ATE365563T1 - Verfahren zur schrittweise bindung von polyethylenglykol (peg) an polypeptide - Google Patents

Verfahren zur schrittweise bindung von polyethylenglykol (peg) an polypeptide

Info

Publication number
ATE365563T1
ATE365563T1 AT04003053T AT04003053T ATE365563T1 AT E365563 T1 ATE365563 T1 AT E365563T1 AT 04003053 T AT04003053 T AT 04003053T AT 04003053 T AT04003053 T AT 04003053T AT E365563 T1 ATE365563 T1 AT E365563T1
Authority
AT
Austria
Prior art keywords
steply
polypeptides
peg
polyethylene glycol
binding polyethylene
Prior art date
Application number
AT04003053T
Other languages
English (en)
Inventor
Tayar Nabil El
Michael J Roberts
Milton Harris
Wayne Sawlivich
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of ATE365563T1 publication Critical patent/ATE365563T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
AT04003053T 1998-04-28 1999-04-28 Verfahren zur schrittweise bindung von polyethylenglykol (peg) an polypeptide ATE365563T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8333998P 1998-04-28 1998-04-28

Publications (1)

Publication Number Publication Date
ATE365563T1 true ATE365563T1 (de) 2007-07-15

Family

ID=22177687

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04003053T ATE365563T1 (de) 1998-04-28 1999-04-28 Verfahren zur schrittweise bindung von polyethylenglykol (peg) an polypeptide
AT99920094T ATE275422T1 (de) 1998-04-28 1999-04-28 Konjugate aus polyole und beta-interferon

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99920094T ATE275422T1 (de) 1998-04-28 1999-04-28 Konjugate aus polyole und beta-interferon

Country Status (31)

Country Link
US (3) US6638500B1 (de)
EP (2) EP1421956B1 (de)
JP (2) JP4574007B2 (de)
KR (1) KR100622796B1 (de)
CN (2) CN1187094C (de)
AR (1) AR020070A1 (de)
AT (2) ATE365563T1 (de)
AU (1) AU762621B2 (de)
BG (2) BG64694B1 (de)
BR (1) BR9910023A (de)
CA (2) CA2330451A1 (de)
CY (1) CY1108022T1 (de)
CZ (2) CZ298579B6 (de)
DE (2) DE69936409T2 (de)
DK (2) DK1075281T3 (de)
EA (2) EA003789B1 (de)
EE (1) EE05214B1 (de)
ES (2) ES2285286T3 (de)
HK (2) HK1038194A1 (de)
HU (1) HUP0300548A3 (de)
IL (1) IL139286A (de)
NO (2) NO329749B1 (de)
NZ (1) NZ507456A (de)
PL (2) PL196533B1 (de)
PT (2) PT1075281E (de)
SI (2) SI1075281T1 (de)
SK (2) SK286217B6 (de)
TR (2) TR200003161T2 (de)
TW (2) TWI232882B (de)
UA (2) UA79430C2 (de)
WO (1) WO1999055377A2 (de)

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Also Published As

Publication number Publication date
CA2330451A1 (en) 1999-11-04
AU3767499A (en) 1999-11-16
UA66857C2 (uk) 2004-06-15
TR200101751T2 (tr) 2002-05-21
CZ298597B6 (cs) 2007-11-21
KR100622796B1 (ko) 2006-09-13
CA2565375A1 (en) 1999-11-04
TR200003161T2 (tr) 2001-01-22
HUP0300548A3 (en) 2005-07-28
WO1999055377A9 (en) 2000-03-02
NO20100324L (no) 2000-12-28
US6638500B1 (en) 2003-10-28
CN1637020A (zh) 2005-07-13
UA79430C2 (en) 2007-06-25
US20040043002A1 (en) 2004-03-04
BG104871A (en) 2001-07-31
DE69920002T2 (de) 2005-09-22
SK286217B6 (sk) 2008-05-06
ES2285286T3 (es) 2007-11-16
NO329749B1 (no) 2010-12-13
HUP0300548A2 (hu) 2003-06-28
ES2224649T3 (es) 2005-03-01
EE200000614A (et) 2002-04-15
EP1421956A1 (de) 2004-05-26
CN1302209A (zh) 2001-07-04
CN100335503C (zh) 2007-09-05
BG65046B1 (bg) 2007-01-31
EP1421956B1 (de) 2007-06-27
NO20005337L (no) 2000-12-28
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IL139286A (en) 2005-12-18
PL344490A1 (en) 2001-11-05
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DE69936409T2 (de) 2008-04-17
CZ20003995A3 (en) 2001-06-13
EA005495B1 (ru) 2005-02-24
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DE69936409D1 (de) 2007-08-09
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EP1075281A2 (de) 2001-02-14
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SI1421956T1 (sl) 2007-10-31
TWI266800B (en) 2006-11-21
IL139286A0 (en) 2001-11-25
NO332224B1 (no) 2012-07-30
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ATE275422T1 (de) 2004-09-15
CZ298579B6 (cs) 2007-11-14

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