ES8609360A1 - Procedimiento para preparar peptidos - Google Patents

Procedimiento para preparar peptidos

Info

Publication number
ES8609360A1
ES8609360A1 ES543973A ES543973A ES8609360A1 ES 8609360 A1 ES8609360 A1 ES 8609360A1 ES 543973 A ES543973 A ES 543973A ES 543973 A ES543973 A ES 543973A ES 8609360 A1 ES8609360 A1 ES 8609360A1
Authority
ES
Spain
Prior art keywords
preparation
amides
esters
peptapeptides
acting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543973A
Other languages
English (en)
Other versions
ES543973A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES543973A0 publication Critical patent/ES543973A0/es
Publication of ES8609360A1 publication Critical patent/ES8609360A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • C07K14/662—Thymopoietins at least 1 amino acid in D-form
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PEPTIDOS DE FORMULA ARG-LYS-S-VAL-Y, EN LA QUE S REPRESENTA ACIDO GLUTAMICO O A-AMINOADIPICO, EN CADA CASO L O D; E Y REPRESENTA TIROSINA O TRIPTOFANO, TAMBIEN EN CADA CASO EN LA CONFIGURACION L O D; Y DE SUS ESTERES, AMIDAS, ALQUILAMIDAS, CICLOALQUILAMIDAS O ARALQUILAMIDAS. CONSISTE EN LA REACCION DE CONDENSACION DE TETRAPEPTIDOS DE FORMULA Z-ARG(ZK2)-LYS-(ZK)-5(BZL)-VAL-OH, EN LA QUE ZK REPRESENTA UN GRUPO PROTECTOR DE AMINO DEL TIPO BENCILO Y S TIENE EL SIGNIFICADO INDICADO ANTERIORMENTE, CON EL CORRESPONDIENTE ESTER O AMIDA DE TIROSINA O TRIPTOFANO; SEGUIDA DE LA SEPARACION DE LOS GRUPOS PROTECTORES DEL TIPO BENCILO MEDIANTE HIDROGENACION CON TRANSFERENCIA CATALITICA CON MEZCLAS DE ACIDO FORMICO/DIMETILFORMAMIDA O DIMETILACETAMIDA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INMUNODEFICIENCIAS, INFECCIONES BACTERIANAS CRONICAS Y ENFERMEDADES AUTOINMUNES.
ES543973A 1984-06-09 1985-06-07 Procedimiento para preparar peptidos Expired ES8609360A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843421614 DE3421614A1 (de) 1984-06-09 1984-06-09 Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens

Publications (2)

Publication Number Publication Date
ES543973A0 ES543973A0 (es) 1986-08-01
ES8609360A1 true ES8609360A1 (es) 1986-08-01

Family

ID=6238068

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543973A Expired ES8609360A1 (es) 1984-06-09 1985-06-07 Procedimiento para preparar peptidos

Country Status (11)

Country Link
US (1) US4658016A (es)
EP (1) EP0164654A3 (es)
JP (1) JPS611700A (es)
AU (1) AU588237B2 (es)
DE (1) DE3421614A1 (es)
DK (1) DK254985A (es)
ES (1) ES8609360A1 (es)
GR (1) GR851394B (es)
IL (1) IL75449A0 (es)
PT (1) PT80619B (es)
ZA (1) ZA854331B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629723A (en) * 1984-06-27 1986-12-16 Ortho Pharmaceutical Corporation Potent thymopentin analogs
EP0215805A1 (en) * 1985-01-18 1987-04-01 MERCK PATENT GmbH Immunoregulatory peptides
IT1186732B (it) * 1985-06-05 1987-12-16 Eniricerche Spa Decapeptidi ad azione ipotensiva e procedimento per la loro preparazione
FR2617169B1 (fr) * 1987-06-25 1991-09-20 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
FR2608160B1 (fr) * 1986-12-15 1989-03-31 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
EP0275748B1 (fr) * 1986-12-15 1992-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouveaux dérivés peptidiques et leur application notamment en thérapeutique
US5807830A (en) * 1987-12-30 1998-09-15 Cytoven J.V. Method for treatment of purulent inflammatory diseases
US5728680A (en) 1987-12-30 1998-03-17 Cytoven J.V. Methods for normalizing numbers of lymphocytes
NZ229004A (en) * 1988-05-19 1993-09-27 Immunobiology Res Inst Inc Tetrapeptides having t cell helper acitivity
US5811399A (en) * 1988-12-14 1998-09-22 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants
HU201964B (en) * 1989-01-13 1991-01-28 Richter Gedeon Vegyeszet Process for producing peptides inhibiting maturation of t-lymphocytes and activity of macrophages, as well as pharmaceutical compositions comprising same
US5770576A (en) * 1989-08-30 1998-06-23 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity
ATE260672T1 (de) * 1991-10-28 2004-03-15 Cytran Ltd Pharmazeutische lysin enthaltende polypeptid- zusammensetzungen und verfahren zu deren verwendung
US6100380A (en) * 1991-10-28 2000-08-08 Cytran, Inc. Immunomodulating peptides and methods of use
US6066622A (en) * 1991-10-28 2000-05-23 Cytran, Inc. Immunomodulating peptides and methods of use
US5516891A (en) * 1992-06-16 1996-05-14 Kinerton, Ltd. Liquid phase synthesis of peptides and peptide derivatives
CN110527080A (zh) * 2019-07-29 2019-12-03 同济大学 两亲性多嵌段类抗菌肽共聚物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1157466A (en) * 1979-04-12 1983-11-22 Gideon Goldstein Peptides having thymopoietin-like activity
AU536640B2 (en) * 1979-04-12 1984-05-17 Ortho Pharmaceutical Corporation Peptides
DE2938420A1 (de) * 1979-09-22 1981-04-09 Hoechst Ag, 6000 Frankfurt Neue peptide und verfahren zu ihrer herstellung
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
US4510082A (en) * 1983-03-07 1985-04-09 Eli Lilly And Company Pharmacologically active peptides

Also Published As

Publication number Publication date
IL75449A0 (en) 1985-10-31
ES543973A0 (es) 1986-08-01
ZA854331B (en) 1986-02-26
EP0164654A3 (de) 1988-01-13
PT80619B (de) 1987-03-18
PT80619A (de) 1985-07-01
GR851394B (es) 1985-11-25
AU4342385A (en) 1985-12-12
JPS611700A (ja) 1986-01-07
DE3421614A1 (de) 1985-12-12
DK254985D0 (da) 1985-06-06
US4658016A (en) 1987-04-14
DK254985A (da) 1985-12-10
AU588237B2 (en) 1989-09-14
EP0164654A2 (de) 1985-12-18

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