DE69433177D1 - Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht - Google Patents

Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht

Info

Publication number
DE69433177D1
DE69433177D1 DE69433177T DE69433177T DE69433177D1 DE 69433177 D1 DE69433177 D1 DE 69433177D1 DE 69433177 T DE69433177 T DE 69433177T DE 69433177 T DE69433177 T DE 69433177T DE 69433177 D1 DE69433177 D1 DE 69433177D1
Authority
DE
Germany
Prior art keywords
hyaluronic acid
molecular weight
culture medium
high molecular
bacterial fermentation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69433177T
Other languages
English (en)
Other versions
DE69433177T2 (de
Inventor
Flavia Cazzola
Michael O'regan
Vincenza Corsa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia Farmaceutici SpA
Original Assignee
Fidia Advanced Biopolymers SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers SRL filed Critical Fidia Advanced Biopolymers SRL
Publication of DE69433177D1 publication Critical patent/DE69433177D1/de
Application granted granted Critical
Publication of DE69433177T2 publication Critical patent/DE69433177T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69433177T 1993-07-30 1994-07-29 Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht Expired - Lifetime DE69433177T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITPD930164A IT1263393B (it) 1993-07-30 1993-07-30 Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
ITPD930164 1993-07-30
PCT/EP1994/002537 WO1995004132A1 (en) 1993-07-30 1994-07-29 Process for the preparation and purification of high molecular weight hyaluronic acid

Publications (2)

Publication Number Publication Date
DE69433177D1 true DE69433177D1 (de) 2003-10-30
DE69433177T2 DE69433177T2 (de) 2004-06-17

Family

ID=11390424

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69433177T Expired - Lifetime DE69433177T2 (de) 1993-07-30 1994-07-29 Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht

Country Status (7)

Country Link
EP (1) EP0716688B1 (de)
AT (1) ATE250663T1 (de)
AU (1) AU7534294A (de)
DE (1) DE69433177T2 (de)
ES (1) ES2211883T3 (de)
IT (1) IT1263393B (de)
WO (1) WO1995004132A1 (de)

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US7044134B2 (en) 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
ITPD20050206A1 (it) 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
US7972359B2 (en) 2005-09-16 2011-07-05 Atritech, Inc. Intracardiac cage and method of delivering same
US20070135826A1 (en) 2005-12-01 2007-06-14 Steve Zaver Method and apparatus for delivering an implant without bias to a left atrial appendage
CN100478360C (zh) * 2006-10-31 2009-04-15 山东福瑞达生物化工有限公司 将浓缩用于透明质酸或其盐的生产的方法
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
ITMI20071724A1 (it) 2007-09-05 2009-03-06 Fidia Farmaceutici Formulazioni topiche antivirali in forma di gel bioadesivo
US20110130473A1 (en) * 2007-11-13 2011-06-02 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
IT1393945B1 (it) 2009-04-21 2012-05-17 Fidia Farmaceutici Composizioni comprendenti acido ialuronico, acido ialuronico solfatato, calcio e vitamina d3 nel trattamento delle malattie osteoarticolari e muscoloscheletriche
JP2011195604A (ja) * 2010-03-17 2011-10-06 Denki Kagaku Kogyo Kk ヒアルロン酸及び／又はその塩の含有液中の異物除去方法
CZ304072B6 (cs) 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
KR101322227B1 (ko) * 2011-09-30 2013-10-28 일동제약주식회사 스트렙토코커스 디스갈락티애 ｉｄ9103 균주 및 이를 이용한 히알루론산 생산 방법
ITPD20120098A1 (it) 2012-03-30 2013-10-01 Fidia Farmaceutici "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico"
ITMI20120664A1 (it) 2012-04-20 2013-10-21 Anika Therapeutics Srl Biomateriali a base di gellano per l'uso come filler in chirurgia
ITPD20130110A1 (it) 2013-04-24 2014-10-25 Fidia Farmaceutici Composizioni farmaceutiche comprendenti acido ialuronico per il trattamento del black disc
IT201600079633A1 (it) * 2016-07-28 2018-01-28 Fidia Farm Spa Procedimento di preparazione e purificazione del sale sodico dell’acido ialuronico
CN110831520B (zh) 2017-04-27 2022-11-15 波士顿科学国际有限公司 具有织物保持倒钩的闭塞医疗装置
IT201700081449A1 (it) * 2017-07-18 2019-01-18 Fidia Farm Spa Procedimento di purificazione dell'acido ialuronico
IT201900006250A1 (it) 2019-04-23 2020-10-23 Fidia Farm Spa Medicazione per il trattamento della cute lesa
CN112714632A (zh) 2018-08-21 2021-04-27 波士顿科学医学有限公司 用于心血管设备的带有倒钩的突出构件
IT201800009444A1 (it) 2018-10-15 2020-04-15 Fidia Farm Spa Coniugati tra acido ialuronico e amminobisfosfonati e loro impiego terapeutico
IT201800009731A1 (it) 2018-10-25 2020-04-25 Fidia Farm Spa Coniugato paclitaxel - acido ialuronico nel trattamento del carcinoma vescicale non infiltrante
CN114126540A (zh) 2019-07-17 2022-03-01 波士顿科学医学有限公司 连续覆盖的左心耳植入物
WO2021041831A1 (en) 2019-08-30 2021-03-04 Boston Scientific Scimed, Inc. Left atrial appendage implant with sealing disk
IT201900019762A1 (it) 2019-10-24 2021-04-24 Fidia Farm Spa Composizione farmaceutica per uso nel trattamento della cistite di varia eziologia
WO2021108790A1 (en) * 2019-11-30 2021-06-03 Lacerta Life Sciences, Llc Purification of reptilian hyaluronic acid and its use for soft and hard tissue repair and regeneration
EP4125634A1 (de) 2020-03-24 2023-02-08 Boston Scientific Scimed Inc. Medizinisches system zur behandlung eines linken herzohrs
IT202000007747A1 (it) 2020-04-10 2021-10-10 Fidia Farm Spa Coniugato acido ialuronico-paclitaxel nel trattamento del mesotelioma
IT202000008209A1 (it) 2020-04-17 2021-10-17 Fidia Farm Spa Procedimento di sintesi di un coniugato acido ialuronico-paclitaxel
IT202000014017A1 (it) 2020-06-11 2021-12-11 Fidia Farm Spa Nuovi derivati ottenuti da acido ialuronico e carnosina
IT202000032243A1 (it) 2020-12-23 2022-06-23 Fidia Farm Spa Nuovi agenti antivirali
IT202100032111A1 (it) 2021-12-22 2023-06-22 Fidia Farm Spa Nuovi sostituti biocompatibili dell’umor vitreo

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2975104A (en) * 1959-05-21 1961-03-14 American Home Prod Medium and method for producing and isolating hyaluronic acid
JPS51139685A (en) * 1975-05-26 1976-12-02 Hitachi Chem Co Ltd Process for preparing glutathione
JPS51139692A (en) * 1975-05-27 1976-12-02 Chugai Pharmaceut Co Ltd Process for preparing a new antibiotic substance ta-146
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
US4780414A (en) * 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US4784990A (en) * 1985-01-18 1988-11-15 Bio-Technology General Corporation High molecular weight sodium hyaluronate
JPS6232893A (ja) * 1985-08-01 1987-02-12 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
JPS6251999A (ja) * 1985-09-02 1987-03-06 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
US5023175A (en) * 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
JPH072117B2 (ja) * 1986-10-09 1995-01-18 三菱レイヨン株式会社 ヒアルロン酸の製造法
US4897349A (en) * 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid

Also Published As

Publication number Publication date
WO1995004132A1 (en) 1995-02-09
EP0716688A1 (de) 1996-06-19
ATE250663T1 (de) 2003-10-15
ITPD930164A1 (it) 1995-01-30
IT1263393B (it) 1996-08-05
EP0716688B1 (de) 2003-09-24
AU7534294A (en) 1995-02-28
ES2211883T3 (es) 2004-07-16
DE69433177T2 (de) 2004-06-17
ITPD930164A0 (it) 1993-07-30

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: FIDIA FARMACEUTICI S.P.A., ABANO TERME, PADUA/PADO

8364 No opposition during term of opposition