ES2154590B1 - Procedimiento de sintesis de peptidos en fase solida - Google Patents

Procedimiento de sintesis de peptidos en fase solida

Info

Publication number
ES2154590B1
ES2154590B1 ES009901090A ES9901090A ES2154590B1 ES 2154590 B1 ES2154590 B1 ES 2154590B1 ES 009901090 A ES009901090 A ES 009901090A ES 9901090 A ES9901090 A ES 9901090A ES 2154590 B1 ES2154590 B1 ES 2154590B1
Authority
ES
Spain
Prior art keywords
amino acids
procedure
solid phase
protecting
final product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009901090A
Other languages
English (en)
Other versions
ES2154590A1 (es
Inventor
I Obiols Berta Ponsati
I Poblet Marc Canas
I Farres Gemma Jodas
Rodriguez Javier Clemente
I Cabado Jordi Bicardit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BCN Peptides SA
Original Assignee
Lipotec SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES009901090A priority Critical patent/ES2154590B1/es
Application filed by Lipotec SA filed Critical Lipotec SA
Priority to PT00925307T priority patent/PT1179537E/pt
Priority to DE60039692T priority patent/DE60039692D1/de
Priority to DK00925307T priority patent/DK1179537T3/da
Priority to JP2000619825A priority patent/JP5138845B2/ja
Priority to US09/979,293 priority patent/US6897289B1/en
Priority to AU44064/00A priority patent/AU4406400A/en
Priority to ES00925307T priority patent/ES2310993T3/es
Priority to PCT/ES2000/000169 priority patent/WO2000071570A1/es
Priority to AT00925307T priority patent/ATE402946T1/de
Priority to EP00925307A priority patent/EP1179537B1/en
Publication of ES2154590A1 publication Critical patent/ES2154590A1/es
Application granted granted Critical
Publication of ES2154590B1 publication Critical patent/ES2154590B1/es
Priority to CY20081101226T priority patent/CY1108465T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimiento de síntesis de péptidos en fase sólida (SPFS), por estrategia lineal o convergentes de péptidos que contengan la secuencia de fórmula general I, en donde n, Y, X y A{sub, 1} a A{sub, n} tiene los significados indicados en la fórmula I. Dicho procedimiento comprende: la utilización de aminoácidos con el grupo N{al} protegido, proteger las cadenas laterales de aquellos aminoácidos que tengan la misma alquilada o acilada en el producto final con protectores lábiles, proteger las cadenas laterales de al menos uno de los aminoácidos que tenga la misma libre en el producto final con protectores hiperlábiles y utilizar un soporte polimérico que proporciona enlaces péptido- resina lábiles. Dicho procedimiento es válido para la síntesis de goserelina y de buserelina.
ES009901090A 1999-05-20 1999-05-20 Procedimiento de sintesis de peptidos en fase solida Expired - Fee Related ES2154590B1 (es)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ES009901090A ES2154590B1 (es) 1999-05-20 1999-05-20 Procedimiento de sintesis de peptidos en fase solida
PCT/ES2000/000169 WO2000071570A1 (es) 1999-05-20 2000-05-05 Procedimiento de sintesis de peptidos en fase solida
DK00925307T DK1179537T3 (da) 1999-05-20 2000-05-05 Fastfasepeptidsyntesefremgangsmåde
JP2000619825A JP5138845B2 (ja) 1999-05-20 2000-05-05 固相中でのペプチド合成法
US09/979,293 US6897289B1 (en) 1999-05-20 2000-05-05 Peptide synthesis procedure in solid phase
AU44064/00A AU4406400A (en) 1999-05-20 2000-05-05 Solid phase peptide synthesis method
PT00925307T PT1179537E (pt) 1999-05-20 2000-05-05 Método de síntese de péptidos em fase sólida
DE60039692T DE60039692D1 (de) 1999-05-20 2000-05-05 Methode festphasensynthese von peptiden
AT00925307T ATE402946T1 (de) 1999-05-20 2000-05-05 Methode festphasensynthese von peptiden
EP00925307A EP1179537B1 (en) 1999-05-20 2000-05-05 Solid phase peptide synthesis method
ES00925307T ES2310993T3 (es) 1999-05-20 2000-05-05 Metodo de sintesis de peptidos en fase solida.
CY20081101226T CY1108465T1 (el) 1999-05-20 2008-10-30 Μεθοδος συνθεσης πεπτιδιων στερεης φασης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901090A ES2154590B1 (es) 1999-05-20 1999-05-20 Procedimiento de sintesis de peptidos en fase solida

Publications (2)

Publication Number Publication Date
ES2154590A1 ES2154590A1 (es) 2001-04-01
ES2154590B1 true ES2154590B1 (es) 2001-11-01

Family

ID=8308492

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009901090A Expired - Fee Related ES2154590B1 (es) 1999-05-20 1999-05-20 Procedimiento de sintesis de peptidos en fase solida
ES00925307T Expired - Lifetime ES2310993T3 (es) 1999-05-20 2000-05-05 Metodo de sintesis de peptidos en fase solida.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES00925307T Expired - Lifetime ES2310993T3 (es) 1999-05-20 2000-05-05 Metodo de sintesis de peptidos en fase solida.

Country Status (11)

Country Link
US (1) US6897289B1 (es)
EP (1) EP1179537B1 (es)
JP (1) JP5138845B2 (es)
AT (1) ATE402946T1 (es)
AU (1) AU4406400A (es)
CY (1) CY1108465T1 (es)
DE (1) DE60039692D1 (es)
DK (1) DK1179537T3 (es)
ES (2) ES2154590B1 (es)
PT (1) PT1179537E (es)
WO (1) WO2000071570A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003084983A1 (fr) * 2002-04-11 2003-10-16 Daiichi Suntory Pharma Co., Ltd. Procede de production d'un peptide modifie
ATE480561T1 (de) 2004-10-19 2010-09-15 Lonza Ag Verfahren zur festphasen-peptidsynthese
ATE452145T1 (de) 2005-05-03 2010-01-15 Novetide Ltd Verfahren zur herstellung von peptidderivaten
CN100355773C (zh) * 2006-01-19 2007-12-19 九江石化波涛生化科技有限公司 高分子量多肽聚合物的合成方法
WO2007130275A2 (en) * 2006-05-03 2007-11-15 Mallinckrodt Inc. Composition and method for the release of protected peptides from a resin
WO2008044890A1 (en) * 2006-10-12 2008-04-17 Dong Kook Pharm. Co., Ltd A method for preparing peptides using by solid phase synthesis
KR101046846B1 (ko) 2006-10-12 2011-07-06 동국제약 주식회사 고체상 합성법을 이용한 펩타이드의 제조방법
US20100311946A1 (en) * 2009-06-03 2010-12-09 Mallinckrodt Inc. Solid Phase Peptide for the Production of Goserelin
WO2011066386A1 (en) * 2009-11-25 2011-06-03 Novetide, Ltd. Process for production of degarelix
DK2678037T3 (en) 2011-02-25 2015-03-09 Lonza Ag Branched linker for protein pharmaceutical conjugates
WO2014047822A1 (zh) * 2012-09-27 2014-04-03 深圳翰宇药业股份有限公司 一种制备布舍瑞林的方法
CN108264538B (zh) * 2017-01-04 2023-08-29 辽宁药联制药有限公司 门冬氨酸缩合物的固相合成方法
CN110922452B (zh) * 2018-09-20 2023-12-26 深圳翰宇药业股份有限公司 一种戈舍瑞林的合成方法
CN110922453B (zh) * 2018-09-20 2023-12-26 深圳翰宇药业股份有限公司 一种戈舍瑞林的合成方法
KR20210104460A (ko) * 2020-02-17 2021-08-25 주식회사 아이바이오코리아 고체상 합성법을 이용한 펩타이드의 제조 방법
CN114324669B (zh) * 2022-01-04 2023-11-14 宁波第二激素厂 一种鲑鱼促性腺激素释放激素类似物中l-精氨酸残留量的柱前手性衍生测定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2438350C3 (de) 1974-08-09 1979-06-13 Hoechst Ag, 6000 Frankfurt Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
GB1524747A (en) 1976-05-11 1978-09-13 Ici Ltd Polypeptide
TW295589B (es) * 1990-08-30 1997-01-11 Hoechst Ag
GB9112825D0 (en) * 1991-06-14 1991-07-31 Ici Plc Process for making peptides
GB9112859D0 (en) 1991-06-14 1991-07-31 Ici Plc Peptide process
CH682662A5 (de) 1991-10-11 1993-10-29 Bachem Feinchemikalien Ag Aminosäurederivate zur Peptidsynthese.
DE4306839A1 (de) * 1993-03-05 1994-09-08 Bayer Ernst Prof Dr Tritylgruppe enthaltendes Festphasensystem, Verfahren zu seiner Herstellung und seine Verwendung in Festphasenreaktionen

Also Published As

Publication number Publication date
JP5138845B2 (ja) 2013-02-06
DE60039692D1 (de) 2008-09-11
ATE402946T1 (de) 2008-08-15
DK1179537T3 (da) 2008-12-01
US6897289B1 (en) 2005-05-24
JP2003500416A (ja) 2003-01-07
WO2000071570A1 (es) 2000-11-30
AU4406400A (en) 2000-12-12
EP1179537B1 (en) 2008-07-30
WO2000071570A8 (es) 2001-04-12
CY1108465T1 (el) 2014-04-09
EP1179537A1 (en) 2002-02-13
PT1179537E (pt) 2008-11-11
ES2154590A1 (es) 2001-04-01
ES2310993T3 (es) 2009-02-01

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