DE602005025805D1 - Stabilisierte polymer-thiol-reagenzien - Google Patents
Stabilisierte polymer-thiol-reagenzienInfo
- Publication number
- DE602005025805D1 DE602005025805D1 DE602005025805T DE602005025805T DE602005025805D1 DE 602005025805 D1 DE602005025805 D1 DE 602005025805D1 DE 602005025805 T DE602005025805 T DE 602005025805T DE 602005025805 T DE602005025805 T DE 602005025805T DE 602005025805 D1 DE602005025805 D1 DE 602005025805D1
- Authority
- DE
- Germany
- Prior art keywords
- thiol reagents
- stabilized polymer
- polymer thiol
- reagents
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63982304P | 2004-12-21 | 2004-12-21 | |
US70596805P | 2005-08-04 | 2005-08-04 | |
PCT/US2005/047337 WO2006069388A2 (en) | 2004-12-21 | 2005-12-21 | Stabilized polymeric thiol reagents |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005025805D1 true DE602005025805D1 (de) | 2011-02-17 |
Family
ID=36440883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005025805T Active DE602005025805D1 (de) | 2004-12-21 | 2005-12-21 | Stabilisierte polymer-thiol-reagenzien |
Country Status (12)
Country | Link |
---|---|
US (5) | US7851565B2 (de) |
EP (1) | EP1827501B2 (de) |
JP (1) | JP5243041B2 (de) |
KR (1) | KR101320936B1 (de) |
CN (1) | CN101111267B (de) |
AT (1) | ATE494012T1 (de) |
AU (1) | AU2005318984B2 (de) |
CA (1) | CA2591233C (de) |
DE (1) | DE602005025805D1 (de) |
ES (1) | ES2357089T5 (de) |
MX (1) | MX2007007471A (de) |
WO (1) | WO2006069388A2 (de) |
Families Citing this family (33)
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US7947261B2 (en) | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
EP1586334A1 (de) * | 2004-04-15 | 2005-10-19 | TRASTEC scpa | G-CSF Konjugate mit PEG |
KR101320936B1 (ko) | 2004-12-21 | 2013-10-23 | 넥타르 테라퓨틱스 | 안정화된 중합체성 티올 시약 |
KR20080033439A (ko) * | 2005-08-04 | 2008-04-16 | 넥타르 테라퓨틱스 에이엘, 코포레이션 | G-csf 부분 및 중합체의 컨주게이트 |
NZ592132A (en) | 2005-08-31 | 2012-12-21 | Abraxis Bioscience Llc | Composition comprising nanoparticles of docitaxel and a citrate |
EP1931321B1 (de) | 2005-08-31 | 2018-12-26 | Abraxis BioScience, LLC | Zusammensetzungen aus schwer wasserlöslichen pharmazeutischen mitteln und antimikrobiellen mitteln |
KR100819064B1 (ko) * | 2006-12-19 | 2008-04-04 | (재)대구경북과학기술연구원 | 생분자 고정화 링커 |
EP2014256A1 (de) | 2007-07-12 | 2009-01-14 | Straumann Holding AG | Verbundmaterial zur Knochenreparatur |
JP2010536986A (ja) * | 2007-08-20 | 2010-12-02 | エンゾン ファーマシューティカルズ,インコーポレーテッド | ピリジルジスルフィド部分を含有するポリマーリンカー |
US7847019B2 (en) | 2007-10-15 | 2010-12-07 | California Institute Of Technology | Functionalized polymers using protected thiols |
JP5225393B2 (ja) * | 2008-02-18 | 2013-07-03 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | 水溶性高分子修飾g−csf複合体 |
CA2723263A1 (en) * | 2008-05-23 | 2009-11-26 | Enzon Pharmaceuticals, Inc. | Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides |
EP2460013A4 (de) * | 2009-07-31 | 2013-04-03 | Endocyte Inc | Auf folate abzielende diagnose und behandlung |
JP2019043961A (ja) * | 2010-04-20 | 2019-03-22 | オクタファルマ・アーゲー | 医薬タンパク質の新規な安定化剤 |
CN103003422B (zh) | 2010-04-20 | 2015-02-11 | 奥克塔法马股份有限公司 | 用于药物蛋白的新型稳定剂 |
CN101885841B (zh) * | 2010-07-02 | 2012-05-16 | 清华大学 | 一种可与巯基发生加成反应且成键水解稳定的高分子 |
WO2012021791A2 (en) * | 2010-08-13 | 2012-02-16 | Scidose Llc | Aqueous formulation with improved stability |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
UA116553C2 (uk) | 2012-12-21 | 2018-04-10 | Санофі | Пептидна сполука - агоніст рецептора glp-1 i glp |
US11162937B2 (en) | 2013-11-19 | 2021-11-02 | Purdue Research Foundation | Patient selection method for inflammation |
WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/gip受體促效劑 |
TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/升糖素受體促效劑 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
WO2019040507A1 (en) * | 2017-08-21 | 2019-02-28 | Prevail Therapeutics, Inc. | MODIFIED LYSOSOMIAL ENZYMES |
CN112654562B (zh) * | 2018-07-20 | 2023-06-02 | 赫尔克里士有限公司 | 水溶性或水分散性组合物 |
CN115785473B (zh) * | 2022-12-20 | 2023-08-18 | 上海赛翠克环保科技有限公司 | 端异硫脲基三羟甲基丙烷芯树枝状聚合物及其制备方法和缓蚀应用 |
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KR20080033439A (ko) † | 2005-08-04 | 2008-04-16 | 넥타르 테라퓨틱스 에이엘, 코포레이션 | G-csf 부분 및 중합체의 컨주게이트 |
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-
2005
- 2005-12-21 KR KR1020077014146A patent/KR101320936B1/ko active IP Right Grant
- 2005-12-21 AU AU2005318984A patent/AU2005318984B2/en active Active
- 2005-12-21 CA CA2591233A patent/CA2591233C/en active Active
- 2005-12-21 AT AT05855832T patent/ATE494012T1/de not_active IP Right Cessation
- 2005-12-21 JP JP2007548599A patent/JP5243041B2/ja active Active
- 2005-12-21 MX MX2007007471A patent/MX2007007471A/es active IP Right Grant
- 2005-12-21 DE DE602005025805T patent/DE602005025805D1/de active Active
- 2005-12-21 EP EP05855832.1A patent/EP1827501B2/de active Active
- 2005-12-21 US US11/316,051 patent/US7851565B2/en active Active
- 2005-12-21 CN CN2005800475071A patent/CN101111267B/zh active Active
- 2005-12-21 ES ES05855832.1T patent/ES2357089T5/es active Active
- 2005-12-21 WO PCT/US2005/047337 patent/WO2006069388A2/en active Application Filing
-
2010
- 2010-11-10 US US12/943,740 patent/US8217123B2/en active Active
-
2012
- 2012-06-20 US US13/528,103 patent/US8492488B2/en active Active
-
2013
- 2013-06-19 US US13/921,889 patent/US8765883B2/en active Active
-
2014
- 2014-05-19 US US14/281,411 patent/US9308274B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20070088727A (ko) | 2007-08-29 |
WO2006069388A2 (en) | 2006-06-29 |
US20130280206A1 (en) | 2013-10-24 |
MX2007007471A (es) | 2007-07-20 |
ATE494012T1 (de) | 2011-01-15 |
CA2591233C (en) | 2014-10-07 |
ES2357089T3 (es) | 2011-04-18 |
CA2591233A1 (en) | 2006-06-29 |
ES2357089T5 (es) | 2014-02-24 |
US9308274B2 (en) | 2016-04-12 |
US20060135586A1 (en) | 2006-06-22 |
US7851565B2 (en) | 2010-12-14 |
CN101111267B (zh) | 2012-12-05 |
EP1827501B1 (de) | 2011-01-05 |
EP1827501A2 (de) | 2007-09-05 |
US8765883B2 (en) | 2014-07-01 |
JP2008524338A (ja) | 2008-07-10 |
US8217123B2 (en) | 2012-07-10 |
WO2006069388A3 (en) | 2007-05-31 |
JP5243041B2 (ja) | 2013-07-24 |
US20140256951A1 (en) | 2014-09-11 |
US20110112277A1 (en) | 2011-05-12 |
AU2005318984B2 (en) | 2011-12-01 |
US20120258985A1 (en) | 2012-10-11 |
AU2005318984A1 (en) | 2006-06-29 |
US8492488B2 (en) | 2013-07-23 |
EP1827501B2 (de) | 2013-11-20 |
KR101320936B1 (ko) | 2013-10-23 |
CN101111267A (zh) | 2008-01-23 |
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ES1059244Y (es) | Sistema de teclado parcialmente vertical. | |
ES1057391Y (es) | Dispositivo difusor de sustancias. | |
ITVA20030051A1 (it) | Cerotto. | |
ES1057247Y (es) | Madriguera artificial. | |
ES1059119Y (es) | Mejoras introducidas en carros portaequipajes. | |
ES1058681Y (es) | Dispositivo de retencion de ballesta. |