|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4263428A
(en)
|
1978-03-24 |
1981-04-21 |
The Regents Of The University Of California |
Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
|
|
US4241174A
(en)
|
1978-11-24 |
1980-12-23 |
Hoffmann-La Roche Inc. |
Interferon assay
|
|
US4289872A
(en)
|
1979-04-06 |
1981-09-15 |
Allied Corporation |
Macromolecular highly branched homogeneous compound based on lysine units
|
|
US6410697B1
(en)
|
1979-04-20 |
2002-06-25 |
Schering Corporation |
Process for purifying human leukocyte interferon
|
|
US4898830A
(en)
|
1979-07-05 |
1990-02-06 |
Genentech, Inc. |
Human growth hormone DNA
|
|
US4342832A
(en)
|
1979-07-05 |
1982-08-03 |
Genentech, Inc. |
Method of constructing a replicable cloning vehicle having quasi-synthetic genes
|
|
IL58765A
(en)
|
1979-11-21 |
1986-09-30 |
Yeda Res & Dev |
Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
|
|
US5554513A
(en)
|
1979-11-21 |
1996-09-10 |
Yeda Research & Development Co. Ltd. |
Production of recombinant human interferon-beta2
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
US6610830B1
(en)
|
1980-07-01 |
2003-08-26 |
Hoffman-La Roche Inc. |
Microbial production of mature human leukocyte interferons
|
|
FR2490675B1
(fr)
|
1980-09-25 |
1985-11-15 |
Genentech Inc |
Production microbienne d'interferon de fibroplaste humain
|
|
EP0064063B1
(en)
|
1980-11-07 |
1985-09-11 |
Celltech Limited |
Assay for interferon
|
|
US4414150A
(en)
|
1980-11-10 |
1983-11-08 |
Genentech, Inc. |
Hybrid human leukocyte interferons
|
|
US4456748A
(en)
|
1981-02-23 |
1984-06-26 |
Genentech, Inc. |
Hybrid human leukocyte interferons
|
|
DE3169595D1
(en)
|
1980-11-10 |
1985-05-02 |
Gersonde Klaus |
Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
|
|
US4364863A
(en)
|
1980-12-29 |
1982-12-21 |
Schering Corporation |
Extraction of interferon from bacteria
|
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
|
FR2504010B1
(fr)
|
1981-04-15 |
1985-10-25 |
Sanofi Sa |
Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
|
|
US4551433A
(en)
|
1981-05-18 |
1985-11-05 |
Genentech, Inc. |
Microbial hybrid promoters
|
|
JPS57206622A
(en)
|
1981-06-10 |
1982-12-18 |
Ajinomoto Co Inc |
Blood substitute
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4614651A
(en)
|
1981-07-12 |
1986-09-30 |
Damon Biotech, Inc. |
Interferon epsilon
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4678751A
(en)
|
1981-09-25 |
1987-07-07 |
Genentech, Inc. |
Hybrid human leukocyte interferons
|
|
US5096705A
(en)
|
1981-10-19 |
1992-03-17 |
Genentech, Inc. |
Human immune interferon
|
|
US5582824A
(en)
|
1981-10-19 |
1996-12-10 |
Genentech, Inc. |
Recombinant DES-CYS-TYR-CYS human immune interferon
|
|
AU561343B2
(en)
|
1981-10-19 |
1987-05-07 |
Genentech Inc. |
Human immune interferon by recombinant dna
|
|
US4672108A
(en)
|
1981-12-07 |
1987-06-09 |
Hoffmann-La Roche Inc. |
Crystalline human leukocyte interferon
|
|
US4973479A
(en)
|
1982-01-15 |
1990-11-27 |
Cetus Corporation |
Interferon-α61
|
|
US4975276A
(en)
|
1982-01-15 |
1990-12-04 |
Cetus Corporation |
Interferon-alpha 54
|
|
US5098703A
(en)
|
1982-01-15 |
1992-03-24 |
Cetus Corporation |
Interferon-alpha 76
|
|
DE3374837D1
(en)
|
1982-02-17 |
1988-01-21 |
Ciba Geigy Ag |
Lipids in the aqueous phase
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
US4589071A
(en)
|
1982-04-19 |
1986-05-13 |
Nissan Motor Co., Ltd. |
Method and apparatus for controlling reduction ratio of continuously variable transmission with acceleration compensation
|
|
US6936694B1
(en)
|
1982-05-06 |
2005-08-30 |
Intermune, Inc. |
Manufacture and expression of large structural genes
|
|
DE3218121A1
(de)
|
1982-05-14 |
1983-11-17 |
Leskovar, Peter, Dr.-Ing., 8000 München |
Arzneimittel zur tumorbehandlung
|
|
EP0102324A3
(de)
|
1982-07-29 |
1984-11-07 |
Ciba-Geigy Ag |
Lipide und Tenside in wässriger Phase
|
|
IL66733A
(en)
|
1982-09-07 |
1986-03-31 |
Yeda Res & Dev |
Assay for ifn and kit therefor
|
|
US4966843A
(en)
|
1982-11-01 |
1990-10-30 |
Cetus Corporation |
Expression of interferon genes in Chinese hamster ovary cells
|
|
US4512922A
(en)
|
1982-12-22 |
1985-04-23 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4511502A
(en)
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4511503A
(en)
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4876197A
(en)
|
1983-02-22 |
1989-10-24 |
Chiron Corporation |
Eukaryotic regulatable transcription
|
|
US5089398A
(en)
|
1983-02-22 |
1992-02-18 |
Chiron Corporation |
Enhanced yeast transcription employing hybrid GAPDH promoter region constructs
|
|
CA1341302C
(en)
|
1983-02-22 |
2001-10-09 |
Rae Lyn Burke |
Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein
|
|
JPS59166086A
(ja)
|
1983-03-09 |
1984-09-19 |
Teruhiko Beppu |
新規な発現型プラスミドとそれらを用いて仔牛プロキモシン遺伝子を大腸菌内で発現させる方法
|
|
US4859600A
(en)
|
1983-04-25 |
1989-08-22 |
Genentech, Inc. |
Recombinant procaryotic cell containing correctly processed human growth hormone
|
|
US4755465A
(en)
|
1983-04-25 |
1988-07-05 |
Genentech, Inc. |
Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
|
|
ATE78293T1
(de)
|
1983-05-27 |
1992-08-15 |
Texas A & M Univ Sys |
Verfahren zur herstellung eines rekombinanten baculovirus-expressionsvektors.
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
|
US4689406A
(en)
|
1983-08-10 |
1987-08-25 |
Amgen |
Enhancement of microbial expression of polypeptides
|
|
US4681930A
(en)
|
1983-09-20 |
1987-07-21 |
Hoffmann-La Roche Inc. |
Immune interferon and a method for its extraction and purification
|
|
US4604284A
(en)
|
1983-09-20 |
1986-08-05 |
Hoffmann-La Roche Inc. |
Homogeneous immune interferon fragment
|
|
ATE159858T1
(de)
|
1983-09-26 |
1997-11-15 |
Ehrenfeld Udo |
Mittel und erzeugnis für die diagnose und therapie von tumoren sowie zur behandlung von schwächen der zelligen und humoralen immunabwehr
|
|
US4615885A
(en)
|
1983-11-01 |
1986-10-07 |
Terumo Kabushiki Kaisha |
Pharmaceutical composition containing urokinase
|
|
US4703008A
(en)
|
1983-12-13 |
1987-10-27 |
Kiren-Amgen, Inc. |
DNA sequences encoding erythropoietin
|
|
NZ210501A
(en)
|
1983-12-13 |
1991-08-27 |
Kirin Amgen Inc |
Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
|
|
KR850004274A
(ko)
|
1983-12-13 |
1985-07-11 |
원본미기재 |
에리트로포이에틴의 제조방법
|
|
US4855238A
(en)
|
1983-12-16 |
1989-08-08 |
Genentech, Inc. |
Recombinant gamma interferons having enhanced stability and methods therefor
|
|
US4892743A
(en)
|
1983-12-21 |
1990-01-09 |
Schering Corporation |
Novel hybrid interferon species
|
|
DK518384A
(da)
|
1984-01-31 |
1985-07-01 |
Idaho Res Found |
Vektor til fremstilling af et gen-produkt i insektceller, fremgangsmaade til dens fremstilling samt dens anvendelse
|
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
|
US5718893A
(en)
|
1984-04-15 |
1998-02-17 |
Foster; Preston F. |
Use of G-CSF to reduce acute rejection
|
|
US4880734A
(en)
|
1984-05-11 |
1989-11-14 |
Chiron Corporation |
Eukaryotic regulatable transcription
|
|
DE3587759T2
(de)
|
1984-05-11 |
1994-07-07 |
Chiron Corp., Emeryville, Calif. |
Erhöhte Hefetranskription unter Verwendung einer Hybridkonstruktion der Promotorregion.
|
|
CA1302320C
(en)
|
1984-06-11 |
1992-06-02 |
Hideo Niwa |
Expression of human cromosomal interferon-_ in animal cells
|
|
US4675282A
(en)
|
1984-07-06 |
1987-06-23 |
Damon Biotech, Inc. |
Assay for interferon epsilon
|
|
JPS6124599A
(ja)
|
1984-07-11 |
1986-02-03 |
Kyowa Hakko Kogyo Co Ltd |
新規ヒトインタ−フエロン−ｒポリペプチド誘導体
|
|
US5120832A
(en)
|
1984-08-27 |
1992-06-09 |
Genentech, Inc. |
Distinct family of human leukocyte interferons
|
|
JPS6156199A
(ja)
|
1984-08-27 |
1986-03-20 |
Shionogi & Co Ltd |
新規ヒトインタ−フエロンα類
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4738921A
(en)
|
1984-09-27 |
1988-04-19 |
Eli Lilly And Company |
Derivative of the tryptophan operon for expression of fused gene products
|
|
US4963495A
(en)
|
1984-10-05 |
1990-10-16 |
Genentech, Inc. |
Secretion of heterologous proteins
|
|
US4659839A
(en)
|
1984-10-10 |
1987-04-21 |
Mallinckrodt, Inc. |
Coupling agents for radiolabeled antibody fragments
|
|
US4837148A
(en)
|
1984-10-30 |
1989-06-06 |
Phillips Petroleum Company |
Autonomous replication sequences for yeast strains of the genus pichia
|
|
US4968618A
(en)
|
1984-11-16 |
1990-11-06 |
University Of Florida |
Composition and method for promoting growth of granulocytes
|
|
GB8430252D0
(en)
|
1984-11-30 |
1985-01-09 |
Beecham Group Plc |
Compounds
|
|
EP0188256B1
(en)
|
1985-01-14 |
1991-08-21 |
NeoRx |
Metal radionuclide labeled proteins for diagnosis and therapy
|
|
US4612367A
(en)
|
1985-04-08 |
1986-09-16 |
Eli Lilly And Company |
Process for purifying growth hormone-like materials
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
US4667016A
(en)
|
1985-06-20 |
1987-05-19 |
Kirin-Amgen, Inc. |
Erythropoietin purification
|
|
DE3676670D1
(de)
|
1985-06-26 |
1991-02-07 |
Cetus Corp |
Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung.
|
|
US4917888A
(en)
|
1985-06-26 |
1990-04-17 |
Cetus Corporation |
Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
|
|
US4810643A
(en)
|
1985-08-23 |
1989-03-07 |
Kirin- Amgen Inc. |
Production of pluripotent granulocyte colony-stimulating factor
|
|
US6004548A
(en)
|
1985-08-23 |
1999-12-21 |
Amgen, Inc. |
Analogs of pluripotent granulocyte colony-stimulating factor
|
|
JPS63500636A
(ja)
|
1985-08-23 |
1988-03-10 |
麒麟麦酒株式会社 |
多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
|
|
US4680338A
(en)
|
1985-10-17 |
1987-07-14 |
Immunomedics, Inc. |
Bifunctional linker
|
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US6673347B1
(en)
|
1986-04-30 |
2004-01-06 |
Gryphon Therapeutics |
Polypeptide and protein derivatives and process for their preparation
|
|
DK173067B1
(da)
|
1986-06-27 |
1999-12-13 |
Univ Washington |
Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa
|
|
JPH0618781B2
(ja)
|
1986-10-18 |
1994-03-16 |
中外製薬株式会社 |
感染症治療剤
|
|
JPS63123383A
(ja)
|
1986-11-11 |
1988-05-27 |
Mitsubishi Kasei Corp |
ハイブリツドプロモ−タ−、発現調節ｄｎａ配列および発現ベクタ−
|
|
US5681720A
(en)
|
1986-12-23 |
1997-10-28 |
Kyowa Hakko Co., Ltd. |
DNA encoding human granulocyte colony stimulating factor plasmids and host cells comprising same, and methods of expressing the encoded polypeptide
|
|
US5186933A
(en)
|
1986-12-30 |
1993-02-16 |
Baylor College Of Medicine |
Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system
|
|
US4908432A
(en)
|
1987-01-09 |
1990-03-13 |
New York University |
Novel polypeptide having gamma-interferon activity
|
|
EP0349594A4
(en)
|
1987-03-16 |
1990-09-26 |
American Biogenetic Sciences, Inc. |
Recombinant baculovirus occlusion bodies in vaccines and biological insecticides
|
|
CA1304020C
(en)
|
1987-03-23 |
1992-06-23 |
Meher H. Irani |
High level expression in yeast
|
|
US5229490A
(en)
|
1987-05-06 |
1993-07-20 |
The Rockefeller University |
Multiple antigen peptide system
|
|
WO1989001037A1
(en)
|
1987-07-24 |
1989-02-09 |
Cetus Corporation |
Production of ricin toxins in a baculovirus-insect cell expression system
|
|
WO1989001038A1
(en)
|
1987-07-24 |
1989-02-09 |
Cetus Corporation |
PRODUCTION OF BIOLOGICALLY ACTIVE FORMS OF CSF USING A BACULOVIRUS (AcNPV)-INSECT CELL EXPRESSION SYSTEM
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
CA1335792C
(en)
|
1987-08-18 |
1995-06-06 |
Chaim O. Jacob |
Method and dosage form using an antagonist to gamma interferon to control mhc-associated autoimmune disease
|
|
US4929555A
(en)
|
1987-10-19 |
1990-05-29 |
Phillips Petroleum Company |
Pichia transformation
|
|
BR8807310A
(pt)
|
1987-11-18 |
1990-03-13 |
Chiron Corp |
Polinucleotidio,polinucleotidio recombinante,vetor recombinante,celula hospedeira,sistema de expressao recombinante,celula transformada,polipeptidio,hcv,preparacao de polipeptidio,polipeptidio de hcv,polipeptidio purificado,polipeptidio recombinante,polipeptidio de fusao,anticorpo monoclonal,preparacao purificada de anticorpos policlonais,particula,sonda de polinucleotidio,kit anticorpo para epetopo de hcv,metodo para producao de polipeptidio,metodo para deteccao de acidos nucleicos de hcv,imunoensaio para detectar antigeno de hcv,imunoensaio para detectar anticorpos dirigidos contra antigeno de hcv,vacina para tratamento de infeccao de hcv,celula,celula infectada com hcv,metodo para producao de anticorpos para hcv e metodo para isolar cdna derivado do genoma de um agente infeccioso nao identificado
|
|
US4904584A
(en)
|
1987-12-23 |
1990-02-27 |
Genetics Institute, Inc. |
Site-specific homogeneous modification of polypeptides
|
|
CA1340772C
(en)
|
1987-12-30 |
1999-09-28 |
Patricia Tekamp-Olson |
Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
|
|
US4847325A
(en)
|
1988-01-20 |
1989-07-11 |
Cetus Corporation |
Conjugation of polymer to colony stimulating factor-1
|
|
CA1324969C
(en)
|
1988-05-06 |
1993-12-07 |
Jeffrey R. Shuster |
High level expression of proteins in yeast
|
|
US5674706A
(en)
|
1988-05-06 |
1997-10-07 |
Chiron Corporation |
High level expression of proteins in yeast
|
|
FR2631974B1
(fr)
|
1988-05-31 |
1992-12-11 |
Agronomique Inst Nat Rech |
Baculovirus modifie, son procede de preparation et son application en tant que vecteur d'expression de genes
|
|
AU4197389A
(en)
|
1988-08-05 |
1990-03-05 |
Mount Sinai School Of Medicine Of The City University Of New York, The |
In vivo infection of live insects with a recombinant baculovirus
|
|
GB8819453D0
(en)
|
1988-08-16 |
1988-09-21 |
Roy P |
Production of bluetongue virus non-structural proteins using baculovirus expression vector
|
|
CA1339071C
(en)
|
1988-08-24 |
1997-07-29 |
Koichiro Tsuji |
Thrombus control agent
|
|
NZ230425A
(en)
|
1988-09-02 |
1992-07-28 |
Molecular Eng Ass |
Production of paramyxovirus fusion (f) protein using recombinant baculovirus expression vector
|
|
US5218092A
(en)
|
1988-09-29 |
1993-06-08 |
Kyowa Hakko Kogyo Co., Ltd. |
Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
|
|
GB8824591D0
(en)
|
1988-10-20 |
1988-11-23 |
Royal Free Hosp School Med |
Fractionation process
|
|
EP0397834B1
(en)
|
1988-10-28 |
2000-02-02 |
Genentech, Inc. |
Method for identifying active domains and amino acid residues in polypeptides and hormone variants
|
|
US5534617A
(en)
|
1988-10-28 |
1996-07-09 |
Genentech, Inc. |
Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
WO1990005785A1
(en)
|
1988-11-18 |
1990-05-31 |
The Regents Of The University Of California |
Method for site-specifically incorporating unnatural amino acids into proteins
|
|
US6166183A
(en)
|
1992-11-30 |
2000-12-26 |
Kirin-Amgen, Inc. |
Chemically-modified G-CSF
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US4902502A
(en)
|
1989-01-23 |
1990-02-20 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
WO1990010078A1
(en)
|
1989-02-23 |
1990-09-07 |
University Of Ottawa |
Improved baculovirus expression system capable of producing foreign gene proteins at high levels
|
|
WO1990010277A1
(en)
|
1989-02-24 |
1990-09-07 |
Cell Analysis Systems, Inc. |
Method and apparatus for determining a proliferation index of a cell sample
|
|
US6372206B1
(en)
|
1989-03-02 |
2002-04-16 |
University Of Florida |
Orally-administered interferon-TAU compositions and methods
|
|
US5705363A
(en)
|
1989-03-02 |
1998-01-06 |
The Women's Research Institute |
Recombinant production of human interferon τ polypeptides and nucleic acids
|
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
ES2136595T5
(es)
|
1989-04-19 |
2004-04-01 |
Enzon, Inc. |
Carbonatos activos de oxidos de polialquileno para la modificacion de polipeptidos.
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
WO1990014428A1
(en)
|
1989-05-17 |
1990-11-29 |
University Of Georgia Research Foundation, Inc. |
Improved baculovirus expression vectors
|
|
EP0400472B1
(en)
|
1989-05-27 |
1996-04-03 |
Sumitomo Pharmaceuticals Company, Limited |
Process for preparing polyethylene glycol derivatives and modified protein.
|
|
FR2649120B1
(fr)
|
1989-06-30 |
1994-01-28 |
Cayla |
Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
|
|
DE3923963A1
(de)
|
1989-07-20 |
1991-01-31 |
Behringwerke Ag |
Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung
|
|
DE3924746A1
(de)
|
1989-07-26 |
1991-01-31 |
Behringwerke Ag |
Erythropoietin (epo)-peptide und dagegen gerichtete antikoerper
|
|
US5856298A
(en)
|
1989-10-13 |
1999-01-05 |
Amgen Inc. |
Erythropoietin isoforms
|
|
US5312808A
(en)
|
1989-11-22 |
1994-05-17 |
Enzon, Inc. |
Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
|
|
US5162601A
(en)
|
1989-11-22 |
1992-11-10 |
The Upjohn Company |
Plant potyvirus expression vector with a gene for protease
|
|
GB9107846D0
(en)
|
1990-04-30 |
1991-05-29 |
Ici Plc |
Polypeptides
|
|
US5399345A
(en)
|
1990-05-08 |
1995-03-21 |
Boehringer Mannheim, Gmbh |
Muteins of the granulocyte colony stimulating factor
|
|
US5219564A
(en)
|
1990-07-06 |
1993-06-15 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
HUT63185A
(en)
|
1990-06-04 |
1993-07-28 |
Schering Corp |
Process for producing crystalline alpha-2-interferon
|
|
FR2664905B1
(fr)
|
1990-07-18 |
1994-08-12 |
Agronomique Inst Nat Rech |
Baculovirus modifie, son procede d'obtention, et vecteurs d'expression obtenus a partir dudit baculovirus.
|
|
WO1992001800A1
(en)
|
1990-07-20 |
1992-02-06 |
Chiron Corporation |
Method for integrative transformation of yeast using dispersed repetitive elements
|
|
IE912365A1
(en)
|
1990-07-23 |
1992-01-29 |
Zeneca Ltd |
Continuous release pharmaceutical compositions
|
|
WO1992002628A1
(en)
|
1990-08-02 |
1992-02-20 |
Chiron Corporation |
Expression of human cmv glycoprotein-h using the baculovirus-insect cell expression system
|
|
FR2665923B1
(fr)
|
1990-08-14 |
1993-01-22 |
Arbona Jean |
Unite de soins modulaire.
|
|
US5594107A
(en)
|
1990-08-22 |
1997-01-14 |
University Of Saskatchewan |
Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or interferon
|
|
CA2090969C
(en)
|
1990-09-04 |
2001-08-21 |
Russell Arthur Brierley |
Production of insulin-like growth factor-1 in methylotrophic yeast cells
|
|
EP0513332A4
(en)
|
1990-11-14 |
1993-03-17 |
Cargill, Incorporated |
Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
WO1992009691A1
(fr)
|
1990-11-29 |
1992-06-11 |
Institut National De La Recherche Agronomique - I.N.R.A. |
Nouveaux variants derives des interferons de type i, leur procede de production, et leurs applications
|
|
ES2113940T3
(es)
|
1990-12-03 |
1998-05-16 |
Genentech Inc |
Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
|
|
US5231178A
(en)
|
1991-01-16 |
1993-07-27 |
The Salk Institute Biotechnology/Industrial Associates, Inc. |
Method for the purification of intact, correctly-folded insulin-like growth factor-1
|
|
CA2081104A1
(en)
|
1991-02-22 |
1992-08-23 |
Glenn Pierce |
Use of gm-csf and g-csf to promote accelerated wound healing
|
|
US6565841B1
(en)
|
1991-03-15 |
2003-05-20 |
Amgen, Inc. |
Pulmonary administration of granulocyte colony stimulating factor
|
|
WO1992016555A1
(en)
|
1991-03-18 |
1992-10-01 |
Enzon, Inc. |
Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
|
|
AU1651992A
(en)
|
1991-03-19 |
1992-10-21 |
United States of America, as represented by the Secretary, U.S. Department of Commerce, The |
Expression of influenza nucleoprotein antigens in baculovirus
|
|
US5595732A
(en)
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US6126944A
(en)
|
1991-04-26 |
2000-10-03 |
The United States Of America As Represented By The Department Of Health And Human Services |
Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies to herpes simplex virus
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
US5290686A
(en)
|
1991-07-31 |
1994-03-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Expression of influenza a M2 protein in baculovirus
|
|
US5540923A
(en)
|
1991-12-06 |
1996-07-30 |
Landsforeningen Til Kraeftens Bekaemplse |
Interferon proteins
|
|
IT1260468B
(it)
|
1992-01-29 |
1996-04-09 |
|
Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
|
|
ATE156158T1
(de)
|
1992-04-14 |
1997-08-15 |
Cornell Res Foundation Inc |
Makromoleküle auf basis von dendritischen polymeren und verfahren zur herstellung
|
|
US5516657A
(en)
|
1992-05-11 |
1996-05-14 |
Cambridge Biotech Corporation |
Baculovirus vectors for expression of secretory and membrane-bound proteins
|
|
ZA933926B
(en)
|
1992-06-17 |
1994-01-03 |
Amgen Inc |
Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
|
|
US6153407A
(en)
|
1992-07-28 |
2000-11-28 |
Beth Israel Deaconess Medical Center |
Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics
|
|
US5614184A
(en)
|
1992-07-28 |
1997-03-25 |
New England Deaconess Hospital |
Recombinant human erythropoietin mutants and therapeutic methods employing them
|
|
WO1994004193A1
(en)
|
1992-08-21 |
1994-03-03 |
Enzon, Inc. |
Novel attachment of polyalkylene oxides to bio-effecting substances
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
US5591974A
(en)
|
1992-09-30 |
1997-01-07 |
Westinghouse Electric Corporation |
Automated collection and processing of environmental samples
|
|
TW402639B
(en)
|
1992-12-03 |
2000-08-21 |
Transkaryotic Therapies Inc |
Protein production and protein delivery
|
|
NZ250375A
(en)
|
1992-12-09 |
1995-07-26 |
Ortho Pharma Corp |
Peg hydrazone and peg oxime linkage forming reagents and protein derivatives
|
|
US5298643A
(en)
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
|
WO1994015625A1
(en)
|
1993-01-15 |
1994-07-21 |
Enzon, Inc. |
Factor viii - polymeric conjugates
|
|
US5349001A
(en)
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
|
US5581476A
(en)
|
1993-01-28 |
1996-12-03 |
Amgen Inc. |
Computer-based methods and articles of manufacture for preparing G-CSF analogs
|
|
US5321095A
(en)
|
1993-02-02 |
1994-06-14 |
Enzon, Inc. |
Azlactone activated polyalkylene oxides
|
|
US5532142A
(en)
|
1993-02-12 |
1996-07-02 |
Board Of Regents, The University Of Texas System |
Method of isolation and purification of fusion polypeptides
|
|
IL104734A0
(en)
|
1993-02-15 |
1993-06-10 |
Univ Bar Ilan |
Bioactive conjugates of cellulose with amino compounds
|
|
US5441734A
(en)
|
1993-02-25 |
1995-08-15 |
Schering Corporation |
Metal-interferon-alpha crystals
|
|
CN1125401A
(zh)
|
1993-04-29 |
1996-06-26 |
艾博特公司 |
促红细胞生成素类似物组合物和方法
|
|
US6001364A
(en)
|
1993-05-05 |
1999-12-14 |
Gryphon Sciences |
Hetero-polyoxime compounds and their preparation by parallel assembly
|
|
ES2146649T3
(es)
|
1993-05-05 |
2000-08-16 |
Keith Rose |
Compuestos de polioximas y su preparacion.
|
|
US6174530B1
(en)
|
1993-05-05 |
2001-01-16 |
Gryphon Sciences |
Homogeneous polyoxime compositions and their preparation by parallel assembly
|
|
EP0626448A3
(de)
|
1993-05-26 |
1998-01-14 |
BOEHRINGER INGELHEIM INTERNATIONAL GmbH |
Verfahren zur Herstellung und Reinigung von alpha-Interferon
|
|
WO1994028024A1
(en)
|
1993-06-01 |
1994-12-08 |
Enzon, Inc. |
Carbohydrate-modified polymer conjugates with erythropoietic activity
|
|
CA2164811A1
(en)
|
1993-06-11 |
1994-12-22 |
Sidney Pestka |
Super proteins including interferons and interleukins
|
|
WO1995000162A1
(en)
|
1993-06-21 |
1995-01-05 |
Enzon, Inc. |
Site specific synthesis of conjugated peptides
|
|
IL192290A0
(en)
|
1993-08-17 |
2008-12-29 |
Kirin Amgen Inc |
Erythropoietin analogs
|
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
|
US5762939A
(en)
|
1993-09-13 |
1998-06-09 |
Mg-Pmc, Llc |
Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5491076A
(en)
|
1993-11-01 |
1996-02-13 |
The Texas A&M University System |
Expression of foreign genes using a replicating polyprotein producing virus vector
|
|
US5605792A
(en)
|
1993-11-04 |
1997-02-25 |
The Ohio State University Research Foundation |
Infectious bursal disease virus VP2 fusion protein expressed by baculovirus, use as diagnostic
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
DE69430251T2
(de)
|
1993-11-10 |
2002-11-07 |
Enzon, Inc. |
Verbesserte interferon-polymerkonjugate
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5599705A
(en)
|
1993-11-16 |
1997-02-04 |
Cameron; Robert B. |
In vitro method for producing differentiated universally compatible mature human blood cells
|
|
US5773569A
(en)
|
1993-11-19 |
1998-06-30 |
Affymax Technologies N.V. |
Compounds and peptides that bind to the erythropoietin receptor
|
|
US5830851A
(en)
|
1993-11-19 |
1998-11-03 |
Affymax Technologies N.V. |
Methods of administering peptides that bind to the erythropoietin receptor
|
|
FR2715664B1
(fr)
|
1994-01-31 |
1996-04-12 |
Proteine Performance Sa |
Baculovirus recombinant et son utilisation pour la production d'anticorps monoclonaux.
|
|
CA2139385C
(en)
|
1994-02-04 |
2001-12-25 |
Gottfried Alber |
Products containing g-csf and tnf binding protein
|
|
US6316254B1
(en)
|
1994-02-14 |
2001-11-13 |
University Of Washington |
Methods for stimulating erythropoiesis using hematopoietic proteins
|
|
JP3090586B2
(ja)
|
1994-03-15 |
2000-09-25 |
片倉工業株式会社 |
システインプロテアーゼ遺伝子欠損バキュロウイルスおよびその製造法並びにこれを利用する有用タンパク質の製造法
|
|
US5494892A
(en)
|
1994-03-17 |
1996-02-27 |
International Flavors & Fragrances Inc. |
Methyl substituted propyl-substituted pentamethyl indane derivatives processes for producing same and perfumery uses thereof
|
|
US5473034A
(en)
|
1994-03-18 |
1995-12-05 |
Hyogo Prefectural Government |
Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
|
|
US5536495A
(en)
|
1994-04-15 |
1996-07-16 |
Foster; Preston F. |
Use of G-CSF to reduce acute rejection
|
|
US5629384A
(en)
|
1994-05-17 |
1997-05-13 |
Consiglio Nazionale Delle Ricerche |
Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
|
|
WO1995033490A1
(en)
|
1994-06-02 |
1995-12-14 |
Enzon, Inc. |
Method of solubilizing substantially water insoluble materials
|
|
US5730990A
(en)
|
1994-06-24 |
1998-03-24 |
Enzon, Inc. |
Non-antigenic amine derived polymers and polymer conjugates
|
|
US6099830A
(en)
|
1994-08-09 |
2000-08-08 |
Zymogenetics, Inc. |
Methods for stimulating erythropoiesis using hematopoietic proteins
|
|
US6403375B1
(en)
|
1994-08-24 |
2002-06-11 |
Boyce Thompson Institute For Plant Research, Inc. |
Establishment of Trichoplusia ni cell lines in serum-free medium for recombinant protein and baculovirus production
|
|
US5650234A
(en)
|
1994-09-09 |
1997-07-22 |
Surface Engineering Technologies, Division Of Innerdyne, Inc. |
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
|
|
US5871986A
(en)
|
1994-09-23 |
1999-02-16 |
The General Hospital Corporation |
Use of a baculovirus to express and exogenous gene in a mammalian cell
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
JP3467515B2
(ja)
|
1994-11-01 |
2003-11-17 |
財団法人ルイ・パストゥール医学研究センター |
インターフェロン活性の測定法
|
|
EP0788375A2
(en)
|
1994-11-09 |
1997-08-13 |
Robin Ewart Offord |
Functionalized polymers for site-specific attachment
|
|
US5738846A
(en)
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
AU720337B2
(en)
|
1995-02-17 |
2000-05-25 |
Stichting Dienst Landbouwkundig Onderzoek |
Production of biologically active recombinant bovine follicle stimulating hormone (REC bFSH) in the baculovirus expression system
|
|
FR2732035B1
(fr)
|
1995-03-23 |
1997-05-30 |
Agronomique Inst Nat Rech |
Procede de regulation de l'expression d'un gene dans un baculovirus, par un site de fixation d'un recepteur de l'acide retinoique, et vecteur pour la mise en oeuvre du dit procede
|
|
US5939286A
(en)
|
1995-05-10 |
1999-08-17 |
University Of Florida |
Hybrid interferon tau/alpha polypeptides, their recombinant production, and methods using them
|
|
IL118201A
(en)
|
1995-05-11 |
2004-12-15 |
Roche Diagnostics Gmbh |
Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
|
|
NZ308772A
(en)
|
1995-05-17 |
1999-04-29 |
Du Pont |
Recombinant baculovirus insecticides
|
|
US5770191A
(en)
|
1995-05-24 |
1998-06-23 |
University Of Florida |
Active C-terminal peptides of interferon--gamma and their use
|
|
US5814485A
(en)
|
1995-06-06 |
1998-09-29 |
Chiron Corporation |
Production of interferon-β (IFN-β) in E. coli
|
|
AU5893696A
(en)
|
1995-06-07 |
1996-12-30 |
Novo Nordisk A/S |
Modification of polypeptides
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
US5780027A
(en)
|
1995-07-14 |
1998-07-14 |
Meiogen Biotechnology Corporation |
Methods of treatment of down syndrome by interferon antagonists
|
|
US5840565A
(en)
|
1995-08-22 |
1998-11-24 |
The Regents Of The University Of California |
Methods for enhancing the production of viral vaccines in PKR-deficient cell culture
|
|
DE19535853C2
(de)
|
1995-09-18 |
1999-04-01 |
Fraunhofer Ges Forschung |
Varianten des rekombinanten humanen Interferon-gamma, Verfahren zu ihrer Herstellung und ihre Verwendung
|
|
AU718439B2
(en)
|
1995-09-21 |
2000-04-13 |
Genentech Inc. |
Human growth hormone variants
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
US6620413B1
(en)
|
1995-12-27 |
2003-09-16 |
Genentech, Inc. |
OB protein-polymer chimeras
|
|
US5723125A
(en)
|
1995-12-28 |
1998-03-03 |
Tanox Biosystems, Inc. |
Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
|
|
AU1690697A
(en)
|
1996-01-17 |
1997-08-11 |
Schering Corporation |
Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin antagonists
|
|
US5861279A
(en)
|
1996-01-17 |
1999-01-19 |
Schering Corporation |
Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists
|
|
ATE236137T1
(de)
|
1996-02-02 |
2003-04-15 |
Merck & Co Inc |
Heterocyclische verbindungen als antidiabetische mittel und für die behandlung von fettleibigkeit
|
|
ES2217392T3
(es)
|
1996-02-02 |
2004-11-01 |
MERCK & CO., INC. |
Agentes antidiabeticos.
|
|
DE69723680T9
(de)
|
1996-02-02 |
2004-11-04 |
Merck & Co., Inc. |
Antidiabetische mittel
|
|
EP1011651B1
(en)
|
1996-02-02 |
2005-04-27 |
Merck & Co., Inc. |
Method of treating diabetes and related disease states
|
|
US5747639A
(en)
|
1996-03-06 |
1998-05-05 |
Amgen Boulder Inc. |
Use of hydrophobic interaction chromatography to purify polyethylene glycols
|
|
US6204022B1
(en)
|
1996-04-12 |
2001-03-20 |
Pepgen Corporation And University Of Florida |
Low-toxicity human interferon-alpha analogs
|
|
TW517067B
(en)
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
TW586933B
(en)
|
1996-06-20 |
2004-05-11 |
Chugai Pharmaceutical Co Ltd |
Compositions for treating liver-complaints using EPO
|
|
IL128229A0
(en)
|
1996-08-02 |
1999-11-30 |
Ortho Mcneil Pharm Inc |
Polypeptides having a single covalently bound n-terminal water-soluble polymer
|
|
US5980948A
(en)
|
1996-08-16 |
1999-11-09 |
Osteotech, Inc. |
Polyetherester copolymers as drug delivery matrices
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
US5998595A
(en)
|
1996-11-05 |
1999-12-07 |
Wako Pure Chemical Industries, Ltd. |
Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups
|
|
WO1998026080A1
(en)
|
1996-12-13 |
1998-06-18 |
Chiron Corporation |
Method for expression of heterologous proteins in yeast
|
|
BR9606270A
(pt)
|
1996-12-18 |
1998-09-22 |
Univ Minas Gerais |
Processo para a produção da proteína do interferon beta-cis humano recombinante e proteína de interferon beta-cis humano recombinante
|
|
JP2001508783A
(ja)
|
1997-01-29 |
2001-07-03 |
ポリマスク・ファーマシューティカルズ・パブリック・リミテッド・カンパニー |
Ｐｅｇ化法
|
|
GB9703406D0
(en)
|
1997-02-19 |
1997-04-09 |
Chiron Spa |
Expression of heterologous proteins
|
|
DE19717864C2
(de)
|
1997-04-23 |
2001-05-17 |
Fraunhofer Ges Forschung |
Humanes rekombinantes Interferon-beta, Verfahren zu seiner Herstellung und seine Verwendung
|
|
IL120733A0
(en)
*
|
1997-04-29 |
1997-08-14 |
Yeda Res & Dev |
Leptin as an inhibitor of cell proliferation
|
|
AU7266698A
(en)
|
1997-04-30 |
1998-11-24 |
Enzon, Inc. |
Polyalkylene oxide-modified single chain polypeptides
|
|
US6162426A
(en)
|
1997-05-05 |
2000-12-19 |
La Gamma; Edmund F. |
Use of G-CSF to enhance the immune system in neonates
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
DE69841682D1
(de)
|
1997-06-06 |
2010-07-08 |
Kyowa Hakko Kirin Co Ltd |
Chemisch modifizierte polypeptide
|
|
US5965393A
(en)
|
1997-07-01 |
1999-10-12 |
National Institute Of Immunology |
Method for enhancing foreign gene expression in baculovirus expression vector system
|
|
CN1269805A
(zh)
|
1997-07-14 |
2000-10-11 |
博尔德生物技术公司 |
生长激素和相关蛋白的衍生物
|
|
ATE341625T1
(de)
|
1997-07-23 |
2006-10-15 |
Roche Diagnostics Gmbh |
Herstellung von erythropoietin durch endogene genaktivierung mit viralen promotoren
|
|
GB9715660D0
(en)
|
1997-07-25 |
1997-10-01 |
Zeneca Ltd |
Proteins
|
|
EP1003889A1
(en)
|
1997-08-05 |
2000-05-31 |
Chiron Corporation |
NOVEL $i(PICHIA PASTORIS) GENE SEQUENCES AND METHODS FOR THEIR USE
|
|
ATE342346T1
(de)
|
1997-08-05 |
2006-11-15 |
Oregon State |
Verfahren und zusammensetzungen zur reduzierung des bierverderbs
|
|
DE19735593C2
(de)
|
1997-08-15 |
1999-08-26 |
Hepavec Ag Fuer Gentherapie |
Hüllprotein-modifizierter Baculovirus-Vektor für die Gentherapie
|
|
US6090584A
(en)
|
1997-08-21 |
2000-07-18 |
University Technologies International Inc. |
Baculovirus artificial chromosomes and methods of use
|
|
DE69726571T2
(de)
|
1997-09-01 |
2004-11-04 |
Aventis Pharma Deutschland Gmbh |
Rekombinantes humanes Erythropoietin mit vorteilhaftem Glykosylierungsmuster
|
|
US5989868A
(en)
|
1997-09-12 |
1999-11-23 |
The Board Of Regents Of The University Of Oklahoma |
Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli
|
|
EP1538206B1
(en)
|
1997-09-16 |
2010-03-24 |
Centocor, Inc. |
Method for the complete chemical synthesis and assembly of genes and genomes
|
|
JP2001517686A
(ja)
|
1997-09-26 |
2001-10-09 |
ユーエイビー リサーチ ファンデーション |
抗原性を減弱させた血球および、その利用法
|
|
US6004573A
(en)
|
1997-10-03 |
1999-12-21 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
US6201072B1
(en)
|
1997-10-03 |
2001-03-13 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
US6165783A
(en)
|
1997-10-24 |
2000-12-26 |
Neuro Spheres Holdings Ltd. |
Erythropoietin-mediated neurogenesis
|
|
DE19748489A1
(de)
|
1997-11-03 |
1999-05-06 |
Roche Diagnostics Gmbh |
Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
|
|
US6448369B1
(en)
|
1997-11-06 |
2002-09-10 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
|
WO1999029863A1
(en)
|
1997-12-08 |
1999-06-17 |
Genentech, Inc. |
Human interferon-epsilon: a type i interferon
|
|
ZA9811070B
(en)
|
1997-12-08 |
2000-07-03 |
Genentech Inc |
Type I interferons.
|
|
EP0924298A1
(en)
|
1997-12-18 |
1999-06-23 |
Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) |
Protein expression in baculovirus vector expression systems
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US5981709A
(en)
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
TW445295B
(en)
|
1997-12-31 |
2001-07-11 |
Shiu Li Wei |
Expression vector pcDNA3.1-HC for human erythropoietin, BHK-21 host cell line transformed therewith, and production of human erythropoietin using the transformed cell
|
|
US6274158B1
(en)
|
1998-02-04 |
2001-08-14 |
Veronica L. Zaharia Czeizler |
Treatment with recombinant human erythropoietin of bleeding in patients with normal and abnormal hemostasis
|
|
JP2002509077A
(ja)
|
1998-02-09 |
2002-03-26 |
ユニヴァースティ オブ サザーン カリフォルニア |
赤血球形成促進方法
|
|
JP2002505110A
(ja)
|
1998-03-04 |
2002-02-19 |
オニックス ファーマシューティカルズ，インコーポレイティド |
遺伝物質の高生産性発現のためのバキュロウイルス発現系及び方法
|
|
DE69921102T2
(de)
|
1998-03-05 |
2006-02-02 |
Chiron Corp., Emeryville |
Verfahren zur verbesserung der serum-halbwertszeit von biologisch aktiven molekülen
|
|
US6362254B2
(en)
|
1998-03-12 |
2002-03-26 |
Shearwater Corporation |
Poly(ethylene glycol) derivatives with proximal reactive groups
|
|
US6180096B1
(en)
|
1998-03-26 |
2001-01-30 |
Schering Corporation |
Formulations for protection of peg-interferon alpha conjugates
|
|
KR100264953B1
(ko)
|
1998-04-03 |
2001-03-02 |
박현우 |
재조합 베큘로바이러스, 이의 제조방법 및 이를 포함하는 미생물 살충제
|
|
IL124015A0
(en)
|
1998-04-08 |
1999-01-26 |
Yeda Res & Dev |
Pharmaceutical compositions comprising a protein
|
|
AR019025A1
(es)
|
1998-04-09 |
2001-12-26 |
Roche Diagnostics Gmbh |
Uso de eritropoyetina en bajas dosis para producir un preparado farmaceutico para el tratamiento de hemocromatosis, preparado farmaceutico combinadoutilizado segun dicho uso y envase farmaceutico unitario que contiene al referido preparado farmaceutico combinado
|
|
US6310078B1
(en)
|
1998-04-20 |
2001-10-30 |
Ortho-Mcneil Pharmaceutical, Inc. |
Substituted amino acids as erythropoietin mimetics
|
|
US6696411B1
(en)
|
1998-04-22 |
2004-02-24 |
Cornell Research Foundation, Inc. |
Canine erythropoietin gene and recombinant protein
|
|
TR200101751T2
(tr)
|
1998-04-28 |
2002-05-21 |
Applied Research Systems Ars Holding N.V. |
Poliol-IFN-beta konjugatları
|
|
HUP0101355A3
(en)
|
1998-05-07 |
2003-08-28 |
Transkaryotic Therapies Inc Ca |
Genomic sequences upstream of the coding region of the g-csf gene for protein production and delivery
|
|
US6346531B1
(en)
|
1998-05-22 |
2002-02-12 |
Smithkline Beecham Corporation |
G-CSF mimetics
|
|
US6630470B1
(en)
|
1998-05-22 |
2003-10-07 |
Smithkline Beecham Corporation |
G-CSF mimetics
|
|
DE69933216T2
(de)
|
1998-06-15 |
2007-09-20 |
GTC Biotherapeutics, Inc., Framingham |
Erythropoietin-analog-menschliches serum-albumin fusionsprotein
|
|
US6451986B1
(en)
|
1998-06-22 |
2002-09-17 |
Immunex Corporation |
Site specific protein modification
|
|
US6160089A
(en)
|
1998-07-08 |
2000-12-12 |
Mitsui Chemicals, Inc. |
Method for secretory production of human growth hormone
|
|
US6168932B1
(en)
|
1998-07-13 |
2001-01-02 |
Parker Hughes Institute |
Recombinant DTctGMCSF fusion toxin in a baculovirus expression vector system
|
|
US6472512B1
(en)
|
1998-07-21 |
2002-10-29 |
Human Genome Sciences, Inc. |
Keratinocyte derived interferon
|
|
US6245528B1
(en)
|
1998-07-28 |
2001-06-12 |
Academia Sinica |
Latent baculovirus expression system
|
|
US6368825B1
(en)
|
1998-08-10 |
2002-04-09 |
Academia Sinica |
Baculovirus containing minimal CMV promoter
|
|
US6777388B1
(en)
|
1998-08-21 |
2004-08-17 |
Clf Medical Technology Acceleration Program, Inc. |
Leptin-related peptides
|
|
HK1043801A1
(zh)
|
1998-08-28 |
2002-09-27 |
格莱风科学公司 |
精确长度的聚酰胺链、其制备方法和其与蛋白质的缀合物
|
|
WO2000020032A1
(en)
|
1998-10-06 |
2000-04-13 |
Trustees Of Dartmouth College |
RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY
|
|
US6420339B1
(en)
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
|
CN100480266C
(zh)
|
1998-10-16 |
2009-04-22 |
拜奥根Idec马萨诸塞公司 |
干扰素-β融合蛋白及用途
|
|
DK1656952T3
(da)
|
1998-10-16 |
2014-01-20 |
Biogen Idec Inc |
Polyalkylenglycolkonjugater af interferon beta-1A og anvendelser deraf
|
|
US6165283A
(en)
|
1998-10-23 |
2000-12-26 |
Dahlin; William G. |
Railcar cleaning method and apparatus
|
|
ATE365210T1
(de)
|
1998-10-30 |
2007-07-15 |
Novozymes As |
Glykosylierte proteine mit reduzierter allergenität
|
|
US6451346B1
(en)
|
1998-12-23 |
2002-09-17 |
Amgen Inc |
Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
|
|
JP4805432B2
(ja)
|
1998-12-28 |
2011-11-02 |
ランクセス・ドイチュランド・ゲーエムベーハー |
木質材又は木質複合材を製造する際に使用される接着剤混入用薬剤
|
|
US6350589B1
(en)
|
1998-12-31 |
2002-02-26 |
Viragen, Inc. |
Compositions of highly-purified natural mixtures of type I interferon derived from leukocytes and methods
|
|
US6433144B1
(en)
|
1999-01-12 |
2002-08-13 |
Viragen, Inc. |
Compositions of highly-purified natural mixtures of type I Interferon derived from leukocytes and methods
|
|
US6703225B1
(en)
|
1999-01-12 |
2004-03-09 |
Sumitomo Pharmaceuticals Company, Limited |
Interferon-α
|
|
US6281211B1
(en)
|
1999-02-04 |
2001-08-28 |
Euro-Celtique S.A. |
Substituted semicarbazides and the use thereof
|
|
JP4707237B2
(ja)
|
1999-03-17 |
2011-06-22 |
ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ |
外因性アミノ酸および新規ａｔｐ再生システムを用いたインビトロ高分子生合成の方法
|
|
US6642353B1
(en)
|
1999-03-17 |
2003-11-04 |
Chugai Seiyaku Kabushiki Kaisha |
Peptide ligands for the erythropoietin receptor
|
|
US6994986B2
(en)
|
1999-03-17 |
2006-02-07 |
The Board Of Trustees Of The Leland Stanford University |
In vitro synthesis of polypeptides by optimizing amino acid metabolism
|
|
US6342216B1
(en)
|
1999-03-17 |
2002-01-29 |
The Board Of Regents, The University Of Texas System |
Therapy of cancer by insect cells containing recombinant baculovirus encoding genes
|
|
US6337191B1
(en)
|
1999-03-22 |
2002-01-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Vitro protein synthesis using glycolytic intermediates as an energy source
|
|
JP2002542349A
(ja)
|
1999-04-16 |
2002-12-10 |
ダブリューエム・マーシュ・ライス・ユニバーシティー |
ポリ（プロピレンフマラート）−ジアクリレートマクロマーで交差結合された生体分解性のポリ（プロピレンフマラート）ネットワーク
|
|
US6555343B1
(en)
|
1999-05-07 |
2003-04-29 |
Genentech Inc. |
Chimpanzee erythropoietin (CHEPO) polypeptides and nucleic acids encoding the same
|
|
US6831060B2
(en)
|
1999-05-07 |
2004-12-14 |
Genentech, Inc. |
Chimpanzee erythropoietin (CHEPO) polypeptides and nucleic acids encoding the same
|
|
JP2003523940A
(ja)
|
1999-05-11 |
2003-08-12 |
オーソ−マクネイル ファーマシューティカル インコーポレイテッド |
エリスロポエチン投与の薬物速度論的および薬力学的モデリング
|
|
CZ299516B6
(cs)
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
|
|
JO2291B1
(en)
|
1999-07-02 |
2005-09-12 |
اف . هوفمان لاروش ايه جي |
Erythropoietin derivatives
|
|
US6261805B1
(en)
|
1999-07-15 |
2001-07-17 |
Boyce Thompson Institute For Plant Research, Inc. |
Sialyiation of N-linked glycoproteins in the baculovirus expression vector system
|
|
US7160924B2
(en)
*
|
2002-07-19 |
2007-01-09 |
The General Hospital Corporation |
Protein conjugates with a water-soluble biocompatible, biodegradable polymer
|
|
US6531122B1
(en)
|
1999-08-27 |
2003-03-11 |
Maxygen Aps |
Interferon-β variants and conjugates
|
|
WO2001027301A2
(en)
|
1999-10-15 |
2001-04-19 |
The Rockefeller University |
System for rapid generation of recombinant baculovirus-based expression vectors for silkworm larvae
|
|
US6703480B1
(en)
|
1999-11-24 |
2004-03-09 |
Palani Balu |
Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
|
|
US6348558B1
(en)
|
1999-12-10 |
2002-02-19 |
Shearwater Corporation |
Hydrolytically degradable polymers and hydrogels made therefrom
|
|
PT1259563E
(pt)
|
1999-12-22 |
2009-04-14 |
Nektar Therapeutics Al Corp |
Processo para a preparação de ésteres de 1-benzotriazolil- -carbonato de polímeros solúveis em água
|
|
DE60026073T2
(de)
|
1999-12-22 |
2006-09-28 |
Nektar Therapeutics Al, Corp., Huntsville |
Sterisch gehinderte derivate von wasserlöslichen polymeren
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
US6555660B2
(en)
|
2000-01-10 |
2003-04-29 |
Maxygen Holdings Ltd. |
G-CSF conjugates
|
|
US6646110B2
(en)
|
2000-01-10 |
2003-11-11 |
Maxygen Holdings Ltd. |
G-CSF polypeptides and conjugates
|
|
US6602498B2
(en)
|
2000-02-22 |
2003-08-05 |
Shearwater Corporation |
N-maleimidyl polymer derivatives
|
|
AU2001257577A1
(en)
|
2000-02-28 |
2001-09-03 |
Shearwater Corporation |
Water-soluble polymer conjugates of artelinic acid
|
|
US6586398B1
(en)
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
|
IL152804A0
(en)
|
2000-05-16 |
2003-06-24 |
Bolder Biotechnology Inc |
Methods for refolding proteins containing free cysteine residues
|
|
GB0012997D0
(en)
|
2000-05-26 |
2000-07-19 |
Eurogene Limited |
Gene delivery
|
|
US6586207B2
(en)
|
2000-05-26 |
2003-07-01 |
California Institute Of Technology |
Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
|
|
JP2002030098A
(ja)
|
2000-07-17 |
2002-01-29 |
Institute Of Immunology Co Ltd |
バキュロウィルスの発芽ウイルスからウイルスエンベロープを回収する方法
|
|
US6436386B1
(en)
|
2000-11-14 |
2002-08-20 |
Shearwater Corporation |
Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
|
|
TW593427B
(en)
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
|
US6531121B2
(en)
|
2000-12-29 |
2003-03-11 |
The Kenneth S. Warren Institute, Inc. |
Protection and enhancement of erythropoietin-responsive cells, tissues and organs
|
|
TWI246524B
(en)
|
2001-01-19 |
2006-01-01 |
Shearwater Corp |
Multi-arm block copolymers as drug delivery vehicles
|
|
RU2003125638A
(ru)
*
|
2001-02-06 |
2005-03-10 |
Мерк Патент ГмбХ (DE) |
Модифицированный лептин с уменьшенной иммуногенностью
|
|
US20070203225A1
(en)
|
2001-04-03 |
2007-08-30 |
Havel Peter J |
Method of increasing endogenous adiponectin production and leptin production
|
|
IL158418A0
(en)
|
2001-04-19 |
2004-05-12 |
Scripps Research Inst |
In vivo incorporation of unnatural amino acids
|
|
PL205971B1
(pl)
*
|
2001-09-24 |
2010-06-30 |
Imp Innovations Ltd |
Zastosowanie PYY₃-₃₆ do wytwarzania leku na ograniczanie apetytu, zmniejszenie otyłości lub do zapobiegania otyłości
|
|
US6908963B2
(en)
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
PL369953A1
(en)
*
|
2001-10-13 |
2005-05-02 |
Asterion Limited |
Glycosylphosphatidylinositol containing polypeptides
|
|
MXPA04004336A
(es)
|
2001-11-07 |
2005-05-16 |
Nektar Therapeutics Al Corp |
Polimeros ramificados y sus conjugados.
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
WO2003101972A1
(en)
|
2002-05-30 |
2003-12-11 |
The Scripps Research Institute |
Copper-catalysed ligation of azides and acetylenes
|
|
WO2004035743A2
(en)
|
2002-10-16 |
2004-04-29 |
The Scripps Research Institute |
Site specific incorporation of keto amino acids into proteins
|
|
MXPA05003978A
(es)
|
2002-10-16 |
2005-06-22 |
Scripps Research Inst |
Sintesis de glicoproteinas.
|
|
CA2510199A1
(en)
*
|
2002-12-17 |
2004-07-08 |
Nastech Pharmaceutical Company Inc. |
Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity
|
|
MXPA05006836A
(es)
|
2002-12-22 |
2005-08-16 |
Scripps Research Inst |
Colecciones ordenadas de proteinas.
|
|
CN103289960B
(zh)
|
2003-04-17 |
2017-04-26 |
斯克利普斯研究院 |
扩展真核生物遗传密码
|
|
EP1666604B1
(en)
|
2003-07-07 |
2008-02-13 |
The Scripps Research Institute |
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
|
|
WO2005007624A2
(en)
|
2003-07-07 |
2005-01-27 |
The Scripps Research Institute |
Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof
|
|
US20060160175A1
(en)
|
2003-07-07 |
2006-07-20 |
The Scripps Research Institute |
Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
|
|
SG176455A1
(en)
|
2003-10-09 |
2011-12-29 |
Ambrx Inc |
Polymer derivatives
|
|
CN103755800B
(zh)
|
2004-02-02 |
2016-02-24 |
Ambrx公司 |
经修饰的人类生长激素多肽与其用途
|
|
AU2005319099B2
(en)
|
2004-02-02 |
2010-09-16 |
Ambrx, Inc. |
Modified human growth hormone
|
|
WO2005094898A2
(en)
*
|
2004-03-23 |
2005-10-13 |
Amgen Inc. |
Chemically modified protein compositions and methods
|
|
US7638299B2
(en)
*
|
2004-07-21 |
2009-12-29 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
|
US7385028B2
(en)
*
|
2004-12-22 |
2008-06-10 |
Ambrx, Inc |
Derivatization of non-natural amino acids and polypeptides
|
|
AR054417A1
(es)
|
2004-12-23 |
2007-06-27 |
Astrazeneca Ab |
Derivados de imidazol. proceso de obtencion y composiciones farmaceuticas.
|
|
US7399786B2
(en)
|
2005-06-30 |
2008-07-15 |
Bexel Pharmaceuticals, Inc. |
Derivatives of amino acids for treatment of obesity and related disorders
|
|
AU2006279680B2
(en)
*
|
2005-08-11 |
2012-12-06 |
Amylin Pharmaceuticals, Llc |
Hybrid polypeptides with selectable properties
|