ATE494012T1 - Stabilisierte polymer-thiol-reagenzien - Google Patents

Stabilisierte polymer-thiol-reagenzien

Info

Publication number
ATE494012T1
ATE494012T1 AT05855832T AT05855832T ATE494012T1 AT E494012 T1 ATE494012 T1 AT E494012T1 AT 05855832 T AT05855832 T AT 05855832T AT 05855832 T AT05855832 T AT 05855832T AT E494012 T1 ATE494012 T1 AT E494012T1
Authority
AT
Austria
Prior art keywords
thiol reagents
stabilized polymer
polymer thiol
reagents
disclosed
Prior art date
Application number
AT05855832T
Other languages
English (en)
Inventor
Samuel Mcmanus
Antoni Kozlowski
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36440883&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE494012(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Application granted granted Critical
Publication of ATE494012T1 publication Critical patent/ATE494012T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT05855832T 2004-12-21 2005-12-21 Stabilisierte polymer-thiol-reagenzien ATE494012T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63982304P 2004-12-21 2004-12-21
US70596805P 2005-08-04 2005-08-04
PCT/US2005/047337 WO2006069388A2 (en) 2004-12-21 2005-12-21 Stabilized polymeric thiol reagents

Publications (1)

Publication Number Publication Date
ATE494012T1 true ATE494012T1 (de) 2011-01-15

Family

ID=36440883

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05855832T ATE494012T1 (de) 2004-12-21 2005-12-21 Stabilisierte polymer-thiol-reagenzien

Country Status (12)

Country Link
US (5) US7851565B2 (de)
EP (1) EP1827501B2 (de)
JP (1) JP5243041B2 (de)
KR (1) KR101320936B1 (de)
CN (1) CN101111267B (de)
AT (1) ATE494012T1 (de)
AU (1) AU2005318984B2 (de)
CA (1) CA2591233C (de)
DE (1) DE602005025805D1 (de)
ES (1) ES2357089T5 (de)
MX (1) MX2007007471A (de)
WO (1) WO2006069388A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947261B2 (en) 2003-05-23 2011-05-24 Nektar Therapeutics Conjugates formed from polymer derivatives having particular atom arrangements
EP1586334A1 (de) * 2004-04-15 2005-10-19 TRASTEC scpa G-CSF Konjugate mit PEG
ATE494012T1 (de) * 2004-12-21 2011-01-15 Nektar Therapeutics Stabilisierte polymer-thiol-reagenzien
MX2008001706A (es) * 2005-08-04 2008-04-07 Nektar Therapeutics Al Corp Conjugados de una porcion g-csf y un polimero.
BRPI0615265A8 (pt) 2005-08-31 2018-03-06 Abraxis Bioscience Llc composições compreendendo agentes farmacêuticos pouco hidrossoluíveis e agentes antimicrobianos
JP5368093B2 (ja) 2005-08-31 2013-12-18 アブラクシス バイオサイエンス， エルエルシー 増大した安定性を有する難水溶性薬剤の組成物および調製の方法
KR100819064B1 (ko) * 2006-12-19 2008-04-04 (재)대구경북과학기술연구원 생분자 고정화 링커
EP2014256A1 (de) 2007-07-12 2009-01-14 Straumann Holding AG Verbundmaterial zur Knochenreparatur
WO2009025669A1 (en) * 2007-08-20 2009-02-26 Enzon Pharmaceuticals, Inc. Polymeric linkers containing pyridyl disulfide moieties
WO2009052148A1 (en) 2007-10-15 2009-04-23 California Institute Of Technology Functionalized polymers using protected thiols
ES2523030T3 (es) * 2008-02-18 2014-11-20 Jiangsu Hengrui Medicine Co., Ltd. Un conjugado del G-CSF modificado por un polímero hidrosoluble
US20110105413A1 (en) * 2008-05-23 2011-05-05 Enzon Pharmaceuticals, Inc. Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides
BR112012002064A2 (pt) * 2009-07-31 2017-05-09 Endocyte Inc método para determinar se ec145 é indicado para o tratamento de um paciente com um tumor ovariano ou um tumor de pulmão; método para prever uma resposta de um tumor ovariano ou um tumor de pulmão de um paciente a terapia com ec145; método de tratamento de câncer ovariano resistente à platina em um paciente necessitando dele; uso de ec145 em combinação com doxorrubicina lipossômica peguilada; uso de ec145 para a fabricação de um medicamento; método para obter um benefício clínico comparado a tratamento com uma quantidade terapêutica de doxorrubicina lipossômica peguilada no tratamento de câncer ovariano resistente à platina em um paciente necessitando dele; método para selecionar um paciente para tratamento; composição farmacêutica; unidade de dosagem, método para determinar se um paciente com um tumor tem receptores de folato funcionalmente ativos presentes no tumor do paciente; método de tratamento de um tumor epitelial expressando receptor de folato em um paciente necessitando dele; e; método para obter um benefício clínico no tratamento de um tumor epitelial expressando receptor de folato em um paciente necessitando dele
JP2019043961A (ja) * 2010-04-20 2019-03-22 オクタファルマ・アーゲー 医薬タンパク質の新規な安定化剤
WO2011131720A1 (en) * 2010-04-20 2011-10-27 Octapharma Ag New stabilizing agent for pharmaceutical proteins
CN101885841B (zh) * 2010-07-02 2012-05-16 清华大学 一种可与巯基发生加成反应且成键水解稳定的高分子
WO2012021791A2 (en) * 2010-08-13 2012-02-16 Scidose Llc Aqueous formulation with improved stability
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
CA2894765A1 (en) 2012-12-21 2014-06-26 Sanofi Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists
WO2015077303A1 (en) 2013-11-19 2015-05-28 Purdue Research Foundation Patient selection method for inflammation
WO2015086730A1 (en) 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
EP3080154B1 (de) 2013-12-13 2018-02-07 Sanofi Duale glp-1/gip-rezeptoragonisten
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
WO2019040507A1 (en) * 2017-08-21 2019-02-28 Prevail Therapeutics, Inc. MODIFIED LYSOSOMIAL ENZYMES
CN112654562B (zh) * 2018-07-20 2023-06-02 赫尔克里士有限公司 水溶性或水分散性组合物
CN115785473B (zh) * 2022-12-20 2023-08-18 上海赛翠克环保科技有限公司 端异硫脲基三羟甲基丙烷芯树枝状聚合物及其制备方法和缓蚀应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1365481A (en) † 1968-07-15 1974-09-04 Ciba Geigy Uk Ltd Process for keratinous fabric
DE2138448A1 (de) † 1968-07-15 1972-02-17 IWS Nominee Co Ltd , London, Ciba Geigy AG, Basel (Schweiz) Behandlung von keratinhaltigen Materialien
GB1379203A (en) 1970-12-14 1975-01-02 Ciba Geigy Ag Textile finishing
DE2238940A1 (de) † 1972-08-08 1974-02-21 Bayer Ag Permanent antistatische acrylnitrilpolymerisate
GB1435085A (en) † 1972-09-01 1976-05-12 Ciba Geigy Ag Keratinous textiles and fibres
US3948820A (en) † 1972-11-02 1976-04-06 Horizons Incorporated Curable polyphosphazene copolymers and terpolymers
CH565275A (de) † 1973-06-21 1975-08-15
EP0370446B1 (de) 1988-11-23 1996-05-15 Ciba-Geigy Ag Polyoxyalkylendithiole und Polyamine enthaltende härtbare Epoxidharz-Stoffgemische
EP0429395B1 (de) 1989-11-21 1995-03-29 Ciba-Geigy Ag Härtbare Epoxidharz-Stoffgemische enthaltend einen latenten Härter, ein Amin und ein Thiol
US5516703A (en) 1993-08-20 1996-05-14 The University Of Utah Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5580923A (en) 1995-03-14 1996-12-03 Collagen Corporation Anti-adhesion films and compositions for medical use
US6306584B1 (en) 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
JPH1138544A (ja) * 1997-07-16 1999-02-12 Konica Corp ハロゲン化銀写真感光材料及びその処理方法
KR100622796B1 (ko) * 1998-04-28 2006-09-13 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 폴리올-ｉｆｎ-베타 공액체
US7053150B2 (en) 2000-12-18 2006-05-30 Nektar Therapeutics Al, Corporation Segmented polymers and their conjugates
TW593427B (en) 2000-12-18 2004-06-21 Nektar Therapeutics Al Corp Synthesis of high molecular weight non-peptidic polymer derivatives
NZ534708A (en) 2002-01-18 2007-05-31 Biogen Idec Inc Polyalkylene glycol with moiety for conjugating biologically active compound
CN1511861A (zh) 2002-12-26 2004-07-14 北京键凯科技有限公司 聚乙二醇-脂肪酸衍生物及其药物结合物
DE60321825D1 (de) 2002-12-31 2008-08-07 Nektar Therapeutics Al Corp Maleinsäureamid polymerderivate und ihre biokonjugate
DE60329627D1 (de) 2002-12-31 2009-11-19 Nektar Therapeutics Al Corp Hydrolysestabile maleimidendgruppen-enthaltende polymere
EP1581582B2 (de) 2003-01-06 2017-06-07 Nektar Therapeutics Thiolselektive wasserlösliche polymerderivate
JP4109559B2 (ja) † 2003-02-19 2008-07-02 独立行政法人科学技術振興機構 オリゴヌクレオチドとポリエチレンオキシドのコンジュゲート
DE602004011660T2 (de) * 2004-06-16 2009-01-29 Straumann Holding Ag Abdeckmembran
ATE494012T1 (de) * 2004-12-21 2011-01-15 Nektar Therapeutics Stabilisierte polymer-thiol-reagenzien
MX2008001706A (es) † 2005-08-04 2008-04-07 Nektar Therapeutics Al Corp Conjugados de una porcion g-csf y un polimero.
WO2007075534A2 (en) † 2005-12-16 2007-07-05 Nektar Therapeutics Al, Corporation Polymer conjugates of glp-1
US20100223106A1 (en) 2009-02-27 2010-09-02 Hallowell Zachary E Wholesale Virtual Inventory and Retail Lead Generation

Also Published As

Publication number Publication date
CA2591233A1 (en) 2006-06-29
US20110112277A1 (en) 2011-05-12
CN101111267B (zh) 2012-12-05
MX2007007471A (es) 2007-07-20
EP1827501B2 (de) 2013-11-20
US8765883B2 (en) 2014-07-01
KR101320936B1 (ko) 2013-10-23
EP1827501B1 (de) 2011-01-05
US20120258985A1 (en) 2012-10-11
AU2005318984A1 (en) 2006-06-29
WO2006069388A2 (en) 2006-06-29
CN101111267A (zh) 2008-01-23
US20060135586A1 (en) 2006-06-22
US8492488B2 (en) 2013-07-23
AU2005318984B2 (en) 2011-12-01
WO2006069388A3 (en) 2007-05-31
ES2357089T3 (es) 2011-04-18
JP5243041B2 (ja) 2013-07-24
US20130280206A1 (en) 2013-10-24
US7851565B2 (en) 2010-12-14
KR20070088727A (ko) 2007-08-29
DE602005025805D1 (de) 2011-02-17
US20140256951A1 (en) 2014-09-11
JP2008524338A (ja) 2008-07-10
ES2357089T5 (es) 2014-02-24
EP1827501A2 (de) 2007-09-05
CA2591233C (en) 2014-10-07
US8217123B2 (en) 2012-07-10
US9308274B2 (en) 2016-04-12

Similar Documents

Publication Publication Date Title
ATE494012T1 (de) Stabilisierte polymer-thiol-reagenzien
DK1940918T3 (da) Dimercaptanterminerede polythioetherpolymerer og fremgangsmåder til at fremstille og anvende samme
HRP20150156T1 (xx) Stabilizirani polimerni prijenosni sustav
EP2022012A4 (de) Muskel-skelett-formhäutung
DE602005010109D1 (de) 1,1a,5,5a-tetrahydro-3-thia-cyclopropaäaüpentaleneptor-agonisten
NO20051346D0 (no) Undervanns produksjonssystem.
DE602005027897D1 (de) Polyhedrisch modifiziertes polymer
EP1919232A4 (de) Basisstation und kommunikationssystem
WO2005096744A3 (en) Oriented polymer fibers and methods for fabricating thereof
FI20045162A0 (fi) Ryhmäviestintä viestinjärjestelmässä
DE602006013151D1 (de) Verfahren zur herstellung von polymermaleimiden
DE602006012525D1 (de) Polymerprothese
SE0402187D0 (sv) Imprinting using dendrimers as tomplates
AU2003233579A8 (en) Synthesis of inorganic structures using templation and catalysis by self assembled repeat protein polymers
PL1836825T3 (pl) Usprawnianie wczesnych mediów w systemie komunikacji
EP1752883A4 (de) Kommunikationssystem
ES1058780Y (es) Brida de union autoblocante.
WO2005118859A3 (en) Carrier tests for albinism in the cat
WO2007012859A3 (en) Denture support composition
ES1057788Y (es) Tapon de corcho.
GEP20074114B (en) Current-conducting polymer composition
ES1057083Y (es) Parche antirozaduras.
ES1057865Y (es) Desatascador de desagues.
ES1058154Y (es) Sujetador femenino.
ITFR20040018A1 (it) Antislavina & i.s.m.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties