EA202192760A1 - Трициклические соединения - Google Patents

Трициклические соединения

Info

Publication number
EA202192760A1
EA202192760A1 EA202192760A EA202192760A EA202192760A1 EA 202192760 A1 EA202192760 A1 EA 202192760A1 EA 202192760 A EA202192760 A EA 202192760A EA 202192760 A EA202192760 A EA 202192760A EA 202192760 A1 EA202192760 A1 EA 202192760A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutically acceptable
compound
tricyclic compounds
formula
methods
Prior art date
Application number
EA202192760A
Other languages
English (en)
Inventor
Сандрин Вендевилль
Original Assignee
Алигос Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алигос Терапьютикс, Инк. filed Critical Алигос Терапьютикс, Инк.
Publication of EA202192760A1 publication Critical patent/EA202192760A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В изобретении предложены соединение формулы (I) или его фармацевтически приемлемые соли, фармацевтические композиции, которые включают в себя описанное в настоящем документе соединение (включая фармацевтически приемлемые соли соединения, описанного в настоящем документе), и способы их синтеза. В настоящем документе также предложены способы лечения заболеваний и/или состояний с помощью соединения формулы (I) или его фармацевтически приемлемой соли.
EA202192760A 2019-05-30 2020-05-27 Трициклические соединения EA202192760A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962854597P 2019-05-30 2019-05-30
PCT/US2020/034746 WO2020243199A1 (en) 2019-05-30 2020-05-27 Tricyclic compounds

Publications (1)

Publication Number Publication Date
EA202192760A1 true EA202192760A1 (ru) 2022-03-05

Family

ID=73552666

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192760A EA202192760A1 (ru) 2019-05-30 2020-05-27 Трициклические соединения

Country Status (18)

Country Link
US (1) US11136321B2 (ru)
EP (1) EP3976618A4 (ru)
JP (1) JP2022534501A (ru)
KR (1) KR20220016177A (ru)
CN (1) CN113906029A (ru)
AU (1) AU2020282707A1 (ru)
BR (1) BR112021023967A2 (ru)
CA (1) CA3138938A1 (ru)
CL (1) CL2021003139A1 (ru)
CO (1) CO2021017202A2 (ru)
EA (1) EA202192760A1 (ru)
IL (1) IL287813A (ru)
MA (1) MA56058A (ru)
MX (1) MX2021014458A (ru)
PE (1) PE20220427A1 (ru)
SG (1) SG11202113214QA (ru)
TW (1) TW202110845A (ru)
WO (1) WO2020243199A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4251625A1 (en) 2020-11-24 2023-10-04 Aligos Therapeutics, Inc. Tricyclic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0701273D0 (en) 2007-01-24 2007-02-28 Angeletti P Ist Richerche Bio New compounds
WO2008157273A1 (en) * 2007-06-14 2008-12-24 Smithkline Beecham Corporation Chemical compounds
EP3063149A1 (en) * 2013-10-29 2016-09-07 Medivir Ab Quinazoline based respiratory syncytial virus inhibitors
CO2018009382A2 (es) 2016-03-09 2018-09-20 Univ Emory Eliminación del virus de la hepatitis b con agentes antivirales
CN110066278B (zh) * 2017-06-01 2021-06-08 广东东阳光药业有限公司 稠合三环类化合物及其在药物中的应用

Also Published As

Publication number Publication date
CL2021003139A1 (es) 2022-09-23
EP3976618A1 (en) 2022-04-06
KR20220016177A (ko) 2022-02-08
US20200407361A1 (en) 2020-12-31
CA3138938A1 (en) 2020-12-03
JP2022534501A (ja) 2022-08-01
US11136321B2 (en) 2021-10-05
BR112021023967A2 (pt) 2022-03-08
CN113906029A (zh) 2022-01-07
MX2021014458A (es) 2022-01-06
WO2020243199A1 (en) 2020-12-03
CO2021017202A2 (es) 2022-01-17
TW202110845A (zh) 2021-03-16
AU2020282707A1 (en) 2021-12-02
IL287813A (en) 2022-01-01
PE20220427A1 (es) 2022-03-29
MA56058A (fr) 2022-04-06
SG11202113214QA (en) 2021-12-30
EP3976618A4 (en) 2023-01-04

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