CN104829705B - 一条c螺旋区突变的瘦素活性肽及其编码基因和应用 - Google Patents
一条c螺旋区突变的瘦素活性肽及其编码基因和应用 Download PDFInfo
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- CN104829705B CN104829705B CN201510228005.4A CN201510228005A CN104829705B CN 104829705 B CN104829705 B CN 104829705B CN 201510228005 A CN201510228005 A CN 201510228005A CN 104829705 B CN104829705 B CN 104829705B
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- leptin
- activity peptide
- spiral region
- leptin activity
- adipocyte
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CN201510228005.4A CN104829705B (zh) | 2015-05-06 | 2015-05-06 | 一条c螺旋区突变的瘦素活性肽及其编码基因和应用 |
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CN201510228005.4A CN104829705B (zh) | 2015-05-06 | 2015-05-06 | 一条c螺旋区突变的瘦素活性肽及其编码基因和应用 |
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CN104829705A CN104829705A (zh) | 2015-08-12 |
CN104829705B true CN104829705B (zh) | 2017-11-14 |
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CN106518971B (zh) * | 2016-12-05 | 2019-12-10 | 华南理工大学 | 一种抗肥胖十肽canphelpnk |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101544692A (zh) * | 2009-05-13 | 2009-09-30 | 广东省昆虫研究所 | 棕果蝠瘦素蛋白及其cDNA序列 |
CN101619101A (zh) * | 2009-05-13 | 2010-01-06 | 广东省昆虫研究所 | 马铁菊头蝠瘦素蛋白及其cDNA序列 |
CN101691402A (zh) * | 2009-05-13 | 2010-04-07 | 广东省昆虫研究所 | 长翼蝠瘦素蛋白及其cDNA序列 |
CN102272163A (zh) * | 2008-12-05 | 2011-12-07 | 安吉奥开米公司 | 瘦素和瘦素类似物结合物及其用途 |
CN103694337A (zh) * | 2008-02-08 | 2014-04-02 | Ambrx公司 | 经修饰瘦素多肽和其用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2001066593A1 (fr) * | 2000-03-07 | 2001-09-13 | Biomolecular Engineering Research Institute | Coordonnee structurelle d'un complexe proteique et utilisation correspondante |
US8778890B2 (en) * | 2009-03-31 | 2014-07-15 | Temple University—Of the Commonwealth System of Higher Education | Leptin antagonist and methods of use |
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103694337A (zh) * | 2008-02-08 | 2014-04-02 | Ambrx公司 | 经修饰瘦素多肽和其用途 |
CN102272163A (zh) * | 2008-12-05 | 2011-12-07 | 安吉奥开米公司 | 瘦素和瘦素类似物结合物及其用途 |
CN101544692A (zh) * | 2009-05-13 | 2009-09-30 | 广东省昆虫研究所 | 棕果蝠瘦素蛋白及其cDNA序列 |
CN101619101A (zh) * | 2009-05-13 | 2010-01-06 | 广东省昆虫研究所 | 马铁菊头蝠瘦素蛋白及其cDNA序列 |
CN101691402A (zh) * | 2009-05-13 | 2010-04-07 | 广东省昆虫研究所 | 长翼蝠瘦素蛋白及其cDNA序列 |
Non-Patent Citations (6)
Title |
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Identification of the hydrophobic strand in the A–B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists;Leonora NIV-SPECTOR等;《Biochemical Society》;20051215;第391卷;第221-230页 * |
Leptin and the Regulation of Body Weight;Jeffrey M. Friedman;《The Keio Journal of Medicine》;20111231;第60卷(第1期);第1-9页 * |
Leptin in Association With Common Variants of MC3R Mediates Hypertension;Osama Alsmadi等;《American Journal of Hypertension》;20140731;第27卷(第7期);第973-981页 * |
Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet;Takeru Sakai等;《Am J Physiol Endocrinol Metab》;20140826;第307卷;全文 * |
Leptin therapy in type 2 diabetes;B.P.Cummings;《Diabetes, Obesity and Metabolism》;20131231;第15卷;摘要部分 * |
Structure-Function Studies of Human Leptin;Keiichi Imagawa等;《THE JOURNAL OF BIOLOGICAL CHEMISTRY》;19981225;第273卷(第52期);第35245-35249页 * |
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CN104829705A (zh) | 2015-08-12 |
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