IL139286A - Polyol-ifn-beta conjugates, their preparation and use - Google Patents

Polyol-ifn-beta conjugates, their preparation and use

Info

Publication number
IL139286A
IL139286A IL13928699A IL13928699A IL139286A IL 139286 A IL139286 A IL 139286A IL 13928699 A IL13928699 A IL 13928699A IL 13928699 A IL13928699 A IL 13928699A IL 139286 A IL139286 A IL 139286A
Authority
IL
Israel
Prior art keywords
ifn
beta
peg
polyol
preparation
Prior art date
Application number
IL13928699A
Other languages
English (en)
Other versions
IL139286A0 (en
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of IL139286A0 publication Critical patent/IL139286A0/xx
Publication of IL139286A publication Critical patent/IL139286A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
IL13928699A 1998-04-28 1999-04-28 Polyol-ifn-beta conjugates, their preparation and use IL139286A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8333998P 1998-04-28 1998-04-28
PCT/US1999/009161 WO1999055377A2 (en) 1998-04-28 1999-04-28 Polyol-ifn-beta conjugates

Publications (2)

Publication Number Publication Date
IL139286A0 IL139286A0 (en) 2001-11-25
IL139286A true IL139286A (en) 2005-12-18

Family

ID=22177687

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13928699A IL139286A (en) 1998-04-28 1999-04-28 Polyol-ifn-beta conjugates, their preparation and use

Country Status (31)

Country Link
US (3) US6638500B1 (xx)
EP (2) EP1421956B1 (xx)
JP (2) JP4574007B2 (xx)
KR (1) KR100622796B1 (xx)
CN (2) CN1187094C (xx)
AR (1) AR020070A1 (xx)
AT (2) ATE365563T1 (xx)
AU (1) AU762621B2 (xx)
BG (2) BG65046B1 (xx)
BR (1) BR9910023A (xx)
CA (2) CA2330451A1 (xx)
CY (1) CY1108022T1 (xx)
CZ (2) CZ298579B6 (xx)
DE (2) DE69920002T2 (xx)
DK (2) DK1075281T3 (xx)
EA (2) EA200300382A1 (xx)
EE (1) EE05214B1 (xx)
ES (2) ES2285286T3 (xx)
HK (2) HK1038194A1 (xx)
HU (1) HUP0300548A3 (xx)
IL (1) IL139286A (xx)
NO (2) NO329749B1 (xx)
NZ (1) NZ507456A (xx)
PL (2) PL193352B1 (xx)
PT (2) PT1421956E (xx)
SI (2) SI1421956T1 (xx)
SK (2) SK286217B6 (xx)
TR (2) TR200003161T2 (xx)
TW (2) TWI266800B (xx)
UA (2) UA66857C2 (xx)
WO (1) WO1999055377A2 (xx)

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Also Published As

Publication number Publication date
ATE365563T1 (de) 2007-07-15
ES2224649T3 (es) 2005-03-01
EE05214B1 (et) 2009-10-15
EP1075281B1 (en) 2004-09-08
AU762621B2 (en) 2003-07-03
US20070141620A1 (en) 2007-06-21
PL193352B1 (pl) 2007-02-28
DE69920002D1 (de) 2004-10-14
CZ298579B6 (cs) 2007-11-14
PL344490A1 (en) 2001-11-05
KR100622796B1 (ko) 2006-09-13
CY1108022T1 (el) 2013-09-04
SK286217B6 (sk) 2008-05-06
BG65046B1 (bg) 2007-01-31
AR020070A1 (es) 2002-04-10
ATE275422T1 (de) 2004-09-15
DE69920002T2 (de) 2005-09-22
UA66857C2 (uk) 2004-06-15
EA005495B1 (ru) 2005-02-24
NO329749B1 (no) 2010-12-13
CA2565375A1 (en) 1999-11-04
PL196533B1 (pl) 2008-01-31
CN100335503C (zh) 2007-09-05
WO1999055377A9 (en) 2000-03-02
TR200003161T2 (tr) 2001-01-22
EP1421956B1 (en) 2007-06-27
PT1421956E (pt) 2007-07-13
CA2330451A1 (en) 1999-11-04
CN1637020A (zh) 2005-07-13
DK1075281T3 (da) 2005-01-03
PT1075281E (pt) 2004-11-30
EP1075281A2 (en) 2001-02-14
EA200300382A1 (ru) 2005-02-24
US7700314B2 (en) 2010-04-20
US7357925B2 (en) 2008-04-15
AU3767499A (en) 1999-11-16
KR20010071158A (ko) 2001-07-28
WO1999055377A2 (en) 1999-11-04
US20040043002A1 (en) 2004-03-04
JP2002512983A (ja) 2002-05-08
JP2010184929A (ja) 2010-08-26
BR9910023A (pt) 2000-12-26
SI1421956T1 (sl) 2007-10-31
WO1999055377A3 (en) 1999-12-29
HK1076115A1 (en) 2006-01-06
NO20005337D0 (no) 2000-10-23
SI1075281T1 (en) 2005-02-28
HUP0300548A2 (hu) 2003-06-28
CN1302209A (zh) 2001-07-04
US6638500B1 (en) 2003-10-28
HUP0300548A3 (en) 2005-07-28
NO20100324L (no) 2000-12-28
CZ298597B6 (cs) 2007-11-21
JP4574007B2 (ja) 2010-11-04
TWI232882B (en) 2005-05-21
CZ20003995A3 (en) 2001-06-13
BG64694B1 (bg) 2005-12-30
BG104871A (en) 2001-07-31
IL139286A0 (en) 2001-11-25
EE200000614A (et) 2002-04-15
EP1421956A1 (en) 2004-05-26
HK1038194A1 (en) 2002-03-08
DK1421956T3 (da) 2007-10-01
TR200101751T2 (tr) 2002-05-21
NO20005337L (no) 2000-12-28
EA200001111A1 (ru) 2001-04-23
DE69936409T2 (de) 2008-04-17
ES2285286T3 (es) 2007-11-16
BG109291A (en) 2006-04-28
EA003789B1 (ru) 2003-10-30
NZ507456A (en) 2003-10-31
TWI266800B (en) 2006-11-21
DE69936409D1 (de) 2007-08-09
NO332224B1 (no) 2012-07-30
CN1187094C (zh) 2005-02-02
UA79430C2 (en) 2007-06-25
SK16222000A3 (sk) 2001-04-09
SK286654B6 (sk) 2009-03-05

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