AR040778A1 - Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). - Google Patents
Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina).Info
- Publication number
- AR040778A1 AR040778A1 AR20030102790A ARP030102790A AR040778A1 AR 040778 A1 AR040778 A1 AR 040778A1 AR 20030102790 A AR20030102790 A AR 20030102790A AR P030102790 A ARP030102790 A AR P030102790A AR 040778 A1 AR040778 A1 AR 040778A1
- Authority
- AR
- Argentina
- Prior art keywords
- mag
- glicoprotein
- honey
- functional fragments
- altered antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
La presente se refiere a anticuerpos alterados a glicoproteína asociada a la mielina (MAG), formulaciones farmacéuticas que los contienen y al uso de dichos anticuerpos en el tratamiento y/o profilaxis de enfermedades/trastornos neurológicos. Reivindicación 1: Un anticuerpo alterado o fragmento funcional del mismo que se une a y neutraliza MAG y que comprende uno o más de las siguientes CDR. Las CDR de cadena ligera según cuadro (1), las CDR de cadena pesada según cuadro (2).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0218232A GB0218232D0 (en) | 2002-08-06 | 2002-08-06 | Antibodies |
GB0218234A GB0218234D0 (en) | 2002-08-06 | 2002-08-06 | Antibodies |
GB0218229A GB0218229D0 (en) | 2002-08-06 | 2002-08-06 | Antibodies |
GB0218230A GB0218230D0 (en) | 2002-08-06 | 2002-08-06 | Antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
AR040778A1 true AR040778A1 (es) | 2005-04-20 |
Family
ID=31721633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20030102790A AR040778A1 (es) | 2002-08-06 | 2003-08-04 | Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). |
Country Status (24)
Country | Link |
---|---|
US (2) | US7612183B2 (es) |
EP (1) | EP1526868B1 (es) |
JP (1) | JP4528121B2 (es) |
KR (1) | KR101078459B1 (es) |
CN (1) | CN100542607C (es) |
AR (1) | AR040778A1 (es) |
AU (1) | AU2003255390B2 (es) |
BR (1) | BR0312456A (es) |
CA (1) | CA2494008C (es) |
CY (1) | CY1114919T1 (es) |
DK (1) | DK1526868T3 (es) |
ES (1) | ES2440652T3 (es) |
HK (1) | HK1077206A1 (es) |
IL (1) | IL165478A (es) |
IS (1) | IS7576A (es) |
MX (1) | MXPA05001468A (es) |
MY (1) | MY148409A (es) |
NO (1) | NO333876B1 (es) |
NZ (1) | NZ537123A (es) |
PL (1) | PL211014B1 (es) |
PT (1) | PT1526868E (es) |
SI (1) | SI1526868T1 (es) |
TW (1) | TWI323265B (es) |
WO (1) | WO2004014953A2 (es) |
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AU2002231736A1 (en) | 2000-12-22 | 2002-07-08 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Use of repulsive guidance molecule (rgm) and its modulators |
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GB0306309D0 (en) * | 2003-03-19 | 2003-04-23 | Glaxo Group Ltd | Method of treatment |
CN105315373B (zh) * | 2005-05-09 | 2018-11-09 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
ES2542501T3 (es) | 2005-09-30 | 2015-08-06 | Abbvie Deutschland Gmbh & Co Kg | Dominios de unión de proteínas de la familia de proteínas de moléculas de orientación repulsiva (RGM) y fragmentos funcionales de las mismas, así como su uso |
KR20170002684A (ko) | 2005-11-04 | 2017-01-06 | 제넨테크, 인크. | 안질환 치료를 위한 보체 경로 억제제의 용도 |
CH701730B1 (de) * | 2006-05-31 | 2011-03-15 | Hanwha Chemical Corp | VCAM-1 spezifischer monoklonaler Antikörper. |
TWI472535B (zh) | 2006-11-02 | 2015-02-11 | Genentech Inc | 人類化之抗-因子d抗體及其用途 |
EP2212431A4 (en) * | 2007-10-16 | 2011-05-11 | Nuvelo Inc | ANTI-IREM-1 ANTIBODIES |
US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
AR071634A1 (es) | 2008-05-06 | 2010-06-30 | Glaxo Group Ltd | Nanoparticulas para encapsulacion de agentes biologicamente activos |
AR074777A1 (es) | 2008-12-19 | 2011-02-09 | Glaxo Group Ltd | Proteinas de union a antigeno |
US20110165063A1 (en) * | 2009-01-29 | 2011-07-07 | Abbott Laboratories | Il-1 binding proteins |
MX2011007987A (es) * | 2009-01-29 | 2011-08-17 | Abbott Lab | Proteinas de enlace il-1. |
ES2562832T3 (es) | 2009-12-08 | 2016-03-08 | Abbvie Deutschland Gmbh & Co Kg | Anticuerpos monoclonales contra la proteína RGM para su uso en el tratamiento de la degeneración de la capa de fibra nerviosa de la retina |
WO2011085289A1 (en) * | 2010-01-11 | 2011-07-14 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Production of a monoclonal antibody therapeutic against west nile virus in plants |
TW201210612A (en) | 2010-06-03 | 2012-03-16 | Glaxo Group Ltd | Humanised antigen binding proteins |
NZ604464A (en) * | 2010-06-14 | 2014-03-28 | Vaccinex Inc | Anti-vegf antibodies and uses thereof |
US8974782B2 (en) * | 2011-02-07 | 2015-03-10 | Glaxo Group Limited | Treatment of stroke comprising anti-MAG antibodies |
LT2807192T (lt) | 2012-01-27 | 2018-07-25 | AbbVie Deutschland GmbH & Co. KG | Kompozicijos ir būdai, skirti ligų, susijusių su neuritų degeneracija, diagnostikai ir gydymui |
US9308196B2 (en) * | 2012-05-18 | 2016-04-12 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1 r,4r) -6'-fluoro-N ,N-dimethyl-4-phenyl-4',9'-d ihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and an oxicam |
WO2015023596A1 (en) | 2013-08-12 | 2015-02-19 | Genentech, Inc. | Compositions and method for treating complement-associated conditions |
US10370692B2 (en) | 2013-12-20 | 2019-08-06 | Hoffmann-La Roche Inc. | Recombinant polypeptide production methods |
PL3116887T3 (pl) | 2014-03-13 | 2021-09-06 | Universität Basel | Ligandy węglowodanowe, które wiążą się z przeciwciałami igm przeciwko glikoproteinie związanej z mieliną |
JP2017515811A (ja) | 2014-05-01 | 2017-06-15 | ジェネンテック, インコーポレイテッド | 抗d因子抗体変異体及びその使用法 |
EP4074730A1 (en) | 2015-06-24 | 2022-10-19 | F. Hoffmann-La Roche AG | Anti-transferrin receptor antibodies with tailored affinity |
US11091591B2 (en) | 2015-09-16 | 2021-08-17 | Universität Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
AU2016332725A1 (en) * | 2015-09-29 | 2018-03-22 | Celgene Corporation | PD-1 binding proteins and methods of use thereof |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
NZ741067A (en) | 2015-10-02 | 2023-07-28 | Hoffmann La Roche | Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use |
JP2018534930A (ja) | 2015-10-30 | 2018-11-29 | ジェネンテック, インコーポレイテッド | 抗d因子抗体及びコンジュゲート |
JP2018536650A (ja) | 2015-10-30 | 2018-12-13 | ジェネンテック, インコーポレイテッド | 抗d因子抗体変異体コンジュゲート及びその使用 |
JP2019534859A (ja) | 2016-09-19 | 2019-12-05 | セルジーン コーポレイション | Pd−1結合タンパク質を使用して白斑を治療する方法 |
EP3515944A4 (en) | 2016-09-19 | 2020-05-06 | Celgene Corporation | METHODS OF TREATING IMMUNE DISORDERS WITH PD-1 BINDING PROTEINS |
CN109481673A (zh) * | 2017-09-12 | 2019-03-19 | 中国科学院苏州纳米技术与纳米仿生研究所 | 促进脑损伤神经修复的组合物及其应用与评价方法 |
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GB0306309D0 (en) | 2003-03-19 | 2003-04-23 | Glaxo Group Ltd | Method of treatment |
-
2003
- 2003-08-04 TW TW092121286A patent/TWI323265B/zh not_active IP Right Cessation
- 2003-08-04 AR AR20030102790A patent/AR040778A1/es not_active Application Discontinuation
- 2003-08-05 BR BR0312456-8A patent/BR0312456A/pt not_active IP Right Cessation
- 2003-08-05 PT PT37841954T patent/PT1526868E/pt unknown
- 2003-08-05 AU AU2003255390A patent/AU2003255390B2/en not_active Ceased
- 2003-08-05 JP JP2004526901A patent/JP4528121B2/ja not_active Expired - Fee Related
- 2003-08-05 ES ES03784195.4T patent/ES2440652T3/es not_active Expired - Lifetime
- 2003-08-05 EP EP03784195.4A patent/EP1526868B1/en not_active Expired - Lifetime
- 2003-08-05 MX MXPA05001468A patent/MXPA05001468A/es active IP Right Grant
- 2003-08-05 CA CA2494008A patent/CA2494008C/en not_active Expired - Fee Related
- 2003-08-05 KR KR1020057002132A patent/KR101078459B1/ko not_active IP Right Cessation
- 2003-08-05 NZ NZ537123A patent/NZ537123A/en not_active IP Right Cessation
- 2003-08-05 SI SI200332328T patent/SI1526868T1/sl unknown
- 2003-08-05 PL PL375405A patent/PL211014B1/pl unknown
- 2003-08-05 WO PCT/EP2003/008749 patent/WO2004014953A2/en active Application Filing
- 2003-08-05 MY MYPI20032945A patent/MY148409A/en unknown
- 2003-08-05 CN CNB03818477XA patent/CN100542607C/zh not_active Expired - Fee Related
- 2003-08-05 DK DK03784195.4T patent/DK1526868T3/da active
- 2003-08-05 US US10/523,295 patent/US7612183B2/en not_active Expired - Fee Related
-
2004
- 2004-11-30 IL IL165478A patent/IL165478A/en not_active IP Right Cessation
- 2004-11-30 IS IS7576A patent/IS7576A/is unknown
- 2004-12-03 NO NO20045323A patent/NO333876B1/no not_active IP Right Cessation
-
2005
- 2005-10-20 HK HK05109282.3A patent/HK1077206A1/xx not_active IP Right Cessation
-
2008
- 2008-04-01 US US12/060,555 patent/US8071731B2/en not_active Expired - Fee Related
-
2014
- 2014-01-14 CY CY20141100027T patent/CY1114919T1/el unknown
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