ES2154590A1 - Procedimiento de sintesis de peptidos en fase solida - Google Patents
Procedimiento de sintesis de peptidos en fase solidaInfo
- Publication number
- ES2154590A1 ES2154590A1 ES009901090A ES9901090A ES2154590A1 ES 2154590 A1 ES2154590 A1 ES 2154590A1 ES 009901090 A ES009901090 A ES 009901090A ES 9901090 A ES9901090 A ES 9901090A ES 2154590 A1 ES2154590 A1 ES 2154590A1
- Authority
- ES
- Spain
- Prior art keywords
- amino acids
- solid phase
- procedure
- phase peptide
- protecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Procedimiento de síntesis de péptidos en fase sólida (SPFS), por estrategia lineal o convergentes de péptidos que contengan la secuencia de fórmula general I, en donde n, Y, X y A{sub, 1} a A{sub, n} tiene los significados indicados en la fórmula I. Dicho procedimiento comprende: la utilización de aminoácidos con el grupo N{al} protegido, proteger las cadenas laterales de aquellos aminoácidos que tengan la misma alquilada o acilada en el producto final con protectores lábiles, proteger las cadenas laterales de al menos uno de los aminoácidos que tenga la misma libre en el producto final con protectores hiperlábiles y utilizar un soporte polimérico que proporciona enlaces péptido- resina lábiles. Dicho procedimiento es válido para la síntesis de goserelina y de buserelina.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901090A ES2154590B1 (es) | 1999-05-20 | 1999-05-20 | Procedimiento de sintesis de peptidos en fase solida |
ES00925307T ES2310993T3 (es) | 1999-05-20 | 2000-05-05 | Metodo de sintesis de peptidos en fase solida. |
DE60039692T DE60039692D1 (de) | 1999-05-20 | 2000-05-05 | Methode festphasensynthese von peptiden |
DK00925307T DK1179537T3 (da) | 1999-05-20 | 2000-05-05 | Fastfasepeptidsyntesefremgangsmåde |
AU44064/00A AU4406400A (en) | 1999-05-20 | 2000-05-05 | Solid phase peptide synthesis method |
PCT/ES2000/000169 WO2000071570A1 (es) | 1999-05-20 | 2000-05-05 | Procedimiento de sintesis de peptidos en fase solida |
EP00925307A EP1179537B1 (en) | 1999-05-20 | 2000-05-05 | Solid phase peptide synthesis method |
JP2000619825A JP5138845B2 (ja) | 1999-05-20 | 2000-05-05 | 固相中でのペプチド合成法 |
AT00925307T ATE402946T1 (de) | 1999-05-20 | 2000-05-05 | Methode festphasensynthese von peptiden |
PT00925307T PT1179537E (pt) | 1999-05-20 | 2000-05-05 | Método de síntese de péptidos em fase sólida |
US09/979,293 US6897289B1 (en) | 1999-05-20 | 2000-05-05 | Peptide synthesis procedure in solid phase |
CY20081101226T CY1108465T1 (el) | 1999-05-20 | 2008-10-30 | Μεθοδος συνθεσης πεπτιδιων στερεης φασης |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901090A ES2154590B1 (es) | 1999-05-20 | 1999-05-20 | Procedimiento de sintesis de peptidos en fase solida |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2154590A1 true ES2154590A1 (es) | 2001-04-01 |
ES2154590B1 ES2154590B1 (es) | 2001-11-01 |
Family
ID=8308492
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009901090A Expired - Fee Related ES2154590B1 (es) | 1999-05-20 | 1999-05-20 | Procedimiento de sintesis de peptidos en fase solida |
ES00925307T Expired - Lifetime ES2310993T3 (es) | 1999-05-20 | 2000-05-05 | Metodo de sintesis de peptidos en fase solida. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00925307T Expired - Lifetime ES2310993T3 (es) | 1999-05-20 | 2000-05-05 | Metodo de sintesis de peptidos en fase solida. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6897289B1 (es) |
EP (1) | EP1179537B1 (es) |
JP (1) | JP5138845B2 (es) |
AT (1) | ATE402946T1 (es) |
AU (1) | AU4406400A (es) |
CY (1) | CY1108465T1 (es) |
DE (1) | DE60039692D1 (es) |
DK (1) | DK1179537T3 (es) |
ES (2) | ES2154590B1 (es) |
PT (1) | PT1179537E (es) |
WO (1) | WO2000071570A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2472235C (en) | 2002-04-11 | 2012-05-22 | Daiichi Suntory Pharma Co., Ltd. | A method for producing a modified peptide |
DE602005023429D1 (de) | 2004-10-19 | 2010-10-21 | Lonza Ag | Verfahren zur festphasen-peptidsynthese |
EP1773870B1 (en) | 2005-05-03 | 2009-12-16 | Novetide Ltd. | Methods for the production of peptide having a c-terminal amide |
CN100355773C (zh) * | 2006-01-19 | 2007-12-19 | 九江石化波涛生化科技有限公司 | 高分子量多肽聚合物的合成方法 |
US8022181B2 (en) * | 2006-05-03 | 2011-09-20 | Mallinckrodt Llc | Composition and method for the release of protected peptides from a resin |
WO2008044890A1 (en) * | 2006-10-12 | 2008-04-17 | Dong Kook Pharm. Co., Ltd | A method for preparing peptides using by solid phase synthesis |
KR101046846B1 (ko) | 2006-10-12 | 2011-07-06 | 동국제약 주식회사 | 고체상 합성법을 이용한 펩타이드의 제조방법 |
US20100311946A1 (en) * | 2009-06-03 | 2010-12-09 | Mallinckrodt Inc. | Solid Phase Peptide for the Production of Goserelin |
WO2011066386A1 (en) * | 2009-11-25 | 2011-06-03 | Novetide, Ltd. | Process for production of degarelix |
WO2012113847A1 (en) | 2011-02-25 | 2012-08-30 | Lonza Ltd | Branched linker for protein drug conjugates |
CN103517915B (zh) * | 2012-09-27 | 2015-11-25 | 深圳翰宇药业股份有限公司 | 一种制备布舍瑞林的方法 |
CN108264538B (zh) * | 2017-01-04 | 2023-08-29 | 辽宁药联制药有限公司 | 门冬氨酸缩合物的固相合成方法 |
CN110922452B (zh) * | 2018-09-20 | 2023-12-26 | 深圳翰宇药业股份有限公司 | 一种戈舍瑞林的合成方法 |
CN110922453B (zh) * | 2018-09-20 | 2023-12-26 | 深圳翰宇药业股份有限公司 | 一种戈舍瑞林的合成方法 |
KR20210104460A (ko) * | 2020-02-17 | 2021-08-25 | 주식회사 아이바이오코리아 | 고체상 합성법을 이용한 펩타이드의 제조 방법 |
CN114324669B (zh) * | 2022-01-04 | 2023-11-14 | 宁波第二激素厂 | 一种鲑鱼促性腺激素释放激素类似物中l-精氨酸残留量的柱前手性衍生测定方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0475184A1 (de) * | 1990-08-30 | 1992-03-18 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung von Peptiden mittels Festphasensynthese |
EP0518655A2 (en) * | 1991-06-14 | 1992-12-16 | Zeneca Limited | Solid phase peptide synthesis |
CH682662A5 (de) * | 1991-10-11 | 1993-10-29 | Bachem Feinchemikalien Ag | Aminosäurederivate zur Peptidsynthese. |
DE4306839A1 (de) * | 1993-03-05 | 1994-09-08 | Bayer Ernst Prof Dr | Tritylgruppe enthaltendes Festphasensystem, Verfahren zu seiner Herstellung und seine Verwendung in Festphasenreaktionen |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2438350C3 (de) | 1974-08-09 | 1979-06-13 | Hoechst Ag, 6000 Frankfurt | Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
GB9112859D0 (en) | 1991-06-14 | 1991-07-31 | Ici Plc | Peptide process |
-
1999
- 1999-05-20 ES ES009901090A patent/ES2154590B1/es not_active Expired - Fee Related
-
2000
- 2000-05-05 US US09/979,293 patent/US6897289B1/en not_active Expired - Lifetime
- 2000-05-05 JP JP2000619825A patent/JP5138845B2/ja not_active Expired - Fee Related
- 2000-05-05 AU AU44064/00A patent/AU4406400A/en not_active Abandoned
- 2000-05-05 ES ES00925307T patent/ES2310993T3/es not_active Expired - Lifetime
- 2000-05-05 DK DK00925307T patent/DK1179537T3/da active
- 2000-05-05 WO PCT/ES2000/000169 patent/WO2000071570A1/es active IP Right Grant
- 2000-05-05 EP EP00925307A patent/EP1179537B1/en not_active Expired - Lifetime
- 2000-05-05 DE DE60039692T patent/DE60039692D1/de not_active Expired - Lifetime
- 2000-05-05 PT PT00925307T patent/PT1179537E/pt unknown
- 2000-05-05 AT AT00925307T patent/ATE402946T1/de active
-
2008
- 2008-10-30 CY CY20081101226T patent/CY1108465T1/el unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0475184A1 (de) * | 1990-08-30 | 1992-03-18 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung von Peptiden mittels Festphasensynthese |
EP0518655A2 (en) * | 1991-06-14 | 1992-12-16 | Zeneca Limited | Solid phase peptide synthesis |
CH682662A5 (de) * | 1991-10-11 | 1993-10-29 | Bachem Feinchemikalien Ag | Aminosäurederivate zur Peptidsynthese. |
DE4306839A1 (de) * | 1993-03-05 | 1994-09-08 | Bayer Ernst Prof Dr | Tritylgruppe enthaltendes Festphasensystem, Verfahren zu seiner Herstellung und seine Verwendung in Festphasenreaktionen |
Also Published As
Publication number | Publication date |
---|---|
EP1179537A1 (en) | 2002-02-13 |
ES2310993T3 (es) | 2009-02-01 |
EP1179537B1 (en) | 2008-07-30 |
JP5138845B2 (ja) | 2013-02-06 |
ATE402946T1 (de) | 2008-08-15 |
ES2154590B1 (es) | 2001-11-01 |
US6897289B1 (en) | 2005-05-24 |
PT1179537E (pt) | 2008-11-11 |
WO2000071570A8 (es) | 2001-04-12 |
DK1179537T3 (da) | 2008-12-01 |
CY1108465T1 (el) | 2014-04-09 |
DE60039692D1 (de) | 2008-09-11 |
JP2003500416A (ja) | 2003-01-07 |
WO2000071570A1 (es) | 2000-11-30 |
AU4406400A (en) | 2000-12-12 |
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KATCHALSKI | NOVEL TECHNIQUES FOR THE SYNTHESIS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20010401 Kind code of ref document: A1 Effective date: 20010401 |
|
PC2A | Transfer of patent |
Owner name: BCN PEPTIDES, S.A. Effective date: 20120905 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20180807 |