MY109649A - Bicyclopol yazamacrocyclocarboxylic acid complexes, and conjugates, processes for their prepration, and use as contrast agents
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Bicyclopol yazamacrocyclocarboxylic acid complexes, and conjugates, processes for their prepration, and use as contrast agents
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Application filed by Dow Chemical CofiledCriticalDow Chemical Co
Priority to MYPI92002316ApriorityCriticalpatent/MY109649A/en
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Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Abstract
COMPLEXES OF BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID WITH GD, MN OF FE IONS ARE DISCLOSED. THE COMPLEXES CAN BE COVALENTLY ATTACHED TO A BIOLOGICALLY ACTIVE MOLECULE, E.G. AN ANTIBODY OR ANTIBODY FRAGMENT, TO FORM CONJUGATES. THE COMPLEXES AND CONJUGATES ARE USEFUL AS CONTRAST AGENTS FOR DIAGNOSTIC PURPOSES. PROCESSES FOR PREPARING BOTH THE COMPLEX AND CONJUGATE ARE DISCLOSED.
MYPI92002316A1992-12-161992-12-16Bicyclopol yazamacrocyclocarboxylic acid complexes, and conjugates, processes for their prepration, and use as contrast agents
MY109649A
(en)
Process for production of celates and their complexes containing ortolizating functional groups, compositions containing such active substances and process for production of conjugates consisting of one complex and linked to it antibody or fragment of antibody