TWI266801B - Polyol-IFN-beta conjugates - Google Patents

Polyol-IFN-beta conjugates

Info

Publication number
TWI266801B
TWI266801B TW94141979A TW94141979A TWI266801B TW I266801 B TWI266801 B TW I266801B TW 94141979 A TW94141979 A TW 94141979A TW 94141979 A TW94141979 A TW 94141979A TW I266801 B TWI266801 B TW I266801B
Authority
TW
Taiwan
Prior art keywords
ifn
beta
peg
polyol
conjugates
Prior art date
Application number
TW94141979A
Other languages
Chinese (zh)
Other versions
TW200619386A (en
Inventor
Tayer Nabil El
Michael J Roberts
Milton Harris
Wayne Sawlivich
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Priority to TW94141979A priority Critical patent/TWI266801B/en
Publication of TW200619386A publication Critical patent/TW200619386A/en
Application granted granted Critical
Publication of TWI266801B publication Critical patent/TWI266801B/en

Links

Abstract

PEG-IFN-beta conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-beta, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-beta.
TW94141979A 1999-07-26 1999-07-26 Polyol-IFN-beta conjugates TWI266801B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW94141979A TWI266801B (en) 1999-07-26 1999-07-26 Polyol-IFN-beta conjugates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW94141979A TWI266801B (en) 1999-07-26 1999-07-26 Polyol-IFN-beta conjugates

Publications (2)

Publication Number Publication Date
TW200619386A TW200619386A (en) 2006-06-16
TWI266801B true TWI266801B (en) 2006-11-21

Family

ID=38191672

Family Applications (1)

Application Number Title Priority Date Filing Date
TW94141979A TWI266801B (en) 1999-07-26 1999-07-26 Polyol-IFN-beta conjugates

Country Status (1)

Country Link
TW (1) TWI266801B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2824028T3 (en) 2014-08-19 2021-05-11 Biogen Ma Inc PEGylation method

Also Published As

Publication number Publication date
TW200619386A (en) 2006-06-16

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