CO2021001277A2 - Inhibidores de triazol glicolato oxidasa - Google Patents
Inhibidores de triazol glicolato oxidasaInfo
- Publication number
- CO2021001277A2 CO2021001277A2 CONC2021/0001277A CO2021001277A CO2021001277A2 CO 2021001277 A2 CO2021001277 A2 CO 2021001277A2 CO 2021001277 A CO2021001277 A CO 2021001277A CO 2021001277 A2 CO2021001277 A2 CO 2021001277A2
- Authority
- CO
- Colombia
- Prior art keywords
- oxidase inhibitors
- glycolate oxidase
- triazole
- useful
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La presente invención proporciona ácidos carboxílicos de triazol y compuestos relacionados, y también sales farmacéuticamente aceptables de estos, que son útiles como inhibidores de glicolato oxidasa. También se describen las composiciones farmacéuticas y los métodos para tratar la hiperoxaluria primaria, tipo I (f) y cálculos renales.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862694918P | 2018-07-06 | 2018-07-06 | |
US201962827573P | 2019-04-01 | 2019-04-01 | |
PCT/US2019/040690 WO2020010309A1 (en) | 2018-07-06 | 2019-07-05 | Triazole glycolate oxidase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2021001277A2 true CO2021001277A2 (es) | 2021-04-30 |
Family
ID=67441692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2021/0001277A CO2021001277A2 (es) | 2018-07-06 | 2021-02-05 | Inhibidores de triazol glicolato oxidasa |
Country Status (14)
Country | Link |
---|---|
US (2) | US11401246B2 (es) |
EP (1) | EP3817816A1 (es) |
JP (1) | JP7348705B2 (es) |
KR (1) | KR20210041564A (es) |
CN (1) | CN112399873A (es) |
AU (1) | AU2019297523A1 (es) |
BR (1) | BR112021000050A2 (es) |
CA (1) | CA3104529A1 (es) |
CO (1) | CO2021001277A2 (es) |
IL (1) | IL279952A (es) |
MX (1) | MX2021000051A (es) |
PE (1) | PE20210859A1 (es) |
SG (1) | SG11202012930RA (es) |
WO (1) | WO2020010309A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11401246B2 (en) | 2018-07-06 | 2022-08-02 | Cantero Therapeutics, Inc. | Triazole glycolate oxidase inhibitors |
CA3155577A1 (en) | 2019-11-01 | 2021-05-06 | GyanRx Sciences, Inc. | Heterocyclic carboxylate compounds as glycolate oxidase inhibitors |
JP2023510758A (ja) * | 2020-01-08 | 2023-03-15 | カンテロ セラピューティクス インコーポレイティド | トリアゾール系グリコール酸オキシダーゼ阻害剤の調製方法 |
WO2022066933A1 (en) * | 2020-09-24 | 2022-03-31 | Chinook Therapeutics Canada, Inc. | Pentafluoro-sulfanyl -substituted triazolyl compounds and methods of use thereof |
WO2023064257A1 (en) * | 2021-10-11 | 2023-04-20 | Cantero Therapeutics, Inc. | 1h-1,2,3-triazole-4-carboxylic acids for treatment of hyperoxaluria and kidney stones |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0774218B2 (ja) * | 1987-03-02 | 1995-08-09 | 第一製薬株式会社 | ベンゾピラノトリアゾ−ル誘導体 |
US6187326B1 (en) | 1998-12-29 | 2001-02-13 | Thomas T. Yamashita | Soil amendment composition |
US7022702B2 (en) | 2000-04-07 | 2006-04-04 | Qlt Inc. | Antiproliferative 1,2,3-thiadiazole compounds |
JP4768628B2 (ja) | 2003-11-19 | 2011-09-07 | アレイ バイオファーマ、インコーポレイテッド | Mekの二環系阻害剤及びその使用方法 |
JP5149009B2 (ja) | 2004-09-20 | 2013-02-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヒトステアロイル−CoAデサチュラーゼを阻害するためのピリダジン誘導体 |
CN104159891B (zh) | 2012-01-10 | 2016-09-07 | 霍夫曼-拉罗奇有限公司 | 哒嗪酰胺化合物和它们作为syk 抑制剂的用途 |
CN103906427B (zh) | 2012-10-25 | 2015-12-02 | 朝日集团控股株式会社 | 胶乳的增产方法 |
US20140213538A1 (en) | 2013-01-15 | 2014-07-31 | Intermune, Inc. | Lysophosphatidic acid receptor antagonists |
US9392796B2 (en) | 2013-03-15 | 2016-07-19 | Spogen Biotech Inc. | Plant growth-promoting bacteria and methods of use |
FR3021843B1 (fr) | 2014-06-06 | 2016-07-08 | Lesaffre & Cie | Methode et composition pour ameliorer la productivite de plantes non legumineuses |
JP5866035B1 (ja) | 2015-01-08 | 2016-02-17 | アサヒグループホールディングス株式会社 | 有効分げつ促進方法 |
WO2016148193A1 (ja) | 2015-03-19 | 2016-09-22 | 興人ライフサイエンス株式会社 | 植物の生長促進や根伸長促進効果且つ付加価値向上効果を有する酵母抽出物 |
WO2017100266A1 (en) | 2015-12-07 | 2017-06-15 | Wake Forest University Health Sciences | Glycolate oxidase inhibitors and methods of use for the treatment of kidney stones |
TWI811282B (zh) | 2017-12-29 | 2023-08-11 | 美商拜奧馬林製藥公司 | 用於疾病治療之乙醇酸酯氧化酶抑制劑 |
AR114065A1 (es) | 2017-12-29 | 2020-07-15 | Orfan Biotech Inc | Inhibidores de glicolato oxidasa y uso de los mismos |
WO2019165159A1 (en) | 2018-02-23 | 2019-08-29 | Oxalurx, Inc. | Compounds and methods for treating oxalate-related diseases |
US11401246B2 (en) | 2018-07-06 | 2022-08-02 | Cantero Therapeutics, Inc. | Triazole glycolate oxidase inhibitors |
TW202115013A (zh) | 2019-06-19 | 2021-04-16 | 美商拜奧馬林製藥公司 | 用於治療疾病之乙醇酸氧化酶(glycolate oxidase)抑制劑 |
-
2019
- 2019-07-05 US US17/255,600 patent/US11401246B2/en active Active
- 2019-07-05 JP JP2021521945A patent/JP7348705B2/ja active Active
- 2019-07-05 MX MX2021000051A patent/MX2021000051A/es unknown
- 2019-07-05 KR KR1020217003486A patent/KR20210041564A/ko unknown
- 2019-07-05 AU AU2019297523A patent/AU2019297523A1/en active Pending
- 2019-07-05 CN CN201980045610.4A patent/CN112399873A/zh active Pending
- 2019-07-05 WO PCT/US2019/040690 patent/WO2020010309A1/en active Application Filing
- 2019-07-05 SG SG11202012930RA patent/SG11202012930RA/en unknown
- 2019-07-05 PE PE2021000011A patent/PE20210859A1/es unknown
- 2019-07-05 CA CA3104529A patent/CA3104529A1/en active Pending
- 2019-07-05 BR BR112021000050-0A patent/BR112021000050A2/pt unknown
- 2019-07-05 EP EP19745452.3A patent/EP3817816A1/en active Pending
-
2021
- 2021-01-04 IL IL279952A patent/IL279952A/en unknown
- 2021-02-05 CO CONC2021/0001277A patent/CO2021001277A2/es unknown
-
2022
- 2022-06-17 US US17/843,455 patent/US20230143491A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2021000051A (es) | 2021-03-25 |
KR20210041564A (ko) | 2021-04-15 |
US20230143491A1 (en) | 2023-05-11 |
BR112021000050A2 (pt) | 2021-04-06 |
EP3817816A1 (en) | 2021-05-12 |
PE20210859A1 (es) | 2021-05-18 |
US11401246B2 (en) | 2022-08-02 |
CA3104529A1 (en) | 2020-01-09 |
IL279952A (en) | 2021-03-01 |
JP7348705B2 (ja) | 2023-09-21 |
JP2021530560A (ja) | 2021-11-11 |
WO2020010309A1 (en) | 2020-01-09 |
AU2019297523A1 (en) | 2021-02-25 |
CN112399873A (zh) | 2021-02-23 |
WO2020010309A9 (en) | 2020-01-30 |
SG11202012930RA (en) | 2021-01-28 |
US20210403439A1 (en) | 2021-12-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2021001277A2 (es) | Inhibidores de triazol glicolato oxidasa | |
DOP2019000030A (es) | Inhibidores de cdk2/4/6 | |
CL2017002994A1 (es) | Compuestos de naftiridina como inhibidores de la quinasa jak | |
UY38196A (es) | Inhibidores de cinasa dependientes de ciclina | |
UY37656A (es) | Compuestos que inhiben la proteína mcl-1 | |
CO2019011809A2 (es) | Compuestos de imidazo-piperidina fusionada como inhibidores de jak | |
NI201600165A (es) | Inhibidores de desmetilasa 1 específica a lisina | |
EA201890308A1 (ru) | Замещенные азасоединения как ингибиторы irak-4 | |
EA201890307A1 (ru) | Индазольные и азаиндазольные соединения как ингибиторы irak-4 | |
CO2017004525A2 (es) | Dihidropirrolopiridinas inhibidoras de ror-gamma | |
CR20190124A (es) | Inhibidores de ssao de aminopirimidina | |
EA201790078A1 (ru) | Ингибиторы mnk и связанные с ними способы | |
CL2020001576A1 (es) | Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5. | |
EA201792214A1 (ru) | Соединения замещенного хиназолина | |
ECSP18083519A (es) | Inhibidores de bromodominios | |
EA201790108A1 (ru) | Гетероарильные соединения, пригодные в качестве ингибиторов sumo-активирующего фермента | |
CO2018011408A2 (es) | Compuestos de pirimidina como inhibidores de la quinasa jak | |
CL2020000283A1 (es) | Compuestos bicíclicos de pirazol y triazolo como inhibidores de las cinasas jak. | |
ECSP17026210A (es) | Compuestos de aminopurina sustituida, composiciones del mismo, y métodos de tratamiento con los mismos | |
MX2020003666A (es) | Compuestos y composiciones para el tratamiento de trastornos hematologicos. | |
CU20170026A7 (es) | Compuestos derivados de 2-(benzamido/picolinamido/nicotinamido/isonicotinamido)-(2-metil-6-morfolino-(fenil/ (3,4´-bipiridin))-2-il)oxi)etil dihidrógeno fosfato como inhibidores de quinasa raf | |
UY36713A (es) | Triazoles para el tratamiento de enfermedades desmielinizantes | |
CL2021001461A1 (es) | Moduladores de trex1 | |
EA202193015A1 (ru) | Ингибиторы cdk | |
CL2019003258A1 (es) | Composiciones y compuestos terapéuticos y métodos para utilizarlos. |