EA200001111A1 - КОНЪЮГАТЫ ПОЛИОЛ-β-ИНТЕРФЕРОН - Google Patents
КОНЪЮГАТЫ ПОЛИОЛ-β-ИНТЕРФЕРОНInfo
- Publication number
- EA200001111A1 EA200001111A1 EA200001111A EA200001111A EA200001111A1 EA 200001111 A1 EA200001111 A1 EA 200001111A1 EA 200001111 A EA200001111 A EA 200001111A EA 200001111 A EA200001111 A EA 200001111A EA 200001111 A1 EA200001111 A1 EA 200001111A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- peg
- interferon
- conjugates
- polyol
- cys
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Abstract
В настоящем изобретении конъюгаты ПЭГ-β-интерферон, где ПЭГ-часть ковалентно связана с Cysчеловеческого β-интерферона, которые получают способом сайт-специфического присоединения ПЭГ с помощью агента для введения ПЭГ, имеющего реакционноспособную тиольную группу. Представлены также фармацевтическая композиция и метод лечения инфекционных заболеваний, опухолей и аутоиммунных и воспалительных заболеваний. Изобретение, кроме того, относится к способу поэтапного присоединения ПЭГ-частей последовательно к полипептиду и особенно к β-интерферону.Отчет о международном поиске был опубликован 1999.12.29.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8333998P | 1998-04-28 | 1998-04-28 | |
PCT/US1999/009161 WO1999055377A2 (en) | 1998-04-28 | 1999-04-28 | Polyol-ifn-beta conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200001111A1 true EA200001111A1 (ru) | 2001-04-23 |
EA003789B1 EA003789B1 (ru) | 2003-10-30 |
Family
ID=22177687
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200300382A EA200300382A1 (ru) | 1998-04-28 | 1999-04-28 | Способ поэтапного присоединения частей полиэтиленгликоля к полипептиду |
EA200001111A EA003789B1 (ru) | 1998-04-28 | 1999-04-28 | КОНЪЮГАТЫ ПОЛИОЛ-β-ИНТЕРФЕРОН |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200300382A EA200300382A1 (ru) | 1998-04-28 | 1999-04-28 | Способ поэтапного присоединения частей полиэтиленгликоля к полипептиду |
Country Status (31)
Country | Link |
---|---|
US (3) | US6638500B1 (ru) |
EP (2) | EP1421956B1 (ru) |
JP (2) | JP4574007B2 (ru) |
KR (1) | KR100622796B1 (ru) |
CN (2) | CN1187094C (ru) |
AR (1) | AR020070A1 (ru) |
AT (2) | ATE365563T1 (ru) |
AU (1) | AU762621B2 (ru) |
BG (2) | BG65046B1 (ru) |
BR (1) | BR9910023A (ru) |
CA (2) | CA2330451A1 (ru) |
CY (1) | CY1108022T1 (ru) |
CZ (2) | CZ298579B6 (ru) |
DE (2) | DE69920002T2 (ru) |
DK (2) | DK1075281T3 (ru) |
EA (2) | EA200300382A1 (ru) |
EE (1) | EE05214B1 (ru) |
ES (2) | ES2285286T3 (ru) |
HK (2) | HK1038194A1 (ru) |
HU (1) | HUP0300548A3 (ru) |
IL (1) | IL139286A (ru) |
NO (2) | NO329749B1 (ru) |
NZ (1) | NZ507456A (ru) |
PL (2) | PL193352B1 (ru) |
PT (2) | PT1421956E (ru) |
SI (2) | SI1421956T1 (ru) |
SK (2) | SK286217B6 (ru) |
TR (2) | TR200003161T2 (ru) |
TW (2) | TWI266800B (ru) |
UA (2) | UA66857C2 (ru) |
WO (1) | WO1999055377A2 (ru) |
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