TW200619386A - Polyol-IFN-beta conjugates - Google Patents
Polyol-IFN-beta conjugatesInfo
- Publication number
- TW200619386A TW200619386A TW094141979A TW94141979A TW200619386A TW 200619386 A TW200619386 A TW 200619386A TW 094141979 A TW094141979 A TW 094141979A TW 94141979 A TW94141979 A TW 94141979A TW 200619386 A TW200619386 A TW 200619386A
- Authority
- TW
- Taiwan
- Prior art keywords
- ifn
- peg
- polyol
- conjugates
- beta conjugates
- Prior art date
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to INF-β.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW94141979A TWI266801B (en) | 1999-07-26 | 1999-07-26 | Polyol-IFN-beta conjugates |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW94141979A TWI266801B (en) | 1999-07-26 | 1999-07-26 | Polyol-IFN-beta conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200619386A true TW200619386A (en) | 2006-06-16 |
TWI266801B TWI266801B (en) | 2006-11-21 |
Family
ID=38191672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW94141979A TWI266801B (en) | 1999-07-26 | 1999-07-26 | Polyol-IFN-beta conjugates |
Country Status (1)
Country | Link |
---|---|
TW (1) | TWI266801B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11318207B2 (en) | 2014-08-19 | 2022-05-03 | Biogen Ma Inc. | Pegylation method |
-
1999
- 1999-07-26 TW TW94141979A patent/TWI266801B/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11318207B2 (en) | 2014-08-19 | 2022-05-03 | Biogen Ma Inc. | Pegylation method |
Also Published As
Publication number | Publication date |
---|---|
TWI266801B (en) | 2006-11-21 |
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