ATE399185T1 - Maleinsäureamid polymerderivate und ihre biokonjugate - Google Patents
Maleinsäureamid polymerderivate und ihre biokonjugateInfo
- Publication number
- ATE399185T1 ATE399185T1 AT03800397T AT03800397T ATE399185T1 AT E399185 T1 ATE399185 T1 AT E399185T1 AT 03800397 T AT03800397 T AT 03800397T AT 03800397 T AT03800397 T AT 03800397T AT E399185 T1 ATE399185 T1 AT E399185T1
- Authority
- AT
- Austria
- Prior art keywords
- bioconjugates
- maleic acid
- acid amide
- polymer derivatives
- amide polymer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
- C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43725102P | 2002-12-31 | 2002-12-31 | |
US46834003P | 2003-05-05 | 2003-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE399185T1 true ATE399185T1 (de) | 2008-07-15 |
Family
ID=32717886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03800397T ATE399185T1 (de) | 2002-12-31 | 2003-12-31 | Maleinsäureamid polymerderivate und ihre biokonjugate |
Country Status (11)
Country | Link |
---|---|
US (4) | US7329721B2 (de) |
EP (1) | EP1578841B2 (de) |
JP (1) | JP4490369B2 (de) |
KR (1) | KR101031206B1 (de) |
AT (1) | ATE399185T1 (de) |
AU (1) | AU2003300139B2 (de) |
CA (1) | CA2509260C (de) |
DE (1) | DE60321825D1 (de) |
ES (1) | ES2308032T5 (de) |
MX (1) | MXPA05007163A (de) |
WO (1) | WO2004060966A2 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7432331B2 (en) * | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
DE60329627D1 (de) * | 2002-12-31 | 2009-11-19 | Nektar Therapeutics Al Corp | Hydrolysestabile maleimidendgruppen-enthaltende polymere |
ATE399185T1 (de) * | 2002-12-31 | 2008-07-15 | Nektar Therapeutics Al Corp | Maleinsäureamid polymerderivate und ihre biokonjugate |
JP4490413B2 (ja) | 2003-01-06 | 2010-06-23 | ネクター セラピューティクス アラバマ,コーポレイション | チオール選択的水溶性ポリマー誘導体 |
US7947261B2 (en) | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
KR101131411B1 (ko) | 2003-07-22 | 2012-07-05 | 넥타르 테라퓨틱스 | 중합체 알코올로부터 관능화된 중합체의 제조 방법 |
WO2005016260A2 (en) * | 2003-08-08 | 2005-02-24 | The Regents Of The University Of California | Prodrugs for the oral and parenteral delivery of amine-containing drugs, amino acids, and peptides |
US20050147581A1 (en) * | 2003-11-19 | 2005-07-07 | The Board Of Trustees Of The University Of Illinois | Macromolecular drug complexes having improved stability and therapeutic use of the same |
AU2004297228A1 (en) | 2003-12-03 | 2005-06-23 | Nektar Therapeutics Al, Corporation | Method of preparing maleimide functionalized polymers |
KR101276422B1 (ko) * | 2004-03-15 | 2013-06-19 | 넥타르 테라퓨틱스 | Hiv 유입 억제제의 중합체-기재 조성물 및 콘쥬게이트 |
JP2008505119A (ja) | 2004-06-30 | 2008-02-21 | ネクター セラピューティクス アラバマ,コーポレイション | 高分子−第ix因子部分の抱合体 |
LT1824988T (lt) | 2004-11-12 | 2017-10-25 | Bayer Healthcare Llc | Nukreipta į užduotą saitą fviii modifikacija |
KR101320936B1 (ko) | 2004-12-21 | 2013-10-23 | 넥타르 테라퓨틱스 | 안정화된 중합체성 티올 시약 |
WO2006069246A2 (en) * | 2004-12-22 | 2006-06-29 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
WO2007011802A1 (en) | 2005-07-18 | 2007-01-25 | Nektar Therapeutics Al, Corporation | Method for preparing branched functionalized polymers using branched polyol cores |
CN101268118B (zh) | 2005-07-19 | 2012-09-19 | 尼克塔治疗公司 | 用于制备马来酰亚胺聚合物的方法 |
US20070160658A1 (en) * | 2005-10-20 | 2007-07-12 | The Penn State Research Foundation | Delivery system for diagnostic and therapeutic agents |
JP5096363B2 (ja) | 2005-12-16 | 2012-12-12 | ネクター セラピューティックス | Glp−1のポリマ複合体 |
US7743730B2 (en) * | 2005-12-21 | 2010-06-29 | Lam Research Corporation | Apparatus for an optimized plasma chamber grounded electrode assembly |
ITMI20060612A1 (it) * | 2006-03-30 | 2007-09-30 | Keryos Spa | New activaded poly-ethylene glycols-and related polymers and their applications |
WO2007139997A2 (en) * | 2006-05-26 | 2007-12-06 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Methods for site-specific pegylation |
JP2008069073A (ja) * | 2006-09-12 | 2008-03-27 | Yokohama Tlo Co Ltd | ラクトフェリン複合体及びその製造方法 |
US7902086B2 (en) * | 2006-12-08 | 2011-03-08 | Spansion Llc | Prevention of oxidation of carrier ions to improve memory retention properties of polymer memory cell |
EP2532369B1 (de) * | 2006-12-15 | 2017-11-01 | Baxalta GmbH | Faktor-VIIa-(poly)sialsäurekonjugat mit verlängerter In-Vivo-Halbwertszeit |
US20110183906A1 (en) * | 2008-04-24 | 2011-07-28 | Celtic Pharma Peg Ltd. | Factor ix conjugates with extended half-lives |
WO2010016938A2 (en) * | 2008-08-07 | 2010-02-11 | Ipsen Pharma S.A.S. | Glucose-dependent insulinotropic polypeptide analogues |
MX2011001028A (es) * | 2008-08-07 | 2011-04-26 | Ipsen Pharma Sas | Analogos truncados de polipeptidos de insulinotropicos dependientes de glucosa. |
CN102272154A (zh) | 2008-10-29 | 2011-12-07 | 惠氏有限责任公司 | 单域抗原结合性分子的纯化方法 |
KR101581986B1 (ko) | 2008-10-29 | 2016-01-04 | 아블린쓰 엔.브이. | 단일 도메인 항원 결합 분자의 제형 |
WO2010083536A1 (en) * | 2009-01-19 | 2010-07-22 | Bayer Healthcare Llc | Protein conjugate having an endopeptidase-cleavable bioprotective moiety |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
HUE028056T2 (en) | 2009-07-27 | 2016-11-28 | Baxalta GmbH | Blood coagulation protein conjugates |
NZ597600A (en) | 2009-07-27 | 2014-05-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
ES2597954T3 (es) * | 2009-07-27 | 2017-01-24 | Baxalta GmbH | Conjugados de proteína de la coagulación sanguínea |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
KR101776976B1 (ko) | 2010-02-21 | 2017-09-08 | 바이엘 헬스케어 엘엘씨 | 생체분자의 활성화 및 접합 방법 |
EP2593476A2 (de) * | 2010-07-16 | 2013-05-22 | Ablynx N.V. | Modifizierte einzeldomänen-antigen-bindungsmoleküle und ihre verwendung |
KR102025442B1 (ko) | 2010-12-22 | 2019-09-25 | 박스알타 인코퍼레이티드 | 단백질에 수용성 지방산 유도체를 접합하기 위한 물질 및 방법 |
WO2012123519A2 (en) | 2011-03-15 | 2012-09-20 | Novo Nordisk A/S | Human insulin analogues and derivatives comprising cysteine substitutions |
US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
BR112013031819B1 (pt) | 2011-06-10 | 2022-05-03 | Mersana Therapeutics, Inc | Suporte polimérico, composição farmacêutica, composto, e, uso do suporte |
US9044515B2 (en) * | 2011-09-06 | 2015-06-02 | University Of Delaware | Chemical conjugates for targeted degradation under reducing conditions |
US9872918B2 (en) | 2012-12-12 | 2018-01-23 | Mersana Therapeutics, Inc. | Hydroxyl-polymer-drug-protein conjugates |
EP3054991B1 (de) | 2013-10-11 | 2019-04-03 | Mersana Therapeutics, Inc. | Protein-polymer-wirkstoffkonjugate |
JP6427564B2 (ja) | 2013-10-11 | 2018-11-21 | アサナ・バイオサイエンシズ,リミテッド・ライアビリティ・カンパニー | タンパク質−ポリマー−薬物共役体 |
CN104862233B (zh) * | 2014-02-25 | 2018-06-05 | 上海多米瑞生物技术有限公司 | 一株产黄青霉及其应用 |
CA3032147A1 (en) * | 2016-08-09 | 2018-02-15 | Seattle Genetics, Inc. | Drug conjugates with self-stabilizing linkers having improved physiochemical properties |
CN106750334B (zh) * | 2016-12-08 | 2020-10-16 | 云南师范大学 | 两亲性蝌蚪形嵌段共聚物及其制备方法 |
WO2020158690A1 (ja) * | 2019-01-28 | 2020-08-06 | 東レ株式会社 | 肝細胞増殖因子又はその活性断片のポリエチレングリコール修飾体 |
CN115028923B (zh) * | 2021-03-08 | 2024-02-13 | 嘉瑞塑胶科技有限公司 | 防细菌聚合物复合材料 |
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EP0273545A1 (de) | 1987-01-02 | 1988-07-06 | Texaco Development Corporation | Reaktionsprodukt und ori-gehemmte Motortreibstoffzusammensetzung |
EP0318162A3 (de) * | 1987-11-25 | 1990-11-07 | Texaco Development Corporation | Bismaleinimid-Derivate |
US5545727A (en) † | 1989-05-10 | 1996-08-13 | Somatogen, Inc. | DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin |
US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
ATE240740T1 (de) | 1991-03-15 | 2003-06-15 | Amgen Inc | Pegylation von polypeptiden |
US6180134B1 (en) * | 1993-03-23 | 2001-01-30 | Sequus Pharmaceuticals, Inc. | Enhanced ciruclation effector composition and method |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5585484A (en) * | 1995-04-19 | 1996-12-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Hemoglobin crosslinkers |
JP3092531B2 (ja) | 1996-11-05 | 2000-09-25 | 日本油脂株式会社 | コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法 |
US6183738B1 (en) * | 1997-05-12 | 2001-02-06 | Phoenix Pharamacologics, Inc. | Modified arginine deiminase |
AU751898B2 (en) | 1997-07-14 | 2002-08-29 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
GB9812545D0 (en) | 1998-06-10 | 1998-08-05 | Celltech Therapeutics Ltd | Biological products |
UA73924C2 (en) | 1998-10-09 | 2005-10-17 | Nektar Therapeutics | Device for delivering active agent formulation to lungs of human patient |
JP2000191700A (ja) | 1998-12-28 | 2000-07-11 | Kyowa Hakko Kogyo Co Ltd | 持続型消化管運動ペプチド |
US7270972B1 (en) † | 1999-04-02 | 2007-09-18 | Ajinomoto Co., Inc. | Process for producing subunit peptide originating in polymer protein |
JO2291B1 (en) † | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythropoietin derivatives |
US6180598B1 (en) * | 1999-10-07 | 2001-01-30 | Deanna J. Nelson | Covalently modified hemoglobin having low temperature-dependent oxygen-binding function |
AU2001238595A1 (en) | 2000-02-22 | 2001-09-03 | Shearwater Corporation | N-maleimidyl polymer derivatives |
EP1284987B1 (de) † | 2000-05-16 | 2007-07-18 | Bolder Biotechnology, Inc. | Verfahren zur rückfaltung von proteinen mit freien cysteinresten |
EP1267170A1 (de) † | 2001-06-07 | 2002-12-18 | Xzillion GmbH & CO.KG | Verfahren zur Charakterisierung von Polypeptiden |
JP4123856B2 (ja) * | 2001-07-31 | 2008-07-23 | 日油株式会社 | 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法 |
ATE399185T1 (de) | 2002-12-31 | 2008-07-15 | Nektar Therapeutics Al Corp | Maleinsäureamid polymerderivate und ihre biokonjugate |
-
2003
- 2003-12-31 AT AT03800397T patent/ATE399185T1/de not_active IP Right Cessation
- 2003-12-31 CA CA2509260A patent/CA2509260C/en not_active Expired - Lifetime
- 2003-12-31 ES ES03800397.6T patent/ES2308032T5/es not_active Expired - Lifetime
- 2003-12-31 KR KR1020057012473A patent/KR101031206B1/ko active IP Right Grant
- 2003-12-31 EP EP03800397.6A patent/EP1578841B2/de not_active Expired - Lifetime
- 2003-12-31 US US10/750,996 patent/US7329721B2/en active Active
- 2003-12-31 DE DE60321825T patent/DE60321825D1/de not_active Expired - Lifetime
- 2003-12-31 JP JP2005508648A patent/JP4490369B2/ja not_active Expired - Lifetime
- 2003-12-31 MX MXPA05007163A patent/MXPA05007163A/es active IP Right Grant
- 2003-12-31 AU AU2003300139A patent/AU2003300139B2/en not_active Expired
- 2003-12-31 WO PCT/US2003/041705 patent/WO2004060966A2/en active Application Filing
-
2007
- 2007-09-27 US US11/904,990 patent/US7659361B2/en not_active Expired - Lifetime
-
2009
- 2009-12-18 US US12/642,413 patent/US7994272B2/en not_active Expired - Lifetime
-
2011
- 2011-06-29 US US13/172,043 patent/US8304511B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2509260C (en) | 2012-10-02 |
KR20050096116A (ko) | 2005-10-05 |
EP1578841B2 (de) | 2016-10-12 |
KR101031206B1 (ko) | 2011-04-27 |
CA2509260A1 (en) | 2004-07-22 |
AU2003300139A1 (en) | 2004-07-29 |
ES2308032T3 (es) | 2008-12-01 |
US8304511B2 (en) | 2012-11-06 |
WO2004060966A3 (en) | 2004-09-16 |
EP1578841B1 (de) | 2008-06-25 |
US7659361B2 (en) | 2010-02-09 |
US7329721B2 (en) | 2008-02-12 |
US20100113329A1 (en) | 2010-05-06 |
JP2006522167A (ja) | 2006-09-28 |
ES2308032T5 (es) | 2017-04-24 |
WO2004060966A2 (en) | 2004-07-22 |
US20080146771A1 (en) | 2008-06-19 |
AU2003300139B2 (en) | 2008-08-28 |
US7994272B2 (en) | 2011-08-09 |
EP1578841A2 (de) | 2005-09-28 |
DE60321825D1 (de) | 2008-08-07 |
MXPA05007163A (es) | 2005-09-21 |
JP4490369B2 (ja) | 2010-06-23 |
US20110262379A1 (en) | 2011-10-27 |
US20040167287A1 (en) | 2004-08-26 |
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