GB1301738A - - Google Patents

Info

Publication number
GB1301738A
GB1301738A GB3111170A GB3111170A GB1301738A GB 1301738 A GB1301738 A GB 1301738A GB 3111170 A GB3111170 A GB 3111170A GB 3111170 A GB3111170 A GB 3111170A GB 1301738 A GB1301738 A GB 1301738A
Authority
GB
United Kingdom
Prior art keywords
boc
trp
phe
ome
met
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3111170A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1301738A publication Critical patent/GB1301738A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C07K14/6955—Corticotropin [ACTH] with at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1301738 Peptides ORGANON LABORATORIES Ltd 26 June 1970 [9 July 1969] 31111/70 Heading C2C Compounds of the formula: X-Met-Glu (or Csln)-His-D-Phe-Arg (or Lys)-Trp-Y(I) where X is H, H-Ser or H-Gly; Y is OH or Gly-OH and where Met- and -Ser are in either the L- or D- forms and their salts, complexes, amides and esters are prepared by methods known for the preparation of peptide. The following compounds are prepared as starting materials and intermediates: BOCMet-Glu(OtBu)OEt and its hydrazide; BOC-DMet-Glu(OtBu)OEt and its hydrazide; BOCGly-Met-OMe and its hydrazide; BOC-Ser-Met- OMe and its hydrazide; BOC-D-Ser-OMe and its hydrazide; BOC-Ser-Met-Glu(OtBu)OEt and its hydrazide; BOC-D-Sri-Met-Glu(OtBu)NHNH 2 ; BOC - Gly-Met - Glu(OtBu)NHNH 2 ; Trit(Trit) His-D-Phe-Arg-Trp OMe and the free acid; Trit- (Trit)His-D-Phe-Arg-Trp NHNH 2 , Trit(Trit)- His-D-Phe-Arg-Trp-Gly OH, HCl and its hexadecylester; glycine hexadecyl ester HCl; H-His- D-Phe-Arg-Trp OH; H-His-D-Phe-Arg-Trp-Gly OH and its hexadecyl ester; Z-(BOC)Lys-Trp OMe; H-(BOC)Lys-Trp OMe; Z-His-D-Phe- (BOC)Lys.Trp OMe; H-His-D-Phe-(BOC)Lys- Trp OMe and BOC-Met-aiu(OtBu)-His-D-Phe- Arg-Tro-Gly OH. Pharmaceutical compositions in forms for enteral and parenteral administration contain compounds (I) and have psychophaimacological activity.
GB3111170A 1969-07-09 1970-06-26 Expired GB1301738A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84051869A 1969-07-09 1969-07-09

Publications (1)

Publication Number Publication Date
GB1301738A true GB1301738A (en) 1973-01-04

Family

ID=25282580

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3111170A Expired GB1301738A (en) 1969-07-09 1970-06-26

Country Status (8)

Country Link
JP (1) JPS4843351B1 (en)
CH (1) CH553162A (en)
DE (1) DE2033703A1 (en)
DK (1) DK128531B (en)
FR (1) FR2059499B1 (en)
GB (1) GB1301738A (en)
HU (1) HU163599B (en)
NL (1) NL7010052A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7203042A (en) * 1972-03-08 1973-09-11
NL175988C (en) * 1972-05-24 1985-02-01 Akzo Nv PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH A PSYCHOPHARMACOLOGICAL EFFECT, THAT A PEPTIDE OR PEPTIDE DERIVATIVE DERIVED FROM AN AMINO ACIDS 4-10, FRAGMENT OF ADRENOCORTICOTROP HORMONE, AS AN PROPERTY, AND ITS PROPERTY, PROPERTY, AND ITS PROPERTY.

Also Published As

Publication number Publication date
DK128531B (en) 1974-05-20
CH553162A (en) 1974-08-30
FR2059499A1 (en) 1971-06-04
DE2033703A1 (en) 1971-01-21
JPS4843351B1 (en) 1973-12-18
HU163599B (en) 1973-09-27
NL7010052A (en) 1971-01-12
FR2059499B1 (en) 1974-03-22

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees