IT1263393B - Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare - Google Patents

Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare

Info

Publication number
IT1263393B
IT1263393B ITPD930164A ITPD930164A IT1263393B IT 1263393 B IT1263393 B IT 1263393B IT PD930164 A ITPD930164 A IT PD930164A IT PD930164 A ITPD930164 A IT PD930164A IT 1263393 B IT1263393 B IT 1263393B
Authority
IT
Italy
Prior art keywords
hyaluronic acid
molecular weight
high molecular
purification
preparation
Prior art date
Application number
ITPD930164A
Other languages
English (en)
Inventor
Flavia Cazzola
Michael O'regan
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Priority to ITPD930164A priority Critical patent/IT1263393B/it
Publication of ITPD930164A0 publication Critical patent/ITPD930164A0/it
Priority to ES94925419T priority patent/ES2211883T3/es
Priority to DE69433177T priority patent/DE69433177T2/de
Priority to PCT/EP1994/002537 priority patent/WO1995004132A1/en
Priority to AU75342/94A priority patent/AU7534294A/en
Priority to EP94925419A priority patent/EP0716688B1/en
Priority to AT94925419T priority patent/ATE250663T1/de
Publication of ITPD930164A1 publication Critical patent/ITPD930164A1/it
Application granted granted Critical
Publication of IT1263393B publication Critical patent/IT1263393B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invenzione si riferisce ad un metodo per la produzione di acido ialuronico sale sodico ad alto peso molecolare mediante tecniche fermentative, utilizzando un ceppo di Streptococcus equi di gruppo C (secondo la classificazione di Lancefield) e un terreno di coltura semidefinito che consente di ottenere un notevole contenimento dei costi. Inoltre si riferisce ad un metodo per estrarre e purificare l'acido ialuronico prodotto e rilasciato nel medium di coltura ed al suo utilizzo come modulatore nel controllo del processo di cicatrizzazione.
ITPD930164A 1993-07-30 1993-07-30 Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare IT1263393B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITPD930164A IT1263393B (it) 1993-07-30 1993-07-30 Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
ES94925419T ES2211883T3 (es) 1993-07-30 1994-07-29 Medio de cultivo y procedimiento para la preparacion de acido hialuronico de peso molecular alto.
DE69433177T DE69433177T2 (de) 1993-07-30 1994-07-29 Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht
PCT/EP1994/002537 WO1995004132A1 (en) 1993-07-30 1994-07-29 Process for the preparation and purification of high molecular weight hyaluronic acid
AU75342/94A AU7534294A (en) 1993-07-30 1994-07-29 Process for the preparation and purification of high molecular weight hyaluronic acid
EP94925419A EP0716688B1 (en) 1993-07-30 1994-07-29 Culture medium and process for the preparation of high molecular weight hyaluronic acid
AT94925419T ATE250663T1 (de) 1993-07-30 1994-07-29 Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPD930164A IT1263393B (it) 1993-07-30 1993-07-30 Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare

Publications (3)

Publication Number Publication Date
ITPD930164A0 ITPD930164A0 (it) 1993-07-30
ITPD930164A1 ITPD930164A1 (it) 1995-01-30
IT1263393B true IT1263393B (it) 1996-08-05

Family

ID=11390424

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPD930164A IT1263393B (it) 1993-07-30 1993-07-30 Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare

Country Status (7)

Country Link
EP (1) EP0716688B1 (it)
AT (1) ATE250663T1 (it)
AU (1) AU7534294A (it)
DE (1) DE69433177T2 (it)
ES (1) ES2211883T3 (it)
IT (1) IT1263393B (it)
WO (1) WO1995004132A1 (it)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7044134B2 (en) 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
ITPD20050206A1 (it) 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
US7972359B2 (en) 2005-09-16 2011-07-05 Atritech, Inc. Intracardiac cage and method of delivering same
US20070135826A1 (en) 2005-12-01 2007-06-14 Steve Zaver Method and apparatus for delivering an implant without bias to a left atrial appendage
CN100478360C (zh) * 2006-10-31 2009-04-15 山东福瑞达生物化工有限公司 将浓缩用于透明质酸或其盐的生产的方法
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
ITMI20071724A1 (it) 2007-09-05 2009-03-06 Fidia Farmaceutici Formulazioni topiche antivirali in forma di gel bioadesivo
EP2209814B1 (en) * 2007-11-13 2017-01-25 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
IT1393945B1 (it) 2009-04-21 2012-05-17 Fidia Farmaceutici Composizioni comprendenti acido ialuronico, acido ialuronico solfatato, calcio e vitamina d3 nel trattamento delle malattie osteoarticolari e muscoloscheletriche
JP2011195604A (ja) * 2010-03-17 2011-10-06 Denki Kagaku Kogyo Kk ヒアルロン酸及び／又はその塩の含有液中の異物除去方法
CZ304072B6 (cs) 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
KR101322227B1 (ko) * 2011-09-30 2013-10-28 일동제약주식회사 스트렙토코커스 디스갈락티애 ｉｄ9103 균주 및 이를 이용한 히알루론산 생산 방법
ITPD20120098A1 (it) 2012-03-30 2013-10-01 Fidia Farmaceutici "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico"
ITMI20120664A1 (it) 2012-04-20 2013-10-21 Anika Therapeutics Srl Biomateriali a base di gellano per l'uso come filler in chirurgia
ITPD20130110A1 (it) 2013-04-24 2014-10-25 Fidia Farmaceutici Composizioni farmaceutiche comprendenti acido ialuronico per il trattamento del black disc
IT201600079633A1 (it) * 2016-07-28 2018-01-28 Fidia Farm Spa Procedimento di preparazione e purificazione del sale sodico dell’acido ialuronico
CN110831520B (zh) 2017-04-27 2022-11-15 波士顿科学国际有限公司 具有织物保持倒钩的闭塞医疗装置
IT201700081449A1 (it) * 2017-07-18 2019-01-18 Fidia Farm Spa Procedimento di purificazione dell'acido ialuronico
IT201900006250A1 (it) 2019-04-23 2020-10-23 Fidia Farm Spa Medicazione per il trattamento della cute lesa
US11596533B2 (en) 2018-08-21 2023-03-07 Boston Scientific Scimed, Inc. Projecting member with barb for cardiovascular devices
IT201800009444A1 (it) 2018-10-15 2020-04-15 Fidia Farm Spa Coniugati tra acido ialuronico e amminobisfosfonati e loro impiego terapeutico
IT201800009731A1 (it) 2018-10-25 2020-04-25 Fidia Farm Spa Coniugato paclitaxel - acido ialuronico nel trattamento del carcinoma vescicale non infiltrante
CN114126540A (zh) 2019-07-17 2022-03-01 波士顿科学医学有限公司 连续覆盖的左心耳植入物
US11540838B2 (en) 2019-08-30 2023-01-03 Boston Scientific Scimed, Inc. Left atrial appendage implant with sealing disk
IT201900019762A1 (it) 2019-10-24 2021-04-24 Fidia Farm Spa Composizione farmaceutica per uso nel trattamento della cistite di varia eziologia
WO2021108790A1 (en) * 2019-11-30 2021-06-03 Lacerta Life Sciences, Llc Purification of reptilian hyaluronic acid and its use for soft and hard tissue repair and regeneration
US11903589B2 (en) 2020-03-24 2024-02-20 Boston Scientific Scimed, Inc. Medical system for treating a left atrial appendage
IT202000007747A1 (it) 2020-04-10 2021-10-10 Fidia Farm Spa Coniugato acido ialuronico-paclitaxel nel trattamento del mesotelioma
IT202000008209A1 (it) 2020-04-17 2021-10-17 Fidia Farm Spa Procedimento di sintesi di un coniugato acido ialuronico-paclitaxel
IT202000014017A1 (it) 2020-06-11 2021-12-11 Fidia Farm Spa Nuovi derivati ottenuti da acido ialuronico e carnosina
IT202000032243A1 (it) 2020-12-23 2022-06-23 Fidia Farm Spa Nuovi agenti antivirali
IT202100032111A1 (it) 2021-12-22 2023-06-22 Fidia Farm Spa Nuovi sostituti biocompatibili dell’umor vitreo

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2975104A (en) * 1959-05-21 1961-03-14 American Home Prod Medium and method for producing and isolating hyaluronic acid
JPS51139685A (en) * 1975-05-26 1976-12-02 Hitachi Chem Co Ltd Process for preparing glutathione
JPS51139692A (en) * 1975-05-27 1976-12-02 Chugai Pharmaceut Co Ltd Process for preparing a new antibiotic substance ta-146
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
US4780414A (en) * 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US4784990A (en) * 1985-01-18 1988-11-15 Bio-Technology General Corporation High molecular weight sodium hyaluronate
JPS6232893A (ja) * 1985-08-01 1987-02-12 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
JPS6251999A (ja) * 1985-09-02 1987-03-06 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
US5023175A (en) * 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
JPH072117B2 (ja) * 1986-10-09 1995-01-18 三菱レイヨン株式会社 ヒアルロン酸の製造法
US4897349A (en) * 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid

Also Published As

Publication number Publication date
EP0716688B1 (en) 2003-09-24
DE69433177T2 (de) 2004-06-17
ES2211883T3 (es) 2004-07-16
ITPD930164A1 (it) 1995-01-30
ITPD930164A0 (it) 1993-07-30
DE69433177D1 (de) 2003-10-30
WO1995004132A1 (en) 1995-02-09
AU7534294A (en) 1995-02-28
EP0716688A1 (en) 1996-06-19
ATE250663T1 (de) 2003-10-15

Similar Documents

Publication Publication Date Title
IT1263393B (it) Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
KR850004983A (ko) 고순도 히알우론산의 제조방법
AU4938690A (en) Fermentation and purification process for succinic acid
DE69015233D1 (de) Verfahren zur Herstellung und Reinigung von Bernsteinsäure.
NZ334211A (en) Antibody fragment comprising a linear heavy chain associated with two light chain fragments
DE69434532D1 (de) Verfahren zur Herstellung eines Produktes mit hohem Trehalosegehalt
ATE126223T1 (de) Verfahren zur herstellung von ascorbinsäure.
NO991863L (no) Nye bakteriestammer og bruken derav i fermenteringsprosesser for 2-keto-L-gulonsyreproduksjon
SE8402861D0 (sv) Rening av biologiskt material
ATE162530T1 (de) 5-methyluridin-verfahren zur herstellung von 2',3'-didehydro-3'-desoxythymidin (d4t) im grossmassstab
ATE256462T1 (de) Wasserlösliche vitaminzubereitung, zur herstellung ausgezeichneter tabletten undverfahren zu deren herstellung
ES8609360A1 (es) Procedimiento para preparar peptidos
BR0014519A (pt) Sequências de sinais para a preparação de leu-herudin através da secreção por e. coli no meio de cultura
EP0228274A3 (en) Method for producing 2-keto-d-glucaric-acid
GR3029574T3 (en) Enzymatic purification process
GR3030759T3 (en) Method for purifying diacetyl rhein
ATA189096A (de) Verfahren zur reinigung von o-phthaldialdehyd
BR0003392A (pt) Processo para produzir xilitol de alta pureza
AU1554592A (en) Interleukin 6 composition and production thereof
ATE323760T1 (de) Verfahren zur herstellung eines eine hyaluronidase enthaltenden präparats
CA2474057A1 (en) Integration of at least two processes to re-use acid
CA2073351A1 (en) Lysozyme dimers and method of preparing them
ATE263735T1 (de) Verfahren zur herstellung von hochreinem magnesiumhydroxid und magnesiumoxid aus magnesiumalkoxiden
RU92004035A (ru) Способ получения адсорбента
DE59406461D1 (de) VERFAHREN ZUR HERSTELLUNG VON 8-g(a),12-OXIDO-13,14,15,16-TETRANORLABDAN

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990614