GB1425099A - Psychopharmacologically active peptides - Google Patents

Psychopharmacologically active peptides

Info

Publication number
GB1425099A
GB1425099A GB1006273A GB1006273A GB1425099A GB 1425099 A GB1425099 A GB 1425099A GB 1006273 A GB1006273 A GB 1006273A GB 1006273 A GB1006273 A GB 1006273A GB 1425099 A GB1425099 A GB 1425099A
Authority
GB
United Kingdom
Prior art keywords
phe
boc
lys
met
otbu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1006273A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of GB1425099A publication Critical patent/GB1425099A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

1425099 Peptides AKZO NV 1 March 1973 [8 March 1972] 10062/73 Heading C3H Novel peptides of the general formula wherein A is H-L-Met, H-D-Met, H-L-Met- (#O), H-D-Met(#O), H-L-Met(#O 2 ), H-DMet(#O 2 ), desamino-Met, desamino-Met(#O), desamino-Met(#O 2 ) or H 2 N-B-CO, in which B is C 1-6 alkylene; X is OH or NH 2 ; and Y is L-Phe-OH, L-Phe-Gly-OH or a group of the formula in which Alk is C 1-6 alkylene and R is hydrogen, halogen, OH, C 1-4 alkyl or C 1-4 alkoxy, and functional derivatives thereof are prepared by conventional methods. Intermediates which are prepared are Boc- Met - Glu(OtBu) - His - OMe, Boc - Met - Glu- (OtBu) - His - N 2 H 3 , Boc - D - Met - Glu(OtBu)- His - OMe, Boc - D - Met - Glu(OtBu) - His- N 2 H 3 , Boc - Val - Glu(OtBu) - His - OMe, Boc - Val - Glu(OtBu) - His - N 2 H 3 , Boc - #- Ala - Glu(OtBu) - His - OMe, Boc - # - Ala- Glu(OtBu) - His - N 2 H 3 , Boc - Gly - Glu(OtBu)- His - OMe, Boc - Gly - Glu(OtBu) - His - N 2 H 3 , Boc - Ala - Glu(OtBu) - His - N 2 H 3 , Boc- (α - Me) - Ala - Glu(OtBu) - His - N 2 H 3 , Desamino - Met - Glu(OtBu) - His - N 2 H 3 , Boc- Met - Gin - His - OMe, Boc - Met - Gln - His- N 2 H 3 , Boc - Phe - Gly - OBzl, H - Phe - Gly- OBzl.HCl, Boc - Arg(NO 2 ) - Phe - Gly - OBzl, H - Arg(NO 2 ) - Phe - Gly - OBzl. HCl, Boc - Phe- Arg(NO 2 ) - Phe - Gly - OBzl, H - Phe - Arg- (NO 2 ) - Phe - Gly - OBzl. TFA, H - Phe - Arg- Phe - Gly - OH.acetate, Z - Lys(Boc) - PPA, H - Lys(Boc) - PPA, Z - Phe - Lys(Boc) - PPA, H - Phe - Lys(Boc) - PPA, H - Phe - Lys(Boc)- Amf, H - Phe - Lys(Boc) - PEA, H - Phe- Lys(Boc) - HPEA, Z - Phe - Lys(Boc) - Phe- OMe, H - Phe - Lys(Boc) - Phe - OMe, H - Phe- Lys(Boc) - Phe - NH 2 , H - Phe - Lys(Boc) - Phe- OH, H - Phe - Lys(Boc) - Phe - O(CH 2 ) 3 C 6 H 5 , Z - Phe - Arg(NO 2 ) - Phe - OMe, Z - Phe - Arg- (NO 2 ) - Phe - NH 2 , Z - Phe - Arg(NO 2 ) - Phe- NMe 2 , Z - Phe - Arg(NO 2 ) - Phe - OH, H - Phe- Arg - Phe - OMe.acetate, H - Phe - Arg - Phe- NH 2 .acetate, H - Phe - Arg - Phe - NMe 2 .acetate, H - Phe - Arg - Phe - OH.acetate, Z - Phe - Lys- (Boc)-N 2 H 3 , Z - Phe - Lys(Boc) - Phe - Gly- OBzl and H - Phe - Lys(Boc) - Phe - Gly - OH. (PPA = N-(3-phenylpropyl)amino, PEA = N- (2-phenylethyl)amino, Bzl=benzyl, Amf= N-(1-phenyl-2-propyl)amino, TFA=trifluoroacetic acid). Pharmaceutical compositions having antidepressant activity comprise, as active ingredient, a peptide of the above general formula or a functional derivative thereof, together with a pharmaceutical carrier.
GB1006273A 1972-03-08 1973-03-01 Psychopharmacologically active peptides Expired GB1425099A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7203042A NL7203042A (en) 1972-03-08 1972-03-08

Publications (1)

Publication Number Publication Date
GB1425099A true GB1425099A (en) 1976-02-18

Family

ID=19815540

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1006273A Expired GB1425099A (en) 1972-03-08 1973-03-01 Psychopharmacologically active peptides

Country Status (12)

Country Link
JP (1) JPS48103575A (en)
AU (1) AU471618B2 (en)
BE (1) BE796478A (en)
CA (1) CA1025439A (en)
CH (1) CH584681A5 (en)
DE (1) DE2311099A1 (en)
FR (1) FR2181803B1 (en)
GB (1) GB1425099A (en)
HU (1) HU169157B (en)
NL (1) NL7203042A (en)
SE (1) SE406761B (en)
ZA (1) ZA731207B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2560486A1 (en) * 2010-04-21 2013-02-27 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4587233A (en) * 1983-11-07 1986-05-06 Board Of Trustees Of The Leland Stanford Junior University Use of Arg-Phe-amide derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1301738A (en) * 1969-07-09 1973-01-04

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2560486A1 (en) * 2010-04-21 2013-02-27 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof
EP2560486A4 (en) * 2010-04-21 2014-09-17 Signature Therapeutics Inc Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof
US11179355B2 (en) 2010-04-21 2021-11-23 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof
US11400062B2 (en) 2010-04-21 2022-08-02 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof

Also Published As

Publication number Publication date
ZA731207B (en) 1973-11-28
NL7203042A (en) 1973-09-11
AU5251173A (en) 1974-08-22
JPS48103575A (en) 1973-12-25
HU169157B (en) 1976-10-28
BE796478A (en) 1973-09-10
AU471618B2 (en) 1976-04-29
FR2181803A1 (en) 1973-12-07
CA1025439A (en) 1978-01-31
DE2311099A1 (en) 1973-09-13
FR2181803B1 (en) 1976-09-03
SE406761B (en) 1979-02-26
CH584681A5 (en) 1977-02-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee