HUP0500541A2 - Rákellenes antraciklin hatóanyag célterápiára alkalmas pH-érzékeny polimer konjugátjai - Google Patents

Rákellenes antraciklin hatóanyag célterápiára alkalmas pH-érzékeny polimer konjugátjai

Info

Publication number
HUP0500541A2
HUP0500541A2 HU0500541A HUP0500541A HUP0500541A2 HU P0500541 A2 HUP0500541 A2 HU P0500541A2 HU 0500541 A HU0500541 A HU 0500541A HU P0500541 A HUP0500541 A HU P0500541A HU P0500541 A2 HUP0500541 A2 HU P0500541A2
Authority
HU
Hungary
Prior art keywords
amino acids
units
targeted therapy
sensitive polymeric
polymeric conjugates
Prior art date
Application number
HU0500541A
Other languages
English (en)
Inventor
Karel Ulbrich
Tomás Etrych
Blanka Rihova
Markéta Jelinkova
Marek Kovar
Original Assignee
Zentiva, A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, A.S. filed Critical Zentiva, A.S.
Publication of HUP0500541A2 publication Critical patent/HUP0500541A2/hu
Publication of HUP0500541A3 publication Critical patent/HUP0500541A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya 30-3000 monomeregység kapcsolódásával polimerláncotalkotó polimerhordozóból álló konjugátok, amelyek tartalmaznak a) 60-99% N-(2-hidroxi-propil)metakrilamid egységet, b) 1-25% rákellenesantraciklin molekulával lezárt metakrilsavval acilezett a-aminosavak,e-aminosavak, aromás aminosavak vagy oligopeptidek hidrazin egységeit,c) 0,5-15% a-aminosavak, e-aminosavak, aromás aminosavak vagyoligopeptidek vagy ezek nátriumsóinak metakrilsavval acilezettegységeit.
HU0500541A 2001-12-20 2002-12-20 Ph-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy HUP0500541A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20014653A CZ293787B6 (cs) 2001-12-20 2001-12-20 pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii
PCT/CZ2002/000070 WO2003053473A2 (en) 2001-12-20 2002-12-20 Ph-sensitive polymeric conjugates of an anthracycline drug

Publications (2)

Publication Number Publication Date
HUP0500541A2 true HUP0500541A2 (hu) 2005-09-28
HUP0500541A3 HUP0500541A3 (en) 2011-08-29

Family

ID=5473644

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500541A HUP0500541A3 (en) 2001-12-20 2002-12-20 Ph-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy

Country Status (18)

Country Link
US (1) US7919076B2 (hu)
EP (2) EP1463529B9 (hu)
JP (1) JP4718117B2 (hu)
KR (1) KR20040076874A (hu)
AT (1) ATE439864T1 (hu)
AU (1) AU2002366715A1 (hu)
CA (1) CA2470976A1 (hu)
CZ (1) CZ293787B6 (hu)
DE (1) DE60233434D1 (hu)
DK (1) DK1463529T5 (hu)
EA (1) EA007353B1 (hu)
ES (1) ES2331303T3 (hu)
HU (1) HUP0500541A3 (hu)
PL (1) PL216518B1 (hu)
PT (1) PT1463529E (hu)
SI (1) SI1463529T1 (hu)
SK (1) SK2912004A3 (hu)
WO (1) WO2003053473A2 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ294996B6 (cs) * 2003-07-16 2005-04-13 Ústav Makromolekulární Chemie Av Čr Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů
EP1877097B1 (en) 2004-08-11 2012-06-20 Arqule, Inc. Aminoacid conjugates of beta-lapachone for tumor targeting
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
CZ297827B6 (cs) * 2005-09-05 2007-04-04 Zentiva, A. S. Zpusob prípravy polymerních konjugátu doxorubicinu s pH-rízeným uvolnováním léciva
CZ2006207A3 (cs) * 2006-03-28 2008-01-16 Zentiva, A. S. Micelární nosiče léčiv s protinádorovou aktivitou
CZ299053B6 (cs) * 2006-08-09 2008-04-09 Zentiva, A. S. Polymerní konjugáty doxorubicinu s pH-rízeným uvolnováním léciva a zpusob jejich prípravy
EP2503332A3 (en) 2006-08-09 2013-11-13 Sumitomo Bakelite Company, Ltd. Sugar chain-capturing substance and use thereof
CZ298945B6 (cs) * 2006-09-18 2008-03-19 Zentiva, A. S. Polymerní lécivo a zpusob jeho výroby
ES2532656T3 (es) 2007-04-30 2015-03-30 Arqule, Inc. Compuestos de hidroxi sulfonato de quinona y sus usos
CZ2008661A3 (cs) * 2008-10-23 2009-12-30 Zentiva, A. S Polymerní prípravek se synergickým úcinkem pri lécbe nádorových onemocnení
CZ302830B6 (cs) * 2009-12-15 2011-11-30 Ústav makromolekulární chemie AV CR, v.v.i. Vysokomolekulární polymerní nosice léciv odvozené od dendrimeru a jejich konjugáty s lécivy pro lécbu zejména pevných nádoru
EP3069715A1 (en) 2015-03-20 2016-09-21 Salmon Pharma GmbH Immediate release dosage forms of Atomoxetine
JP7390000B2 (ja) * 2016-10-14 2023-12-01 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション 抗体－ポリマー－薬物コンジュゲート
CZ309828B6 (cs) * 2019-10-09 2023-11-15 I.T.A.-Intertact S.R.O. Fluorescenční polymer, fluorescenční sonda a konjugační sada pro pokročilé funkční analýzy buněk v hematologii, imunologii a mikrobiologii, způsob jejich přípravy a jejich použití
WO2021084087A1 (en) * 2019-10-30 2021-05-06 Cis Pharma Ag Biocompatible polymeric drug carriers for delivering active agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8500209D0 (en) 1985-01-04 1985-02-13 Ceskoslovenska Akademie Ved Synthetic polymeric drugs

Also Published As

Publication number Publication date
EP1463529B1 (en) 2009-08-19
EP1463529B9 (en) 2011-03-23
WO2003053473A2 (en) 2003-07-03
US7919076B2 (en) 2011-04-05
ATE439864T1 (de) 2009-09-15
HUP0500541A3 (en) 2011-08-29
EA007353B1 (ru) 2006-10-27
EP1782833A3 (en) 2008-03-19
KR20040076874A (ko) 2004-09-03
EP1782833A2 (en) 2007-05-09
CZ20014653A3 (cs) 2003-08-13
DK1463529T5 (da) 2011-06-27
DK1463529T3 (da) 2009-10-19
WO2003053473A3 (en) 2004-04-29
CZ293787B6 (cs) 2004-07-14
SI1463529T1 (sl) 2010-01-29
EA200400802A1 (ru) 2005-02-24
US20060057099A1 (en) 2006-03-16
ES2331303T9 (es) 2011-08-18
SK2912004A3 (en) 2004-12-01
CA2470976A1 (en) 2003-07-03
PL370719A1 (en) 2005-05-30
ES2331303T3 (es) 2009-12-29
PL216518B1 (pl) 2014-04-30
EP1463529A2 (en) 2004-10-06
AU2002366715A1 (en) 2003-07-09
AU2002366715A8 (en) 2003-07-09
PT1463529E (pt) 2009-11-03
DE60233434D1 (de) 2009-10-01
JP2005519044A (ja) 2005-06-30
JP4718117B2 (ja) 2011-07-06

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