AU1406497A - Mutational variants of mammalian ob gene proteins - Google Patents

Mutational variants of mammalian ob gene proteins

Info

Publication number
AU1406497A
AU1406497A AU14064/97A AU1406497A AU1406497A AU 1406497 A AU1406497 A AU 1406497A AU 14064/97 A AU14064/97 A AU 14064/97A AU 1406497 A AU1406497 A AU 1406497A AU 1406497 A AU1406497 A AU 1406497A
Authority
AU
Australia
Prior art keywords
mammalian
gene proteins
mutational variants
mutational
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU14064/97A
Inventor
Scott W. Altmann
J. Fernando Bazan
Robert A. Kastelein
Fernando Rock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AU1406497A publication Critical patent/AU1406497A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
AU14064/97A 1995-12-06 1996-12-03 Mutational variants of mammalian ob gene proteins Abandoned AU1406497A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56807795A 1995-12-06 1995-12-06
US568077 1995-12-06
PCT/US1996/018561 WO1997020933A2 (en) 1995-12-06 1996-12-03 MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS

Publications (1)

Publication Number Publication Date
AU1406497A true AU1406497A (en) 1997-06-27

Family

ID=24269846

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14064/97A Abandoned AU1406497A (en) 1995-12-06 1996-12-03 Mutational variants of mammalian ob gene proteins

Country Status (2)

Country Link
AU (1) AU1406497A (en)
WO (1) WO1997020933A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
ES2093593T1 (en) * 1995-05-05 1997-01-01 Hoffmann La Roche RECOMBINANT OBESE PROTEINS (OB).
US5831017A (en) * 1996-01-25 1998-11-03 Eli Lilly And Company Obesity protein analog compounds and formulations thereof
US6025324A (en) * 1996-05-15 2000-02-15 Hoffmann-La Roche Inc. Pegylated obese (ob) protein compositions
US6590088B1 (en) 1996-07-19 2003-07-08 Human Genome Sciences, Inc. CD33-like protein
WO1999025824A1 (en) * 1997-11-14 1999-05-27 Centre National De La Recherche Scientifique (Cnrs) cDNA SEQUENCE CODING FOR A MUTATED LEPTIN AND APPLICATIONS
EP1101112B1 (en) 1998-07-28 2004-10-06 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Leptin-mediated gene-induction
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
PT1151102E (en) * 1999-02-12 2006-07-31 Amgen Inc GLYCOSILATED LEPTINE COMPOSITIONS AND RELATED METHODS
EP1169350A2 (en) * 1999-04-02 2002-01-09 Eli Lilly And Company Human obesity protein binding protein-2 homolog compositions and uses thereof
WO2001066593A1 (en) * 2000-03-07 2001-09-13 Biomolecular Engineering Research Institute Structural coordinate of protein complex and utilization of the structural coordinate
CA2407872C (en) 2000-05-22 2013-11-12 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Receptor-based interaction trap
US7235629B2 (en) 2000-11-14 2007-06-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Functional fragment of the leptin receptor
ATE475094T1 (en) 2001-10-22 2010-08-15 Amgen Inc USE OF LEPTIN FOR TREATING LIPOATROPHY IN HUMAN BEINGS AND METHOD FOR DETERMINING PREDIPOSITION TO TREATMENT
DE60314412T2 (en) * 2003-08-21 2008-02-14 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. New leptin antagonist
US7423113B2 (en) 2004-08-25 2008-09-09 Vib Vzw Leptin antagonist
CA2585549A1 (en) 2004-11-18 2006-05-26 Vib Vzw Novel type leptin receptor antagonist
US7307142B2 (en) * 2004-11-26 2007-12-11 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Leptin antagonists
WO2010118384A2 (en) 2009-04-10 2010-10-14 Amylin Pharmaceuticals, Inc. Amylin agonist compounds for estrogen-deficient mammals
DK3241558T3 (en) 2010-09-28 2021-04-26 Aegerion Pharmaceuticals Inc HIGH RESOLUTION LEPTINES
CN104829708B (en) * 2015-05-06 2017-11-28 广东省生物资源应用研究所 The leptin activity peptide of one D spiral region mutation and its encoding gene and application
CN104829707B (en) * 2015-05-06 2017-12-19 广东省生物资源应用研究所 The leptin activity peptide and its encoding gene and application of one CD ring and E spiral region mutations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
JPH10513450A (en) * 1995-01-31 1998-12-22 イーライ・リリー・アンド・カンパニー Anti-obesity protein
WO1996024670A1 (en) * 1995-02-06 1996-08-15 Eli Lilly And Company Human obesity gene
ZA963915B (en) * 1995-05-19 1997-11-17 Lilly Co Eli Obesity gene product.
CA2221824A1 (en) * 1995-05-26 1996-11-28 Eli Lilly And Company Rhesus ob protein and dna

Also Published As

Publication number Publication date
WO1997020933A2 (en) 1997-06-12
WO1997020933A3 (en) 1997-10-02

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