MX2021004410A - Inhibidores de la proteina tirosina fosfatasa. - Google Patents

Inhibidores de la proteina tirosina fosfatasa.

Info

Publication number
MX2021004410A
MX2021004410A MX2021004410A MX2021004410A MX2021004410A MX 2021004410 A MX2021004410 A MX 2021004410A MX 2021004410 A MX2021004410 A MX 2021004410A MX 2021004410 A MX2021004410 A MX 2021004410A MX 2021004410 A MX2021004410 A MX 2021004410A
Authority
MX
Mexico
Prior art keywords
protein tyrosine
tyrosine phosphatase
phosphatase inhibitors
tautomer
stereoisomer
Prior art date
Application number
MX2021004410A
Other languages
English (en)
Inventor
James F Blake
Mark Joseph Chicarelli
Mark Laurence Boys
John P Fischer
Ronald Jay Hinklin
Macedonio J Mejia
Adam Cook
Oren T Mcnulty
Martha E Rodriguez
Mohamed S A Elsayed
Jay B Fell
Christina E Wong
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of MX2021004410A publication Critical patent/MX2021004410A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Se proporcionan compuestos de la Fórmula I o un estereoisómero, tautómero, profármaco o sal farmacéuticamente aceptable del mismo, los cuales son útiles para el tratamiento de enfermedades hiperproliferativas. Se describen métodos para utilizar los compuestos de la Fórmula I o un estereoisómero, tautómero, profármaco o sal farmacéuticamente aceptable del mismo, para su diagnóstico, prevención o tratamiento in vitro, in situ e in vivo, de tales trastornos en células de mamífero o padecimientos asociados. (ver Fórmula).
MX2021004410A 2018-10-17 2019-10-17 Inhibidores de la proteina tirosina fosfatasa. MX2021004410A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862746952P 2018-10-17 2018-10-17
US201962916119P 2019-10-16 2019-10-16
PCT/US2019/056786 WO2020081848A1 (en) 2018-10-17 2019-10-17 Protein tyrosine phosphatase inhibitors

Publications (1)

Publication Number Publication Date
MX2021004410A true MX2021004410A (es) 2021-07-06

Family

ID=68536896

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021004410A MX2021004410A (es) 2018-10-17 2019-10-17 Inhibidores de la proteina tirosina fosfatasa.

Country Status (27)

Country Link
US (1) US20210380582A1 (es)
EP (1) EP3867238B1 (es)
JP (1) JP7449282B2 (es)
KR (1) KR102649419B1 (es)
CN (1) CN114341124A (es)
AU (1) AU2019359885B2 (es)
BR (1) BR112021005733A2 (es)
CA (1) CA3116561C (es)
CL (1) CL2021000972A1 (es)
CO (1) CO2021004966A2 (es)
CR (1) CR20210189A (es)
CU (1) CU20210029A7 (es)
CY (1) CY1126122T1 (es)
DO (1) DOP2021000070A (es)
EC (1) ECSP21027049A (es)
ES (1) ES2947464T3 (es)
HU (1) HUE062404T2 (es)
IL (1) IL282179A (es)
MA (1) MA53921A (es)
MX (1) MX2021004410A (es)
NI (1) NI202100027A (es)
PE (1) PE20211465A1 (es)
PH (1) PH12021550674A1 (es)
PL (1) PL3867238T3 (es)
SG (1) SG11202102985YA (es)
WO (1) WO2020081848A1 (es)
ZA (1) ZA202101960B (es)

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EP3630770A1 (en) 2017-05-26 2020-04-08 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
US11701354B2 (en) 2017-09-29 2023-07-18 D. E. Shaw Research, Llc Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
CA3094690A1 (en) 2018-03-21 2019-09-26 Relay Therapeutics, Inc. Shp2 phosphatase inhibitors and methods of use thereof
WO2020072656A1 (en) 2018-10-03 2020-04-09 Gilead Sciences, Inc. Imidozopyrimidine derivatives
AU2020251841A1 (en) 2019-04-02 2021-10-07 Array Biopharma Inc. Protein tyrosine phosphatase inhibitors
EP4034539A1 (en) 2019-09-24 2022-08-03 Relay Therapeutics, Inc. Shp2 phosphatase inhibitors and methods of making and using the same
MX2022005525A (es) 2019-11-08 2022-06-08 Revolution Medicines Inc Compuestos de heteroarilo bicíclicos y usos de estos.
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IL301062A (en) 2020-09-03 2023-05-01 Revolution Medicines Inc Use of SOS1 inhibitors to treat malignancies with SHP2 mutations
TW202227460A (zh) 2020-09-15 2022-07-16 美商銳新醫藥公司 Ｒａｓ抑制劑
TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶－１，６（２ｈ，７ｈ）－二酮
CN117500811A (zh) 2021-05-05 2024-02-02 锐新医药公司 共价ras抑制剂及其用途
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CN115960109A (zh) * 2021-05-31 2023-04-14 药雅科技(上海)有限公司 稠环类shp2磷酸酶抑制剂的制备及其应用
CN115340561A (zh) * 2021-05-14 2022-11-15 药雅科技(上海)有限公司 Shp2磷酸酶稠环类抑制剂的制备及其应用
TW202244049A (zh) * 2021-05-12 2022-11-16 大陸商藥雅科技（上海）有限公司 Shp2磷酸酶抑制劑的製備及其應用
TW202313041A (zh) 2021-06-09 2023-04-01 瑞士商諾華公司 包含達拉菲尼、曲美替尼和shp2抑制劑之三重藥物組合
TW202317100A (zh) 2021-06-23 2023-05-01 瑞士商諾華公司 包含ｋｒａｓ ｇ１２ｃ抑制劑的藥物組合及其用於治療癌症之用途
AU2022309195A1 (en) 2021-07-09 2024-01-25 Kanaph Therapeutics Inc. Shp2 inhibitor and use thereof
KR20240055778A (ko) 2021-09-01 2024-04-29 노파르티스 아게 Tead 억제제를 포함하는 제약 조합물 및 암의 치료를 위한 이의 용도
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
WO2023133225A1 (en) * 2022-01-05 2023-07-13 Remix Therapeutics Inc. Compounds and methods for modulating splicing
WO2023172940A1 (en) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Methods for treating immune refractory lung cancer
CN114621186A (zh) * 2022-05-12 2022-06-14 上海维申医药有限公司 作为ras信号通路调控剂的杂环化合物
TW202404581A (zh) 2022-05-25 2024-02-01 美商醫肯納腫瘤學公司 Ｍｅｋ抑制劑及其用途
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Also Published As

Publication number Publication date
CN114341124A (zh) 2022-04-12
BR112021005733A2 (pt) 2021-07-27
PH12021550674A1 (en) 2021-12-13
ZA202101960B (en) 2023-11-29
US20210380582A1 (en) 2021-12-09
DOP2021000070A (es) 2021-05-16
NI202100027A (es) 2021-08-24
EP3867238A1 (en) 2021-08-25
IL282179A (en) 2021-05-31
HUE062404T2 (hu) 2023-10-28
PL3867238T3 (pl) 2023-09-11
PE20211465A1 (es) 2021-08-05
CA3116561C (en) 2023-09-12
JP2022504936A (ja) 2022-01-13
ES2947464T3 (es) 2023-08-09
CU20210029A7 (es) 2021-11-04
KR102649419B1 (ko) 2024-03-21
CY1126122T1 (el) 2023-11-15
EP3867238C0 (en) 2023-06-07
CA3116561A1 (en) 2020-04-23
KR20210076098A (ko) 2021-06-23
MA53921A (fr) 2022-01-26
ECSP21027049A (es) 2021-05-31
SG11202102985YA (en) 2021-05-28
JP7449282B2 (ja) 2024-03-13
EP3867238B1 (en) 2023-06-07
CL2021000972A1 (es) 2021-10-15
AU2019359885B2 (en) 2024-01-18
AU2019359885A1 (en) 2021-04-15
CR20210189A (es) 2021-09-14
WO2020081848A1 (en) 2020-04-23
CO2021004966A2 (es) 2021-04-30

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