YU48703A - Novi interferonu beta-slični molekuli - Google Patents
Novi interferonu beta-slični molekuliInfo
- Publication number
- YU48703A YU48703A YU48703A YUP48703A YU48703A YU 48703 A YU48703 A YU 48703A YU 48703 A YU48703 A YU 48703A YU P48703 A YUP48703 A YU P48703A YU 48703 A YU48703 A YU 48703A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- polypeptide
- interferon
- amino acid
- parent
- moiety
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Pronalazak se odnosi na konjugat koji ispoljava aktivnost interferona á i obuhvata najmanje jedan ne-polipeptidni deo, kjoi je kovalentno vezan za polipeptid interferona á, aminokiselinsku sekvencu koja se razlikuje od one kod prirodnog humanog interferona á po najmanje jednom uvedenom i najmanje jednom uklonjenom aminokiselinskom ostatku, ukljucujuci veznu grupu za navedeni prvi nepolipeptidni deo. Prvi ne-polipeptidni deo je npr. polimerni molekul ili secerni deo. Konjugat pronalazi narocito uptorebu u terapiji. Pronalazak se, takodje, odnosi na glikoziliranu varijantu originalnog interferona á (IFNB), polipeptid koji obuhvata najmanje jedno <l>in vivo<l> glikozilaciono mesto, u kom se aminokiselinski ostatak navedenog originalnog poilpeptida, postavljen blizu navedenog glikozilacionog polozaja, modifikuje da bi se dobila varijanta polipeptida koji ima uvecanu glikozilaciju u poredjenju sa glikozilacijom originalnog polipeptida.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200100323 | 2001-02-27 | ||
DKPA200100333 | 2001-03-01 | ||
DKPA200101040 | 2001-06-29 | ||
DKPA200101277 | 2001-08-30 | ||
DKPA200101954 | 2001-12-21 | ||
DKPA200200257 | 2002-02-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU48703A true YU48703A (sh) | 2006-05-25 |
Family
ID=27545246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU48703A YU48703A (sh) | 2001-02-27 | 2002-02-26 | Novi interferonu beta-slični molekuli |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP2080771A3 (sh) |
JP (1) | JP2004534523A (sh) |
AT (1) | ATE432288T1 (sh) |
BR (1) | BR0207576A (sh) |
CA (1) | CA2469846A1 (sh) |
CZ (1) | CZ20032526A3 (sh) |
DE (1) | DE60232434D1 (sh) |
HU (1) | HUP0303251A2 (sh) |
IL (1) | IL156059A0 (sh) |
IS (1) | IS6927A (sh) |
MX (1) | MXPA03007619A (sh) |
NO (1) | NO20033781L (sh) |
PL (1) | PL367154A1 (sh) |
RU (1) | RU2003128955A (sh) |
SK (1) | SK11882003A3 (sh) |
WO (1) | WO2002074806A2 (sh) |
YU (1) | YU48703A (sh) |
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US7265085B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycoconjugation methods and proteins/peptides produced by the methods |
ES2556338T3 (es) | 2001-10-10 | 2016-01-15 | Novo Nordisk A/S | Remodelación y glicoconjugación de péptidos |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
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US7439043B2 (en) | 2001-10-10 | 2008-10-21 | Neose Technologies, Inc. | Galactosyl nucleotide sugars |
US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
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-
2002
- 2002-02-26 DE DE60232434T patent/DE60232434D1/de not_active Expired - Lifetime
- 2002-02-26 HU HU0303251A patent/HUP0303251A2/hu unknown
- 2002-02-26 JP JP2002573813A patent/JP2004534523A/ja active Pending
- 2002-02-26 RU RU2003128955/13A patent/RU2003128955A/ru not_active Application Discontinuation
- 2002-02-26 EP EP09075066A patent/EP2080771A3/en not_active Withdrawn
- 2002-02-26 IL IL15605902A patent/IL156059A0/xx unknown
- 2002-02-26 BR BR0207576-8A patent/BR0207576A/pt not_active Application Discontinuation
- 2002-02-26 PL PL02367154A patent/PL367154A1/xx unknown
- 2002-02-26 MX MXPA03007619A patent/MXPA03007619A/es unknown
- 2002-02-26 YU YU48703A patent/YU48703A/sh unknown
- 2002-02-26 AT AT02702228T patent/ATE432288T1/de not_active IP Right Cessation
- 2002-02-26 SK SK1188-2003A patent/SK11882003A3/sk unknown
- 2002-02-26 CZ CZ20032526A patent/CZ20032526A3/cs unknown
- 2002-02-26 CA CA002469846A patent/CA2469846A1/en not_active Abandoned
- 2002-02-26 EP EP02702228A patent/EP1366075B1/en not_active Expired - Lifetime
- 2002-02-26 WO PCT/DK2002/000128 patent/WO2002074806A2/en not_active Application Discontinuation
-
2003
- 2003-08-26 IS IS6927A patent/IS6927A/is unknown
- 2003-08-26 NO NO20033781A patent/NO20033781L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0303251A2 (hu) | 2003-12-29 |
CA2469846A1 (en) | 2002-09-26 |
NO20033781D0 (no) | 2003-08-26 |
DE60232434D1 (de) | 2009-07-09 |
JP2004534523A (ja) | 2004-11-18 |
WO2002074806A2 (en) | 2002-09-26 |
EP2080771A3 (en) | 2010-01-06 |
EP1366075B1 (en) | 2009-05-27 |
EP2080771A2 (en) | 2009-07-22 |
CZ20032526A3 (cs) | 2003-12-17 |
BR0207576A (pt) | 2004-04-27 |
RU2003128955A (ru) | 2005-04-10 |
IL156059A0 (en) | 2003-12-23 |
PL367154A1 (en) | 2005-02-21 |
NO20033781L (no) | 2003-08-26 |
ATE432288T1 (de) | 2009-06-15 |
WO2002074806A3 (en) | 2003-05-01 |
MXPA03007619A (es) | 2003-12-04 |
IS6927A (is) | 2003-08-26 |
EP1366075A2 (en) | 2003-12-03 |
SK11882003A3 (sk) | 2004-03-02 |
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