)
AU (1) AU2020251841A1 (es)
BR (1) BR112021018664A2 (es)
CA (1) CA3135555C (es)
CL (1) CL2021002542A1 (es)
CO (1) CO2021013030A2 (es)
CR (1) CR20210501A (es)
CU (1) CU20210080A7 (es)
DO (1) DOP2021000206A (es)
EC (1) ECSP21072994A (es)
GE (1) GEP20237561B (es)
IL (1) IL286462A (es)
MA (1) MA55511A (es)
MX (1) MX2021012122A (es)
PE (1) PE20220141A1 (es)
SG (1) SG11202110502PA (es)
TW (1) TWI766261B (es)
UY (1) UY38628A (es)
WO (1) WO2020201991A1 (es)
ZA (1) ZA202108443B (es)

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Publication number Publication date
US20220251083A1 (en) 2022-08-11
UY38628A (es) 2020-10-30
EP3947367A1 (en) 2022-02-09
WO2020201991A1 (en) 2020-10-08
BR112021018664A2 (pt) 2021-11-23
JP2023078421A (ja) 2023-06-06
AU2020251841A1 (en) 2021-10-07
SG11202110502PA (en) 2021-10-28
MX2021012122A (es) 2021-11-03
CN113874363A (zh) 2021-12-31
ZA202108443B (en) 2023-04-26
TWI766261B (zh) 2022-06-01
CU20210080A7 (es) 2022-05-11
GEP20237561B (en) 2023-10-25
IL286462A (en) 2021-10-31
US11634417B2 (en) 2023-04-25
US11884664B2 (en) 2024-01-30
JP2022527796A (ja) 2022-06-06
JP7284830B2 (ja) 2023-05-31
CL2021002542A1 (es) 2022-06-24
TW202102490A (zh) 2021-01-16
PE20220141A1 (es) 2022-01-27
CR20210501A (es) 2021-11-02
MA55511A (fr) 2022-02-09
US20200317665A1 (en) 2020-10-08
ECSP21072994A (es) 2021-11-18
DOP2021000206A (es) 2021-11-21
KR20210146389A (ko) 2021-12-03
CA3135555A1 (en) 2020-10-08
CA3135555C (en) 2023-09-19
US20240124453A1 (en) 2024-04-18

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