FI933507A0 - BICYCLOPOLYAZAMAKROCYKLOFOSFONSYROR, KOMPLEX OCH KONJUGAT DAERAV ATT ANVAENDAS SOM KONTRASTMEDEL OCH FOERFARANDE FOER DERAS FRAMSTAELLNING - Google Patents

BICYCLOPOLYAZAMAKROCYKLOFOSFONSYROR, KOMPLEX OCH KONJUGAT DAERAV ATT ANVAENDAS SOM KONTRASTMEDEL OCH FOERFARANDE FOER DERAS FRAMSTAELLNING

Info

Publication number
FI933507A0
FI933507A0 FI933507A FI933507A FI933507A0 FI 933507 A0 FI933507 A0 FI 933507A0 FI 933507 A FI933507 A FI 933507A FI 933507 A FI933507 A FI 933507A FI 933507 A0 FI933507 A0 FI 933507A0
Authority
FI
Finland
Prior art keywords
och
kontrastmedel
bicyclopolyazamakrocyklofosfonsyror
konjugat
daerav
Prior art date
Application number
FI933507A
Other languages
Finnish (fi)
Other versions
FI933507A (en
Inventor
Garry E Kiefer
Jaime Simon
Joseph R Garlich
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of FI933507A0 publication Critical patent/FI933507A0/en
Publication of FI933507A publication Critical patent/FI933507A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FI933507A 1993-05-06 1993-08-09 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates for use as contrast agents and process for their preparation FI933507A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1993/004325 WO1994026754A1 (en) 1993-05-06 1993-05-06 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation

Publications (2)

Publication Number Publication Date
FI933507A0 true FI933507A0 (en) 1993-08-09
FI933507A FI933507A (en) 1994-11-07

Family

ID=22236574

Family Applications (2)

Application Number Title Priority Date Filing Date
FI933507A FI933507A (en) 1993-05-06 1993-08-09 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates for use as contrast agents and process for their preparation
FI955335A FI955335A0 (en) 1993-05-06 1995-11-06 Bicyclopolyazamacrocyclophosphonium complex, complex and conjugate form

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI955335A FI955335A0 (en) 1993-05-06 1995-11-06 Bicyclopolyazamacrocyclophosphonium complex, complex and conjugate form

Country Status (8)

Country Link
EP (1) EP0696290A1 (en)
JP (1) JPH08509976A (en)
KR (2) KR960702470A (en)
AU (1) AU665689B2 (en)
FI (2) FI933507A (en)
NO (2) NO304985B1 (en)
NZ (1) NZ252554A (en)
WO (1) WO1994026754A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
JPH10508036A (en) * 1995-03-27 1998-08-04 アイシス・ファーマシューティカルス・インコーポレーテッド Nitrogen-containing macrocyclic compounds
ATE254129T1 (en) * 1996-04-19 2003-11-15 Dow Global Technologies Inc FLUORESCENT CHELATES AS TISSUE-SPECIFIC IMAGING AGENTS
US6005083A (en) * 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
CN106518896A (en) * 2016-10-27 2017-03-22 南京大学 A zinc-tetraazatricyclo complex, a preparing method thereof and applications of the complex in antitumor drugs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636632B1 (en) * 1988-09-16 1996-02-02 Oris Ind RADIOPHARMACEUTICAL PRODUCTS CONSTITUTED BY TC COMPLEXES, RE OR INCLUDING LETTERS WITH TETRAPHOSPHONATES AND THEIR PREPARATION
FR2644785B1 (en) * 1989-03-24 1991-07-05 Guerbet Sa NOVEL NITROGEN MACROCYCLIC LIGANDS, PROCESS FOR THEIR PREPARATION, METAL COMPLEXES FORMED BY SUCH LIGANDS AND DIAGNOSTIC COMPOSITION CONTAINING THEM
WO1991010669A1 (en) * 1990-01-19 1991-07-25 Cockbain, Julian, Roderick, Michaelson Chelating compounds
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
ZA929576B (en) * 1991-12-10 1994-06-10 Dow Chemical Co Bicyclopolyazamacrocyclophosphonic acids their complexes and conjugates for use as contrast agents and processes for their preparation

Also Published As

Publication number Publication date
NO932823D0 (en) 1993-08-09
NO932823L (en) 1993-10-08
AU4238293A (en) 1994-12-12
NO304985B1 (en) 1999-03-15
NO954442D0 (en) 1995-11-06
FI955335A0 (en) 1995-11-06
KR950700916A (en) 1995-02-20
NO954442L (en) 1996-01-05
KR960702470A (en) 1996-04-27
NZ252554A (en) 1998-01-26
WO1994026754A1 (en) 1994-11-24
JPH08509976A (en) 1996-10-22
FI933507A (en) 1994-11-07
EP0696290A1 (en) 1996-02-14
AU665689B2 (en) 1996-01-11

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