CN104829707B - 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 - Google Patents
一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 Download PDFInfo
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- CN104829707B CN104829707B CN201510228093.8A CN201510228093A CN104829707B CN 104829707 B CN104829707 B CN 104829707B CN 201510228093 A CN201510228093 A CN 201510228093A CN 104829707 B CN104829707 B CN 104829707B
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- leptin
- rings
- spiral region
- region mutations
- activity peptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
Description
Claims (4)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510228093.8A CN104829707B (zh) | 2015-05-06 | 2015-05-06 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
JP2017540624A JP2018504913A (ja) | 2015-05-06 | 2015-08-31 | Cdループとeへリックス領域とでの突然変異を有するレプチン活性ペプチド、そのコード遺伝子およびその応用 |
PCT/CN2015/088554 WO2016176935A1 (zh) | 2015-05-06 | 2015-08-31 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
US15/805,113 US10342854B2 (en) | 2015-05-06 | 2017-11-06 | Leptin active peptide having cd loop and E helix region mutations, coding gene thereof, and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510228093.8A CN104829707B (zh) | 2015-05-06 | 2015-05-06 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104829707A CN104829707A (zh) | 2015-08-12 |
CN104829707B true CN104829707B (zh) | 2017-12-19 |
Family
ID=53807938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510228093.8A Expired - Fee Related CN104829707B (zh) | 2015-05-06 | 2015-05-06 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
Country Status (4)
Country | Link |
---|---|
US (1) | US10342854B2 (zh) |
JP (1) | JP2018504913A (zh) |
CN (1) | CN104829707B (zh) |
WO (1) | WO2016176935A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104829707B (zh) * | 2015-05-06 | 2017-12-19 | 广东省生物资源应用研究所 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
CN106749524B (zh) * | 2016-12-05 | 2020-08-18 | 华南理工大学 | 一种抗肥胖七肽npvwkrk |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101544692A (zh) * | 2009-05-13 | 2009-09-30 | 广东省昆虫研究所 | 棕果蝠瘦素蛋白及其cDNA序列 |
CN101619101A (zh) * | 2009-05-13 | 2010-01-06 | 广东省昆虫研究所 | 马铁菊头蝠瘦素蛋白及其cDNA序列 |
CN101691402A (zh) * | 2009-05-13 | 2010-04-07 | 广东省昆虫研究所 | 长翼蝠瘦素蛋白及其cDNA序列 |
CN102272163A (zh) * | 2008-12-05 | 2011-12-07 | 安吉奥开米公司 | 瘦素和瘦素类似物结合物及其用途 |
CN103694337A (zh) * | 2008-02-08 | 2014-04-02 | Ambrx公司 | 经修饰瘦素多肽和其用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1406497A (en) * | 1995-12-06 | 1997-06-27 | Schering Corporation | Mutational variants of mammalian ob gene proteins |
WO1997046585A2 (en) * | 1996-06-06 | 1997-12-11 | Smithkline Beecham P.L.C. | Fragments of leptin (ob protein) |
CN1230966A (zh) | 1996-09-20 | 1999-10-06 | 赫彻斯特股份公司 | 勒帕素拮抗剂在用于治疗ii型糖尿病胰岛素耐受性中的用途 |
AU782230B2 (en) * | 1999-09-22 | 2005-07-14 | Serono Genetics Institute S.A. | Methods of screening for compounds that modulate the LSR-leptin interaction and their use in the prevention and treatment of obesity-related diseases |
WO2001066593A1 (fr) * | 2000-03-07 | 2001-09-13 | Biomolecular Engineering Research Institute | Coordonnee structurelle d'un complexe proteique et utilisation correspondante |
US7307142B2 (en) * | 2004-11-26 | 2007-12-11 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | Leptin antagonists |
US7629315B2 (en) * | 2005-03-09 | 2009-12-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions for blocking the inhibitory effect of human CRP on human leptin |
US8778890B2 (en) * | 2009-03-31 | 2014-07-15 | Temple University—Of the Commonwealth System of Higher Education | Leptin antagonist and methods of use |
WO2011132189A2 (en) * | 2010-04-22 | 2011-10-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | High affinity leptins and leptin antagonists |
CN104829707B (zh) * | 2015-05-06 | 2017-12-19 | 广东省生物资源应用研究所 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
-
2015
- 2015-05-06 CN CN201510228093.8A patent/CN104829707B/zh not_active Expired - Fee Related
- 2015-08-31 JP JP2017540624A patent/JP2018504913A/ja active Pending
- 2015-08-31 WO PCT/CN2015/088554 patent/WO2016176935A1/zh active Application Filing
-
2017
- 2017-11-06 US US15/805,113 patent/US10342854B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103694337A (zh) * | 2008-02-08 | 2014-04-02 | Ambrx公司 | 经修饰瘦素多肽和其用途 |
CN102272163A (zh) * | 2008-12-05 | 2011-12-07 | 安吉奥开米公司 | 瘦素和瘦素类似物结合物及其用途 |
CN101544692A (zh) * | 2009-05-13 | 2009-09-30 | 广东省昆虫研究所 | 棕果蝠瘦素蛋白及其cDNA序列 |
CN101619101A (zh) * | 2009-05-13 | 2010-01-06 | 广东省昆虫研究所 | 马铁菊头蝠瘦素蛋白及其cDNA序列 |
CN101691402A (zh) * | 2009-05-13 | 2010-04-07 | 广东省昆虫研究所 | 长翼蝠瘦素蛋白及其cDNA序列 |
Non-Patent Citations (5)
Title |
---|
Identification of the hydrophobic strand in the A–B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists;Leonora NIV-SPECTOR等;《Biochemical Society》;20051215;第391卷;第221-230页 * |
Leptin and the Regulation of Body Weight;Jeffrey M. Friedman;《The Keio Journal of Medicine》;20111231;第60卷(第1期);第1-9页 * |
Leptin in Association With Common Variants of MC3R Mediates Hypertension;Osama Alsmadi等;《American Journal of Hypertension》;20140731;第27卷(第7期);第973-981页 * |
Leptin therapy in type 2 diabetes;B.P.Cummings;《Diabetes, Obesity and Metabolism》;20131231;第15卷;摘要部分 * |
Positional cloning of the mouse obese gene and its human homologue;yiying zhang等;《nature》;19941201;第372卷;第425-432页 * |
Also Published As
Publication number | Publication date |
---|---|
US20180050094A1 (en) | 2018-02-22 |
CN104829707A (zh) | 2015-08-12 |
US10342854B2 (en) | 2019-07-09 |
WO2016176935A1 (zh) | 2016-11-10 |
JP2018504913A (ja) | 2018-02-22 |
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Address after: 510260 Xingang West Road, Guangdong, Guangzhou, No. 105, No. Applicant after: Guangdong Institute of biological resources application Address before: 510260 Xingang West Road, Guangdong, Guangzhou, No. 105, No. Applicant before: Guangdong Entomological Institute |
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Address after: 510260 No. 105 West Xingang Road, Guangzhou, Guangdong, Haizhuqu District Patentee after: Institute of zoology, Guangdong Academy of Sciences Address before: 510260 No. 105 West Xingang Road, Guangzhou, Guangdong, Haizhuqu District Patentee before: Guangdong Institute of Applied Biological Resources |
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