MX344166B - Leptina-polipeptidos modificados y sus usos. - Google Patents

Leptina-polipeptidos modificados y sus usos.

Info

Publication number
MX344166B
MX344166B MX2013007824A MX2013007824A MX344166B MX 344166 B MX344166 B MX 344166B MX 2013007824 A MX2013007824 A MX 2013007824A MX 2013007824 A MX2013007824 A MX 2013007824A MX 344166 B MX344166 B MX 344166B
Authority
MX
Mexico
Prior art keywords
leptin polypeptides
modified leptin
modified
polypeptides
modified human
Prior art date
Application number
MX2013007824A
Other languages
English (en)
Inventor
Nick Knudsen
Vadim Kraynov
Jason Pinkstaff
Heather Myler
Anna-Maria A Hays Putnam
Lorraine Sullivan
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of MX344166B publication Critical patent/MX344166B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se refiere a un leptina-polipéptido que comprende uno o más aminoácidos no naturalmente codificados, sustituidos en las posiciones seleccionadas de 46, 66, 67, 100, 105, 108 y 111 de la SEQ ID NO: 4 o el aminoácido correspondiente codificado por la SEQ ID NO: 3 o las posiciones 45, 65, 66, 99, 104, 107 y 110 de la SEQ ID NO; 2, en donde un polímero soluble en agua se une a un aminoácido codificado no naturalmente, presente en dicho polipéptido de leptina.
MX2013007824A 2008-02-08 2009-02-05 Leptina-polipeptidos modificados y sus usos. MX344166B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2741408P 2008-02-08 2008-02-08
PCT/US2009/033277 WO2009100255A2 (en) 2008-02-08 2009-02-05 Modified leptin polypeptides and their uses

Publications (1)

Publication Number Publication Date
MX344166B true MX344166B (es) 2016-12-07

Family

ID=40952687

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2010008632A MX2010008632A (es) 2008-02-08 2009-02-05 Leptina-polipeptidos modificados y sus usos.
MX2013007824A MX344166B (es) 2008-02-08 2009-02-05 Leptina-polipeptidos modificados y sus usos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2010008632A MX2010008632A (es) 2008-02-08 2009-02-05 Leptina-polipeptidos modificados y sus usos.

Country Status (11)

Country Link
US (1) US9938333B2 (es)
EP (2) EP3103880A1 (es)
JP (2) JP5702150B2 (es)
CN (2) CN101939443B (es)
AU (1) AU2009212311B8 (es)
CA (1) CA2712606A1 (es)
IL (1) IL207096A (es)
MX (2) MX2010008632A (es)
NZ (3) NZ602170A (es)
SG (1) SG188143A1 (es)
WO (1) WO2009100255A2 (es)

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US10099157B2 (en) 2014-06-23 2018-10-16 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
CN105392569B (zh) 2014-06-23 2019-08-20 生物辐射实验室股份有限公司 磷灰石预处理
CN104829708B (zh) * 2015-05-06 2017-11-28 广东省生物资源应用研究所 一条d螺旋区突变的瘦素活性肽及其编码基因和应用
CN104829705B (zh) * 2015-05-06 2017-11-14 广东省生物资源应用研究所 一条c螺旋区突变的瘦素活性肽及其编码基因和应用
CN104829707B (zh) * 2015-05-06 2017-12-19 广东省生物资源应用研究所 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
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SG11201907209QA (en) 2017-02-08 2019-09-27 Bristol Myers Squibb Co Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
EP3994168A4 (en) * 2019-07-02 2023-04-05 Shanghaitech University ANTIBODIES AGAINST THE LEPTIN RECEPTOR

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CN103694337B (zh) 2016-03-02
AU2009212311B2 (en) 2013-01-31
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SG188143A1 (en) 2013-03-28
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CN101939443A (zh) 2011-01-05
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CA2712606A1 (en) 2009-08-13
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