TW200619386A - Polyol-IFN-beta conjugates - Google Patents

Polyol-IFN-beta conjugates

Info

Publication number
TW200619386A
TW200619386A TW094141979A TW94141979A TW200619386A TW 200619386 A TW200619386 A TW 200619386A TW 094141979 A TW094141979 A TW 094141979A TW 94141979 A TW94141979 A TW 94141979A TW 200619386 A TW200619386 A TW 200619386A
Authority
TW
Taiwan
Prior art keywords
ifn
peg
polyol
conjugates
beta conjugates
Prior art date
Application number
TW094141979A
Other languages
Chinese (zh)
Other versions
TWI266801B (en
Inventor
Tayer Nabil El
Michael J Roberts
Milton Harris
Wayne Sawlivich
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Priority to TW94141979A priority Critical patent/TWI266801B/en
Publication of TW200619386A publication Critical patent/TW200619386A/en
Application granted granted Critical
Publication of TWI266801B publication Critical patent/TWI266801B/en

Links

Abstract

PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to INF-β.
TW94141979A 1999-07-26 1999-07-26 Polyol-IFN-beta conjugates TWI266801B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW94141979A TWI266801B (en) 1999-07-26 1999-07-26 Polyol-IFN-beta conjugates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW94141979A TWI266801B (en) 1999-07-26 1999-07-26 Polyol-IFN-beta conjugates

Publications (2)

Publication Number Publication Date
TW200619386A true TW200619386A (en) 2006-06-16
TWI266801B TWI266801B (en) 2006-11-21

Family

ID=38191672

Family Applications (1)

Application Number Title Priority Date Filing Date
TW94141979A TWI266801B (en) 1999-07-26 1999-07-26 Polyol-IFN-beta conjugates

Country Status (1)

Country Link
TW (1) TWI266801B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11318207B2 (en) 2014-08-19 2022-05-03 Biogen Ma Inc. Pegylation method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11318207B2 (en) 2014-08-19 2022-05-03 Biogen Ma Inc. Pegylation method

Also Published As

Publication number Publication date
TWI266801B (en) 2006-11-21

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