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Application filed by Applied Research SystemsfiledCriticalApplied Research Systems
Priority to TW94141979ApriorityCriticalpatent/TWI266801B/en
Publication of TW200619386ApublicationCriticalpatent/TW200619386A/en
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Publication of TWI266801BpublicationCriticalpatent/TWI266801B/en
PEG-IFN-beta conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-beta, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-beta.
Process for the production of conjugates containing orto ligating functional group from chelate complexes and joint antibodies or antibody fragments and the medical preparations containing thereof