KR950700916A - 비사이클로폴리아자매크로사이클로포스폰산, 그의 착체 및 결합체, 조영제로서의 그의 용도 및 그의 제조방법 - Google Patents
비사이클로폴리아자매크로사이클로포스폰산, 그의 착체 및 결합체, 조영제로서의 그의 용도 및 그의 제조방법Info
- Publication number
- KR950700916A KR950700916A KR1019930702371A KR930702371A KR950700916A KR 950700916 A KR950700916 A KR 950700916A KR 1019930702371 A KR1019930702371 A KR 1019930702371A KR 930702371 A KR930702371 A KR 930702371A KR 950700916 A KR950700916 A KR 950700916A
- Authority
- KR
- South Korea
- Prior art keywords
- conjugate
- complex
- preparation
- contrast agent
- bicyclopolyazamacrocyclophosphonic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1993/004325 WO1994026754A1 (en) | 1993-05-06 | 1993-05-06 | Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
KR950700916A true KR950700916A (ko) | 1995-02-20 |
Family
ID=22236574
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950704946A KR960702470A (ko) | 1993-05-06 | 1993-05-06 | 콘트라스트제로서 사용하기 위한 비사이클로폴리아자매크로사이클로포스폰산, 그의 착체 및 복합제, 및 이들의 제조방법(bicyclopolyaza-macrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation) |
KR1019930702371A KR950700916A (ko) | 1993-05-06 | 1993-08-09 | 비사이클로폴리아자매크로사이클로포스폰산, 그의 착체 및 결합체, 조영제로서의 그의 용도 및 그의 제조방법 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950704946A KR960702470A (ko) | 1993-05-06 | 1993-05-06 | 콘트라스트제로서 사용하기 위한 비사이클로폴리아자매크로사이클로포스폰산, 그의 착체 및 복합제, 및 이들의 제조방법(bicyclopolyaza-macrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation) |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0696290A1 (ko) |
JP (1) | JPH08509976A (ko) |
KR (2) | KR960702470A (ko) |
AU (1) | AU665689B2 (ko) |
FI (2) | FI933507A (ko) |
NO (2) | NO304985B1 (ko) |
NZ (1) | NZ252554A (ko) |
WO (1) | WO1994026754A1 (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6207826B1 (en) | 1995-03-27 | 2001-03-27 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds having nitrogen-containing linkages |
US6107482A (en) | 1995-03-27 | 2000-08-22 | Isis Pharmaceuticals, Inc. | Nitrogenous macrocyclic compounds |
CA2251924C (en) * | 1996-04-19 | 2006-05-30 | The Dow Chemical Company | Fluorescent chelates as visual tissue specific imaging agents |
US6005083A (en) * | 1997-03-28 | 1999-12-21 | Neorx Corporation | Bridged aromatic substituted amine ligands with donor atoms |
US6776977B2 (en) | 2001-01-09 | 2004-08-17 | Bristol-Myers Squibb Pharma Company | Polypodal chelants for metallopharmaceuticals |
GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
CN106518896A (zh) * | 2016-10-27 | 2017-03-22 | 南京大学 | 锌‑四氮环配合物及其制备方法和在抗肿瘤药物中的应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2636632B1 (fr) * | 1988-09-16 | 1996-02-02 | Oris Ind | Produits radiopharmaceutiques constitues par des complexes de tc, re ou y comportant des ligands tetraphosphonates et leur preparation |
FR2644785B1 (fr) * | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
EP0511275A1 (en) * | 1990-01-19 | 1992-11-04 | Nycomed Imaging As | Chelating compounds |
GB9001245D0 (en) * | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
ZA929576B (en) * | 1991-12-10 | 1994-06-10 | Dow Chemical Co | Bicyclopolyazamacrocyclophosphonic acids their complexes and conjugates for use as contrast agents and processes for their preparation |
-
1993
- 1993-05-06 NZ NZ252554A patent/NZ252554A/en unknown
- 1993-05-06 WO PCT/US1993/004325 patent/WO1994026754A1/en not_active Application Discontinuation
- 1993-05-06 KR KR1019950704946A patent/KR960702470A/ko not_active Application Discontinuation
- 1993-05-06 AU AU42382/93A patent/AU665689B2/en not_active Ceased
- 1993-05-06 JP JP6525356A patent/JPH08509976A/ja active Pending
- 1993-05-06 EP EP93911136A patent/EP0696290A1/en not_active Withdrawn
- 1993-08-09 NO NO932823A patent/NO304985B1/no not_active IP Right Cessation
- 1993-08-09 KR KR1019930702371A patent/KR950700916A/ko not_active Application Discontinuation
- 1993-08-09 FI FI933507A patent/FI933507A/fi unknown
-
1995
- 1995-11-06 NO NO954442A patent/NO954442L/no unknown
- 1995-11-06 FI FI955335A patent/FI955335A0/fi unknown
Also Published As
Publication number | Publication date |
---|---|
AU665689B2 (en) | 1996-01-11 |
FI955335A0 (fi) | 1995-11-06 |
WO1994026754A1 (en) | 1994-11-24 |
JPH08509976A (ja) | 1996-10-22 |
NO932823L (no) | 1993-10-08 |
NO954442L (no) | 1996-01-05 |
FI933507A (fi) | 1994-11-07 |
KR960702470A (ko) | 1996-04-27 |
NZ252554A (en) | 1998-01-26 |
NO932823D0 (no) | 1993-08-09 |
AU4238293A (en) | 1994-12-12 |
FI933507A0 (fi) | 1993-08-09 |
NO954442D0 (no) | 1995-11-06 |
NO304985B1 (no) | 1999-03-15 |
EP0696290A1 (en) | 1996-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |