FI955335A0 - Bicyklopolyazamakrocyklofosfonsyror, komplex och konjugat daerav foer anvaendning som kontrastmedel och foerfarande foer framstaellning av dessa - Google Patents

Bicyklopolyazamakrocyklofosfonsyror, komplex och konjugat daerav foer anvaendning som kontrastmedel och foerfarande foer framstaellning av dessa

Info

Publication number
FI955335A0
FI955335A0 FI955335A FI955335A FI955335A0 FI 955335 A0 FI955335 A0 FI 955335A0 FI 955335 A FI955335 A FI 955335A FI 955335 A FI955335 A FI 955335A FI 955335 A0 FI955335 A0 FI 955335A0
Authority
FI
Finland
Prior art keywords
complex
bicyclopolyazamacrocyclophosphonium
conjugate form
conjugate
bicyclopolyazamacrocyclophosphonium complex
Prior art date
Application number
FI955335A
Other languages
English (en)
Inventor
Garry E Kiefer
Jaime Simon
Joseph R Garlich
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of FI955335A0 publication Critical patent/FI955335A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FI955335A 1993-05-06 1995-11-06 Bicyklopolyazamakrocyklofosfonsyror, komplex och konjugat daerav foer anvaendning som kontrastmedel och foerfarande foer framstaellning av dessa FI955335A0 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1993/004325 WO1994026754A1 (en) 1993-05-06 1993-05-06 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation

Publications (1)

Publication Number Publication Date
FI955335A0 true FI955335A0 (fi) 1995-11-06

Family

ID=22236574

Family Applications (2)

Application Number Title Priority Date Filing Date
FI933507A FI933507A (fi) 1993-05-06 1993-08-09 Bisyklopolyatsamakrosyklofosfonihappoja, niiden komplekseja ja konjugaatteja käytettäväksi varjoaineina ja menetelmä niiden valmistamiseksi
FI955335A FI955335A0 (fi) 1993-05-06 1995-11-06 Bicyklopolyazamakrocyklofosfonsyror, komplex och konjugat daerav foer anvaendning som kontrastmedel och foerfarande foer framstaellning av dessa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI933507A FI933507A (fi) 1993-05-06 1993-08-09 Bisyklopolyatsamakrosyklofosfonihappoja, niiden komplekseja ja konjugaatteja käytettäväksi varjoaineina ja menetelmä niiden valmistamiseksi

Country Status (8)

Country Link
EP (1) EP0696290A1 (fi)
JP (1) JPH08509976A (fi)
KR (2) KR960702470A (fi)
AU (1) AU665689B2 (fi)
FI (2) FI933507A (fi)
NO (2) NO304985B1 (fi)
NZ (1) NZ252554A (fi)
WO (1) WO1994026754A1 (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
EP0817787A4 (en) * 1995-03-27 2000-09-13 Isis Pharmaceuticals Inc NITROGEN MACROCYCLIC COMPOUNDS
CA2251924C (en) * 1996-04-19 2006-05-30 The Dow Chemical Company Fluorescent chelates as visual tissue specific imaging agents
US6005083A (en) * 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
CN106518896A (zh) * 2016-10-27 2017-03-22 南京大学 锌‑四氮环配合物及其制备方法和在抗肿瘤药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636632B1 (fr) * 1988-09-16 1996-02-02 Oris Ind Produits radiopharmaceutiques constitues par des complexes de tc, re ou y comportant des ligands tetraphosphonates et leur preparation
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
EP0511275A1 (en) * 1990-01-19 1992-11-04 Nycomed Imaging As Chelating compounds
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
SG46598A1 (en) * 1991-12-10 1998-02-20 Dow Chemical Co Bicycloazamacroyclophosphonic acid conjugates contrast agents and preparation

Also Published As

Publication number Publication date
JPH08509976A (ja) 1996-10-22
EP0696290A1 (en) 1996-02-14
WO1994026754A1 (en) 1994-11-24
FI933507A (fi) 1994-11-07
NO304985B1 (no) 1999-03-15
NO954442D0 (no) 1995-11-06
NO932823D0 (no) 1993-08-09
AU665689B2 (en) 1996-01-11
NZ252554A (en) 1998-01-26
FI933507A0 (fi) 1993-08-09
KR950700916A (ko) 1995-02-20
NO932823L (no) 1993-10-08
NO954442L (no) 1996-01-05
AU4238293A (en) 1994-12-12
KR960702470A (ko) 1996-04-27

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