EA200001041A1 - Антитела к cd23, их производные и их терапевтическое применение - Google Patents

Антитела к cd23, их производные и их терапевтическое применение

Info

Publication number
EA200001041A1
EA200001041A1 EA200001041A EA200001041A EA200001041A1 EA 200001041 A1 EA200001041 A1 EA 200001041A1 EA 200001041 A EA200001041 A EA 200001041A EA 200001041 A EA200001041 A EA 200001041A EA 200001041 A1 EA200001041 A1 EA 200001041A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies
derivatives
therapeutic application
fcεrii
bind
Prior art date
Application number
EA200001041A
Other languages
English (en)
Inventor
Жан-Ив Марсель Поль Боннефуа
Скотт Джеймс Кроу
Джонатан Генри Эллис
Николас Тимоти Рапсон
Джин Ширин
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200001041A1 publication Critical patent/EA200001041A1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Изобретение относится к антителам, которые связываются с молекулой CD23 типа II (FCεRII), в частности к измененным антителам, включая антитела, которые связываются с молекулой CD23 типа II (FCεRII), отличающимся константой аффинности, равной или превышающей Ka 1x10моль, получению таких антител, фармацевтическим композициям, которые содержат такие антитела, и их применению в терапии, особенно при лечении аутоиммунных и воспалительных заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001041A 1998-05-09 1999-05-07 Антитела к cd23, их производные и их терапевтическое применение EA200001041A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9809839.5A GB9809839D0 (en) 1998-05-09 1998-05-09 Antibody
PCT/GB1999/001434 WO1999058679A1 (en) 1998-05-09 1999-05-07 Antibodies to cd23, derivatives thereof, and their therapeutic uses

Publications (1)

Publication Number Publication Date
EA200001041A1 true EA200001041A1 (ru) 2001-06-25

Family

ID=10831668

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001041A EA200001041A1 (ru) 1998-05-09 1999-05-07 Антитела к cd23, их производные и их терапевтическое применение

Country Status (25)

Country Link
US (1) US7008623B1 (ru)
EP (1) EP1076701A1 (ru)
JP (1) JP2002514421A (ru)
KR (1) KR20010043470A (ru)
CN (1) CN1308676A (ru)
AP (1) AP1547A (ru)
AU (1) AU763491B2 (ru)
BR (1) BR9910327A (ru)
CA (1) CA2328606A1 (ru)
EA (1) EA200001041A1 (ru)
EE (1) EE200000658A (ru)
GB (1) GB9809839D0 (ru)
HR (1) HRP20000762A2 (ru)
HU (1) HUP0102005A3 (ru)
ID (1) ID28088A (ru)
IL (1) IL139384A0 (ru)
IS (1) IS5696A (ru)
NO (1) NO20005632L (ru)
NZ (1) NZ507879A (ru)
PL (1) PL344019A1 (ru)
SK (1) SK16762000A3 (ru)
TR (1) TR200003281T2 (ru)
WO (1) WO1999058679A1 (ru)
YU (1) YU69000A (ru)
ZA (1) ZA200006312B (ru)

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US20060246075A1 (en) * 2004-09-29 2006-11-02 Marc Mercken Anti-amyloid antibodies, compositions, methods and uses
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
AP2008004467A0 (en) * 2005-11-14 2008-06-30 Rinat Neurosciene Corp Antagonist antibodies directed against calcitonin generelated peptide anf methods using same
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US7680868B2 (en) * 2005-12-20 2010-03-16 Roche Molecular Systems, Inc. PCR elbow determination by use of a double sigmoid function curve fit with the Levenburg-Marquardt algorithm and normalization
EP1804172B1 (en) * 2005-12-20 2021-08-11 Roche Diagnostics GmbH PCR elbow determination using curvature analysis of a double sigmoid
WO2009043051A2 (en) * 2007-09-27 2009-04-02 Biogen Idec Ma Inc. Cd23 binding molecules and methods of use thereof
KR101710472B1 (ko) 2007-11-30 2017-02-27 글락소 그룹 리미티드 항원-결합 작제물
JP5537441B2 (ja) 2008-03-04 2014-07-02 ファイザー・リミテッド 慢性疼痛を治療する方法
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JP2012518400A (ja) 2009-02-24 2012-08-16 グラクソ グループ リミテッド 多価および/または複数特異的rankl結合性構築物
CA2757237A1 (en) 2009-04-01 2010-10-14 Jane Elizabeth Clarkson Anti-il-23 immunoglobulins
US20120058116A1 (en) 2009-04-24 2012-03-08 Andrew Beaton Fgfr1c antibody combinations
MX2012002464A (es) 2009-08-28 2012-03-14 Rinat Neuroscience Corp El uso de anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de la calcitonina para tratar dolor visceral.
FR2957598B1 (fr) * 2010-03-17 2015-12-04 Lfb Biotechnologies Nouveau peptide signal, et son utilisation pour la production de proteines recombinantes
JP6351973B2 (ja) 2010-11-23 2018-07-04 グラクソ グループ リミテッドGlaxo Group Limited 抗原結合タンパク質
BR112013013003A2 (pt) 2010-11-24 2016-08-09 Glaxo Group Ltd proteína de ligação de antígeno, e, composição farmacêutica
US8974782B2 (en) 2011-02-07 2015-03-10 Glaxo Group Limited Treatment of stroke comprising anti-MAG antibodies
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JP6568099B2 (ja) 2014-03-21 2019-08-28 テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーTeva Pharmaceuticals International GmbH カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法
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Also Published As

Publication number Publication date
AU3836799A (en) 1999-11-29
ZA200006312B (en) 2003-02-26
EE200000658A (et) 2002-04-15
HUP0102005A3 (en) 2003-10-28
CN1308676A (zh) 2001-08-15
AU763491B2 (en) 2003-07-24
ID28088A (id) 2001-05-03
SK16762000A3 (sk) 2001-07-10
GB9809839D0 (en) 1998-07-08
IS5696A (is) 2000-10-31
NZ507879A (en) 2004-02-27
TR200003281T2 (tr) 2001-03-21
HUP0102005A2 (hu) 2001-10-28
IL139384A0 (en) 2001-11-25
YU69000A (sh) 2003-08-29
CA2328606A1 (en) 1999-11-18
JP2002514421A (ja) 2002-05-21
US7008623B1 (en) 2006-03-07
HRP20000762A2 (en) 2001-06-30
PL344019A1 (en) 2001-09-24
WO1999058679A1 (en) 1999-11-18
NO20005632L (no) 2001-01-08
BR9910327A (pt) 2001-01-30
AP2000001983A0 (en) 2000-12-31
KR20010043470A (ko) 2001-05-25
AP1547A (en) 2006-01-13
EP1076701A1 (en) 2001-02-21
NO20005632D0 (no) 2000-11-08

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