DE69613144T2 - Harnstoff- und urethangruppen enthaltendes lineares blockpolymer, verfahren zur herstellung von linearen blockpolymeren sowie verwendung der blockpolymeren als implantate - Google Patents

Harnstoff- und urethangruppen enthaltendes lineares blockpolymer, verfahren zur herstellung von linearen blockpolymeren sowie verwendung der blockpolymeren als implantate

Info

Publication number
DE69613144T2
DE69613144T2 DE69613144T DE69613144T DE69613144T2 DE 69613144 T2 DE69613144 T2 DE 69613144T2 DE 69613144 T DE69613144 T DE 69613144T DE 69613144 T DE69613144 T DE 69613144T DE 69613144 T2 DE69613144 T2 DE 69613144T2
Authority
DE
Germany
Prior art keywords
linear block
block polymers
implants
urethane groups
polymer containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69613144T
Other languages
English (en)
Other versions
DE69613144D1 (de
Inventor
Per Flodin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Artimplant Development Artdev AB
Original Assignee
Artimplant Development Artdev AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Artimplant Development Artdev AB filed Critical Artimplant Development Artdev AB
Publication of DE69613144D1 publication Critical patent/DE69613144D1/de
Application granted granted Critical
Publication of DE69613144T2 publication Critical patent/DE69613144T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/67—Unsaturated compounds having active hydrogen
    • C08G18/675—Low-molecular-weight compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30—Low-molecular-weight compounds
    • C08G18/32—Polyhydroxy compounds; Polyamines; Hydroxyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4236—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups
    • C08G18/4238—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups derived from dicarboxylic acids and dialcohols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269—Lactones
    • C08G18/4277—Caprolactone and/or substituted caprolactone
DE69613144T 1995-12-15 1996-11-25 Harnstoff- und urethangruppen enthaltendes lineares blockpolymer, verfahren zur herstellung von linearen blockpolymeren sowie verwendung der blockpolymeren als implantate Expired - Lifetime DE69613144T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9504495A SE505703C2 (sv) 1995-12-15 1995-12-15 Linjär blockpolymer innefattande urea- och uretangrupper, förfarande för framställning av linjära blockpolymerer samt användning av blockpolymererna som implantat
PCT/SE1996/001530 WO1997022643A1 (en) 1995-12-15 1996-11-25 Linear block polymer comprising urea and urethane groups, method for the production of linear block polymers and use of the block polymers as implants

Publications (2)

Publication Number Publication Date
DE69613144D1 DE69613144D1 (de) 2001-07-05
DE69613144T2 true DE69613144T2 (de) 2001-11-29

Family

ID=20400606

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69613144T Expired - Lifetime DE69613144T2 (de) 1995-12-15 1996-11-25 Harnstoff- und urethangruppen enthaltendes lineares blockpolymer, verfahren zur herstellung von linearen blockpolymeren sowie verwendung der blockpolymeren als implantate

Country Status (26)

Country Link
US (1) US6210441B1 (de)
EP (1) EP0866816B1 (de)
JP (1) JP4059524B2 (de)
KR (1) KR20000064383A (de)
CN (1) CN1152899C (de)
AT (1) ATE201704T1 (de)
AU (1) AU709440B2 (de)
BR (1) BR9612032A (de)
CA (1) CA2240061A1 (de)
CZ (1) CZ179398A3 (de)
DE (1) DE69613144T2 (de)
DK (1) DK0866816T3 (de)
ES (1) ES2159769T3 (de)
GR (1) GR3036469T3 (de)
HU (1) HUP9901201A3 (de)
IL (1) IL124884A (de)
NO (1) NO982703L (de)
NZ (1) NZ324479A (de)
PL (1) PL327246A1 (de)
PT (1) PT866816E (de)
RU (1) RU2189993C2 (de)
SE (1) SE505703C2 (de)
SI (1) SI0866816T1 (de)
SK (1) SK79798A3 (de)
TR (1) TR199801091T2 (de)
WO (1) WO1997022643A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE510868C2 (sv) 1997-11-03 1999-07-05 Artimplant Dev Artdev Ab Formkroppar för användning som implantat i humanmedicin samt förfarande för framställning av sådana formkroppar
SE513491C2 (sv) * 1998-12-15 2000-09-18 Artimplant Dev Artdev Ab Implantat för insättning i människor eller djur innefattande böjliga trådformiga element
SE514064C2 (sv) * 1999-02-02 2000-12-18 Artimplant Dev Artdev Ab Film för medicinsk användning bestående av linjära blockpolymerer av polyuretaner samt förfarande för framställning av en sådan film
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
SE0101523L (sv) * 2000-12-29 2002-06-30 Artimplant Ab Linjär polymer
AR032052A1 (es) * 2000-12-29 2003-10-22 Artimplant Ab Polimero lineal de bloques, procedimiento para su preparacion, su uso, implantes, material para relleno, composiciones farmaceuticas y material polimerico poroso que comprenden dicho polimero lineal de bloques
SE526106C2 (sv) * 2002-06-20 2005-07-05 Artimplant Ab Linjär blockpolymer samt fiber, film, poröst material och implantat innefattande polymeren
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
WO2004065450A2 (en) * 2003-01-16 2004-08-05 Carnegie Mellon University Biodegradable polyurethanes and use thereof
US20070160622A1 (en) * 2005-12-07 2007-07-12 Medivas, Llc Method for assembling a polymer-biologic delivery composition
US8791073B2 (en) * 2004-05-14 2014-07-29 William Marsh Rice University Peptide-modified polyurethane compositions and associated methods
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US20070167617A1 (en) * 2006-01-17 2007-07-19 Fitz Benjamin D Method of making a diisocyanate terminated macromer
US20060153796A1 (en) * 2005-01-10 2006-07-13 Fitz Benjamin D Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US7968668B2 (en) 2005-01-10 2011-06-28 Ethicon Inc. Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US8470954B2 (en) 2005-01-10 2013-06-25 Ethicon, Inc. Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US7728097B2 (en) * 2005-01-10 2010-06-01 Ethicon, Inc. Method of making a diisocyanate terminated macromer
EP1700872A3 (de) * 2005-03-10 2008-07-23 Radi Medical Systems Ab Polyharnstoffurethanmaterialien und Verfahren zur Herstellung
WO2007035938A2 (en) 2005-09-22 2007-03-29 Medivas, Llc BIS-(α-AMINO)-DIOL-DIESTER-CONTAINING POLY(ESTER AMIDE) AND POLY(ESTER URETHANE) COMPOSITIONS AND METHODS OF USE
WO2007038246A2 (en) * 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
US20070093805A1 (en) * 2005-10-17 2007-04-26 Coaptus Medical Corporation Systems and methods for securing cardiovascular tissue, including via asymmetric electrodes
EP1945682A2 (de) * 2005-10-21 2008-07-23 Medivas, LLC Poly(esterharnstoff)-polymere und verwendungsverfahren
JP5445130B2 (ja) * 2006-05-02 2014-03-19 メディバス エルエルシー 眼の外部または内部への眼科用薬剤の送達法
WO2007133616A2 (en) * 2006-05-09 2007-11-22 Medivas, Llc Biodegradable water soluble polymers
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
EP1985319B1 (de) * 2007-04-23 2012-06-13 Jointsphere B.V. Vorrichtung zur Knorpelreparatur
CA2709412A1 (en) * 2007-07-24 2009-01-29 Medivas, Llc Biodegradable cationic polymer gene transfer compositions and methods of use
US8071663B2 (en) * 2008-02-29 2011-12-06 Ethicon, Inc. Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant
US8324292B2 (en) * 2008-02-29 2012-12-04 Ethicon, Inc. Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant
JP2012500207A (ja) * 2008-08-13 2012-01-05 メディバス エルエルシー Ａａｂｂ−ポリ（デプシペプチド）生分解性ポリマー及び使用方法
US8962784B2 (en) 2008-12-19 2015-02-24 Ethicon, Inc. Isocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
EP2413838A4 (de) * 2009-04-03 2012-09-19 Biomerix Corp Zumindest teilweise resorbierbare retikulierte elastomermatrixpartikel und herstellungsverfahren
WO2012097381A1 (en) 2011-01-14 2012-07-19 Biomerix Corporation At least partially resorbable reticulated elastomeric matrix elements and methods of making same
CN103748139B (zh) 2011-06-23 2016-08-17 帝斯曼知识产权资产管理有限公司 用于递送生物活性剂的包含生物可降解的聚酯酰胺共聚物的微米颗粒或纳米颗粒
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
TWI641396B (zh) * 2011-09-23 2018-11-21 Bvw控股公司 醫療共聚物
CN107106509B (zh) 2014-12-18 2021-11-30 帝斯曼知识产权资产管理有限公司 用于递送酸敏感药物的药物递送系统
CN112011049A (zh) * 2019-05-30 2020-12-01 中国科学院化学研究所 一种热塑性聚脲弹性体及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790976A (fr) * 1971-11-06 1973-05-07 Bayer Ag Derives silyles de l'uree et leur preparation
US4549010A (en) * 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
JPH03501496A (ja) * 1987-12-02 1991-04-04 ティンダル　プレインズ‐ハンター，リミテッド 強度が改善された親水性ポリウレタン
CA2038605C (en) * 1990-06-15 2000-06-27 Leonard Pinchuk Crack-resistant polycarbonate urethane polymer prostheses and the like
WO1992000338A1 (en) * 1990-06-26 1992-01-09 Commonwealth Scientific And Industrial Research Organisation Polyurethane or polyurethane-urea elastomeric compositions
EP0548256A4 (en) * 1990-09-12 1993-07-07 Polymedica Industries, Inc. Biostable polyurethane products

Also Published As

Publication number Publication date
HUP9901201A2 (hu) 1999-07-28
EP0866816A1 (de) 1998-09-30
ES2159769T3 (es) 2001-10-16
AU709440B2 (en) 1999-08-26
HUP9901201A3 (en) 2000-04-28
PL327246A1 (en) 1998-12-07
DE69613144D1 (de) 2001-07-05
SE505703C2 (sv) 1997-09-29
NO982703D0 (no) 1998-06-11
CZ179398A3 (cs) 1998-11-11
NO982703L (no) 1998-07-14
SI0866816T1 (de) 2001-10-31
IL124884A0 (en) 1999-01-26
WO1997022643A1 (en) 1997-06-26
NZ324479A (en) 1999-05-28
ATE201704T1 (de) 2001-06-15
US6210441B1 (en) 2001-04-03
RU2189993C2 (ru) 2002-09-27
SE9504495D0 (sv) 1995-12-15
SK79798A3 (en) 1999-03-12
SE9504495L (sv) 1997-06-16
JP4059524B2 (ja) 2008-03-12
PT866816E (pt) 2001-10-31
AU1154797A (en) 1997-07-14
CN1152899C (zh) 2004-06-09
TR199801091T2 (xx) 2001-12-21
GR3036469T3 (en) 2001-11-30
EP0866816B1 (de) 2001-05-30
DK0866816T3 (da) 2001-09-10
IL124884A (en) 2002-03-10
CN1214057A (zh) 1999-04-14
JP2000502142A (ja) 2000-02-22
CA2240061A1 (en) 1997-06-26
BR9612032A (pt) 1999-12-28
KR20000064383A (ko) 2000-11-06

Similar Documents

Publication Publication Date Title
DE69613144T2 (de) Harnstoff- und urethangruppen enthaltendes lineares blockpolymer, verfahren zur herstellung von linearen blockpolymeren sowie verwendung der blockpolymeren als implantate
DE59601880D1 (de) Verfahren zur herstellung hydrophiler oder teilweise hydrophiler, anorganischer aerogele
DE69826994D1 (de) Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung
DE69626996D1 (de) Unter gewebebedingungen abbaubares material und verfahren zu seiner herstellung
DE69433177D1 (de) Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht
DE69832523D1 (de) Polymere produkte enthaltend modifizierte kohlenstoffprodukte sowie verfahren zur herstellung und ihre verwendung
DK0981381T3 (da) Polyhydroxyalkanoater ti anvendelser in vivo
ATE308979T1 (de) Lipasehemmende polymere
RU98113712A (ru) Линейный блок-полимер, содержащий группу мочевины и уретановую группу, способ получения линейных блок-полимеров и использование блок-полимеров в качестве имплантатов
DE59305882D1 (de) Mitogenfreie substanz, deren herstellung sowie verwendung
SE9704003L (sv) Formkroppar för användning som implantat i humanmedicin samt förfarande för framställning av sådana formkroppar
AT501700A1 (de) Mit strahlung härtbare, biologisch abbaubare zusammensetzungen und deren verwendung als stützmaterialien für den knochenersatz
DE69002657T2 (de) Limulustest-positives Pflanzenglykolipid und Verfahren zur Stimulierung des Immunsystems eines Tieres.
DE69517191D1 (de) Wasserlösliche derivate epipodophyllotoxine, verfahren zu ihrer herstellung, ihre verwendung als medikament und ihre verwendung zur herstellung eines antikrebsmittels
EP2301593A1 (de) Thermoplastische paste zur reparatur von lebendem gewebe
SE0101523L (sv) Linjär polymer
ATE219505T1 (de) Verfahren zur herstellung von polyhydroxycarbonsäure
ATE156842T1 (de) Oligosaccharide mit biologischer aktivität und verfahren zur herstellung aus glykosaminoglykanen
DE59404739D1 (de) Dextranester, verfahren zu ihrer herstellung und ihre verwendung zur umhüllung oder einbettung von arzneimitteln
DE69832281D1 (de) Mikropartikel auf der grundlage von hybridpolymermaterialen zur kontrollierten abgabe von biologisch aktiven molekülen, verfahren zu ihrer herstellung und deren verwendung in der in-vivo oder in-vitrotherapie, prophylaxe und diagnostik

Legal Events

Date Code Title Description
8364 No opposition during term of opposition