EA200600259A1 - Реакционноспособные полимеры и сополимеры на основе n-(2-гидроксипропил)метакриламида, способ их получения и их применение для синтеза полимерных лекарственных средств, для модификации биологически активных белков и получения систем доставки генов - Google Patents

Реакционноспособные полимеры и сополимеры на основе n-(2-гидроксипропил)метакриламида, способ их получения и их применение для синтеза полимерных лекарственных средств, для модификации биологически активных белков и получения систем доставки генов

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Publication number
EA200600259A1
EA200600259A1 EA200600259A EA200600259A EA200600259A1 EA 200600259 A1 EA200600259 A1 EA 200600259A1 EA 200600259 A EA200600259 A EA 200600259A EA 200600259 A EA200600259 A EA 200600259A EA 200600259 A1 EA200600259 A1 EA 200600259A1
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EA
Eurasian Patent Office
Prior art keywords
development
synthesis
preparation
polymers
protocolymalida
Prior art date
Application number
EA200600259A
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English (en)
Inventor
Владимир Шубр
Карел Ульбрих
Бланка Ржигова
Original Assignee
Устав Макромолекуларни Хемие Авчр
Микробиологицкий Устав Авчр
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Устав Макромолекуларни Хемие Авчр, Микробиологицкий Устав Авчр filed Critical Устав Макромолекуларни Хемие Авчр
Publication of EA200600259A1 publication Critical patent/EA200600259A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/40—Chemical modification of a polymer taking place solely at one end or both ends of the polymer backbone, i.e. not in the side or lateral chains

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к реакционноспособным полимерам и сополимерам на основе N-(2-гидроксипропил)метакриламида, содержащих реакционноспособные тиазолидин-2-тионовые группы в боковых цепях или на концах полимерных цепей. Изобретение также относится к способу их получения и их применению для синтеза полимерных лекарственных средств и конъюгатов с белками и получения систем доставки генов.
EA200600259A 2003-07-16 2004-07-15 Реакционноспособные полимеры и сополимеры на основе n-(2-гидроксипропил)метакриламида, способ их получения и их применение для синтеза полимерных лекарственных средств, для модификации биологически активных белков и получения систем доставки генов EA200600259A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20031950A CZ294996B6 (cs) 2003-07-16 2003-07-16 Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů
PCT/IB2004/052127 WO2005007798A2 (en) 2003-07-16 2004-07-15 Hydroxypropyl methacrylamide polymers and copolymers comprising reactive thiazoline-2-thione

Publications (1)

Publication Number Publication Date
EA200600259A1 true EA200600259A1 (ru) 2006-08-25

Family

ID=34070025

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600259A EA200600259A1 (ru) 2003-07-16 2004-07-15 Реакционноспособные полимеры и сополимеры на основе n-(2-гидроксипропил)метакриламида, способ их получения и их применение для синтеза полимерных лекарственных средств, для модификации биологически активных белков и получения систем доставки генов

Country Status (5)

Country Link
US (1) US20060275250A1 (ru)
CA (1) CA2533199A1 (ru)
CZ (1) CZ294996B6 (ru)
EA (1) EA200600259A1 (ru)
WO (1) WO2005007798A2 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2005558A3 (cs) * 2005-09-05 2007-04-04 Zentiva, A. S. Zpusob prípravy polymerních konjugátu doxorubicinu s pH-rízeným uvolnováním léciva
CZ298945B6 (cs) * 2006-09-18 2008-03-19 Zentiva, A. S. Polymerní lécivo a zpusob jeho výroby
US8017141B2 (en) 2006-12-15 2011-09-13 Advanced Cardiovascular Systems, Inc. Coatings of acrylamide-based copolymers
BRPI0823363A2 (pt) * 2008-12-11 2015-06-16 Psioxus Therapeutics Ltd Modificação de ácido nucleico com polímeros compreendendo grupos amino quaternário carregados .
EP2210616A1 (en) 2009-01-21 2010-07-28 Centre National de la Recherche Scientifique Multifunctional stealth nanoparticles for biomedical use
GB0907989D0 (en) 2009-05-08 2009-06-24 Hybrid Systems Ltd Multivalent adjuvant display
TW201722994A (zh) 2013-08-13 2017-07-01 賽諾菲公司 胞漿素原活化素抑制劑-１（ｐａｉ-１）之抗體及其用途
CZ308742B6 (cs) * 2015-01-14 2021-04-21 Ústav Organické Chemie A Biochemie Av Čr, V.V.I. Makromolekulární konjugáty pro izolaci, imobilizaci a vizualizaci proteinů
CZ308807B6 (cs) * 2015-01-14 2021-06-02 Ústav Organické Chemie A Biochemie Av Čr, V.V.I. Makromolekulární konjugáty pro vizualizaci a separaci proteinů a buněk
WO2018071767A1 (en) * 2016-10-14 2018-04-19 University Of Utah Research Foundation Antibody-polymer-drug conjugates
CZ2022167A3 (cs) * 2022-04-22 2023-11-01 Ústav makromolekulární chemie AV ČR, v. v. i. Polymerní konjugát pro blokování nespecifických interakcí v imunochemických stanoveních, způsob jeho výroby a jeho použití

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9623051D0 (en) * 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
AU1825299A (en) * 1997-12-17 1999-07-05 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
DE60233315D1 (de) * 2001-03-23 2009-09-24 Enzon Inc Prodrugs von krebsmitteln mit substituierten aromatischen säuren
CZ293787B6 (cs) * 2001-12-20 2004-07-14 Zentiva, A.S. pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii
US7122189B2 (en) * 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers

Also Published As

Publication number Publication date
WO2005007798A3 (en) 2006-04-06
US20060275250A1 (en) 2006-12-07
CZ20031950A3 (cs) 2005-02-16
CZ294996B6 (cs) 2005-04-13
WO2005007798A2 (en) 2005-01-27
CA2533199A1 (en) 2005-01-27

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