NO954442L - Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and methods for their preparation - Google Patents

Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and methods for their preparation

Info

Publication number
NO954442L
NO954442L NO954442A NO954442A NO954442L NO 954442 L NO954442 L NO 954442L NO 954442 A NO954442 A NO 954442A NO 954442 A NO954442 A NO 954442A NO 954442 L NO954442 L NO 954442L
Authority
NO
Norway
Prior art keywords
complexes
conjugates
methods
contrast agents
preparation
Prior art date
Application number
NO954442A
Other languages
Norwegian (no)
Other versions
NO954442D0 (en
Inventor
Garry E Kiefer
Jaime Simon
Joseph R Garlich
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of NO954442D0 publication Critical patent/NO954442D0/en
Publication of NO954442L publication Critical patent/NO954442L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Det beskrives bicyklopolyazamakrocyklofosfonsyre- forbindelser som kan danne inerte komplekser med Gd-, Mn- eller Fe-ioner. Kompleksets totalladning kan varieres for å endre in vivo biolokaliseringen. Slike komplekser kan bindes kovalent til et antistoff, antistoff-fragment eller et annet biologisk aktivt molekyl, for å danne konjugater. Kompleksene og konjugatene kan benyttes som kontrastmidler for diagnostiske formål. Fremgangsmåter for fremstilling av ligander, komplekser og konjugater er også beskrevet.Bicyclopolyazamacrocyclophosphonic acid compounds are described which can form inert complexes with Gd, Mn or Fe ions. The total charge of the complex can be varied to alter in vivo biolocation. Such complexes can be covalently bound to an antibody, antibody fragment, or other biologically active molecule to form conjugates. The complexes and conjugates can be used as contrast agents for diagnostic purposes. Methods for preparing ligands, complexes and conjugates are also described.

NO954442A 1993-05-06 1995-11-06 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and methods for their preparation NO954442L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1993/004325 WO1994026754A1 (en) 1993-05-06 1993-05-06 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation

Publications (2)

Publication Number Publication Date
NO954442D0 NO954442D0 (en) 1995-11-06
NO954442L true NO954442L (en) 1996-01-05

Family

ID=22236574

Family Applications (2)

Application Number Title Priority Date Filing Date
NO932823A NO304985B1 (en) 1993-05-06 1993-08-09 Bicyclopolyazamacrocyclophosphonic acids, their complexes and pharmaceutical formulation
NO954442A NO954442L (en) 1993-05-06 1995-11-06 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and methods for their preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO932823A NO304985B1 (en) 1993-05-06 1993-08-09 Bicyclopolyazamacrocyclophosphonic acids, their complexes and pharmaceutical formulation

Country Status (8)

Country Link
EP (1) EP0696290A1 (en)
JP (1) JPH08509976A (en)
KR (2) KR960702470A (en)
AU (1) AU665689B2 (en)
FI (2) FI933507A (en)
NO (2) NO304985B1 (en)
NZ (1) NZ252554A (en)
WO (1) WO1994026754A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
EP0817787A4 (en) * 1995-03-27 2000-09-13 Isis Pharmaceuticals Inc Nitrogenous macrocyclic compounds
CA2251924C (en) * 1996-04-19 2006-05-30 The Dow Chemical Company Fluorescent chelates as visual tissue specific imaging agents
US6005083A (en) * 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
CN106518896A (en) * 2016-10-27 2017-03-22 南京大学 A zinc-tetraazatricyclo complex, a preparing method thereof and applications of the complex in antitumor drugs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636632B1 (en) * 1988-09-16 1996-02-02 Oris Ind RADIOPHARMACEUTICAL PRODUCTS CONSTITUTED BY TC COMPLEXES, RE OR INCLUDING LETTERS WITH TETRAPHOSPHONATES AND THEIR PREPARATION
FR2644785B1 (en) * 1989-03-24 1991-07-05 Guerbet Sa NOVEL NITROGEN MACROCYCLIC LIGANDS, PROCESS FOR THEIR PREPARATION, METAL COMPLEXES FORMED BY SUCH LIGANDS AND DIAGNOSTIC COMPOSITION CONTAINING THEM
EP0511275A1 (en) * 1990-01-19 1992-11-04 Nycomed Imaging As Chelating compounds
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
SG46598A1 (en) * 1991-12-10 1998-02-20 Dow Chemical Co Bicycloazamacroyclophosphonic acid conjugates contrast agents and preparation

Also Published As

Publication number Publication date
JPH08509976A (en) 1996-10-22
EP0696290A1 (en) 1996-02-14
WO1994026754A1 (en) 1994-11-24
FI933507A (en) 1994-11-07
NO304985B1 (en) 1999-03-15
NO954442D0 (en) 1995-11-06
FI955335A0 (en) 1995-11-06
NO932823D0 (en) 1993-08-09
AU665689B2 (en) 1996-01-11
NZ252554A (en) 1998-01-26
FI933507A0 (en) 1993-08-09
KR950700916A (en) 1995-02-20
NO932823L (en) 1993-10-08
AU4238293A (en) 1994-12-12
KR960702470A (en) 1996-04-27

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