ES2159769T3 - Polimero en bloque lineal que comprende grupos urea y uretano, procedimiento para producirlo y su utilizacion en forma de implantes. - Google Patents

Polimero en bloque lineal que comprende grupos urea y uretano, procedimiento para producirlo y su utilizacion en forma de implantes.

Info

Publication number
ES2159769T3
ES2159769T3 ES96942698T ES96942698T ES2159769T3 ES 2159769 T3 ES2159769 T3 ES 2159769T3 ES 96942698 T ES96942698 T ES 96942698T ES 96942698 T ES96942698 T ES 96942698T ES 2159769 T3 ES2159769 T3 ES 2159769T3
Authority
ES
Spain
Prior art keywords
groups
block polymer
implants
procedure
uretane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96942698T
Other languages
English (en)
Inventor
Per Flodin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Artimplant Development Artdev AB
Original Assignee
Artimplant Development Artdev AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Artimplant Development Artdev AB filed Critical Artimplant Development Artdev AB
Application granted granted Critical
Publication of ES2159769T3 publication Critical patent/ES2159769T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/67—Unsaturated compounds having active hydrogen
    • C08G18/675—Low-molecular-weight compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30—Low-molecular-weight compounds
    • C08G18/32—Polyhydroxy compounds; Polyamines; Hydroxyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4236—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups
    • C08G18/4238—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups derived from dicarboxylic acids and dialcohols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269—Lactones
    • C08G18/4277—Caprolactone and/or substituted caprolactone

Abstract

LA PRESENTE INVENCION TRATA DE UN POLIMERO EN BLOQUE LINEAL QUE ES PARTICULARMENTE ADECUADO PARA UTILIZARSE COMO IMPLANTE EN HUMANOS Y ANIMALES, POR EJEMPLO COMO LIGAMENTOS. EL POLIMERO EN BLOQUE LLEVA GRUPOS UREA Y URETANO Y TIENE UN PESO MOLECULAR DE AL MENOS 10 4 DALTON, PREFERIBLEMENTE AL MENOS 10 5 DALTON, Y TAMBIEN LLEVA GRUPOS FINALES DE NH 2 PRIMARIOS Y/O OH. ADEMAS DE LA UTILIZACION DEL POLIMERO EN BLOQUE PARA IMPLANTES EN UN AMBIENTE BIOLOGICO, LA INVENCION INCLUYE TAMBIEN UN PROCEDIMIENTO PARA SU SINTESIS, QUE SE CARACTERIZA PORQUE SE ALARGA LA CADENA DE UN PREPOLIMERO, QUE TIENE DOS GRUPOS ISOCIANATO POR MOLECULA, CON UNA DIAMINA ALIFATICA O AROMATICA EN UNA RELACION MOLAR NH 2 /NCO DE 0,95 A 1,05.
ES96942698T 1995-12-15 1996-11-25 Polimero en bloque lineal que comprende grupos urea y uretano, procedimiento para producirlo y su utilizacion en forma de implantes. Expired - Lifetime ES2159769T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9504495A SE505703C2 (sv) 1995-12-15 1995-12-15 Linjär blockpolymer innefattande urea- och uretangrupper, förfarande för framställning av linjära blockpolymerer samt användning av blockpolymererna som implantat

Publications (1)

Publication Number Publication Date
ES2159769T3 true ES2159769T3 (es) 2001-10-16

Family

ID=20400606

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96942698T Expired - Lifetime ES2159769T3 (es) 1995-12-15 1996-11-25 Polimero en bloque lineal que comprende grupos urea y uretano, procedimiento para producirlo y su utilizacion en forma de implantes.

Country Status (26)

Country Link
US (1) US6210441B1 (es)
EP (1) EP0866816B1 (es)
JP (1) JP4059524B2 (es)
KR (1) KR20000064383A (es)
CN (1) CN1152899C (es)
AT (1) ATE201704T1 (es)
AU (1) AU709440B2 (es)
BR (1) BR9612032A (es)
CA (1) CA2240061A1 (es)
CZ (1) CZ179398A3 (es)
DE (1) DE69613144T2 (es)
DK (1) DK0866816T3 (es)
ES (1) ES2159769T3 (es)
GR (1) GR3036469T3 (es)
HU (1) HUP9901201A3 (es)
IL (1) IL124884A (es)
NO (1) NO982703L (es)
NZ (1) NZ324479A (es)
PL (1) PL327246A1 (es)
PT (1) PT866816E (es)
RU (1) RU2189993C2 (es)
SE (1) SE505703C2 (es)
SI (1) SI0866816T1 (es)
SK (1) SK79798A3 (es)
TR (1) TR199801091T2 (es)
WO (1) WO1997022643A1 (es)

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SE510868C2 (sv) 1997-11-03 1999-07-05 Artimplant Dev Artdev Ab Formkroppar för användning som implantat i humanmedicin samt förfarande för framställning av sådana formkroppar
SE513491C2 (sv) * 1998-12-15 2000-09-18 Artimplant Dev Artdev Ab Implantat för insättning i människor eller djur innefattande böjliga trådformiga element
SE514064C2 (sv) * 1999-02-02 2000-12-18 Artimplant Dev Artdev Ab Film för medicinsk användning bestående av linjära blockpolymerer av polyuretaner samt förfarande för framställning av en sådan film
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
SE0101523L (sv) * 2000-12-29 2002-06-30 Artimplant Ab Linjär polymer
AR032052A1 (es) * 2000-12-29 2003-10-22 Artimplant Ab Polimero lineal de bloques, procedimiento para su preparacion, su uso, implantes, material para relleno, composiciones farmaceuticas y material polimerico poroso que comprenden dicho polimero lineal de bloques
SE526106C2 (sv) * 2002-06-20 2005-07-05 Artimplant Ab Linjär blockpolymer samt fiber, film, poröst material och implantat innefattande polymeren
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
WO2004065450A2 (en) * 2003-01-16 2004-08-05 Carnegie Mellon University Biodegradable polyurethanes and use thereof
US20070160622A1 (en) * 2005-12-07 2007-07-12 Medivas, Llc Method for assembling a polymer-biologic delivery composition
US8791073B2 (en) * 2004-05-14 2014-07-29 William Marsh Rice University Peptide-modified polyurethane compositions and associated methods
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US20070167617A1 (en) * 2006-01-17 2007-07-19 Fitz Benjamin D Method of making a diisocyanate terminated macromer
US20060153796A1 (en) * 2005-01-10 2006-07-13 Fitz Benjamin D Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US7968668B2 (en) 2005-01-10 2011-06-28 Ethicon Inc. Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US8470954B2 (en) 2005-01-10 2013-06-25 Ethicon, Inc. Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US7728097B2 (en) * 2005-01-10 2010-06-01 Ethicon, Inc. Method of making a diisocyanate terminated macromer
EP1700872A3 (en) * 2005-03-10 2008-07-23 Radi Medical Systems Ab Polyureaurethane material and method of producing a polyureaurethane material
WO2007035938A2 (en) 2005-09-22 2007-03-29 Medivas, Llc BIS-(α-AMINO)-DIOL-DIESTER-CONTAINING POLY(ESTER AMIDE) AND POLY(ESTER URETHANE) COMPOSITIONS AND METHODS OF USE
WO2007038246A2 (en) * 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
US20070093805A1 (en) * 2005-10-17 2007-04-26 Coaptus Medical Corporation Systems and methods for securing cardiovascular tissue, including via asymmetric electrodes
EP1945682A2 (en) * 2005-10-21 2008-07-23 Medivas, LLC Poly(ester urea) polymers and methods of use
JP5445130B2 (ja) * 2006-05-02 2014-03-19 メディバス エルエルシー 眼の外部または内部への眼科用薬剤の送達法
WO2007133616A2 (en) * 2006-05-09 2007-11-22 Medivas, Llc Biodegradable water soluble polymers
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
EP1985319B1 (en) * 2007-04-23 2012-06-13 Jointsphere B.V. Device for cartilage repair
CA2709412A1 (en) * 2007-07-24 2009-01-29 Medivas, Llc Biodegradable cationic polymer gene transfer compositions and methods of use
US8071663B2 (en) * 2008-02-29 2011-12-06 Ethicon, Inc. Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant
US8324292B2 (en) * 2008-02-29 2012-12-04 Ethicon, Inc. Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant
JP2012500207A (ja) * 2008-08-13 2012-01-05 メディバス エルエルシー Ａａｂｂ−ポリ（デプシペプチド）生分解性ポリマー及び使用方法
US8962784B2 (en) 2008-12-19 2015-02-24 Ethicon, Inc. Isocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
EP2413838A4 (en) * 2009-04-03 2012-09-19 Biomerix Corp AT LEAST PARTIALLY RESORBIBLE RETICULATED ELASTOMER MATRIX PARTICLES AND PRODUCTION METHOD
WO2012097381A1 (en) 2011-01-14 2012-07-19 Biomerix Corporation At least partially resorbable reticulated elastomeric matrix elements and methods of making same
CN103748139B (zh) 2011-06-23 2016-08-17 帝斯曼知识产权资产管理有限公司 用于递送生物活性剂的包含生物可降解的聚酯酰胺共聚物的微米颗粒或纳米颗粒
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
TWI641396B (zh) * 2011-09-23 2018-11-21 Bvw控股公司 醫療共聚物
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CN112011049A (zh) * 2019-05-30 2020-12-01 中国科学院化学研究所 一种热塑性聚脲弹性体及其制备方法

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Also Published As

Publication number Publication date
HUP9901201A2 (hu) 1999-07-28
EP0866816A1 (en) 1998-09-30
AU709440B2 (en) 1999-08-26
HUP9901201A3 (en) 2000-04-28
PL327246A1 (en) 1998-12-07
DE69613144D1 (de) 2001-07-05
SE505703C2 (sv) 1997-09-29
NO982703D0 (no) 1998-06-11
CZ179398A3 (cs) 1998-11-11
NO982703L (no) 1998-07-14
SI0866816T1 (es) 2001-10-31
IL124884A0 (en) 1999-01-26
WO1997022643A1 (en) 1997-06-26
NZ324479A (en) 1999-05-28
ATE201704T1 (de) 2001-06-15
US6210441B1 (en) 2001-04-03
RU2189993C2 (ru) 2002-09-27
SE9504495D0 (sv) 1995-12-15
SK79798A3 (en) 1999-03-12
SE9504495L (sv) 1997-06-16
JP4059524B2 (ja) 2008-03-12
PT866816E (pt) 2001-10-31
AU1154797A (en) 1997-07-14
CN1152899C (zh) 2004-06-09
TR199801091T2 (xx) 2001-12-21
GR3036469T3 (en) 2001-11-30
EP0866816B1 (en) 2001-05-30
DK0866816T3 (da) 2001-09-10
IL124884A (en) 2002-03-10
CN1214057A (zh) 1999-04-14
JP2000502142A (ja) 2000-02-22
DE69613144T2 (de) 2001-11-29
CA2240061A1 (en) 1997-06-26
BR9612032A (pt) 1999-12-28
KR20000064383A (ko) 2000-11-06

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