SI1075281T1 - Polyol-ifn-beta conjugates - Google Patents

Polyol-ifn-beta conjugates

Info

Publication number
SI1075281T1
SI1075281T1 SI9930662T SI9930662T SI1075281T1 SI 1075281 T1 SI1075281 T1 SI 1075281T1 SI 9930662 T SI9930662 T SI 9930662T SI 9930662 T SI9930662 T SI 9930662T SI 1075281 T1 SI1075281 T1 SI 1075281T1
Authority
SI
Slovenia
Prior art keywords
ifn
polyol
beta conjugates
conjugates
beta
Prior art date
Application number
SI9930662T
Other languages
English (en)
Slovenian (sl)
Inventor
Tayar Nabil El
Michael J. Roberts
Milton Harris
Wayne Sawlivich
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of SI1075281T1 publication Critical patent/SI1075281T1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
SI9930662T 1998-04-28 1999-04-28 Polyol-ifn-beta conjugates SI1075281T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8333998P 1998-04-28 1998-04-28
PCT/US1999/009161 WO1999055377A2 (en) 1998-04-28 1999-04-28 Polyol-ifn-beta conjugates
EP99920094A EP1075281B1 (de) 1998-04-28 1999-04-28 Konjugate aus polyole und beta-interferon

Publications (1)

Publication Number Publication Date
SI1075281T1 true SI1075281T1 (en) 2005-02-28

Family

ID=22177687

Family Applications (2)

Application Number Title Priority Date Filing Date
SI9930974T SI1421956T1 (sl) 1998-04-28 1999-04-28 Postopek za stopenjsko vezavo polietilenglikola (peg) na polipeptid
SI9930662T SI1075281T1 (en) 1998-04-28 1999-04-28 Polyol-ifn-beta conjugates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI9930974T SI1421956T1 (sl) 1998-04-28 1999-04-28 Postopek za stopenjsko vezavo polietilenglikola (peg) na polipeptid

Country Status (31)

Country Link
US (3) US6638500B1 (de)
EP (2) EP1421956B1 (de)
JP (2) JP4574007B2 (de)
KR (1) KR100622796B1 (de)
CN (2) CN100335503C (de)
AR (1) AR020070A1 (de)
AT (2) ATE365563T1 (de)
AU (1) AU762621B2 (de)
BG (2) BG65046B1 (de)
BR (1) BR9910023A (de)
CA (2) CA2330451A1 (de)
CY (1) CY1108022T1 (de)
CZ (2) CZ298579B6 (de)
DE (2) DE69936409T2 (de)
DK (2) DK1075281T3 (de)
EA (2) EA200300382A1 (de)
EE (1) EE05214B1 (de)
ES (2) ES2285286T3 (de)
HK (2) HK1038194A1 (de)
HU (1) HUP0300548A3 (de)
IL (1) IL139286A (de)
NO (2) NO329749B1 (de)
NZ (1) NZ507456A (de)
PL (2) PL193352B1 (de)
PT (2) PT1421956E (de)
SI (2) SI1421956T1 (de)
SK (2) SK286217B6 (de)
TR (2) TR200101751T2 (de)
TW (2) TWI232882B (de)
UA (2) UA79430C2 (de)
WO (1) WO1999055377A2 (de)

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Also Published As

Publication number Publication date
IL139286A0 (en) 2001-11-25
EP1075281A2 (de) 2001-02-14
SK286654B6 (sk) 2009-03-05
HUP0300548A3 (en) 2005-07-28
JP4574007B2 (ja) 2010-11-04
CZ298579B6 (cs) 2007-11-14
HK1076115A1 (en) 2006-01-06
CA2565375A1 (en) 1999-11-04
BG64694B1 (bg) 2005-12-30
TR200101751T2 (tr) 2002-05-21
DE69920002T2 (de) 2005-09-22
SK16222000A3 (sk) 2001-04-09
TWI266800B (en) 2006-11-21
JP2002512983A (ja) 2002-05-08
CN1187094C (zh) 2005-02-02
US7357925B2 (en) 2008-04-15
CN1637020A (zh) 2005-07-13
NZ507456A (en) 2003-10-31
IL139286A (en) 2005-12-18
CN100335503C (zh) 2007-09-05
SI1421956T1 (sl) 2007-10-31
NO20005337L (no) 2000-12-28
NO20005337D0 (no) 2000-10-23
EA005495B1 (ru) 2005-02-24
BG109291A (en) 2006-04-28
US7700314B2 (en) 2010-04-20
TWI232882B (en) 2005-05-21
US6638500B1 (en) 2003-10-28
PT1075281E (pt) 2004-11-30
CZ298597B6 (cs) 2007-11-21
HK1038194A1 (en) 2002-03-08
NO20100324L (no) 2000-12-28
US20040043002A1 (en) 2004-03-04
AU3767499A (en) 1999-11-16
NO332224B1 (no) 2012-07-30
WO1999055377A2 (en) 1999-11-04
US20070141620A1 (en) 2007-06-21
DE69936409T2 (de) 2008-04-17
ATE275422T1 (de) 2004-09-15
EE200000614A (et) 2002-04-15
AU762621B2 (en) 2003-07-03
BG65046B1 (bg) 2007-01-31
JP2010184929A (ja) 2010-08-26
DK1421956T3 (da) 2007-10-01
UA79430C2 (en) 2007-06-25
EA200001111A1 (ru) 2001-04-23
BG104871A (en) 2001-07-31
EP1421956A1 (de) 2004-05-26
CN1302209A (zh) 2001-07-04
TR200003161T2 (tr) 2001-01-22
EA003789B1 (ru) 2003-10-30
ES2224649T3 (es) 2005-03-01
EA200300382A1 (ru) 2005-02-24
KR20010071158A (ko) 2001-07-28
BR9910023A (pt) 2000-12-26
DE69936409D1 (de) 2007-08-09
KR100622796B1 (ko) 2006-09-13
AR020070A1 (es) 2002-04-10
UA66857C2 (uk) 2004-06-15
HUP0300548A2 (hu) 2003-06-28
WO1999055377A9 (en) 2000-03-02
CY1108022T1 (el) 2013-09-04
CZ20003995A3 (en) 2001-06-13
PL344490A1 (en) 2001-11-05
DE69920002D1 (de) 2004-10-14
DK1075281T3 (da) 2005-01-03
EP1421956B1 (de) 2007-06-27
CA2330451A1 (en) 1999-11-04
NO329749B1 (no) 2010-12-13
ATE365563T1 (de) 2007-07-15
WO1999055377A3 (en) 1999-12-29
EE05214B1 (et) 2009-10-15
EP1075281B1 (de) 2004-09-08
SK286217B6 (sk) 2008-05-06
PL193352B1 (pl) 2007-02-28
PL196533B1 (pl) 2008-01-31
ES2285286T3 (es) 2007-11-16
PT1421956E (pt) 2007-07-13

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