TR200101751T2 - Poliol-IFN-beta konjugatları - Google Patents
Poliol-IFN-beta konjugatlarıInfo
- Publication number
- TR200101751T2 TR200101751T2 TR2001/01751T TR200101751T TR200101751T2 TR 200101751 T2 TR200101751 T2 TR 200101751T2 TR 2001/01751 T TR2001/01751 T TR 2001/01751T TR 200101751 T TR200101751 T TR 200101751T TR 200101751 T2 TR200101751 T2 TR 200101751T2
- Authority
- TR
- Turkey
- Prior art keywords
- ifn
- beta
- polyol
- peg
- beta conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Abstract
PEG ünitesi, insan IFN-beta Cys17 ile kovalent bag yapan PEG-IFN-beta konjugatlari bir tiolreaktif PEGilasyon ajani kullanimi ile site spesifik PEGilasyon prosesi üzerinden üretilir. Enfeksiyon, tümör ve otoimün ve enflamatör hastaliklarin tedavi edilmesine yönelik bir farmasotik kompozisyon ve bir metot da temin edilir Bu bulus, PEG ünitelerinin bir polipeptide ve daha özel anlamda IFN-beta'ya seri sekilde, adim adim eklenmesi metodu ile de ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8333998P | 1998-04-28 | 1998-04-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200101751T2 true TR200101751T2 (tr) | 2002-05-21 |
Family
ID=22177687
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/03161T TR200003161T2 (tr) | 1998-04-28 | 1999-04-28 | Poliol-IFN-Beta konjugatları |
TR2001/01751T TR200101751T2 (tr) | 1998-04-28 | 1999-04-28 | Poliol-IFN-beta konjugatları |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/03161T TR200003161T2 (tr) | 1998-04-28 | 1999-04-28 | Poliol-IFN-Beta konjugatları |
Country Status (31)
Country | Link |
---|---|
US (3) | US6638500B1 (tr) |
EP (2) | EP1421956B1 (tr) |
JP (2) | JP4574007B2 (tr) |
KR (1) | KR100622796B1 (tr) |
CN (2) | CN1187094C (tr) |
AR (1) | AR020070A1 (tr) |
AT (2) | ATE365563T1 (tr) |
AU (1) | AU762621B2 (tr) |
BG (2) | BG65046B1 (tr) |
BR (1) | BR9910023A (tr) |
CA (2) | CA2330451A1 (tr) |
CY (1) | CY1108022T1 (tr) |
CZ (2) | CZ298579B6 (tr) |
DE (2) | DE69920002T2 (tr) |
DK (2) | DK1075281T3 (tr) |
EA (2) | EA200300382A1 (tr) |
EE (1) | EE05214B1 (tr) |
ES (2) | ES2285286T3 (tr) |
HK (2) | HK1038194A1 (tr) |
HU (1) | HUP0300548A3 (tr) |
IL (1) | IL139286A (tr) |
NO (2) | NO329749B1 (tr) |
NZ (1) | NZ507456A (tr) |
PL (2) | PL193352B1 (tr) |
PT (2) | PT1421956E (tr) |
SI (2) | SI1421956T1 (tr) |
SK (2) | SK286217B6 (tr) |
TR (2) | TR200003161T2 (tr) |
TW (2) | TWI266800B (tr) |
UA (2) | UA66857C2 (tr) |
WO (1) | WO1999055377A2 (tr) |
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ES2630278T3 (es) * | 1998-10-16 | 2017-08-21 | Biogen Ma Inc. | Conjugados poliméricos de interferón beta-1a y usos de los mismos |
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US7238368B2 (en) * | 1999-04-23 | 2007-07-03 | Alza Corporation | Releasable linkage and compositions containing same |
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DE60138364D1 (de) | 2000-02-11 | 2009-05-28 | Bayer Healthcare Llc | Gerinnungsfaktor vii oder viia konjugate |
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EP1234583A1 (en) | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-conjugates of HGF-NK4 |
YU48703A (sh) | 2001-02-27 | 2006-05-25 | Maxygen Aps | Novi interferonu beta-slični molekuli |
NZ530545A (en) | 2001-07-11 | 2006-10-27 | Maxygen Holdings Ltd | Specific conjugates comprising a polypeptide exhibiting G-CSF activity and a non-polypeptide moiety |
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PL219741B1 (pl) | 2002-12-26 | 2015-07-31 | Mountain View Pharmaceuticals | Sposób zwiększania antyproliferacyjnego potencjału nieglikozylowanego interferonu-beta-1b in vitro, koniugat wytworzony tym sposobem i jego zastosowanie oraz kompozycja farmaceutyczna zawierająca koniugat i jej zastosowanie |
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1999
- 1999-04-28 CA CA002330451A patent/CA2330451A1/en not_active Abandoned
- 1999-04-28 DK DK99920094T patent/DK1075281T3/da active
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