FI955335A0 - Bicyclopolyazamacrocyclophosphonium complex, complex and conjugate form - Google Patents

Bicyclopolyazamacrocyclophosphonium complex, complex and conjugate form

Info

Publication number
FI955335A0
FI955335A0 FI955335A FI955335A FI955335A0 FI 955335 A0 FI955335 A0 FI 955335A0 FI 955335 A FI955335 A FI 955335A FI 955335 A FI955335 A FI 955335A FI 955335 A0 FI955335 A0 FI 955335A0
Authority
FI
Finland
Prior art keywords
complex
bicyclopolyazamacrocyclophosphonium
conjugate form
conjugate
bicyclopolyazamacrocyclophosphonium complex
Prior art date
Application number
FI955335A
Other languages
Finnish (fi)
Inventor
Garry E Kiefer
Jaime Simon
Joseph R Garlich
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of FI955335A0 publication Critical patent/FI955335A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FI955335A 1993-05-06 1995-11-06 Bicyclopolyazamacrocyclophosphonium complex, complex and conjugate form FI955335A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1993/004325 WO1994026754A1 (en) 1993-05-06 1993-05-06 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation

Publications (1)

Publication Number Publication Date
FI955335A0 true FI955335A0 (en) 1995-11-06

Family

ID=22236574

Family Applications (2)

Application Number Title Priority Date Filing Date
FI933507A FI933507A (en) 1993-05-06 1993-08-09 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates for use as contrast agents and process for their preparation
FI955335A FI955335A0 (en) 1993-05-06 1995-11-06 Bicyclopolyazamacrocyclophosphonium complex, complex and conjugate form

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI933507A FI933507A (en) 1993-05-06 1993-08-09 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates for use as contrast agents and process for their preparation

Country Status (8)

Country Link
EP (1) EP0696290A1 (en)
JP (1) JPH08509976A (en)
KR (2) KR960702470A (en)
AU (1) AU665689B2 (en)
FI (2) FI933507A (en)
NO (2) NO304985B1 (en)
NZ (1) NZ252554A (en)
WO (1) WO1994026754A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
US6107482A (en) 1995-03-27 2000-08-22 Isis Pharmaceuticals, Inc. Nitrogenous macrocyclic compounds
CA2251924C (en) * 1996-04-19 2006-05-30 The Dow Chemical Company Fluorescent chelates as visual tissue specific imaging agents
US6005083A (en) * 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
CN106518896A (en) * 2016-10-27 2017-03-22 南京大学 A zinc-tetraazatricyclo complex, a preparing method thereof and applications of the complex in antitumor drugs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636632B1 (en) * 1988-09-16 1996-02-02 Oris Ind RADIOPHARMACEUTICAL PRODUCTS CONSTITUTED BY TC COMPLEXES, RE OR INCLUDING LETTERS WITH TETRAPHOSPHONATES AND THEIR PREPARATION
FR2644785B1 (en) * 1989-03-24 1991-07-05 Guerbet Sa NOVEL NITROGEN MACROCYCLIC LIGANDS, PROCESS FOR THEIR PREPARATION, METAL COMPLEXES FORMED BY SUCH LIGANDS AND DIAGNOSTIC COMPOSITION CONTAINING THEM
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
JP3131219B2 (en) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト Chelate compounds
AU3246893A (en) * 1991-12-10 1993-07-19 Dow Chemical Company, The Bicycloazamacrocyclophosphonic acid, conjugates, contrast agents and preparation

Also Published As

Publication number Publication date
NZ252554A (en) 1998-01-26
AU665689B2 (en) 1996-01-11
AU4238293A (en) 1994-12-12
WO1994026754A1 (en) 1994-11-24
NO954442D0 (en) 1995-11-06
JPH08509976A (en) 1996-10-22
NO932823L (en) 1993-10-08
FI933507A0 (en) 1993-08-09
NO954442L (en) 1996-01-05
KR950700916A (en) 1995-02-20
KR960702470A (en) 1996-04-27
NO932823D0 (en) 1993-08-09
EP0696290A1 (en) 1996-02-14
NO304985B1 (en) 1999-03-15
FI933507A (en) 1994-11-07

Similar Documents

Publication Publication Date Title
FI943570A (en) 1-Benzenesulfonyl-1,3-dihydroindole-2-undivate, their preparation and drugs containing them
FI954980A (en) Joints, joints and joints, which comprise the joints
DE69103503D1 (en) Adriamycin derivatives.
FI945662A0 (en) Roerformad stomme, i synnerhet som sleselement och med medselselement foersedd stomme
FI963183A (en) Aqueous dispersion composition, and composition using the same
FI923558A (en) TETRAHYDROINDAZOLE, TETRAHYDROCYCLOPENTAPYRAZOLE- OCH HEXAHYDROCYKLOHEPTAPYRAZOLFOERENINGAR OCH DERAS ANVAENDNING SOM INHIBITORER AV HMG-COA-REDUCTAS
FI923756A0 (en) POLYOLEFINKOMPOSITIONER SOM OMFATTAR GLYCEROLMONOESTRAR AV C20-24-FETTSYROR OCH DAERAV FRAMSTAELLDA SKUMPRODUKTER.
FI941307A0 (en) Tjulvalarm, som activeras fo foemaolets, som skall skyddas, roerelse
FI955679A (en) Piperidine derivatives, preparation and use thereof
FI955335A0 (en) Bicyclopolyazamacrocyclophosphonium complex, complex and conjugate form
FI915609A (en) FOERFARANDE OCH ANORDNING FOER STYRNING AV EN M-PULSVAEXELRIKTARANORDNING SOM BESTAOR AV EN MASTERVAEXELRIKTARE OCH AOTMINSTONE EN SLAVVAEXELRIKTARE.
FI911720A (en) ANMAENDNING AV MACROCYCLISKA FOERENINGAR SOM KOMPONENTER FOER FERROELEKTRISKA VAETSKEKRISTALLBLANDNINGAR.
FI912287A0 (en) ANVAENDNING AV HEMINNEHAOLLANDE PROTEINER SOM STABILISATORER FOER ENZYMMAERKTA IMMUNREAKTANTER.
FI933506A0 (en) BICYCLOPOLYAZAMAKROCYKLOKARBOXYLSYRAKOMPLEX, CONJUGATED DAERAV, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH ANVAENDNING SOM KONTRASTMEDEL
FI933099A0 (en) FOERPACKNING, SOM LAETT KAN OEPPNAS
FI932549A0 (en) Haollfast, enhetligt, plastbaserat kompositmaterial och foerfaranden foerframstaellning daerav
TR28056A (en) Reactive dyes, their preparation and uses.
FI904251A0 (en) FOERFARANDE OCH ANORDNING FOER AVLAEGSNANDE AV AEMNEN FRAON GAS SOM FLOEDAR UNDER LAOGT TRYCK.
FI950352A0 (en) Vaermeisolerad takkonstruktion, foerfarande Foer vaermeisolering av takkonstruktionen and dhkonstruktion av vaermeisoleringsskivor
FI940053A0 (en) Vaeggstock, stockvaegg and foerfarande Foer framstaellning av vaeggstockar
FIU930425U0 (en) Anordningar Foer utfoerand verok av en skyddsteckning, saerskiltfoer foerebyggande och avsloejande av bilstoelder
FI935806A0 (en) Foerfarande Foer samling av avfall, avfallsamlingssystem och lastningsanordning
FI932243A0 (en) Foerfarande Foer toemning av en Transportvagn, och Transportvagn
FI650U1 (en) Byggnad som omfattar flera vaoningar och som bestaor av moduler
FI651U1 (en) Byggnad som omfattar flera vaoningar och som bestaor av moduler