EA200000331A1 - Фармацевтические композиции, содержащие белок плазмы - Google Patents
Фармацевтические композиции, содержащие белок плазмыInfo
- Publication number
- EA200000331A1 EA200000331A1 EA200000331A EA200000331A EA200000331A1 EA 200000331 A1 EA200000331 A1 EA 200000331A1 EA 200000331 A EA200000331 A EA 200000331A EA 200000331 A EA200000331 A EA 200000331A EA 200000331 A1 EA200000331 A1 EA 200000331A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical compositions
- plasma protein
- compositions containing
- active compound
- water
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 108010017384 Blood Proteins Proteins 0.000 title abstract 2
- 102000004506 Blood Proteins Human genes 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108010058237 plasma protein fraction Proteins 0.000 abstract 1
- 229940081857 plasma protein fraction Drugs 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Abstract
Изобретение касается водорастворимых препаратов и фармацевтических композиций в твердой или жидкой форме, в основном для парентерального применения. Они состоят или в их состав входят терапевтически активное соединение (имеющее низкую растворимость в воде и существенное сродство связывания с белками плазмы) и белковая фракция плазмы в контролируемом агрегационном состоянии, вследствие чего указанное активное соединение и указанная белковая фракция связаны друг с другом нековалентными связями. Оно также охватывает способы получения препарата и фармацевтической композиции.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9701554A HUP9701554D0 (en) | 1997-09-18 | 1997-09-18 | Pharmaceutical composition containing plazma proteins |
PCT/HU1998/000086 WO1999013914A1 (en) | 1997-09-18 | 1998-09-17 | Pharmaceutical compositions containing plasma protein |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200000331A1 true EA200000331A1 (ru) | 2000-10-30 |
EA004700B1 EA004700B1 (ru) | 2004-06-24 |
Family
ID=90014222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200000331A EA004700B1 (ru) | 1997-09-18 | 1998-09-17 | Фармацевтические композиции, содержащие белок плазмы |
Country Status (33)
Country | Link |
---|---|
US (5) | US6743826B1 (ru) |
EP (1) | EP0981375B1 (ru) |
JP (1) | JP2001508806A (ru) |
KR (1) | KR100587962B1 (ru) |
CN (1) | CN1189216C (ru) |
AR (1) | AR017120A1 (ru) |
AT (1) | ATE230611T1 (ru) |
AU (1) | AU734695B2 (ru) |
BG (1) | BG64749B1 (ru) |
BR (1) | BR9812469A (ru) |
CA (1) | CA2269923C (ru) |
CZ (1) | CZ301326B6 (ru) |
DE (1) | DE69810612T2 (ru) |
DK (1) | DK0981375T3 (ru) |
EA (1) | EA004700B1 (ru) |
ES (1) | ES2187062T3 (ru) |
HR (1) | HRP980499A2 (ru) |
HU (1) | HUP9701554D0 (ru) |
IL (1) | IL135055A (ru) |
LT (1) | LT4736B (ru) |
LV (1) | LV12493B (ru) |
NO (1) | NO325294B1 (ru) |
NZ (1) | NZ503302A (ru) |
PL (1) | PL193067B1 (ru) |
PT (1) | PT981375E (ru) |
RO (1) | RO118695B1 (ru) |
RS (1) | RS50102B (ru) |
SI (1) | SI20189B (ru) |
SK (1) | SK284683B6 (ru) |
TR (1) | TR200001545T2 (ru) |
TW (1) | TWI222365B (ru) |
WO (1) | WO1999013914A1 (ru) |
ZA (1) | ZA988585B (ru) |
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US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
US8137684B2 (en) * | 1996-10-01 | 2012-03-20 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
HUP9701554D0 (en) * | 1997-09-18 | 1997-11-28 | Human Oltoanyagtermeloe Gyogys | Pharmaceutical composition containing plazma proteins |
AU2530700A (en) * | 1999-02-11 | 2000-08-29 | Kinetana Inc. | Serum albumin-based parenteral formulations of polyene macrolides |
MXPA02002439A (es) | 1999-09-16 | 2002-07-30 | Novo Nordisk As | Composicion para fertilizacion in vitro. |
AU2001253336A1 (en) * | 2000-04-10 | 2001-10-23 | Teva Pharmaceutical Industries Ltd. | Method 0f administration of paclitaxel-plasma protein formulation |
BR0110150A (pt) * | 2000-04-10 | 2004-04-27 | Teva Pharma | Método e composição para o tratamento de câncer por meio da administração de agentes quimioterápicos indutores da apoptose |
EP1387676A2 (en) * | 2001-05-01 | 2004-02-11 | Angiotech Pharmaceuticals, Inc. | Compositions comprising an anti-microtubule agent and a polypeptide or a polysaccharide and the use thereof for the preparation of a medicament for the treatment of inflammatory conditions |
ES2425738T3 (es) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Proteínas de fusión de la albúmina |
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EA200500210A1 (ru) | 2002-07-16 | 2005-06-30 | Медексис С. А. | Конъюгаты стероидов, их получение и их применение |
WO2004024188A1 (ja) * | 2002-09-12 | 2004-03-25 | Nihon Medi-Physics Co., Ltd. | 薬物の血漿蛋白質結合を制御するための製剤 |
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US20050079546A1 (en) * | 2003-05-01 | 2005-04-14 | Dasa Lipovsek | Serum albumin scaffold-based proteins and uses thereof |
US20040225022A1 (en) * | 2003-05-09 | 2004-11-11 | Desai Neil P. | Propofol formulation containing reduced oil and surfactants |
US7659310B2 (en) | 2004-04-27 | 2010-02-09 | Formatech, Inc. | Methods of enhancing solubility of agents |
US7345093B2 (en) | 2004-04-27 | 2008-03-18 | Formatech, Inc. | Methods of enhancing solubility of compounds |
US20050277584A1 (en) * | 2004-06-09 | 2005-12-15 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
EP1804609A2 (en) * | 2004-09-29 | 2007-07-11 | Tel Hashomer Medical Research Infrastructure and Services Ltd. | Monitoring of convection enhanced drug delivery |
US20060198891A1 (en) * | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
CN101677964A (zh) * | 2007-04-04 | 2010-03-24 | 希格默伊德药业有限公司 | 他克莫司药物组合物 |
ES2963291T3 (es) | 2007-04-26 | 2024-03-26 | Sublimity Therapeutics Ltd | Fabricación de múltiples minicápsulas |
JPWO2009116557A1 (ja) * | 2008-03-21 | 2011-07-21 | 富士フイルム株式会社 | 薬剤含有組成物 |
CN101658516B (zh) * | 2008-08-26 | 2011-10-05 | 齐鲁制药有限公司 | 紫杉醇类药物组合物及其制备方法 |
ES2649112T3 (es) | 2009-05-18 | 2018-01-10 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
CN107582526A (zh) | 2009-08-12 | 2018-01-16 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
EP2480209A1 (en) | 2009-09-23 | 2012-08-01 | Indu Javeri | Methods for the preparation of liposomes comprising docetaxel |
US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
EP2512460A4 (en) * | 2009-12-18 | 2015-01-21 | Exodos Life Sciences Ltd Partnership | METHOD AND COMPOSITIONS FOR STABLE LIQUID ACTIVE FORMULATIONS |
EP2531173B1 (en) * | 2010-02-03 | 2018-09-26 | Oncbiomune, L.L.C. | Taxane- and taxoid-protein compositions |
AR093275A1 (es) | 2010-03-17 | 2015-05-27 | Centro De Excelencia En Productos Y Procesos De Cordoba (Ceprocor) | Una composicion farmaceutica soluble en agua que comprende al menos una sustancia terapeuticamente activa de caracteristicas hidrofobicas y al menos un compuesto seleccionado entre los sialoglicoesfingolipidos, los glicoesfingolipidos o una mezcla de sialoglicoesfingolipidos y glicoesfingolipidos |
GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
EP3119391A4 (en) * | 2014-03-18 | 2017-12-27 | Izun Pharmaceuticals Corp. | Protein-bound cannabinoid compositions |
SI3215127T1 (sl) | 2014-11-07 | 2021-03-31 | Sublimity Therapeutics Limited DCU Alpha Innovation Campus | Sestavki, obsegajoči ciklosporin |
AR100034A1 (es) | 2015-01-30 | 2016-09-07 | Consejo Nac De Investig Científicas Y Técnicas (Conicet) | Una composición farmacéutica soluble en agua que comprende, al menos, una sustancia terapéuticamente activa y, al menos, una sustancia con capacidad para formar micelas |
US10071141B2 (en) | 2015-05-08 | 2018-09-11 | Spectral Platforms, Inc. | Albumin-based non-covalent complexes and methods of use thereof |
US10500285B2 (en) | 2015-05-15 | 2019-12-10 | Zhuhai Beihai Biotech Co., Ltd. | Docetaxel and human serum albumin complexes |
WO2016205654A1 (en) * | 2015-06-18 | 2016-12-22 | Aquarius Biotechnologies, Inc. | Compositions and methods for treating inflammatory disease or conditions |
US20170128480A1 (en) * | 2015-11-09 | 2017-05-11 | Max A. Cayo | Cardiac Glycosides for the Treatment of Hypercholesterolemia |
EP4019023A1 (en) * | 2016-08-03 | 2022-06-29 | Zhuhai Beihai Biotech Co., Ltd. | Formulations of fosaprepitant and aprepitant |
US11419842B2 (en) | 2016-10-27 | 2022-08-23 | Zhuhai Beihai Biotech Co., Ltd. | Neutral pH compositions of Docetaxel and human serum albumin |
WO2018175346A1 (en) | 2017-03-20 | 2018-09-27 | Spectral Platforms, Inc. | Spectroscopic methods to detect and characterize microorganisms |
CN111511350B (zh) | 2017-07-07 | 2023-10-13 | 埃皮辛特瑞柯斯公司 | 用于治疗剂的肠胃外施用的组合物 |
AU2019232153B2 (en) * | 2018-03-09 | 2023-07-13 | Panoptes Pharma Ges.M.B.H. | Ophthalmic formulation |
EP3811982A1 (en) * | 2019-10-25 | 2021-04-28 | Université de Strasbourg | Protein-based biomaterial with viscoelastic behaviour, process for obtaining it and uses thereof |
CN111529506B (zh) * | 2020-05-18 | 2021-09-03 | 同济大学 | 一种两性霉素b白蛋白纳米制剂及其制备方法和应用 |
US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
CN114544926A (zh) * | 2021-12-02 | 2022-05-27 | 浙江鑫科医疗科技有限公司 | 一种血清蛋白稳定剂 |
CN115236216B (zh) * | 2022-06-07 | 2024-03-01 | 合肥和合医疗科技有限公司 | 高效液相色谱串联质谱检测全血中免疫抑制剂的试剂盒,其制备方法和检测方法 |
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US5439686A (en) | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
GB9510716D0 (en) * | 1995-05-26 | 1995-07-19 | Pharmacia Spa | Substituted camptothecin derivatives and process for their preparation |
TR199600775A2 (tr) | 1996-09-27 | 1997-09-21 | Tureks Turunc Madencilik Ic Ve | Taslara eskitilmis görüntü kazandirilmasi icin bir yöntem. |
US5776912A (en) * | 1996-12-20 | 1998-07-07 | Schering Corporation | Lipophilic oligosaccharide antibiotic compositions |
HUP9701554D0 (en) * | 1997-09-18 | 1997-11-28 | Human Oltoanyagtermeloe Gyogys | Pharmaceutical composition containing plazma proteins |
ITMI20001107A1 (it) * | 2000-05-18 | 2001-11-18 | Acs Dobfar Spa | Metodo per il trattamento di tumori solici mediante microparticelle di albumina incorporanti paclitaxel |
-
1997
- 1997-09-18 HU HU9701554A patent/HUP9701554D0/hu unknown
-
1998
- 1998-09-10 HR HRP9701554A patent/HRP980499A2/hr not_active Application Discontinuation
- 1998-09-17 RS YUP-166/00A patent/RS50102B/sr unknown
- 1998-09-17 PT PT98946629T patent/PT981375E/pt unknown
- 1998-09-17 AU AU93623/98A patent/AU734695B2/en not_active Ceased
- 1998-09-17 CN CNB988092514A patent/CN1189216C/zh not_active Expired - Fee Related
- 1998-09-17 ES ES98946629T patent/ES2187062T3/es not_active Expired - Lifetime
- 1998-09-17 KR KR1020007002810A patent/KR100587962B1/ko not_active IP Right Cessation
- 1998-09-17 TR TR2000/01545T patent/TR200001545T2/xx unknown
- 1998-09-17 CZ CZ20000952A patent/CZ301326B6/cs not_active IP Right Cessation
- 1998-09-17 NZ NZ503302A patent/NZ503302A/en unknown
- 1998-09-17 SK SK329-2000A patent/SK284683B6/sk not_active IP Right Cessation
- 1998-09-17 DK DK98946629T patent/DK0981375T3/da active
- 1998-09-17 WO PCT/HU1998/000086 patent/WO1999013914A1/en not_active Application Discontinuation
- 1998-09-17 JP JP51757699A patent/JP2001508806A/ja not_active Withdrawn
- 1998-09-17 CA CA002269923A patent/CA2269923C/en not_active Expired - Lifetime
- 1998-09-17 SI SI9820067A patent/SI20189B/sl active Search and Examination
- 1998-09-17 BR BR9812469-2A patent/BR9812469A/pt not_active Application Discontinuation
- 1998-09-17 EA EA200000331A patent/EA004700B1/ru not_active IP Right Cessation
- 1998-09-17 IL IL13505598A patent/IL135055A/en not_active IP Right Cessation
- 1998-09-17 PL PL339369A patent/PL193067B1/pl unknown
- 1998-09-17 AT AT98946629T patent/ATE230611T1/de active
- 1998-09-17 EP EP98946629A patent/EP0981375B1/en not_active Expired - Lifetime
- 1998-09-17 RO ROA200000315A patent/RO118695B1/ro unknown
- 1998-09-17 DE DE69810612T patent/DE69810612T2/de not_active Expired - Lifetime
- 1998-09-18 ZA ZA9808585A patent/ZA988585B/xx unknown
- 1998-09-18 TW TW087115619A patent/TWI222365B/zh not_active IP Right Cessation
- 1998-09-18 AR ARP980104659A patent/AR017120A1/es not_active Application Discontinuation
-
1999
- 1999-04-27 US US09/299,562 patent/US6743826B1/en not_active Expired - Lifetime
-
2000
- 2000-03-14 LV LVP-00-38A patent/LV12493B/en unknown
- 2000-03-16 NO NO20001371A patent/NO325294B1/no not_active IP Right Cessation
- 2000-03-16 BG BG104245A patent/BG64749B1/bg unknown
- 2000-03-17 LT LT2000018A patent/LT4736B/lt not_active IP Right Cessation
-
2003
- 2003-01-21 US US10/349,492 patent/US7119124B2/en not_active Expired - Lifetime
-
2004
- 2004-03-17 US US10/802,528 patent/US7501455B2/en not_active Expired - Fee Related
-
2006
- 2006-10-10 US US11/546,518 patent/US20070232536A1/en not_active Abandoned
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2009
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