NI202100027A - Inhibidores de la proteína tirosina fosfatasa - Google Patents

Inhibidores de la proteína tirosina fosfatasa

Info

Publication number
NI202100027A
NI202100027A NI202100027A NI202100027A NI202100027A NI 202100027 A NI202100027 A NI 202100027A NI 202100027 A NI202100027 A NI 202100027A NI 202100027 A NI202100027 A NI 202100027A NI 202100027 A NI202100027 A NI 202100027A
Authority
NI
Nicaragua
Prior art keywords
protein tyrosine
tyrosine phosphatase
phosphatase inhibitors
tautomer
stereoisomer
Prior art date
Application number
NI202100027A
Other languages
English (en)
Inventor
F Blakl James
Laurence Boys Mark
Joseph Chicarelli Mark
Cook Adam
S A Elsayed Mohamed
B Fell Jay
P Fischer John
Jay Hinklin Ronald
T Mcnulty Oren
J Mejia Macedonio
E Rodríguez Martha
E Wong Christina
F Blake James
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of NI202100027A publication Critical patent/NI202100027A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Se proporcionan compuestos de la Fórmula I o un estereoisómero, tautómero, profármaco o sal farmacéuticamente aceptable del mismo, los cuales son útiles para el tratamiento de enfermedades hiperproliferativas. Se describen métodos para utilizar los compuestos de la Fórmula I o un estereoisómero, tautómero, profármaco o sal farmacéuticamente aceptable del mismo, para su diagnóstico, prevención o tratamiento in vitro, in situ e in vivo, de tales trastornos en células de mamífero o padecimientos asociados.
NI202100027A 2018-10-17 2021-04-16 Inhibidores de la proteína tirosina fosfatasa NI202100027A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862746952P 2018-10-17 2018-10-17
US201962916119P 2019-10-16 2019-10-16

Publications (1)

Publication Number Publication Date
NI202100027A true NI202100027A (es) 2021-08-24

Family

ID=68536896

Family Applications (1)

Application Number Title Priority Date Filing Date
NI202100027A NI202100027A (es) 2018-10-17 2021-04-16 Inhibidores de la proteína tirosina fosfatasa

Country Status (27)

Country Link
US (1) US20210380582A1 (es)
EP (1) EP3867238B1 (es)
JP (1) JP7449282B2 (es)
KR (1) KR102649419B1 (es)
CN (1) CN114341124A (es)
AU (1) AU2019359885B2 (es)
BR (1) BR112021005733A2 (es)
CA (1) CA3116561C (es)
CL (1) CL2021000972A1 (es)
CO (1) CO2021004966A2 (es)
CR (1) CR20210189A (es)
CU (1) CU20210029A7 (es)
CY (1) CY1126122T1 (es)
DO (1) DOP2021000070A (es)
EC (1) ECSP21027049A (es)
ES (1) ES2947464T3 (es)
HU (1) HUE062404T2 (es)
IL (1) IL282179A (es)
MA (1) MA53921A (es)
MX (1) MX2021004410A (es)
NI (1) NI202100027A (es)
PE (1) PE20211465A1 (es)
PH (1) PH12021550674A1 (es)
PL (1) PL3867238T3 (es)
SG (1) SG11202102985YA (es)
WO (1) WO2020081848A1 (es)
ZA (1) ZA202101960B (es)

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US11591336B2 (en) 2017-05-26 2023-02-28 D. E. Shaw Research, Llc Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
US11701354B2 (en) 2017-09-29 2023-07-18 D. E. Shaw Research, Llc Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
EP3768668A1 (en) 2018-03-21 2021-01-27 Relay Therapeutics, Inc. Shp2 phosphatase inhibitors and methods of use thereof
US11179397B2 (en) 2018-10-03 2021-11-23 Gilead Sciences, Inc. Imidazopyrimidine derivatives
CA3135555C (en) 2019-04-02 2023-09-19 Array Biopharma Inc. Protein tyrosine phosphatase inhibitors
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CN115916194A (zh) 2020-06-18 2023-04-04 锐新医药公司 用于延迟、预防和治疗针对ras抑制剂的获得性抗性的方法
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Also Published As

Publication number Publication date
MA53921A (fr) 2022-01-26
CL2021000972A1 (es) 2021-10-15
ZA202101960B (en) 2023-11-29
PE20211465A1 (es) 2021-08-05
CR20210189A (es) 2021-09-14
AU2019359885A1 (en) 2021-04-15
CY1126122T1 (el) 2023-11-15
AU2019359885B2 (en) 2024-01-18
HUE062404T2 (hu) 2023-10-28
BR112021005733A2 (pt) 2021-07-27
CU20210029A7 (es) 2021-11-04
IL282179A (en) 2021-05-31
KR20210076098A (ko) 2021-06-23
CN114341124A (zh) 2022-04-12
CA3116561C (en) 2023-09-12
EP3867238A1 (en) 2021-08-25
EP3867238B1 (en) 2023-06-07
PL3867238T3 (pl) 2023-09-11
DOP2021000070A (es) 2021-05-16
JP7449282B2 (ja) 2024-03-13
MX2021004410A (es) 2021-07-06
SG11202102985YA (en) 2021-05-28
EP3867238C0 (en) 2023-06-07
WO2020081848A1 (en) 2020-04-23
ECSP21027049A (es) 2021-05-31
US20210380582A1 (en) 2021-12-09
JP2022504936A (ja) 2022-01-13
PH12021550674A1 (en) 2021-12-13
ES2947464T3 (es) 2023-08-09
CO2021004966A2 (es) 2021-04-30
CA3116561A1 (en) 2020-04-23
KR102649419B1 (ko) 2024-03-21

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