DE69915103D1 - Neue oligomere konjugate zum transfer biologischer moleküle in zellen - Google Patents
Neue oligomere konjugate zum transfer biologischer moleküle in zellenInfo
- Publication number
- DE69915103D1 DE69915103D1 DE69915103T DE69915103T DE69915103D1 DE 69915103 D1 DE69915103 D1 DE 69915103D1 DE 69915103 T DE69915103 T DE 69915103T DE 69915103 T DE69915103 T DE 69915103T DE 69915103 D1 DE69915103 D1 DE 69915103D1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- transfer
- organic molecules
- oligomer conjugates
- new oligomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A61K47/6455—Polycationic oligopeptides, polypeptides or polyamino acids, e.g. for complexing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Polyamides (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98403015 | 1998-12-02 | ||
EP98403015 | 1998-12-02 | ||
PCT/EP1999/008980 WO2000032764A1 (en) | 1998-12-02 | 1999-11-22 | New oligomeric conjugates liable to transfer biological molecules into cells |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69915103D1 true DE69915103D1 (de) | 2004-04-01 |
DE69915103T2 DE69915103T2 (de) | 2004-12-09 |
Family
ID=8235574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69915103T Expired - Fee Related DE69915103T2 (de) | 1998-12-02 | 1999-11-22 | Neue oligomere konjugate zum transfer biologischer moleküle in zellen |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1135481B1 (de) |
JP (1) | JP2002532388A (de) |
AT (1) | ATE260337T1 (de) |
AU (1) | AU770963B2 (de) |
CA (1) | CA2348823A1 (de) |
DE (1) | DE69915103T2 (de) |
ES (1) | ES2213397T3 (de) |
WO (1) | WO2000032764A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001047496A1 (en) | 1999-12-29 | 2001-07-05 | Mixson A James | Histidine copolymer and methods for using same |
US7070807B2 (en) | 1999-12-29 | 2006-07-04 | Mixson A James | Branched histidine copolymers and methods for using same |
IL154044A0 (en) * | 2000-07-21 | 2003-07-31 | Essentia Biosystems Inc | Multi-component pharmaceutical compositions containing a complex of a positively charged backbone and a negatively charged backbone and methods for the preparation thereof |
US20040220100A1 (en) * | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
WO2003066054A1 (en) * | 2002-02-01 | 2003-08-14 | Intradigm Corporation | Cationic polymers for use in therapeutic agent delivery |
US7465708B2 (en) | 2002-11-25 | 2008-12-16 | Mixson A James | Branched cationic copolymers and methods for antimicrobial use |
CA3031270A1 (en) | 2004-03-03 | 2005-12-22 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
RU2007136616A (ru) | 2005-03-03 | 2009-04-10 | Риванс Терапьютикс, Инк. (Us) | Композиция и способ для местного применения и чрескожного введения ботулинового токсина |
SG160358A1 (en) | 2005-03-03 | 2010-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of an oligopeptide |
FR2928373B1 (fr) | 2008-03-05 | 2010-12-31 | Centre Nat Rech Scient | Polymere derive de la polyethylenimine lineaire pour le transfert de gene. |
JP2016503300A (ja) | 2012-11-15 | 2016-02-04 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S | 抗ApoBアンチセンス複合体化合物 |
WO2015078995A1 (en) * | 2013-11-28 | 2015-06-04 | Institut National de la Santé et de la Recherche Médicale | Agents for treating cystic fibrosis |
CN114716518A (zh) * | 2021-01-06 | 2022-07-08 | 圣诺制药公司 | 一种能够抑制pcsk9表达的分子构造及药物组合物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5627270A (en) * | 1991-12-13 | 1997-05-06 | Trustees Of Princeton University | Glycosylated steroid derivatives for transport across biological membranes and process for making and using same |
AU4770093A (en) * | 1992-07-02 | 1994-01-31 | Hybridon, Inc. | Self-stabilized oligonucleotides as therapeutic agents |
US5656609A (en) * | 1992-09-24 | 1997-08-12 | University Of Connecticut | Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine |
AU681192B2 (en) * | 1993-09-28 | 1997-08-21 | Hisamitsu Pharmaceutical Co., Inc. | Polyamino acid oligonucleotide carrier |
GB9623051D0 (en) * | 1996-11-06 | 1997-01-08 | Schacht Etienne H | Delivery of DNA to target cells in biological systems |
FR2755976B1 (fr) * | 1996-11-15 | 1999-01-15 | Idm Immuno Designed Molecules | Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires |
-
1999
- 1999-11-22 JP JP2000585395A patent/JP2002532388A/ja active Pending
- 1999-11-22 EP EP99959296A patent/EP1135481B1/de not_active Expired - Lifetime
- 1999-11-22 AU AU16526/00A patent/AU770963B2/en not_active Ceased
- 1999-11-22 ES ES99959296T patent/ES2213397T3/es not_active Expired - Lifetime
- 1999-11-22 AT AT99959296T patent/ATE260337T1/de not_active IP Right Cessation
- 1999-11-22 CA CA002348823A patent/CA2348823A1/en not_active Abandoned
- 1999-11-22 WO PCT/EP1999/008980 patent/WO2000032764A1/en active IP Right Grant
- 1999-11-22 DE DE69915103T patent/DE69915103T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2000032764A1 (en) | 2000-06-08 |
DE69915103T2 (de) | 2004-12-09 |
CA2348823A1 (en) | 2000-06-08 |
AU770963B2 (en) | 2004-03-11 |
ES2213397T3 (es) | 2004-08-16 |
EP1135481A1 (de) | 2001-09-26 |
JP2002532388A (ja) | 2002-10-02 |
ATE260337T1 (de) | 2004-03-15 |
EP1135481B1 (de) | 2004-02-25 |
AU1652600A (en) | 2000-06-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69915103D1 (de) | Neue oligomere konjugate zum transfer biologischer moleküle in zellen | |
DE50006269D1 (de) | Kombinationen zur einführung von nucleinsäuren in zellen | |
EA200100365A1 (ru) | Синтазы | |
BR9913532A (pt) | Novos inibidores heteroaromáticos de frutose 1,6-bifosfatase | |
EP0293852A3 (de) | Organopolysiloxanzusammensetzungen, die funktionelle alpha,beta-ungesättigte Carbonylgruppen enthalten | |
DE60209560D1 (de) | Thermoplastische zusammensetzung, welche einen hyperverzweigten polymer enthält, und daraus hergestellte gegenstände | |
DE69430312D1 (de) | Peralkylierte oligopeptidmischungen | |
EP0590071A4 (en) | Substantially pure receptor like tgf--g(b)1 binding molecules and uses thereof | |
DK1210357T3 (da) | Oligonukleotid-N3' -P5' -thiophosphoramidater: syntese og anvendelse deraf | |
BR0211200A (pt) | Peptìdeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células | |
PL345561A1 (en) | Substituted benzoylcyclohexandiones | |
EP0882454A3 (de) | Herstellungsverfahren für die Konjugation von Chelaten mit Molekülen enthaltend Aminogruppen | |
PL336000A1 (en) | Cosmetic compositions containing a cationic polymer of low molecular weight and a silicone as well as their application | |
AU1062997A (en) | Novel polymer supports for nucleic acid synthesis | |
ES2154590A1 (es) | Procedimiento de sintesis de peptidos en fase solida | |
HUP0500541A2 (hu) | Rákellenes antraciklin hatóanyag célterápiára alkalmas pH-érzékeny polimer konjugátjai | |
CA2258802A1 (fr) | Conjugues d'un oligonucleotide/polymere conducteur electronique avec une molecule d'interet, et leurs utilisations | |
CA2316113A1 (en) | Method for nucleic acid purification using iodine | |
CA2340934A1 (en) | Novel collectin | |
RU96106897A (ru) | Рецептор глюканового активатора и кодирующая его молекула днк | |
IT8948114A0 (it) | Mezzi leganti per composizioni di alta energia, che utilizzano il cis-, cis-1,3,5-tri (isocianatometil) cicloesano | |
WO2000040607A3 (en) | Tiam2 (t-cell lymphoma invasion and metastasis 2) nucleotide exchange factor | |
DE69430261T2 (de) | Thermotrope poly(esteramide)e enthaltende monomereinheiten abgeleitet aus 4,4'-biphenyldicarbonsäure | |
DE69801814T2 (de) | Polymere amine | |
PT1537210E (pt) | Inibicao de oliconucleotidos decoy de expressao cd-40 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |