DK0437563T3 - Bioligiske aktive lægemiddelpolymerderivater - Google Patents

Bioligiske aktive lægemiddelpolymerderivater

Info

Publication number
DK0437563T3
DK0437563T3 DK90910711.2T DK90910711T DK0437563T3 DK 0437563 T3 DK0437563 T3 DK 0437563T3 DK 90910711 T DK90910711 T DK 90910711T DK 0437563 T3 DK0437563 T3 DK 0437563T3
Authority
DK
Denmark
Prior art keywords
active drug
polymer derivatives
drug polymer
combined
adjacent
Prior art date
Application number
DK90910711.2T
Other languages
English (en)
Inventor
Francesco Veronese
Luciana Sartore
Piero Orsolini
Romano Deghenghi
Original Assignee
Debio Rech Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898918009A external-priority patent/GB8918009D0/en
Priority claimed from GB898919618A external-priority patent/GB8919618D0/en
Application filed by Debio Rech Pharma Sa filed Critical Debio Rech Pharma Sa
Application granted granted Critical
Publication of DK0437563T3 publication Critical patent/DK0437563T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK90910711.2T 1989-08-07 1990-07-26 Bioligiske aktive lægemiddelpolymerderivater DK0437563T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898918009A GB8918009D0 (en) 1989-08-07 1989-08-07 New biologically active drug polymer derivatives and method for preparing same
GB898919618A GB8919618D0 (en) 1989-08-30 1989-08-30 New biologically active drug polymer derivatives and method for preparing same

Publications (1)

Publication Number Publication Date
DK0437563T3 true DK0437563T3 (da) 1995-05-29

Family

ID=26295714

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90910711.2T DK0437563T3 (da) 1989-08-07 1990-07-26 Bioligiske aktive lægemiddelpolymerderivater

Country Status (8)

Country Link
EP (1) EP0437563B1 (da)
JP (1) JP2662311B2 (da)
AT (1) ATE118686T1 (da)
CA (1) CA2038935C (da)
DE (1) DE69017180T2 (da)
DK (1) DK0437563T3 (da)
ES (1) ES2069082T3 (da)
WO (1) WO1991001758A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
HUT75533A (en) * 1993-11-10 1997-05-28 Schering Corp Improved interferon polymer conjugates
US5951974A (en) * 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
US5738846A (en) * 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
DE19514087A1 (de) * 1995-04-13 1996-10-17 Deutsches Krebsforsch Konjugat aus einem Wirkstoff, einem Polyether und ggfs. einem nicht als körperfremd angesehenen, nativen Protein
AU5893796A (en) * 1995-06-07 1996-12-30 Novo Nordisk A/S Modification of polypeptides
AU5893696A (en) * 1995-06-07 1996-12-30 Novo Nordisk A/S Modification of polypeptides
GB9812550D0 (en) * 1998-06-11 1998-08-05 Aepact Ltd Tumour therapy and imaging
EP1008355A1 (en) * 1998-12-08 2000-06-14 Debio Recherche Pharmaceutique S.A. Method for identifying or analyzing polymer linkage sites on macromolecules using amino acid report binding
US6309633B1 (en) * 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
GB0202906D0 (en) 2002-02-07 2002-03-27 Univ London Prevention of myocardial damage
WO2004099245A1 (de) * 2003-05-05 2004-11-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Stabilisiertes interferon-ϝ
US8470315B2 (en) 2004-04-13 2013-06-25 Quintessence Biosciences, Inc. Non-natural ribonuclease conjugates as cytotoxic agents
JP4877225B2 (ja) 2005-02-18 2012-02-15 日油株式会社 ポリオキシアルキレン誘導体
EP2044097A4 (en) 2006-06-23 2010-10-06 Quintessence Biosciences Inc Modified ribonucleases
US8298801B2 (en) 2006-07-17 2012-10-30 Quintessence Biosciences, Inc. Methods and compositions for the treatment of cancer
US20110059921A1 (en) * 2008-03-27 2011-03-10 Ektar Therapeutics Oligomer-Nitrogenous Base Conjugates
US8029782B2 (en) 2008-10-01 2011-10-04 Quintessence Biosciences, Inc. Therapeutic ribonucleases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4609546A (en) * 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
JPS60176586A (ja) * 1984-02-21 1985-09-10 Sanwa Kagaku Kenkyusho:Kk 新規な修飾ウロキナ−ゼ、その製法並びにこれを含有する血栓溶解剤
DE3676670D1 (de) * 1985-06-26 1991-02-07 Cetus Corp Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung.
CA1283046C (en) * 1986-05-29 1991-04-16 Nandini Katre Tumor necrosis factor formulation
AU611932B2 (en) * 1987-08-21 1991-06-27 Wellcome Foundation Limited, The Novel complex

Also Published As

Publication number Publication date
CA2038935A1 (en) 1991-02-08
ES2069082T3 (es) 1995-05-01
DE69017180T2 (de) 1995-07-20
JPH04501121A (ja) 1992-02-27
CA2038935C (en) 1998-12-08
DE69017180D1 (de) 1995-03-30
JP2662311B2 (ja) 1997-10-08
EP0437563A1 (en) 1991-07-24
ATE118686T1 (de) 1995-03-15
EP0437563B1 (en) 1995-02-22
WO1991001758A1 (en) 1991-02-21

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