US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
GB9417742D0
(en)
*
|
1994-09-03 |
1994-10-19 |
Univ Nottingham |
Macrophage stimulating composition
|
US5738846A
(en)
*
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
CA2236591C
(en)
|
1995-11-02 |
2012-01-03 |
Schering Corporation |
Continuous low-dose cytokine infusion therapy
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
US20030190307A1
(en)
|
1996-12-24 |
2003-10-09 |
Biogen, Inc. |
Stable liquid interferon formulations
|
US6472373B1
(en)
*
|
1997-09-21 |
2002-10-29 |
Schering Corporation |
Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
|
US5985263A
(en)
*
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
US5981709A
(en)
*
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
TWI243057B
(en)
*
|
1998-03-26 |
2005-11-11 |
Schering Corp |
Formulations for protection of peg-interferon alpha conjugates
|
US6180096B1
(en)
|
1998-03-26 |
2001-01-30 |
Schering Corporation |
Formulations for protection of peg-interferon alpha conjugates
|
JP4574007B2
(ja)
|
1998-04-28 |
2010-11-04 |
メルク・セローノ・ソシエテ・アノニム |
ポリオール−ifn−ベータ複体
|
CZ300540B6
(cs)
*
|
1998-05-15 |
2009-06-10 |
Schering Corporation |
Farmaceutický prostredek obsahující ribavirin v kombinaci s interferonem alfa pro lécbu pacientu s chronickou infekcí hepatitidy C genotypu 1
|
ITMI981148A1
(it)
*
|
1998-05-22 |
1999-11-22 |
Therapicon Srl |
Utilizzo di lisozima c modificato per preparare composizioni medicinali per il trattamento di alcune gravi malattie
|
PL192364B1
(pl)
*
|
1998-06-08 |
2006-10-31 |
Hoffmann La Roche |
Zastosowanie koniugatu PEG-IFN-α 2A w połączeniu z rybawiryną
|
US6783965B1
(en)
|
2000-02-10 |
2004-08-31 |
Mountain View Pharmaceuticals, Inc. |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
|
CA2338665C
(en)
|
1998-08-06 |
2011-01-18 |
Mountain View Pharmaceuticals, Inc. |
Peg-urate oxidase conjugates and use thereof
|
DE69930015T2
(de)
*
|
1998-10-16 |
2006-10-12 |
Biogen Idec Ma Inc., Cambridge |
Polymerkonjugate von interferon-beta-1a und deren verwendungen
|
BR9915548A
(pt)
*
|
1998-10-16 |
2001-08-14 |
Biogen Inc |
Proteìnas de fusão de interferon-beta e usos
|
US6824768B2
(en)
*
|
1998-12-18 |
2004-11-30 |
Schering Corporation |
Ribavirin-pegylated interferon alfa induction HCV combination therapy
|
AR029337A1
(es)
*
|
1999-03-02 |
2003-06-25 |
Schering Corp |
Uso de interferon alfa pegilado para la preparacion de un medicamento para la terapia contra el hiv
|
US6605273B2
(en)
|
1999-04-08 |
2003-08-12 |
Schering Corporation |
Renal cell carcinoma treatment
|
CN1390132A
(zh)
|
1999-04-08 |
2003-01-08 |
先灵公司 |
聚乙二醇化干扰素α在黑素瘤治疗中的应用
|
US6923966B2
(en)
|
1999-04-08 |
2005-08-02 |
Schering Corporation |
Melanoma therapy
|
PE20010288A1
(es)
|
1999-07-02 |
2001-03-07 |
Hoffmann La Roche |
Derivados de eritropoyetina
|
WO2001026677A1
(fr)
*
|
1999-10-12 |
2001-04-19 |
Santen Pharmaceutical Co., Ltd. |
Complexe a base d'interferon et son utilisation en medecine
|
TR200101086A3
(de)
*
|
1999-10-15 |
2001-08-21 |
|
|
CN1309423C
(zh)
|
1999-11-12 |
2007-04-11 |
马克西根控股公司 |
干扰素γ偶联物
|
SK8292002A3
(en)
*
|
1999-11-12 |
2002-12-03 |
Maxygen Holdings Ltd |
A conjugate exhibiting interferon gamma activity, nucleotide sequence encoding for a polypeptide fraction of conjugate, an expression vector and a host cell containing nucleotide sequence, pharmaceutical composition comprising the same and use thereof
|
ES2327606T3
(es)
|
2000-01-10 |
2009-11-02 |
Maxygen Holdings Ltd |
Conjugados de g-csf.
|
EP1908477A3
(de)
*
|
2000-01-24 |
2008-06-11 |
Schering Corporation |
Kombination aus Temozolomid und pegyliertem Interferon-alpha zur Krebsbehandlung
|
MXPA02007172A
(es)
*
|
2000-01-24 |
2002-12-13 |
Schering Corp |
Combinacion de temozolomida y alfa interferon pegilado para tratamiento de cancer.
|
DE60138364D1
(de)
|
2000-02-11 |
2009-05-28 |
Bayer Healthcare Llc |
Gerinnungsfaktor vii oder viia konjugate
|
AU2001249120A1
(en)
*
|
2000-03-09 |
2001-09-17 |
Schering Corporation |
Hiv immune adjuvant therapy
|
US20030147874A1
(en)
*
|
2000-12-14 |
2003-08-07 |
Volker Schellenberger |
Targeted enzyme prodrug therapy
|
US20030068792A1
(en)
*
|
2000-12-14 |
2003-04-10 |
Yiyou Chen |
Targeted enzymes
|
US20080248544A1
(en)
*
|
2000-12-14 |
2008-10-09 |
Murray Christopher J |
Methods And Compositions For Grafting Functional Loops Into A Protein
|
US20030049689A1
(en)
*
|
2000-12-14 |
2003-03-13 |
Cynthia Edwards |
Multifunctional polypeptides
|
ATE432288T1
(de)
|
2001-02-27 |
2009-06-15 |
Maxygen Aps |
Neue interferon-beta-ähnliche moleküle
|
US7038015B2
(en)
*
|
2001-04-06 |
2006-05-02 |
Maxygen Holdings, Ltd. |
Interferon gamma polypeptide variants
|
US6958388B2
(en)
|
2001-04-06 |
2005-10-25 |
Maxygen, Aps |
Interferon gamma polypeptide variants
|
UA78726C2
(en)
|
2001-11-01 |
2007-04-25 |
Sciclone Pharmaceuticals Inc |
Pharmaceutical composition of thymosin alpha 1 conjugated with polyethylene glycol, method for production, and method for treatment
|
EP1461067A1
(de)
*
|
2001-12-07 |
2004-09-29 |
Intermune, Inc. |
Zusammensetzungen und verfahren zur behandlung von infektionen mit dem hepatitis-virus
|
WO2003061577A2
(en)
|
2002-01-18 |
2003-07-31 |
Biogen Idec Ma Inc. |
Polyalkylene glycol with moiety for conjugating biologically active compound
|
DE10209821A1
(de)
|
2002-03-06 |
2003-09-25 |
Biotechnologie Ges Mittelhesse |
Kopplung von Proteinen an ein modifiziertes Polysaccharid
|
TW200400818A
(en)
|
2002-05-21 |
2004-01-16 |
Wyeth Corp |
Method for the use of pyranoindole derivatives to treat infection with hepatitis C virus
|
CN1671420A
(zh)
|
2002-06-21 |
2005-09-21 |
诺和诺德医疗保健公司 |
Peg化因子ⅶ糖型
|
WO2004002999A2
(en)
|
2002-06-28 |
2004-01-08 |
Idenix (Cayman) Limited |
Modified 2' and 3' -nucleoside produgs for treating flaviridae infections
|
CA2491178A1
(en)
*
|
2002-07-03 |
2004-01-15 |
Maxygen Holdings Ltd. |
Full-length interferon gamma polypeptide variants
|
WO2004012773A1
(en)
*
|
2002-07-24 |
2004-02-12 |
F. Hoffmann-La Roche Ag |
Polyalkylene glycol acid additives
|
US8193318B2
(en)
*
|
2002-08-14 |
2012-06-05 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
US8946387B2
(en)
*
|
2002-08-14 |
2015-02-03 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
CA2495251C
(en)
*
|
2002-08-14 |
2018-03-06 |
Macrogenics, Inc. |
Fc.gamma.riib-specific antibodies and methods of use thereof
|
US8044180B2
(en)
*
|
2002-08-14 |
2011-10-25 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
US8968730B2
(en)
*
|
2002-08-14 |
2015-03-03 |
Macrogenics Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
KR20050083677A
(ko)
*
|
2002-09-05 |
2005-08-26 |
더 제너럴 하스피탈 코포레이션 |
변형 아시알로 인터페론 및 그의 용도
|
US8129330B2
(en)
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
AU2003295838B2
(en)
|
2002-11-25 |
2008-05-22 |
Sciclone Pharmaceuticals, Inc. |
Methods of protecting against radiation damage using alpha thymosin
|
RS20050501A
(en)
*
|
2002-12-26 |
2007-08-03 |
Mountain View Pharmaceuticals Inc., |
Polymer conjugates of cytokines,chemokines,growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
|
RS20050502A
(en)
*
|
2002-12-26 |
2007-08-03 |
Mountain View Pharmaceuticals Inc., |
Polymer conjugates of interferon- beta with enhanced biological potency
|
US7355008B2
(en)
*
|
2003-01-09 |
2008-04-08 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
US7960512B2
(en)
|
2003-01-09 |
2011-06-14 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
WO2004078127A2
(en)
*
|
2003-02-28 |
2004-09-16 |
Intermune, Inc. |
Continuous delivery methods for treating hepatitis virus infection
|
CA2734052A1
(en)
|
2003-05-30 |
2005-01-13 |
Pharmasset, Inc. |
Modified fluorinated nucleoside analogues
|
WO2005014655A2
(en)
|
2003-08-08 |
2005-02-17 |
Fresenius Kabi Deutschland Gmbh |
Conjugates of hydroxyalkyl starch and a protein
|
GB0320638D0
(en)
|
2003-09-03 |
2003-10-01 |
Novartis Ag |
Organic compounds
|
EP2263684A1
(de)
|
2003-10-10 |
2010-12-22 |
Novo Nordisk A/S |
IL-21 Derivate
|
EP2407470A3
(de)
|
2003-10-14 |
2015-06-10 |
F. Hoffmann-La Roche Ltd. |
Makrocyclische Carbonsäuren und Acylsulfonamide als Hemmer der HCV-Replikation
|
EP2633866A3
(de)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Kombinationstherapie
|
US20110160440A1
(en)
*
|
2003-12-12 |
2011-06-30 |
Genencor International, Inc. |
Cab Molecules
|
GB2429207A
(en)
|
2004-02-02 |
2007-02-21 |
Ambrx Inc |
Modified human interferon polypeptides and their uses
|
AU2005319099B2
(en)
|
2004-02-02 |
2010-09-16 |
Ambrx, Inc. |
Modified human growth hormone
|
WO2005084303A2
(en)
*
|
2004-03-01 |
2005-09-15 |
Enzon Pharmaceuticals, Inc. |
Interferon-beta polymer conjugates
|
EP1735350B1
(de)
|
2004-04-15 |
2010-08-25 |
Genencor International, Inc. |
Anti-cea scfv-beta-lactamase konstrukte (cab moleküle) in adept
|
MXPA06011796A
(es)
*
|
2004-04-16 |
2007-05-07 |
Macrogenics Inc |
Anticuerpos especificos de fc(riib y metodos para el uso de los mismos.
|
KR101297146B1
(ko)
*
|
2004-05-10 |
2013-08-21 |
마크로제닉스, 인크. |
인간화 FcγRIIB 특이적 항체 및 그의 사용 방법
|
KR101699142B1
(ko)
|
2004-06-18 |
2017-01-23 |
암브룩스, 인코포레이티드 |
신규 항원-결합 폴리펩티드 및 이의 용도
|
US20080233100A1
(en)
*
|
2004-06-30 |
2008-09-25 |
Yiyou Chen |
Targeted enzymes
|
CN101023094B
(zh)
*
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
DE602005022895D1
(de)
|
2004-08-12 |
2010-09-23 |
Schering Corp |
Stabile pegylierte interferon-formulierung
|
RU2433124C2
(ru)
*
|
2004-09-14 |
2011-11-10 |
Фармассет, Инк. |
Способ получения 2'-фтор-2'-алкилзамещенных или других замещенных рибофуранозилпиримидинов и пуринов и их производных
|
WO2007024249A2
(en)
|
2004-11-10 |
2007-03-01 |
Macrogenics, Inc. |
Engineering fc antibody regions to confer effector function
|
US20080044400A1
(en)
*
|
2004-12-09 |
2008-02-21 |
Volker Schellenberger |
Targeted enzyme prodrug therapy
|
US7816320B2
(en)
|
2004-12-22 |
2010-10-19 |
Ambrx, Inc. |
Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35
|
EP1836298B1
(de)
|
2004-12-22 |
2012-01-18 |
Ambrx, Inc. |
Zusammensetzungen von aminoacyl-trna-synthetase und verwendungen davon
|
US8080391B2
(en)
|
2004-12-22 |
2011-12-20 |
Ambrx, Inc. |
Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer
|
US7365127B2
(en)
*
|
2005-02-04 |
2008-04-29 |
Enzon Pharmaceuticals, Inc. |
Process for the preparation of polymer conjugates
|
ES2856881T3
(es)
|
2005-04-11 |
2021-09-28 |
Horizon Pharma Rheumatology Llc |
Formas variantes de urato oxidasa y su uso
|
EP1877102B1
(de)
*
|
2005-04-28 |
2014-05-07 |
Danisco US Inc. |
Tab moleküle
|
ATE529442T1
(de)
|
2005-06-03 |
2011-11-15 |
Ambrx Inc |
Verbesserte humane interferon-moleküle und ihre verwendungen
|
JP2008546708A
(ja)
|
2005-06-17 |
2008-12-25 |
ノバルティス アクチエンゲゼルシャフト |
Hcvにおけるサングリフェリンの使用
|
ES2553160T3
(es)
|
2005-06-17 |
2015-12-04 |
Novo Nordisk Health Care Ag |
Reducción y derivatización selectivas de proteínas Factor VII transformadas por ingeniería que comprenden al menos una cisteína no nativa
|
CA2612901A1
(en)
*
|
2005-06-20 |
2007-01-04 |
Pepgen Corporation |
Low-toxicity, long-circulating chimeras of human interferon- alpha analogs and interferon tau
|
US7695710B2
(en)
*
|
2005-06-20 |
2010-04-13 |
Pepgen Corporation |
Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs
|
BRPI0613962A2
(pt)
|
2005-07-25 |
2009-03-24 |
Intermune Inc |
inibidores macrocìclicos inovadores de replicação de vìrus da hepatite c
|
US8217147B2
(en)
|
2005-08-10 |
2012-07-10 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
GEP20104956B
(en)
|
2005-10-11 |
2010-04-12 |
Array Biopharma Inc |
Compounds for inhibiting hepatitis c viral replication and use thereof
|
PT2339014E
(pt)
|
2005-11-16 |
2015-10-13 |
Ambrx Inc |
Métodos e composições compreendendo aminoácidos não-naturais
|
EP1999470A4
(de)
*
|
2006-03-10 |
2009-08-19 |
Macrogenics Inc |
Identifizierung und herstellung von antikörpern mit variierenden schweren ketten und anwendungsverfahren dafür
|
CA2643680A1
(en)
|
2006-04-11 |
2007-11-22 |
Novartis Ag |
Hcv/hiv inhibitors and their uses
|
US20080096819A1
(en)
|
2006-05-02 |
2008-04-24 |
Allozyne, Inc. |
Amino acid substituted molecules
|
JP5313129B2
(ja)
|
2006-05-02 |
2013-10-09 |
アロザイン, インコーポレイテッド |
非天然アミノ酸置換ポリペプチド
|
EP2029738A2
(de)
|
2006-05-24 |
2009-03-04 |
Novo Nordisk Health Care AG |
Faktor-ix-analoge mit verlängerter in-vivo-halbwertszeit
|
WO2008105886A2
(en)
|
2006-05-26 |
2008-09-04 |
Macrogenics, Inc. |
HUMANIZED FCγRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
|
EP2032159B1
(de)
|
2006-06-26 |
2015-01-07 |
MacroGenics, Inc. |
Kombination aus fcgammariib-antikörpern und cd20-spezifischen antikörpern sowie verwendungsverfahren dafür
|
HUE030269T2
(en)
*
|
2006-06-26 |
2017-04-28 |
Macrogenics Inc |
FC RIIB-specific antibodies and methods for their use
|
WO2008030614A2
(en)
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Suppressor trna transcription in vertebrate cells
|
DK2615108T3
(en)
|
2006-09-08 |
2017-01-30 |
Ambrx Inc |
Modified human plasma polypeptide or fc scaffolds and their applications
|
WO2008030613A2
(en)
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Hybrid suppressor trna for vertebrate cells
|
ATE487497T1
(de)
*
|
2006-09-29 |
2010-11-15 |
Canji Inc |
Verfahren und zusammensetzungen für gentherapie
|
US20080112961A1
(en)
*
|
2006-10-09 |
2008-05-15 |
Macrogenics, Inc. |
Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same
|
BRPI0717674A2
(pt)
*
|
2006-11-24 |
2014-04-08 |
Cadila Healthcare Ltd |
' formulação compreendendo conjugados de peg-interferon alfa, processo de liofilização da formulação e formulação liofilizada '
|
US8652466B2
(en)
|
2006-12-08 |
2014-02-18 |
Macrogenics, Inc. |
Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
KR20140012199A
(ko)
|
2007-03-30 |
2014-01-29 |
암브룩스, 인코포레이티드 |
변형된 fgf-21 폴리펩티드 및 그 용도
|
CN103965347B
(zh)
|
2007-05-02 |
2017-07-18 |
Ambrx公司 |
经修饰干扰素β多肽和其用途
|
US7625555B2
(en)
|
2007-06-18 |
2009-12-01 |
Novagen Holding Corporation |
Recombinant human interferon-like proteins
|
CA2707840A1
(en)
|
2007-08-20 |
2009-02-26 |
Allozyne, Inc. |
Amino acid substituted molecules
|
JPWO2009028573A1
(ja)
|
2007-08-27 |
2010-12-09 |
国立大学法人名古屋大学 |
血液凝固障害におけるリバビリンの利用
|
US8216571B2
(en)
|
2007-10-22 |
2012-07-10 |
Schering Corporation |
Fully human anti-VEGF antibodies and methods of using
|
AU2008326324B9
(en)
|
2007-11-20 |
2012-11-15 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
EP3103880A1
(de)
|
2008-02-08 |
2016-12-14 |
Ambrx, Inc. |
Modifizierte leptinpolypeptide und deren verwendungen
|
TW200946541A
(en)
|
2008-03-27 |
2009-11-16 |
Idenix Pharmaceuticals Inc |
Solid forms of an anti-HIV phosphoindole compound
|
CN106349390B
(zh)
|
2008-04-02 |
2019-12-10 |
宏观基因有限公司 |
Bcr-复合体-特异性抗体和其使用方法
|
PL2247304T3
(pl)
|
2008-04-02 |
2017-01-31 |
Macrogenics, Inc. |
Przeciwciała specyficzne wobec HER2/neu oraz sposoby ich zastosowania
|
WO2010033279A2
(en)
*
|
2008-06-04 |
2010-03-25 |
Macrogenics, Inc. |
Antibodies with altered binding to fcrn and methods of using same
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
WO2010005807A2
(en)
|
2008-07-08 |
2010-01-14 |
Board Of Regents, The University Of Texas System |
Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (stats)
|
UA118536C2
(uk)
|
2008-07-23 |
2019-02-11 |
Амбркс, Інк. |
Модифікований поліпептид бичачого гранулоцитарного колонієстимулювального фактора та його застосування
|
EP3216800A1
(de)
|
2008-09-26 |
2017-09-13 |
Ambrx, Inc. |
Modifizierte tierische erythropoietin-polypeptide und deren verwendungen
|
MX348657B
(es)
|
2008-09-26 |
2017-06-21 |
Ambrx Inc |
Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
|
EA201100851A1
(ru)
|
2008-12-23 |
2012-04-30 |
Фармассет, Инк. |
Аналоги нуклеозидов
|
NZ593648A
(en)
*
|
2008-12-23 |
2013-09-27 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
CL2009002206A1
(es)
|
2008-12-23 |
2011-08-26 |
Gilead Pharmasset Llc |
Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
|
US8512690B2
(en)
|
2009-04-10 |
2013-08-20 |
Novartis Ag |
Derivatised proline containing peptide compounds as protease inhibitors
|
US20110182850A1
(en)
|
2009-04-10 |
2011-07-28 |
Trixi Brandl |
Organic compounds and their uses
|
TWI576352B
(zh)
|
2009-05-20 |
2017-04-01 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
AU2010265964B2
(en)
|
2009-06-25 |
2014-09-18 |
Horizon Therapeutics Usa, Inc. |
Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy
|
WO2011014882A1
(en)
|
2009-07-31 |
2011-02-03 |
Medtronic, Inc. |
CONTINUOUS SUBCUTANEOUS ADMINISTRATION OF INTERFERON-α TO HEPATITIS C INFECTED PATIENTS
|
RU2583298C2
(ru)
|
2009-10-07 |
2016-05-10 |
Макродженикс, Инк. |
ПОЛИПЕПТИДЫ, СОДЕРЖАЩИЕ Fc-УЧАСТОК, КОТОРЫЕ ДЕМОНСТРИРУЮТ ПОВЫШЕННУЮ ЭФФЕКТОРНУЮ ФУНКЦИЮ БЛАГОДАРЯ ИЗМЕНЕНИЯМ СТЕПЕНИ ФУКОЗИЛИРОВАНИЯ, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
NZ598465A
(en)
|
2009-10-30 |
2013-10-25 |
Boehringer Ingelheim Int |
Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
|
NZ600363A
(en)
|
2009-12-21 |
2014-07-25 |
Ambrx Inc |
Modified porcine somatotropin polypeptides and their uses
|
CN102753573A
(zh)
|
2009-12-21 |
2012-10-24 |
Ambrx公司 |
经过修饰的牛促生长素多肽和其用途
|
US8802091B2
(en)
|
2010-03-04 |
2014-08-12 |
Macrogenics, Inc. |
Antibodies reactive with B7-H3 and uses thereof
|
NZ602161A
(en)
|
2010-03-04 |
2014-12-24 |
Macrogenics Inc |
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
|
WO2011107591A1
(en)
|
2010-03-05 |
2011-09-09 |
Rigshospitalet |
Chimeric inhibitor molecules of complement activation
|
BR112012024884A2
(pt)
|
2010-03-31 |
2016-10-18 |
Gilead Pharmasset Llc |
síntese estereosseletiva de ativos contendo fósforo
|
US8563530B2
(en)
|
2010-03-31 |
2013-10-22 |
Gilead Pharmassel LLC |
Purine nucleoside phosphoramidate
|
EP2569331A1
(de)
|
2010-05-10 |
2013-03-20 |
Perseid Therapeutics LLC |
Polypeptid-inhibitoren von vla4
|
WO2011159930A2
(en)
|
2010-06-16 |
2011-12-22 |
Medtronic, Inc. |
Damping systems for stabilizing medications in drug delivery devices
|
IN2012MN02896A
(de)
|
2010-06-24 |
2015-06-12 |
Panmed Ltd |
|
BR112013003522B1
(pt)
|
2010-08-17 |
2021-05-25 |
Ambrx, Inc. |
polipeptídeos relaxina modificados compreendendo um aminoácido não codificado naturalmente, seu método de preparação e seu uso, bem como ácido nucleico e célula hospedeira
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
KR20140035305A
(ko)
|
2010-10-05 |
2014-03-21 |
노파르티스 아게 |
C형 간염 바이러스 감염의 새로운 치료법
|
US9011833B2
(en)
|
2010-10-08 |
2015-04-21 |
Novartis Ag |
Vitamin E formulations of sulfamide NS3 inhibitors
|
RU2013129824A
(ru)
|
2010-11-30 |
2015-01-10 |
Новартис Аг |
Новое лечение инфекции вируса гепатита с
|
AR084044A1
(es)
|
2010-11-30 |
2013-04-17 |
Pharmasset Inc |
Compuestos 2’-espiro-nucleosidos
|
BR112013025021A2
(pt)
|
2011-03-31 |
2017-03-01 |
Novartis Ag |
alisporivir para tratar infecções por vírus de hepatite c.
|
PT2694087E
(pt)
|
2011-04-01 |
2015-04-09 |
Novartis Ag |
Tratamento para infecção com vírus de hepatite b sozinho ou em combinação com vírus de hepatite delta e doenças do fígado associadas
|
BR112013025934A2
(pt)
|
2011-04-13 |
2016-09-06 |
Debiopharm Int Sa |
tratamento de infecção pelo vírus da hepatite c com alisporivir
|
BR112014000055A2
(pt)
|
2011-07-01 |
2017-06-13 |
Bayer Ip Gmbh |
polipeptídeos de fusão de relaxina e usos dos mesmos
|
WO2013024156A2
(en)
|
2011-08-17 |
2013-02-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combinations of anti-hcv-entry factor antibodies and interferons for the treatment and the prevention of hcv infection
|
WO2013024158A1
(en)
|
2011-08-17 |
2013-02-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection
|
US20140228281A1
(en)
|
2011-09-27 |
2014-08-14 |
Novartis Ag |
Alisporivr for treatment of hepatitis c virus infection
|
US8889159B2
(en)
|
2011-11-29 |
2014-11-18 |
Gilead Pharmasset Llc |
Compositions and methods for treating hepatitis C virus
|
JP2015509980A
(ja)
|
2012-03-14 |
2015-04-02 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Hcv−hiv同時感染患者集団のhcv感染症を治療するための併用療法
|
JP2015512900A
(ja)
|
2012-03-28 |
2015-04-30 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
特別な患者の遺伝子亜型分集団のhcv感染症を治療するための併用療法
|
EP3505534A1
(de)
|
2012-06-08 |
2019-07-03 |
Sutro Biopharma, Inc. |
Antikörper mit nichtnatürlichen stellenspezifischen aminosäureresten, verfahren zu deren herstellung und verfahren zu deren verwendung
|
ES2611788T3
(es)
|
2012-06-26 |
2017-05-10 |
Sutro Biopharma, Inc. |
Proteínas de Fc modificadas que comprenden residuos de aminoácidos no naturales específicos del sitio, conjugados de las mismas, métodos para su preparación y métodos para su uso
|
CN102716469B
(zh)
*
|
2012-07-07 |
2013-09-11 |
北京三元基因工程有限公司 |
干扰素α的干粉吸入剂
|
BR112015004022B1
(pt)
|
2012-08-31 |
2023-04-25 |
Sutro Biopharma, Inc |
Aminoácidos modificados compreendendo um grupo azido
|
WO2014033266A1
(en)
|
2012-08-31 |
2014-03-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Anti-sr-bi antibodies for the inhibition of hepatitis c virus infection
|
US20140205566A1
(en)
|
2012-11-30 |
2014-07-24 |
Novartis Ag |
Cyclic nucleuoside derivatives and uses thereof
|
US9487587B2
(en)
|
2013-03-05 |
2016-11-08 |
Macrogenics, Inc. |
Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
|
US9764039B2
(en)
|
2013-07-10 |
2017-09-19 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
ES2792503T3
(es)
|
2013-08-27 |
2020-11-11 |
Gilead Pharmasset Llc |
Formulación combinada de dos compuestos antivirales
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
US9388239B2
(en)
|
2014-05-01 |
2016-07-12 |
Consejo Nacional De Investigation Cientifica |
Anti-human VEGF antibodies with unusually strong binding affinity to human VEGF-A and cross reactivity to human VEGF-B
|
SI3183264T1
(sl)
|
2014-08-19 |
2021-03-31 |
Biogen Ma Inc. |
Metoda pegilacije
|
KR20240024362A
(ko)
|
2014-10-24 |
2024-02-23 |
브리스톨-마이어스 스큅 컴퍼니 |
변형된 fgf-21 폴리펩티드 및 그의 용도
|
MX2018005230A
(es)
|
2015-11-03 |
2018-08-15 |
Hoffmann La Roche |
Terapia de combinacion de un inhibidor del ensamble de la capside del hbv y un interferon.
|
KR102514317B1
(ko)
|
2016-04-15 |
2023-03-27 |
마크로제닉스, 인크. |
신규 b7-h3-결합 분자, 그것의 항체 약물 콘쥬게이트 및 그것의 사용 방법
|
PT3471755T
(pt)
*
|
2016-06-20 |
2020-05-22 |
Elanco Us Inc |
Interferão suíno peguilado e métodos de utilização do mesmo
|
WO2018087345A1
(en)
|
2016-11-14 |
2018-05-17 |
F. Hoffmann-La Roche Ag |
COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
|
CN110637027A
(zh)
|
2017-02-08 |
2019-12-31 |
百时美施贵宝公司 |
包含药代动力学增强子的修饰的松弛素多肽及其用途
|
US20220056093A1
(en)
|
2018-09-11 |
2022-02-24 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and their uses
|
EP3867265A1
(de)
|
2018-10-19 |
2021-08-25 |
Ambrx, Inc. |
Interleukin-10 -polypeptid-konjugate, dimere davon und ihre verwendungen
|
BR112021015832A2
(pt)
|
2019-02-12 |
2022-01-18 |
Ambrx Inc |
Composições que contêm conjugados de anticorpo-agonista de tlr, métodos e usos dos mesmos
|
KR20220151202A
(ko)
|
2020-03-11 |
2022-11-14 |
암브룩스, 인코포레이티드 |
인터류킨-2 폴리펩타이드 접합체 및 그의 사용 방법
|
JP2023538071A
(ja)
|
2020-08-20 |
2023-09-06 |
アンブルックス,インコーポレイテッド |
抗体-tlrアゴニストコンジュゲート、その方法及び使用
|
CA3213805A1
(en)
|
2021-04-03 |
2022-10-06 |
Feng Tian |
Anti-her2 antibody-drug conjugates and uses thereof
|